Three‐dimensional structure, ground rupture hazards, and static stress models for complex non‐planar thrust faults in the Ventura basin, southern California

To investigate the subsurface geometry of a recently discovered, seismically‐active fault in the Ventura basin, southern California, USA, we present a series of cross sections and a new three‐dimensional fault model across the Southern San Cayetano fault (SSCF) based on integration of surface data with petroleum industry well‐log data. Additionally, the fault model for the SSCF, along with models of other regional faults extracted from the Southern California Earthquake Center three‐dimensional Community Fault Model, are incorporated in static Coulomb stress modeling to investigate static Coulomb stress transfer between thrust faults with complex geometry and to further our understanding of stress transfer in the Ventura basin. The results of the subsurface well investigation provide evidence for a low‐angle SSCF that dips ~15° north and connects with the western section of the San Cayetano fault around 1.5–3.5 km depth. We interpret the results of static Coulomb stress models to partly explain contrasting geomorphic expression between different sections of the San Cayetano fault and a potential mismatch in timings between large‐magnitude uplift events suggested by paleoseismic studies on the Pitas Point, Ventura, and San Cayetano faults. In addition to new insights into the structure and potential rupture hazard of a recently discovered active reverse fault in a highly populated area of southern California, this study provides a simple method to model static Coulomb stress transfer on complex geometry faults in fold and thrust belts

Tectonic controls on Quaternary landscape evolution in the Ventura basin, southern California, quantified using cosmogenic isotopes and topographic analyses

The quantification of rates for the competing forces of tectonic uplift and erosion has important implications for understanding topographic evolution. Here, we quantify the complex interplay between tectonic uplift, topographic development, and erosion recorded in the hanging walls of several active reverse faults in the Ventura basin, southern California, USA. We use cosmogenic 26Al/10Be isochron burial dating and 10Be surface exposure dating to construct a basin-wide geochronology, which includes burial dating of the Saugus Formation: an important, but poorly dated, regional Quaternary strain marker. Our ages for the top of the exposed Saugus Formation range from 0.36 +0.18/-0.22 Ma to 1.06 +0.23/-0.26 Ma and our burial ages near the base of shallow marine deposits, which underlie the Saugus Formation, increase eastwards from 0.55 +0.08/-0.07 Ma to 3.30 +0.30/-0.42 Ma. Our geochronology is used the calculate a rapid long-term fault throw rate of 4.7–6.3 mm yr-1 since ~1.5 Ma for the San Cayetano fault and a slip rate of 1.3–3.0 mm yr-1 since ~1.5 Ma for the Oak Ridge fault, both of which agree with contemporary reverse slip rates derived from GPS data. We also calculate total cosmogenic nuclide (TCN)-derived catchment-averaged erosion rates that range from 0.18–2.21mm yr-1 and discuss the applicability of TCN-derived catchment-averaged erosion rates in rapidly-uplifting, landslide-prone landscapes. We compare patterns in erosion rates and tectonic rates to fluvial response times and geomorphic landscape parameters to show that in young, rapidly-uplifting mountain belts, catchments may attain a quasi-steady state on timescales <105 years, even if catchment-averaged erosion rates are still 34 adjusting to tectonic forcing

Geomorphic evidence for the geometry and slip rate of a young, low-angle thrust fault: Implications for hazard assessment and fault interaction in complex tectonic environments

We present surface evidence and displacement rates for a young, active, low-angle (∼20°) reverse thrust fault in close proximity to major population centers in southern California (USA), the Southern San Cayetano fault (SSCF). Active faulting along the northern flank of the Santa Clara River Valley displaces young landforms, such as late Quaternary river terraces and alluvial fans. Geomorphic strain markers are examined using field mapping, high-resolution lidar topographic data, 10Be surface exposure dating, and subsurface well data to provide evidence for a young, active SSCF along the northern flank of the Santa Clara River Valley. Displacement rates for the SSCF are calculated over 103–104 yr timescales with maximum slip rates for the central SSCF of 1.9[Formula presented] mm yr−1 between ∼19–7 ka and minimum slip rates of 1.3[Formula presented] mm yr−1 since ∼7 ka. Uplift rates for the central SSCF have not varied significantly over the last ∼58 ka, with a maximum value of 1.7[Formula presented] mm yr−1 for the interval ∼58–19 ka, and a minimum value of 1.2±0.3 mm yr−1 since ∼7 ka. The SSCF is interpreted as a young, active structure with onset of activity at some time after ∼58 ka. The geometry for the SSCF presented here, with a ∼20° north dip in the subsurface, is the first interpretation of the SSCF based on geological field data. Our new interpretation is significantly different from the previously proposed model-derived geometry, which dips more steeply at 45–60° and intersects the surface in the middle of the Santa Clara River Valley. We suggest that the SSCF may rupture in tandem with the main San Cayetano fault. Additionally, the SSCF could potentially act as a rupture pathway between the Ventura and San Cayetano faults in large-magnitude, multi-fault earthquakes in southern California. However, given structural complexities, including significant changes in dip and varying Holocene displacement rates along strike, further work is required to examine the possible mechanism, likelihood, and frequency of potential through-going ruptures between the Ventura and San Cayetano faults. Confirmation of the SSCF in a previously well-studied area, such as southern California, demonstrates that identification of young faults is critical for accurate seismic hazard assessment. We suggest that many young, active faults remain undetected in other structurally complex and tectonically active regions globally, and that significant seismic hazards can be overlooked

Methylated SEPTIN9 plasma test for colorectal cancer detection may be applicable to Lynch syndrome.

ObjectiveThe plasma-based methylated SEPTIN9 (mSEPT9) is a colorectal cancer (CRC) screening test for adults aged 50-75 years who are at average risk for CRC and have refused colonoscopy or faecal-based screening tests. The applicability of mSEPT9 for high-risk persons with Lynch syndrome (LS), the most common hereditary CRC condition, has not been assessed. This study sought preliminary evidence for the utility of mSEPT9 for CRC detection in LS.DesignFirstly, SEPT9 methylation was measured in LS-associated CRC, advanced adenoma, and subject-matched normal colorectal mucosa tissues by pyrosequencing. Secondly, to detect mSEPT9 as circulating tumor DNA, the plasma-based mSEPT9 test was retrospectively evaluated in LS subjects using the Epi proColon 2.0 CE assay adapted for 1mL plasma using the "1/1 algorithm". LS case groups included 20 peri-surgical cases with acolonoscopy-based diagnosis of CRC (stages I-IV), 13 post-surgical metastatic CRC, and 17 pre-diagnosis cases. The control group comprised 31 cancer-free LS subjects.ResultsDifferential hypermethylation was found in 97.3% (36/37) of primary CRC and 90.0% (18/20) of advanced adenomas, showing LS-associated neoplasia frequently produce the mSEPT9 biomarker. Sensitivity of plasma mSEPT9 to detect CRC was 70.0% (95% CI, 48%-88%)in cases with a colonoscopy-based CRC diagnosis and 92.3% (95% CI, 64%-100%) inpost-surgical metastatic cases. In pre-diagnosis cases, plasma mSEPT9 was detected within two months prior to colonoscopy-based CRC diagnosis in 3/5 cases. Specificity in controls was 100% (95% CI 89%-100%).ConclusionThese preliminary findings suggest mSEPT9 may demonstrate similar diagnostic performance characteristics in LS as in the average-risk population, warranting a well-powered prospective case-control study