Genetic improvement technologies to support the sustainable growth of UK aquaculture

While the UK is the fourth largest aquaculture producer in Europe by volume, it is the second largest by value with an annual first sale value of around £1 billion. Over 90% of this value is from Atlantic salmon farmed in Scotland, but other finfish and shellfish aquaculture species are important to several UK regions. In this review, we describe the state of the art in UK aquaculture breeding and stock supply, and how innovation in genetics technologies can help achieve the Scottish Government’s ambitious target of doubling its aquaculture industry by 2030. Particular attention is given to the four most important UK aquaculture species: Atlantic salmon, rainbow trout, blue mussel and Pacific oyster, and we contrast the highly variable level of selective breeding and genomics technologies used in these sectors. A major factor in the success of Atlantic salmon farming has been large‐scale investment in modern breeding programmes, including family selection programmes and genomic selection. This has proven cost‐effective at scale, leading to improved production efficiency and reduction of some infectious diseases. We discuss the feasibility of applying similar technologies to the UK shellfish sectors, to ensure consistent and robust spat supply and begin trait selection. Furthermore, we discuss species‐specific application of modern breeding technologies in a global context, and the future potential of genomics and genome editing technologies to improve commercially desirable traits. Increased adoption of modern breeding technologies will assist UK aquaculture industries to meet the challenges for sustainable expansion, and remain competitive in a global market

Development of Fecal Coliform TMDL Protocols for Bass and Cinder Creeks on Kiawah Island

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

Collaboration and modelling – tools for integration in the Motueka catchment, New Zealand

A conceptual model of integrated catchment management (ICM) is presented in which ICM is defined as a process to achieve both ecosystem resilience and community resilience. It requires not only biophysical knowledge developed by hydrologists and other environmental scientists, but an active partnership with catchment communities and stakeholders to break the ‘paradigm lock’ described by the UNESCO-HELP programme.This paper reports observations from ICM research in the Motueka HELP demonstration basin in the upper South Island of New Zealand. The Motueka occupies 2 170 km2 of land yet the river effects are felt on the seabed more than 50 km2 offshore, so the true ‘catchment’ is larger. A hydrologically temperate mountainous catchment with horticultural, agricultural, plantation forestry and conservation land uses, the Motueka also hosts an internationally recognised brown trout fishery. Land and water management issues driving ICM research include water allocation conflicts between instream and irrigation water uses, impacts on water quality of runoff from intensifying land uses, catchment impacts on coastal productivity and aquaculture, and how to manage catchment processes in an integrated way that addresses cumulative effects of development.Collaboration with catchment stakeholders can be viewed as having two primary purposes:• Building knowledge and commitment of resource users towards sustainable resource management (collaborative learning)• Stakeholder involvement in resource management itself (governance).Examples are presented of a Collaborative Learning Group on Sediment learning of their differing perspectives on fine sediment impacts, and a Catchment Landcare Group working with scientists to improve water quality in their river. Success factors for water user committees making decisions about water resource management include creating opportunities to communicate and build trust, share scientific knowledge on the issue, and willingness to compromise. Functioning catchment groups have potential to take on delegated governance responsibility for meeting agreed water quality and other community goals.Finally a scenario modelling framework IDEAS (Integrated Dynamic Environmental Assessment System) is presented, in which environmental indicators such as nutrient fluxes are simulated alongside socio-economic indicators such as job numbers and catchment GDP for a range of land and marine use options.Keywords: integrated catchment management (ICM), resilience, HELP, UNESCO, water governance, Landcare, scenario modelling, collaborative learning, water allocation, water user committees, catchment groups, watershed managemen

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

SPL7013 Gel (VivaGel®) is a microbicide in development for prevention of HIV and HSV. This clinical study assessed retention and duration of antiviral activity following vaginal administration of 3% SPL7013 Gel in healthy women. Participants received 5 single doses of product with ≥5 days between doses. A cervicovaginal fluid (CVF) sample was collected using a SoftCup™ pre-dose, and immediately, or 1, 3, 12 or 24 h post-dose. HIV-1 and HSV-2 antiviral activities of CVF samples were determined in cell culture assays. Antiviral activity in the presence of seminal plasma was also tested. Mass and concentration of SPL7013 in CVF samples was determined. Safety was assessed by reporting of adverse events. Statistical analysis was performed using the Wilcoxon signed-rank test with Bonferroni adjustment; p≤0.003 was significant. Eleven participants completed the study. Inhibition of HIV-1 and HSV-2 by pre-dose CVF samples was negligible. CVF samples obtained immediately after dosing almost completely inhibited (median, interquartile range) HIV-1 [96% (95,97)] and HSV-2 [86% (85,94)], and activity was maintained in all women at 3 h (HIV-1 [96% (95,98), p = 0.9]; HSV-2 [94% (91,97), p = 0.005]). At 24 h, >90% of initial HIV-1 and HSV-2 inhibition was maintained in 6/11 women. SPL7013 was recovered in CVF samples obtained at baseline (46% of 105 mg dose). At 3 and 24 h, 22 mg and 4 mg SPL7013, respectively, were recovered. More than 70% inhibition of HIV-1 and HSV-2 was observed if there was >0.5 mg SPL7013 in CVF samples. High levels of antiviral activity were retained in the presence of seminal plasma. VivaGel was well tolerated with no signs or symptoms of vaginal, vulvar or cervical irritation reported. Potent antiviral activity was observed against HIV-1 and HSV-2 immediately following vaginal administration of VivaGel, with activity maintained for at least 3 h post-dose. The data provide evidence of antiviral activity in a clinical setting, and suggest VivaGel could be administered up to 3 h before coitus

Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber

Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortunately, the process of remyelination often fails, particularly with ageing. Even when remyelination occurs, it is characterised by the regeneration of myelin sheaths that are abnormally thin and short. This imperfect remyelination is likely to have implications for the restoration of normal circuit function and possibly the optimal metabolic support of axons. Here we describe a larval zebrafish model of demyelination and remyelination. We employ a drug-inducible cell ablation system with which we can consistently ablate 2/3rds of oligodendrocytes in the larval zebrafish spinal cord. This leads to a concomitant demyelination of 2/3rds of axons in the spinal cord, and an innate immune response over the same time period. We find restoration of the normal number of oligodendrocytes and robust remyelination approximately two weeks after induction of cell ablation, whereby myelinated axon number is restored to control levels. Remarkably, we find that myelin sheaths of normal length and thickness are regenerated during this time. Interestingly, we find that axons grow significantly in caliber during this period of remyelination. This suggests the possibility that the active growth of axons may stimulate the regeneration of myelin sheaths of normal dimensions

‘Never waste a crisis’: a commentary on the COVID‐19 pandemic as a driver for innovation in maternity care

Abstract unavailable

The United Kingdom and the Netherlands maternity care responses to COVID-19: A comparative study

BackgroundThe national health care response to coronavirus (COVID-19) has varied between countries. The United Kingdom (UK) and the Netherlands (NL) have comparable maternity and neonatal care systems, and experienced similar numbers of COVID-19 infections, but had different organisational responses to the pandemic. Understanding why and how similarities and differences occurred in these two contexts could inform optimal care in normal circumstances, and during future crises.AimTo compare the UK and Dutch COVID-19 maternity and neonatal care responses in three key domains: choice of birthplace, companionship, and families in vulnerable situations.MethodA multi-method study, including documentary analysis of national organisation policy and guidance on COVID-19, and interviews with national and regional stakeholders.FindingsBoth countries had an infection control focus, with less emphasis on the impact of restrictions, especially for families in vulnerable situations. Differences included care providers’ fear of contracting COVID-19; the extent to which community- and personalised care was embedded in the care system before the pandemic; and how far multidisciplinary collaboration and service-user involvement were prioritised.ConclusionWe recommend that countries should 1) make a systematic plan for crisis decision-making before a serious event occurs, and that this must include authentic service-user involvement, multidisciplinary collaboration, and protection of staff wellbeing 2) integrate women’s and families’ values into the maternity and neonatal care system, ensuring equitable inclusion of the most vulnerable and 3) strengthen community provision to ensure system wide resilience to future shocks from pandemics, or other unexpected large-scale events

‘Never waste a crisis’: a commentary on the COVID‐19 pandemic as a driver for innovation in maternity care

Abstract unavailable

Evaluating seasonal soil water dynamics using a simple soil water balance model in northern Ghana

Soil water management is critical for sustainable crop production, particularly in drought-prone environments. A range of strategies can be used to address spatial (need to improve in-situ infiltration) and temporal (need to improve water holding capacity /storage) to increase soil water availability for crop water uptake and improved yield production and productivity. This paper presents the results from field studies of rainfall and run-off monitoring in rainfed maize-based cropping systems in northern Ghana. Rainfall was measured using rain gauges and run-off was estimated using run-off pits in selected fields plots. Long-term 20-year weather data were used in simulation experiments using a deterministic water balance model to represent smallholder rainfed maize crop system. The field studies in the three regions of northern Ghana resulted in the development of regression rainfall-runoff relationships with R2 in the range 0.75 to 0.97 for fields with/without in situ. Further, estimation of size of water conservation/storage structures could be designed based on long-term rainfall-runoff relations to increase timely crop water availability and reduce spatial losses of water through surface runoff