107 research outputs found
Historical embayed coastal evolution under a high energetic hydrodynamic event
The Portuguese coast of Estremadura (NW of Lisbon) is a present day cliff coast with narrow embayed beaches, most of them with estuaries of small catchment rivers. The case study covers 2100m coastline and an indentation ranging between 200m to 300m. The embayment is open to W and SW waves, but sheltered to NW dominant waves. The waves can reach 2,5m of significant height (Hs) during winter and storms (Hs>5m) are frequent. The research was developed in the framework of the FMI 5000 Project dealing with the evaluation of the balance between fluvial and marine influences, as well as the impact of extreme events.info:eu-repo/semantics/publishedVersio
Identification of differentially methylated CpG Sites in fibroblasts from Keloid Scars
As a part of an abnormal healing process of dermal injuries and irritation, keloid scars arise on the skin as benign fibroproliferative tumors. Although the etiology of keloid scarring remains unsettled, considerable recent evidence suggested that keloidogenesis may be driven by epigenetic changes, particularly, DNA methylation. Therefore, genome-wide scanning of methylated cytosine-phosphoguanine (CpG) sites in extracted DNA from 12 keloid scar fibroblasts (KF) and 12 control skin fibroblasts (CF) (six normal skin fibroblasts and six normotrophic fibroblasts) was conducted using the Illumina Human Methylation 450K BeadChip in two replicates for each sample. Comparing KF and CF used a Linear Models for Microarray Data (Limma) model revealed 100,000 differentially methylated (DM) CpG sites, 20,695 of which were found to be hypomethylated and 79,305 were hypermethylated. The top DM CpG sites were associated with TNKS2, FAM45B, LOC723972, GAS7, RHBDD2 and CAMKK1. Subsequently, the most functionally enriched genes with the top 100 DM CpG sites were significantly (p †0.05) associated with SH2 domain binding, regulation of transcription, DNA-templated, nucleus, positive regulation of protein targeting to mitochondrion, nucleoplasm, Swr1 complex, histone exchange, and cellular response to organic substance. In addition, NLK, CAMKK1, LPAR2, CASP1, and NHS showed to be the most common regulators in the signaling network analysis. Taken together, these findings shed light on the methylation status of keloids that could be implicated in the underlying mechanism of keloid scars formation and remission
A study of pseudoscalar states produced centrally in pp interactions at 450 GeV/c
A study has been made of pseudoscalar mesons produced centrally in pp
interactions. The results show that the eta and etaprime appear to have a
similar production mechanism which differs from that of the pi0. The production
properties of the eta and etaprime are not consistent with what is expected
from double Pomeron exchange. In addition the production mechanism for the eta
and etaprime is such that the production cross section are greatest when the
azimuthal angle between the pT vectors of the two protons is 90 degrees.Comment: 11 pages, Latex, 3 Figure
A study of the centrally produced phiphi system in pp interactions at 450 GeV/c
The reaction pp to pfps(K+K-K+K-) in which the K+K-K+K- system is centrally
produced has been studied at 450 GeV/c. Phi phi production has been found to
dominate this reaction and is compatible with being produced by double Pomeron
exchange. An angular analysis of the phi phi system favours JPC = 2++ and its
dPT dependence is similar to that observed for glueball candidates.Comment: 11 pages, Latex, 4 Figure
Citizen science in environmental and ecological sciences
Citizen science is an increasingly acknowledged approach applied in many scientific domains, and particularly within the environmental and ecological sciences, in which non-professional participants contribute to data collection to advance scientific research. We present contributory citizen science as a valuable method to scientists and practitioners within the environmental and ecological sciences, focusing on the full life cycle of citizen science practice, from design to implementation, evaluation and data management. We highlight key issues in citizen science and how to address them, such as participant engagement and retention, data quality assurance and bias correction, as well as ethical considerations regarding data sharing. We also provide a range of examples to illustrate the diversity of applications, from biodiversity research and land cover assessment to forest health monitoring and marine pollution. The aspects of reproducibility and data sharing are considered, placing citizen science within an encompassing open science perspective. Finally, we discuss its limitations and challenges and present an outlook for the application of citizen science in multiple science domains
Search for the Flavor-Changing Neutral Current Decay with the HERA-B Detector
We report on a search for the flavor-changing neutral current decay using events recorded with a dimuon trigger in
interactions of 920 GeV protons with nuclei by the HERA-B experiment. We find
no evidence for such decays and set a 90% confidence level upper limit on the
branching fraction .Comment: 17 pages, 4 figures (of which 1 double), paper to be submitted to
Physics Letters
Measurement of the J/Psi Production Cross Section in 920 GeV/c Fixed-Target Proton-Nucleus Interactions
The mid-rapidity (dsigma_(pN)/dy at y=0) and total sigma_(pN) production
cross sections of J/Psi mesons are measured in proton-nucleus interactions.
Data collected by the HERA-B experiment in interactions of 920 GeV/c protons
with carbon, titanium and tungsten targets are used for this analysis. The
J/Psi mesons are reconstructed by their decay into lepton pairs. The total
production cross section obtained is sigma_(pN)(J/Psi) = 663 +- 74 +- 46
nb/nucleon. In addition, our result is compared with previous measurements
A study of the centrally produced 4pi channel in pp interactions at 450 GeV/c
The reaction pp -> pf (pi+pi-pi+pi-) ps has been studied at 450 GeV/c in an
experiment designed to search for gluonic states. A spin analysis has been
performed and the dPT filter applied. In addition to the well known f1(1285)
there is evidence for two JPC=2-+ states called the eta2(1620) and eta2(1875)
and a broad scalar called the f0(2000). The production of these states as a
function of the dPT kinematical filter shows the behaviour expected for qqbar
states. In contrast, there is evidence for two states at 1.45 GeV and at 1.9
GeV which do not show the behaviour observed for qqbar states.Comment: 14 pages, Latex, 3 Figure
Behavioural activation produced by crh but not α-helical CRH (CRH-receptor antagonist) when microinfused into the central nucleus of the amygdala under stress-free conditions
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
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