Paper Session III-B - Utilization of Common Pressurized Modules of Space Station Freedom

Typical of past space projects following preliminary design review, most of the major Space Station critical subsystems will be required to reduce costs, weight, and power consumption prior to flight article hardware production. One such subsystem consists of the pressurized modules which provide the environment in which the crew members live and work. The current baseline station has two types of U.S. pressurized vessels: four resource nodes, and two modules 44 feet in length which must be transported to orbit nearly empty due to structural weight alone. Thus, user and system racks must be outfitted on-orbit rather than integrated on the ground. In this feasibility study, a shorter common pressurized module concept is assessed. The size, transportation, location, and accommodation of system racks and user experiments are considered and compared to baseline. It is shown that the total number of flights required for station assembly can be reduced, assuming both nominal Space Shuttle capacity, as well as Advanced Solid Rocket Motor capability. Baseline module requirements regarding crew size and rack accommodation are preserved. Considering the criteria listed above and current weight estimates, a six module option appears optimal. The resulting common module is 28 feet in length, and, in addition to two end cones, contains three radial ports near one end, which allows for a racetrack configuration pattern. This pattern exhibits several desirable attributes, including dual egress capability from any U.S. module, logical functional allocation distribution, no adverse impact to international partner accommodation, and favorable air lock, cupola, Assured Crew Return Vehicle, and logistics module accommodation

Utilization of common pressurized modules on the Space Station Freedom

During the preliminary design review of Space Station Freedom elements and subsystems, it was shown that reductions of cost, weight, and on-orbit integration and verification would be necessary in order to meet program constraints, particularly nominal Orbiter payload launch capability. At that time, the Baseline station consisted of four resource nodes and two 44 ft modules. In this study, the viability of a common module which maintains crew and payload accommodation is assessed. The size, transportation, and orientation of modules and the accommodation of system racks and user experiments are considered and compared to baseline. Based on available weight estimates, a module pattern consisting of six 28 ft. common elements with three radial and two end ports is shown to be nearly optimal. Advantageous characteristics include a reduction in assembly flights, dual egress from all elements, logical functional allocation, no adverse impacts to international partners, favorable airlock, cupola, ACRV (Assured Crew Return Vehicle), and logistics module accommodation, and desirable flight attitude and control characteristics

Analisis Sentimen Masyarakat Tentang Provider Telekomunikasi Indonesia Pada Twitter Menggunakan Naïve Bayes Classifier

Perkembangan media sosial menjadikan media sosial sebagai salah satu media pengambilan data yang besar. Salah satu pemanfaatan dari data media sosial adalah untuk mengetahui pendapat atau sentimen pengguna media sosial terhadap suatu topik dan masalah. Topik penting yang dibicarakan oleh pengguna jejaring sosial adalah provider telekomunikasi. Masyarakat dapat mengungkapkan pendapat, pernyataan, maupun tanggapan tentang provider telekomunikasi melalui internet terkhusus jejaring sosial. Pendapat masyarakat melalui Twitter disampaikan dengan cara memposting tweets. Postingan tweets tersebut dapat dilakukan analisis sentimen terhadap topik provider telekomunikasi. Analisis sentimen adalah salah satu cabang penelitian dari Text Mining yang berguna untuk mengklasifikasikan dokumen teks berupa opini berdasarkan sentimen. Pendapat tentang provider telekomunikasi dikumpulkan dan dijadikan sebagai data untuk dianalisis dan diamati. Salah satu pembelajaran mesin untuk analisis sentimen adalah Naïve Bayes Classifier (NBC). Metode Naïve Bayes Classifier (NBC) terkenal dengan metode yang sederhana tetapi memiliki keakuratan yang tinggi dalam kasus analisis sentimen berupa dokumen dibandingkan SVM. Hasil analisis sentimen dengan metode Naïve Bayes Classifier (NBC) akan mendapatkan informasi dan pengetahuan yang dapat dijadikan pedoman dan masukan kepada pihak-pihak terkait untuk dapat meningkatkan layanan dan mempertahankan xii kepercayaan masyarakat terhadap provider telekomunikasi di Indonesia terutama Telkomsel

Підготовка адвокатом позовної заяви до суду

Аналізуються питання, пов’язані із підготовкою адвокатом позовної заяви до суду.Анализируется вопросы связаны с подготовкой адвокатом искового заявления в суд.The question connected with preparation of the point of claim to the court by the lawyer is analysed

Parity transitions in the superconducting ground state of hybrid InSb-Al Coulomb islands

The number of electrons in small metallic or semiconducting islands is quantized. When tunnelling is enabled via opaque barriers this number can change by an integer. In superconductors the addition is in units of two electron charges (2e), reflecting that the Cooper pair condensate must have an even parity. This ground state (GS) is foundational for all superconducting qubit devices. Here, we study a hybrid superconducting-semiconducting island and find three typical GS evolutions in a parallel magnetic field: a robust 2e-periodic even-parity GS, a transition to a 2e-periodic odd-parity GS,and a transition from a 2e- to a 1e-periodic GS. The 2e-periodic odd-parity GS persistent in gate-voltage occurs when a spin-resolved subgap state crosses zero energy. For our 1e-periodic GSs we explicitly show the origin being a single zero-energy state gapped from the continuum, i.e. compatible with an Andreev bound states stabilized at zero energy or the presence of Majorana zero modes

Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation

Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signaling cascade that coordinates break repair with cell cycle progression. Here, we performed whole-cell quantitative proteomics to identify global changes in protein ubiquitination that are induced by DNA double-strand breaks. In total, we quantified more than 9,400 ubiquitin sites and found that the relative abundance of similar to 10% of these sites was altered in response to DNA double-strand breaks. Interestingly, a large proportion of ribosomal proteins, including those from the 40S as well as the 60S subunit, were ubiquitinated in response to DNA damage. In parallel, we discovered that DNA damage leads to the inhibition of ribosome function. Taken together, these data uncover the ribosome as a major target of the DNA damage response.This work is funded by a TOP-GO grant from the Netherlands Organization for Scientific Research (NWO ZonMW 912100651 to R.H.M., S.M., and V.A.H.). I.G.S. was supported with a postdoctoral fellowship from the Basque Country Government (Spain). We thank Christian Frese and Teck Yew Low for fruitful discussions. We also thank Teck Yew Low for submitting the raw files and annotated spectra to PRIDE. We thank Fabricio Loayza-Puch for his technical help with the sucrose gradients

Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine

Transcriptome analysis of a zebrafish mutant that does not respond to amphetamine identifies a network of coordinated gene regulation that may underlie the susceptibility to addiction

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class I molecules that elicit CD8(+) T cell responses. Reports of proteasome-generated spliced epitopes exist, but they have been regarded as rare events. Here, however, we show that the proteasome-generated spliced peptide pool accounts for one-third of the entire HLA class I immunopeptidome in terms of diversity and one-fourth in terms of abundance. This pool also represents a unique set of antigens, possessing particular and distinguishing features. We validated this observation using a range of complementary experimental and bioinformatics approaches, as well as multiple cell types. The widespread appearance and abundance of proteasome-catalyzed peptide splicing events has implications for immunobiology and autoimmunity theories and may provide a previously untapped source of epitopes for use in vaccines and cancer immunotherapy

Peeling the Otolith of Fish: Optimal Parameterization for Micro-CT Scanning

In this paper, we aim to provide optimal parameters for micro-computed tomography scans of fish otoliths. We tested fifteen different combinations to sagittae. The images were scaled to Hounsfield units, and segmented in two distinct volumes-of-interest (external and internal). The strategy we applied, for identifying optimum scan settings for otoliths, included analyses of the sinogram, the distribution of the Hounsfield units and the signal-to-noise ratio. Based on these tests, the optimum sets of parameters for the acquisition of tomographic images of sagittal otoilths were 80 kV, 220 μA, and 0.5 mm aluminum filter. The method allowed 3D shape analysis, internal and external density distribution, layer-by-layer density segmentation, and a potential objective method to count growth rings in otoliths. It was possible to compare mean densities between species, and we observed a significant difference among them. In addition, there are ontogenic changes, which could be increasing or decreasing the density. In this study, we applied tomography for several otolith analysis, that could be of great interest for future studies in diverse areas that use otoliths as the basic structure of analysis, or represents a new research line called eco-densitometry of otoliths, where tomography could be applied to explore the density within an ecological perspective.Fil: Vasconcelos Filho, Jonas. Universidad Federal Rural Pernambuco; BrasilFil: Thomsen, Felix Sebastian Leo. Universidad Nacional del Sur. Departamento de Ingeniería Eléctrica y de Computadoras; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; ArgentinaFil: Stosic, Borko. Universidad Federal Rural Pernambuco; BrasilFil: Antonino, Antonio C. D.. Universidad Federal Rural Pernambuco; BrasilFil: Duarte, Daniel A.. Universidad Federal Rural Pernambuco; BrasilFil: Heck, Richard J.. University of Guelph; CanadáFil: Lessa, Rosangela P. T.. Universidad Federal Rural Pernambuco; BrasilFil: Santana, Francisco M.. Universidad Federal Rural Pernambuco; BrasilFil: Ferreira, Beatrice P.. Universidad Federal Rural Pernambuco; BrasilFil: Duarte Neto, Paulo J.. Universidad Federal Rural Pernambuco; Brasi