Active paper for active learning

Recent research into distance learning and the virtual campus has focused on the use of electronic documents and computer‐based demonstrations to replace or reinforce traditional learning material. We show how a computer‐augmented desk, the DigitalDesk, can provide the benefits of both paper and electronic documents using a natural interface based on real paper documents. Many electronic documents, particularly those created using the guidelines produced by the Text Encoding Initiative (TEI), include detailed semantic and linguistic information that can be used to good effect in learning material. We discuss potential uses of TEI texts, and describe one simple application that allows a student's book to become an active part of a grammar lesson when placed on the DigitalDesk. The book is integrated into an interactive point‐and‐click interface, and feedback is related to the currently visible pages of the boo

New technology for interactive CAL: The origami project

Origami is a three‐year EPSRC project that forms part of a general research programme on human‐computer interaction. The goal of this research is to investigate and implement new methods for human‐computer interaction, and to apply and evaluate their use. The research centres on the DigitalDesk, an ordinary desk augmented with a computer display using projection television and a video camera to monitor inputs. The DigitalDesk allows electronic and printed documents to be combined to give richer presentation and interaction possibilities than are possible with either separate medium. This paper examines the implications of such a system for CAL, and presents two prototype applications that demonstrate the possibilities

Linear and nonlinear waveguides induced by optical vortex solitons

We study, numerically and analytically, linear and nonlinear waveguides induced by optical vortex solitons in a Kerr medium. Both fundamental and first-order guided modes are analyzed, as well as the cases of effectively defocusing and focusing nonlinearity.Comment: 3 pages, 3 figures, changed conten

Comparative performance of airyscan and structured illumination superresolution microscopy in the study of the surface texture and 3D shape of pollen

The visualization of taxonomically diagnostic features of individual pollen grains can be a challenge for many ecologically and phylogenetically important pollen types. The resolution of traditional optical microscopy is limited by the diffraction of light (250 nm), while high resolution tools such as electron microscopy are limited by laborious preparation and imaging workflows. Airyscan confocal superresolution and structured illumination superresolution (SR-SIM) microscopy are powerful new tools for the study of nanoscale pollen morphology and three-dimensional structure that can overcome these basic limitations. This study demonstrates their utility in capturing morphological details below the diffraction limit of light. Using three distinct pollen morphotypes (Croton hirtus, Dactylis glomerata, and Helianthus sp.) and contrast-enhancing fluorescent staining, we were able to assess the effectiveness of the Airyscan and SR-SIM. We further demonstrate that these new superresolution methods can be easily applied to the study of fossil pollen material

Ensembl regulation resources

New experimental techniques in epigenomics allow researchers to assay a diversity of highly dynamic features such as histone marks, DNA modifications or chromatin structure. The study of their fluctuations should provide insights into gene expression regulation, cell differentiation and disease. The Ensembl project collects and maintains the Ensembl regulation data resources on epigenetic marks, transcription factor binding and DNA methylation for human and mouse, as well as microarray probe mappings and annotations for a variety of chordate genomes. From this data, we produce a functional annotation of the regulatory elements along the human and mouse genomes with plans to expand to other species as data becomes available. Starting from well-studied cell lines, we will progressively expand our library of measurements to a greater variety of samples. Ensembl's regulation resources provide a central and easy-to-query repository for reference epigenomes. As with all Ensembl data, it is freely available at http://www.ensembl.org, from the Perl and REST APIs and from the public Ensembl MySQL database server at ensembldb.ensembl.org.Database URL: http://www.ensembl.org.Wellcome Trust grant: (WT098051); National Human Genome Research Institute grants: (U41HG007234, 1U01 HG004695); Biotechnology and Biological Sciences Research Council grant: (BB/L024225/1); European Molecular Biology Laboratory; European Union’s Seventh Framework Programme; European Research Council

The Fungal Cell Wall : Structure, Biosynthesis, and Function

N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M. are part of the MRC Centre for Medical Mycology. J.P.L. acknowledges support from ANR, Aviesan, and FRM.Peer reviewedPublisher PD

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or those with lesion activity on imaging. We sought to assess whether natalizumab slows disease progression in secondary progressive multiple sclerosis, independent of relapses. Methods: ASCEND was a phase 3, randomised, double-blind, placebo-controlled trial (part 1) with an optional 2 year open-label extension (part 2). Enrolled patients aged 18–58 years were natalizumab-naive and had secondary progressive multiple sclerosis for 2 years or more, disability progression unrelated to relapses in the previous year, and Expanded Disability Status Scale (EDSS) scores of 3·0–6·5. In part 1, patients from 163 sites in 17 countries were randomly assigned (1:1) to receive 300 mg intravenous natalizumab or placebo every 4 weeks for 2 years. Patients were stratified by site and by EDSS score (3·0–5·5 vs 6·0–6·5). Patients completing part 1 could enrol in part 2, in which all patients received natalizumab every 4 weeks until the end of the study. Throughout both parts, patients and staff were masked to the treatment received in part 1. The primary outcome in part 1 was the proportion of patients with sustained disability progression, assessed by one or more of three measures: the EDSS, Timed 25-Foot Walk (T25FW), and 9-Hole Peg Test (9HPT). The primary outcome in part 2 was the incidence of adverse events and serious adverse events. Efficacy and safety analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01416181. Findings: Between Sept 13, 2011, and July 16, 2015, 889 patients were randomly assigned (n=440 to the natalizumab group, n=449 to the placebo group). In part 1, 195 (44%) of 439 natalizumab-treated patients and 214 (48%) of 448 placebo-treated patients had confirmed disability progression (odds ratio [OR] 0·86; 95% CI 0·66–1·13; p=0·287). No treatment effect was observed on the EDSS (OR 1·06, 95% CI 0·74–1·53; nominal p=0·753) or the T25FW (0·98, 0·74–1·30; nominal p=0·914) components of the primary outcome. However, natalizumab treatment reduced 9HPT progression (OR 0·56, 95% CI 0·40–0·80; nominal p=0·001). In part 1, 100 (22%) placebo-treated and 90 (20%) natalizumab-treated patients had serious adverse events. In part 2, 291 natalizumab-continuing patients and 274 natalizumab-naive patients received natalizumab (median follow-up 160 weeks [range 108–221]). Serious adverse events occurred in 39 (13%) patients continuing natalizumab and in 24 (9%) patients initiating natalizumab. Two deaths occurred in part 1, neither of which was considered related to study treatment. No progressive multifocal leukoencephalopathy occurred. Interpretation: Natalizumab treatment for secondary progressive multiple sclerosis did not reduce progression on the primary multicomponent disability endpoint in part 1, but it did reduce progression on its upper-limb component. Longer-term trials are needed to assess whether treatment of secondary progressive multiple sclerosis might produce benefits on additional disability components. Funding: Biogen

Minibix: Item banking with web services

The Minibix system was developed from an existing prototype item bank system in use for high-stakes testing at the University of Cambridge. The system has been developed over the last year with support from the JISC e- Learning Programme. This project has redeveloped the system based on version 2 of the IMS Question and Test Interoperability (QTI) specification and is publishing the resulting system under an open source license. In this paper, we propose a simple service model for describing the authoring, banking, test construction and delivery of assessment content. The item banking model is implemented by the Minibix system and will be demonstrated in conjunction with authoring, test construction and delivery systems developed by the sister projects: AQuRate (Kingston University) and AsDel (University of Southampton). These services, as part of a wider e-Framework, could enable tool integration on a scale suitable for interacting with large-scale item banks. Private banks are already used routinely in high-stakes summative assessment but open repositories of items for formative use are now becoming available. For example, the E3AN item bank for Electrical and Electronic Engineering or the item bank for the Physical Sciences recently announced by the HEA

The cross-scale role of reef fish behaviour in mediating space use and behavioural cascades on coral reefs

Interspecific interactions play a fundamental role in shaping ecological communities. Whilst the non-consumptive effects of predation on animal behaviour and interspecific interactions are widely studied, the role of aggressive interactions between competitors in behavioural cascades is largely unknown. Using coral reef fish as a model system, I address this significant knowledge gap and improve our understanding of how competitive interactions may drive behavioural cascades across multiple ecological levels and taxa. Firstly, I take a macroecological approach to demonstrate strong links between coral reef benthic state and herbivorous fish functional group co-occurrence and their functional group diversity. Secondly, I demonstrate that between-individual variation in aggressive behaviour by farming damselfish creates a competitive landscape of risk on coral reefs. Thirdly, I identify that competitive risk avoidance between reef fish drives behavioural cascades in other taxa, reducing cleaning rates and client diversity at Pederson’s cleaner shrimp Ancylomenes pedersoni stations. Finally, I demonstrate that intraspecific aggression between territorial farming damselfish can be predicted by familiarity and differences in body size. The results presented in this thesis improve our knowledge of both the driving mechanisms and ultimate consequences of competition to community dynamics and ecosystem function. Furthermore, by drawing links across ecological scales, from between-individual behavioural variation to the macroecology of co-occurrence patterns, my thesis highlights the multiple pathways through which co-occurrence and competition may drive behaviourally mediated cascades throughout ecosystems