1,213 research outputs found
Model based optimization of transflection near infrared spectroscopy as a process analytical tool in a continuous flash pasteurizer
Near infrared spectroscopy in combination with a transflection probe was investigated as inline measurement in a continuous flash pasteurizer system with a sugar–water model solution. Robustness and reproducibility of fluctuations of recorded spectra as well as trueness of the chemometric analysis were compared under different process parameter settings. Variable parameters were the flow rate (from laminar flow at 30 L/h to turbulent flow at 90 L/h), temperature (20 to 100 °C) and the path length of the transflection probe (2 and 4 mm) while the pressure was kept constant at 2.5 bar. Temperature and path length were identified as the most affecting parameters, in case of homogenous test medium. In case of particle containing systems, the flow rate could have an impact as well. However, the application of a PLS model, which includes a broad temperature range, and the correction of prediction results by applying a polynomial regression function for prediction errors, was able to compensate these effects. Also, a path length of 2 mm leads to a higher accuracy. The applied strategy shows that by the identification of relevant process parameters and settings as well as the establishment of a compensation strategy, near infrared spectroscopy is a powerful process analytical tool for continuous flash pasteurization systems.BMBF, 13FH024IX6, IngenieurNachwuchs 2016: Cyber-Physisches System (CPS) zur thermischen Entkeimung von Getränken unter Nutzung der NIR-Sensorik als Schlüsseltechnologi
Angle resolved photoelectron spectroscopy of two-color XUV-NIR ionization with polarization control
Electron emission caused by extreme ultraviolet (XUV) radiation in the presence of a strong near infrared (NIR) field leads to multiphoton interactions that depend on several parameters. Here, a comprehensive study of the influence of the angle between the polarization directions of the NIR and XUV fields on the two-color angle-resolved photoelectron spectra of He and Ne is presented. The resulting photoelectron angular distribution strongly depends on the orientation of the NIR polarization plane with respect to that of the XUV field. The prevailing influence of the intense NIR field over the angular emission characteristics for He(1s) and Ne(2p) ionization lines is shown. The underlying processes are modeled in the frame of the strong field approximation (SFA) which shows very consistent agreement with the experiment reaffirming the power of the SFA for multicolor-multiphoton ionization in this regime
The Dynamic Exponent of the Two-Dimensional Ising Model and Monte Carlo Computation of the Sub-Dominant Eigenvalue of the Stochastic Matrix
We introduce a novel variance-reducing Monte Carlo algorithm for accurate
determination of autocorrelation times. We apply this method to two-dimensional
Ising systems with sizes up to , using single-spin flip dynamics,
random site selection and transition probabilities according to the heat-bath
method. From a finite-size scaling analysis of these autocorrelation times, the
dynamical critical exponent is determined as (12)
Nonequilibrium relaxation of the two-dimensional Ising model: Series-expansion and Monte Carlo studies
We study the critical relaxation of the two-dimensional Ising model from a
fully ordered configuration by series expansion in time t and by Monte Carlo
simulation. Both the magnetization (m) and energy series are obtained up to
12-th order. An accurate estimate from series analysis for the dynamical
critical exponent z is difficult but compatible with 2.2. We also use Monte
Carlo simulation to determine an effective exponent, z_eff(t) = - {1/8} d ln t
/d ln m, directly from a ratio of three-spin correlation to m. Extrapolation to
t = infinity leads to an estimate z = 2.169 +/- 0.003.Comment: 9 pages including 2 figure
Cerebral palsy and placental infection: a case-cohort study
BACKGROUND: The association between cerebral palsy in very preterm infants and clinical, histopathologic and microbiological indicators of chorioamnionitis, including the identification of specific micro-organisms in the placenta, was evaluated in a case-cohort study. METHODS: Children with a diagnosis of cerebral palsy at five years of age were identified from amongst participants in a long-term follow-up program of preterm infants. The comparison group was a subcohort of infants randomly selected from all infants enrolled in the program. The placentas were examined histopathologically for chorioamnionitis and funisitis, and the chorioamnionic interface was aseptically swabbed and comprehensively cultured for aerobic and anaerobic bacteria, yeast and genital mycoplasmas. Associations between obstetric and demographic variables, indicators of chorioamnionitis and cerebral palsy status were examined by univariate analysis. RESULTS: Eighty-two infants with cerebral palsy were compared with the subcohort of 207 infants. Threatened preterm labor was nearly twice as common among the cases as in the subcohort (p < 0.01). Recorded clinical choroamnionitis was similar in the two groups and there was no difference in histopathologic evidence of infection between the two groups. E. coli was cultured from the placenta in 6/30 (20%) of cases as compared with 4/85 (5%) of subcohort (p = 0.01). Group B Streptococcus was more frequent among the cases, but the difference was not statistically significant. CONCLUSIONS: The association between E. coli in the chorioamnion and cerebral palsy in preterm infants identified in this study requires confirmation in larger multicenter studies which include microbiological study of placentas
Heuristic derivation of continuum kinetic equations from microscopic dynamics
We present an approximate and heuristic scheme for the derivation of
continuum kinetic equations from microscopic dynamics for stochastic,
interacting systems. The method consists of a mean-field type, decoupled
approximation of the master equation followed by the `naive' continuum limit.
The Ising model and driven diffusive systems are used as illustrations. The
equations derived are in agreement with other approaches, and consequences of
the microscopic dependences of coarse-grained parameters compare favorably with
exact or high-temperature expansions. The method is valuable when more
systematic and rigorous approaches fail, and when microscopic inputs in the
continuum theory are desirable.Comment: 7 pages, RevTeX, two-column, 4 PS figures include
Instantaneous sea ice drift speed from TanDEM-X interferometry
The drift of sea ice is an important geophysical process with
widespread implications for the ocean energy budget and ecosystems. Drifting
sea ice can also threaten marine operations and present a hazard for ocean
vessels and installations. Here, we evaluate single-pass along-track
synthetic aperture radar (SAR) interferometry (S-ATI) as a tool to assess
ice drift while discussing possible applications and inherent limitations.
Initial validation shows that TanDEM-X phase-derived drift speed corresponds
well with drift products from a ground-based radar at Utqiaġvik, Alaska.
Joint analysis of TanDEM-X and Sentinel-1 data covering the Fram Strait
demonstrates that S-ATI can help quantify the opening/closing rate of leads
with possible applications for navigation. S-ATI enables an instantaneous
assessment of ice drift and dynamic processes that are otherwise difficult
to observe. For instance, by evaluating sea ice drift through the Vilkitsky
Strait, Russia, we identified short-lived transient convergence patterns. We
conclude that S-ATI enables the identification and analysis of potentially
important dynamic processes (e.g., drift, rafting, and ridging). However,
current limitations of S-ATI are significant (e.g., data availability and
they presently only provide the cross-track vector component of the ice drift
field) but may be significantly reduced with future SAR systems.</p
The DLR Scout Rover during the 2022 Arches Demomission Space on Mount Etna: Operating the Rover outside of its Comfort Zone
Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors
In this work, we are reporting that “Shock and Kill”, a therapeutic approach designed to eliminate latent HIV from cell reservoirs, is extrapolatable to cancer therapy. This is based on the observation that malignant cells express a spectrum of human endogenous retroviral elements (HERVs) which can be transcriptionally boosted by HDAC inhibitors. The endoretroviral gene HERV-V2 codes for an envelope protein, which resembles syncytins. It is significantly overexpressed upon exposure to HDAC inhibitors and can be effectively targeted by simultaneous application of TLR7/8 agonists, triggering intrinsic apoptosis. We demonstrated that this synergistic cytotoxic effect was accompanied by the functional disruption of the TLR7/8-NFκB, Akt/PKB, and Ras-MEK-ERK signalling pathways. CRISPR/Cas9 ablation of TLR7 and HERV-V1/V2 curtailed apoptosis significantly, proving the pivotal role of these elements in driving cell death. The effectiveness of this new approach was confirmed in ovarian tumour xenograft studies, revealing a promising avenue for future cancer therapies
Measurements of branching fraction ratios and CP-asymmetries in suppressed B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^- decays
We report the first reconstruction in hadron collisions of the suppressed
decays B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^-, sensitive to the
CKM phase gamma, using data from 7 fb^-1 of integrated luminosity collected by
the CDF II detector at the Tevatron collider. We reconstruct a signal for the
B^- -> D(-> K^+ pi^-)K^- suppressed mode with a significance of 3.2 standard
deviations, and measure the ratios of the suppressed to favored branching
fractions R(K) = [22.0 \pm 8.6(stat)\pm 2.6(syst)]\times 10^-3, R^+(K) =
[42.6\pm 13.7(stat)\pm 2.8(syst)]\times 10^-3, R^-(K)= [3.8\pm 10.3(stat)\pm
2.7(syst]\times 10^-3, as well as the direct CP-violating asymmetry A(K) =
-0.82\pm 0.44(stat)\pm 0.09(syst) of this mode. Corresponding quantities for
B^- -> D(-> K^+ pi^-)pi^- decay are also reported.Comment: 8 pages, 1 figure, accepted by Phys.Rev.D Rapid Communications for
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