Multiband Fitting to Three Long GRBs with Fermi/LAT Data: Structured Ejecta Sweeping up a Density-Jump Medium

We present broadband (radio, optical, X-ray and GeV) fits to the afterglow light curves and spectra of three long-duration gamma-ray bursts (GRBs 080916C, 090902B, and 090926A) detected by the Gamma-Ray Burst Monitor (GBM) and Large Area Telescope (LAT) instruments on the Fermi satellite. Using the observed broadband data, we study the origin of the high energy emission, and suggest that the early-time GeV emission and the late-time radio, optical, and X-ray afterglows can be understood as being due to synchrotron emission from an external forward shock caused by structured ejecta propagating in a wind bubble jumping to a homogeneous density medium. If the ceasing time for majority of the energy injection is assumed to be close to the deceleration time of the forward shock, the structured ejecta with continuous energy injection to the forward shock can well explain the early rising feature of the GeV mission from these burst, and the density-jump medium can account for some certain plateaus or flares in the late afterglows. From our fits, we find that, on one hand, the external shock origin of the GeV photons will make the optical depth have not significant contribution to the early LAT rising part, which will loosen strong constraint of lower limits of Lorentz factor. On the other hand, these Fermi-LAT events preferentially occur in a low-density circumburst environment, in which case the Klein-Nishina cutoff will significantly suppress the Self-Synchrotron Compton (SSC) radiation. Such an environment might result from superbubbles or low-metallicity progenitor stars (which have a low mass-loss rate at late times of stellar evolution) of type Ib/c supernovae.Comment: 32 pages, 4 figures, 2 tables; some minor typo corrected, optical depth does not have significant contribution to the result, major conclusions unchange

Organization of GC/MS and LC/MS metabolomics data into chemical libraries

<p>Abstract</p> <p>Background</p> <p>Metabolomics experiments involve generating and comparing small molecule (metabolite) profiles from complex mixture samples to identify those metabolites that are modulated in altered states (e.g., disease, drug treatment, toxin exposure). One non-targeted metabolomics approach attempts to identify and interrogate all small molecules in a sample using GC or LC separation followed by MS or MSⁿdetection. Analysis of the resulting large, multifaceted data sets to rapidly and accurately identify the metabolites is a challenging task that relies on the availability of chemical libraries of metabolite spectral signatures. A method for analyzing spectrometry data to identify and <b>Qu</b>antify <b>I</b>ndividual <b>C</b>omponents in a <b>S</b>ample, (QUICS), enables generation of chemical library entries from known standards and, importantly, from unknown metabolites present in experimental samples but without a corresponding library entry. This method accounts for all ions in a sample spectrum, performs library matches, and allows review of the data to quality check library entries. The QUICS method identifies ions related to any given metabolite by correlating ion data across the complete set of experimental samples, thus revealing subtle spectral trends that may not be evident when viewing individual samples and are likely to be indicative of the presence of one or more otherwise obscured metabolites.</p> <p>Results</p> <p>LC-MS/MS or GC-MS data from 33 liver samples were analyzed simultaneously which exploited the inherent biological diversity of the samples and the largely non-covariant chemical nature of the metabolites when viewed over multiple samples. Ions were partitioned by both retention time (RT) and covariance which grouped ions from a single common underlying metabolite. This approach benefitted from using mass, time and intensity data in aggregate over the entire sample set to reject outliers and noise thereby producing higher quality chemical identities. The aggregated data was matched to reference chemical libraries to aid in identifying the ion set as a known metabolite or as a new unknown biochemical to be added to the library.</p> <p>Conclusion</p> <p>The QUICS methodology enabled rapid, in-depth evaluation of all possible metabolites (known and unknown) within a set of samples to identify the metabolites and, for those that did not have an entry in the reference library, to create a library entry to identify that metabolite in future studies.</p

Poly[μ2-benzene-1,3-dicarboxyl­ato-κ2 O:O′-μ2-1,3-di-4-pyridylpropane-κ2 N:N′-zinc(II)]

The title compound, [Zn(C8H4O4)(C13H14N2)]n, was obtained by the hydro­thermal reaction of Zn(OAc)2·H2O with 1,3-di-4-pyridylpropane (bpp) and isophthalic acid (H2ip). The ZnII ion is coordinated by two bpp and two ip ligands in a distorted tetra­hedral environment. Each ligand coordinates in a bridging mode to connect ZnII ions into a three-dimensional diamondoid-type structure

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function

&lt;b&gt;Objective:&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Mitochondria-derived reactive oxygen species (ROS) play important roles in the development of cardiovascular disease highlighting the need for novel targeted therapies. This study assessed the potential therapeutic benefit of combining the mitochondria-specific antioxidant, MitoQ&lt;sub&gt;10&lt;/sub&gt;, with the low-dose angiotensin receptor blocker (ARB), losartan, on attenuation of hypertension and left ventricular hypertrophy. In parallel, we investigated the impact of MitoQ&lt;sub&gt;10&lt;/sub&gt; on cardiac hypertrophy in a neonatal cardiomyocyte cell line.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methods and results:&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Eight-week-old male stroke-prone spontaneously hypertensive rats (SHRSPs, &lt;i&gt;n&lt;/i&gt; = 8–11) were treated with low-dose losartan (2.5 mg/kg per day); MitoQ&lt;sub&gt;10&lt;/sub&gt; (500 μmol/l); a combination of MitoQ&lt;sub&gt;10&lt;/sub&gt; and losartan (M + L); or vehicle for 8 weeks. Systolic pressure and pulse pressure were significantly lower in M + L rats (167.1 ± 2.9 mmHg; 50.2 ± 2.05 mmHg) than in untreated SHRSP (206.6 ± 9 mmHg, P &lt; 0.001; 63.7 ± 2.7 mmHg, P = 0.001) and demonstrated greater improvement than MitoQ10 or low-dose losartan alone, as measured by radiotelemetry. Left ventricular mass index was significantly reduced from 22.8 ± 0.74 to 20.1 ± 0.61 mg/mm in the combination group (P &lt; 0.05). Picrosirius red staining showed significantly reduced cardiac fibrosis in M + L rats (0.82 ± 0.22 A.U.) compared with control (5.94 ± 1.35 A.U., P &lt; 0.01). In H9c2 neonatal rat cardiomyocytes, MitoQ&lt;sub&gt;10&lt;/sub&gt; significantly inhibited angiotensin II mediated hypertrophy in a dose-dependent manner (500 nmol/l MitoQ&lt;sub&gt;10&lt;/sub&gt; 153.7 ± 3.1 microns vs. angiotensin II 200.1 ± 3.6 microns, P &lt;0.001).&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusion:&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Combining MitoQ&lt;sub&gt;10&lt;/sub&gt; and low-dose losartan provides additive therapeutic benefit, significantly attenuating development of hypertension and reducing left ventricular hypertrophy. In addition, MitoQ&lt;sub&gt;10&lt;/sub&gt; mediates a direct antihypertrophic effect on rat cardiomyocytes &lt;i&gt;in vitro&lt;/i&gt;. MitoQ&lt;sub&gt;10&lt;/sub&gt; has potential as a novel therapeutic intervention in conjunction with current antihypertensive drugs.&lt;p&gt;&lt;/p&gt

The shallow-decay phase in both optical and x-ray afterglows of Swift GRB 090529A: Energy injection into a wind-type medium?

The energy injection model is usually proposed to interpret the shallow-decay phase in Swift GRB X-ray afterglows. However, very few GRBs have simultaneous signatures of energy injection in their optical and X-ray afterglows. Here, we report optical observations of GRB 090529A from 2000 sec to $\sim10^6$ sec after the burst, in which an achromatic decay is seen at both wavelengths. The optical light curve shows a decay from 0.37 to 0.99 with a break at $\sim10^5$ sec. In the same time interval, the decay indices of the X-ray light curve changed from 0.04 to 1.2. Comparing these values with the closure relations, the segment after 3$\times10^{4}$ sec is consistent with the prediction of the forward shock in an ISM medium without any energy injection. The shallow-decay phase between 2000 to 3$\times10^{4}$ sec could be due to the external shock in a wind-type-like medium with an energy injection under the condition of $\nu_o < \nu_c < \nu_x$. However, the constraint of the spectral region is not well consistent with the multi-band observations. For this shallow-decay phase, other models are also possible, such as energy injection with evolving microphysical parameters, or a jet viewed off-axis,etc.Comment: 19pages,2gigures, accepted by MNRA

Divergence-Free Adaptive Mesh Refinement for Magnetohydrodynamics

In this paper we present a full-fledged scheme for the second order accurate, divergence-free evolution of vector fields on an adaptive mesh refinement (AMR) hierarchy. We focus here on adaptive mesh MHD. The scheme is based on making a significant advance in the divergence-free reconstruction of vector fields. In that sense, it complements the earlier work of Balsara and Spicer (1999) where we discussed the divergence-free time-update of vector fields which satisfy Stoke's law type evolution equations. Our advance in divergence-free reconstruction of vector fields is such that it reduces to the total variation diminishing (TVD) property for one-dimensional evolution and yet goes beyond it in multiple dimensions. Divergence-free restriction is also discussed. An electric field correction strategy is presented for use on AMR meshes. The electric field correction strategy helps preserve the divergence-free evolution of the magnetic field even when the time steps are sub-cycled on refined meshes. The above-mentioned innovations have been implemented in Balsara's RIEMANN framework for parallel, self-adaptive computational astrophysics which supports both non-relativistic and relativistic MHD. Several rigorous, three dimensional AMR-MHD test problems with strong discontinuities have been run with the RIEMANN framework showing that the strategy works very well.Comment: J.C.P., figures of reduced qualit

Piecewise Parabolic Method on a Local Stencil for Magnetized Supersonic Turbulence Simulation

Stable, accurate, divergence-free simulation of magnetized supersonic turbulence is a severe test of numerical MHD schemes and has been surprisingly difficult to achieve due to the range of flow conditions present. Here we present a new, higher order-accurate, low dissipation numerical method which requires no additional dissipation or local "fixes" for stable execution. We describe PPML, a local stencil variant of the popular PPM algorithm for solving the equations of compressible ideal magnetohydrodynamics. The principal difference between PPML and PPM is that cell interface states are evolved rather that reconstructed at every timestep, resulting in a compact stencil. Interface states are evolved using Riemann invariants containing all transverse derivative information. The conservation laws are updated in an unsplit fashion, making the scheme fully multidimensional. Divergence-free evolution of the magnetic field is maintained using the higher order-accurate constrained transport technique of Gardiner and Stone. The accuracy and stability of the scheme is documented against a bank of standard test problems drawn from the literature. The method is applied to numerical simulation of supersonic MHD turbulence, which is important for many problems in astrophysics, including star formation in dark molecular clouds. PPML accurately reproduces in three-dimensions a transition to turbulence in highly compressible isothermal gas in a molecular cloud model. The low dissipation and wide spectral bandwidth of this method make it an ideal candidate for direct turbulence simulations.Comment: 28 pages, 18 figure

Smoothed Particle Magnetohydrodynamics III. Multidimensional tests and the div B = 0 constraint

In two previous papers (Price & Monaghan 2004a,b) (papers I,II) we have described an algorithm for solving the equations of Magnetohydrodynamics (MHD) using the Smoothed Particle Hydrodynamics (SPH) method. The algorithm uses dissipative terms in order to capture shocks and has been tested on a wide range of one dimensional problems in both adiabatic and isothermal MHD. In this paper we investigate multidimensional aspects of the algorithm, refining many of the aspects considered in papers I and II and paying particular attention to the code's ability to maintain the div B = 0 constraint associated with the magnetic field. In particular we implement a hyperbolic divergence cleaning method recently proposed by Dedner et al. (2002) in combination with the consistent formulation of the MHD equations in the presence of non-zero magnetic divergence derived in papers I and II. Various projection methods for maintaining the divergence-free condition are also examined. Finally the algorithm is tested against a wide range of multidimensional problems used to test recent grid-based MHD codes. A particular finding of these tests is that in SPMHD the magnitude of the divergence error is dependent on the number of neighbours used to calculate a particle's properties and only weakly dependent on the total number of particles. Whilst many improvements could still be made to the algorithm, our results suggest that the method is ripe for application to problems of current theoretical interest, such as that of star formation.Comment: Here is the latest offering in my quest for a decent SPMHD algorithm. 26 pages, 15 figures, accepted for publication in MNRAS. Version with high res figures available from http://www.astro.ex.ac.uk/people/dprice/pubs/spmhd/spmhdpaper3.pd