38 research outputs found
The AMIGA sample of isolated galaxies. V. Quantification of the isolation
The AMIGA project aims to build a well defined and statistically significant
reference sample of isolated galaxies in order to estimate the environmental
effects on the formation and evolution of galaxies. The goal of this paper is
to provide a measure of the environment of the isolated galaxies in the AMIGA
sample, quantifying the influence of the candidate neighbours identified in our
previous work and their potential effects on the evolution of the primary
galaxies. Here we provide a quantification of the isolation degree of the
galaxies in this sample. Our starting sample is the Catalogue of Isolated
Galaxies (CIG). We used two parameters to estimate the influence exerted by the
neighbour galaxies on the CIG galaxy: the local number density of neighbour
galaxies and the tidal strength affecting the CIG galaxy. We show that both
parameters together provide a comprehensive picture of the environment. For
comparison, those parameters have also been derived for galaxies in denser
environments such as triplets, groups and clusters. The CIG galaxies show a
continuous spectrum of isolation, as quantified by the two parameters, from
very isolated to interacting. The fraction of CIG galaxies whose properties are
expected to be influenced by the environment is however low (159 out of 950
galaxies). The isolated parameters derived for the comparsion samples gave
higher values than for the CIG and we found clear differences for the average
values of the 4 samples considered, proving the sensitivity of these
parameters. The environment of the galaxies in the CIG has been characterised,
using two complementary parameters quantifying the isolation degree, the local
number density of the neighbour galaxies and the tidal forces affecting the
isolated galaxies. (Abridged)Comment: 10 pages, 12 figures, proposed for acceptance A&
Photometric study of the IC 65 group of galaxies
We carry out a photometric study of a poor group of late-type galaxies around
IC 65, with the aim: (a) to search for new dwarf members and to measure their
photometric characteristics; (b) to search for possible effects of mutual
interactions on the morphology and star-formation characteristics of luminous
and faint group members; (c) to evaluate the evolutionary status of this
particular group. We make use of our BRI CCD observations, DPOSS blue and red
frames, and the 2MASS JHK frames. In addition, we use the HI imaging data, the
far-infrared and radio data from the literature. Search for dwarf galaxies is
made using the SExtractor software. Detailed surface photometry is performed
with the MIDAS package. Four LSB galaxies were classified as probable dwarf
members of the group and the BRI physical and model parameters were derived for
the first time for all true and probable group members. Newly found dIrr
galaxies around the IC 65 contain a number of H II regions, which show a range
of ages and propagating star-formation. Mildly disturbed gaseous and/or stellar
morphology is found in several group members. Various structural, dynamical,
and star-forming characteristics let us conclude that the IC 65 group is a
typical poor assembly of late-type galaxies at an early stage of its dynamical
evolution with some evidence of intragroup (tidal) interactions.Comment: 21 pages, 16 figures, submitted to A&
VISIR/VLT mid-infrared imaging of Seyfert nuclei: Nuclear dust emission and the Seyfert-2 dichotomy
Half of the Seyfert-2 galaxies escaped detection of broad lines in their
polarised spectra observed so far. Some authors have suspected that these
non-HBLRs contain real Sy2 nuclei without intrinsic broad line region hidden
behind a dust torus. If this were true, then their nuclear structure would
fundamentally differ from that of Sy2s with polarised broad lines: in
particular, they would not be explained by orientation-based AGN unification.
Further arguments for two physically different Sy2 populations have been
derived from the warm and cool IRAS F25/F60 ratios. These ratios, however,
refer to the entire host galaxies and are unsuitable to conclusively establish
the absence of a nuclear dust torus. Instead, a study of the Seyfert-2
dichotomy should be performed on the basis of nuclear properties only. Here we
present the first comparison between [OIII] 5007A and mid-infrared imaging at
matching spatial resolution. Exploring the Seyfert-2 dichotomy we find that the
distributions of nuclear mid-infrared/[OIII] luminosity ratios are
indistinguishable for Sy1s and Sy2s with and without detected polarised broad
lines and irrespective of having warm or cool IRAS F25/F60 ratios. We find no
evidence for the existence of a population of real Sy2s with a deficit of
nuclear dust emission. Our results suggest 1) that all Seyfert nuclei possess
the same physical structure including the putative dust torus and 2) that the
cool IRAS colours are caused by a low contrast of AGN to host galaxy. Then the
Seyfert-2 dichotomy is explained in part by unification of non-HBLRs with
narrow-line Sy1s and to a larger rate by observational biases caused by a low
AGN/host contrast and/or an unfavourable scattering geometry.Comment: 11 pages, 6 figures, accepted by A&
Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host
Genetic variability is a hallmark of RNA virus populations. However, transmission to a new host often results in a marked decrease in population diversity. This genetic bottlenecking is observed during hepatitis C virus (HCV) transmission and can arise via a selective sweep or through the founder effect. To model HCV transmission, we utilized chimeric SCID/Alb-uPA mice with transplanted human hepatocytes and infected them with a human serum HCV inoculum. E1E2 glycoprotein gene sequences in the donor inoculum and recipient mice were determined following single-genome amplification (SGA). In independent experiments, using mice with liver cells grafted from different sources, an E1E2 variant undetectable in the source inoculum was selected for during transmission. Bayesian coalescent analyses indicated that this variant arose in the inoculum pretransmission. Transmitted variants that established initial infection harbored key substitutions in E1E2 outside HVR1. Notably, all posttransmission E1E2s had lost a potential N-linked glycosylation site (PNGS) in E2. In lentiviral pseudoparticle assays, the major posttransmission E1E2 variant conferred an increased capacity for entry compared to the major variant present in the inoculum. Together, these data demonstrate that increased envelope glycoprotein fitness can drive selective outgrowth of minor variants posttransmission and that loss of a PNGS is integral to this improved phenotype. Mathematical modeling of the dynamics of competing HCV variants indicated that relatively modest differences in glycoprotein fitness can result in marked shifts in virus population composition. Overall, these data provide important insights into the dynamics and selection of HCV populations during transmission
The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus
Many pathogens associated with chronic infections evolve so rapidly that strains found late in an infection have little in common with the initial strain. This raises questions at different levels of analysis because rapid within-host evolution affects the course of an infection, but it can also affect the possibility for natural selection to act at the between-host level. We present a nested approach that incorporates within-host evolutionary dynamics of a rapidly mutating virus (hepatitis C virus) targeted by a cellular cross-reactive immune response, into an epidemiological perspective. The viral trait we follow is the replication rate of the strain initiating the infection. We find that, even for rapidly evolving viruses, the replication rate of the initial strain has a strong effect on the fitness of an infection. Moreover, infections caused by slowly replicating viruses have the highest infection fitness (i.e., lead to more secondary infections), but strains with higher replication rates tend to dominate within a host in the long-term. We also study the effect of cross-reactive immunity and viral mutation rate on infection life history traits. For instance, because of the stochastic nature of our approach, we can identify factors affecting the outcome of the infection (acute or chronic infections). Finally, we show that anti-viral treatments modify the value of the optimal initial replication rate and that the timing of the treatment administration can have public health consequences due to within-host evolution. Our results support the idea that natural selection can act on the replication rate of rapidly evolving viruses at the between-host level. It also provides a mechanistic description of within-host constraints, such as cross-reactive immunity, and shows how these constraints affect the infection fitness. This model raises questions that can be tested experimentally and underlines the necessity to consider the evolution of quantitative traits to understand the outcome and the fitness of an infection
Malaysian shopping mall behavior: an exploratory study
The ascendancy of the shopping mall as a significant shopping, social interaction and/or
entertainment destination has had amajor impact on retail strategies and the retail landscape in numerous
countries, especially the USA. Shopping malls are not nearly as well established in developing and
newly industrialized countries, however. Hence, the purpose of this paper is to assess international
consumer behavior in regards to shopping malls in a non-Western country, specifically, Malaysia
Pharmacodynamics of PEG-IFN-α-2a in HIV/HCV co-infected patients: Implications for treatment outcomes
Background & Aims: The pharmacokinetics and pharmacodynamics of pegylated-interferon-alpha-2a (PEG-IFN) have not been described in HCV/HIV co-infected patients. We sought to estimate the pharmacokinetics and pharmacodynamics of PEG-IFN and determine whether these parameters predict treatment outcome. Methods: Twenty-six HCV/human immunodeficiency virus (HIV)-co-infected patients were treated with a 48-week regimen of PEG-IFN (180 mu g/week) plus ribavirin (11 mg/kg/day). HCV RNA and PEG-IFN concentrations were obtained from samples collected until week 12. A modeling framework that includes pharmacokinetic and pharmacodynamic parameters was developed. Results: Five patients discontinued treatment. Seven patients achieved a sustained virological response (SVR). PEG-IFN concentrations at day 8 were similar to steady-state levels (p = 0.15) and overall pharmacokinetic parameters were similar in SVRs and non-SVRs. The maximum PEG-IFN effectiveness during the first PEG-IFN dose and the HCV-infected cell loss rate (delta), were significantly higher in SVRs compared to non-SVRs (median 95% vs. 86% [p = 0.013], 0.27 vs. 0.11 day(-1) [p = 0.006], respectively). Patients infected with HCV genotype 1 had a significantly lower average first-week PEG-IFN effectiveness (median 70% vs. 88% [p = 0.043]), however, 4- to 12-week PEG-IFN effectiveness was not significantly different compared to those with genotype 3 (p = 0.114). Genotype 1 had a significantly lower delta compared to genotype 3 (median 0.14 vs. 0.23 day(-1) [p = 0.021]). The PEG-IFN concentration that decreased HCV production by 50% (EC(50)) was lower in genotype 3 compared to genotype 1 (median 1.3 vs. 3.4 [p = 0.034]). Conclusions: Both the HCV-infected cell loss rate (delta) and the maximum effectiveness of the first dose of PEG-IFN-alpha-2a characterised HIV co-infected patients and were highly predictive of SVR. Further studies are needed to validate these viral kinetic parameters as early on-treatment prognosticators of response in patients with HCV and HIV. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved