Fairness through the Lens of Cooperative Game Theory: An Experimental Approach

This paper experimentally investigates cooperative game theory from a normative perspective. Subjects designated as Decision Makers express their view on what is fair for others, by recommending a payoff allocation for three subjects (Recipients) whose substitutabilities and complementarities are captured by a characteristic function. We show that axioms and solution concepts from cooperative game theory provide valuable insights into the data. Axiomatic and regression analysis suggest that Decision Makers’ choices can be (noisily) described as a convex combination of the Shapley value and equal split solution. A mixture model analysis, examining the distribution of Just Deserts indices describing how far one goes in the direction of the Shapley value, reveals heterogeneity across characteristic functions. Aggregating opinions by averaging, however, shows that the societal view of what is fair remains remarkably consistent across problems

Competing for Consumer Inattention

Consumers purchase multiple types of goods and services, but may be able to examine only a limited number of markets for the best price. We propose a simple model which captures these features, conveying some new insights. A firm’s price can deflect or draw attention to its market, and consequently, limited attention introduces a new dimension of competition across markets. We fully characterize the resulting equilibrium, and show that the presence of partially attentive consumers improves consumer welfare as a whole. When consumers are less attentive, they are more likely to miss the best offer in each market; but the enhanced cross-market competition decreases average price paid, as leading firms try to stay under the consumers’ radar

Dynamics of Fixation of Advantageous Mutations

We investigate the process of fixation of advantageous mutations in an asexual population. We assume that the effect of each beneficial mutation is exponentially distributed with mean value $\omega_{med}=1/\beta$. The model also considers that the effect of each new deleterious mutation reduces the fitness of the organism independent on the previous number of mutations. We use the branching process formulation and also extensive simulations to study the model. The agreement between the analytical predictions and the simulational data is quite satisfactory. Surprisingly, we observe that the dependence of the probability of fixation $P_{fix}$ on the parameter $\omega_{med}$ is precisely described by a power-law relation, $P_{fix} \sim \omega_{med}^{\gamma}$. The exponent $\gamma$ is an increase function of the rate of deleterious mutations $U$, whereas the probability $P_{fix}$ is a decreasing function of $U$. The mean value $\omega_{fix}$ of the beneficial mutations which reach ultimate fixation depends on $U$ and $\omega_{med}$. The ratio $\omega_{fix}/\omega_{med}$ increases as we consider higher values of mutation value $U$ in the region of intermediate to large values of $\omega_{med}$, whereas for low $\omega_{med}$ we observe the opposite behavior.Comment: 13 page

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba dictyostelium discoideum

Mutations in either of two presenilin genes can cause familial Alzheimer's disease. Presenilins have both proteolysis-dependent functions, as components of the γ-secretase complex, and proteolysis-independent functions in signalling. In this study, we investigate a conserved function of human presenilins in the development of the simple model organism Dictyostelium discoideum. We show that the block in Dictyostelium development caused by the ablation of both Dictyostelium presenilins is rescued by the expression of human presenilin 1, restoring the terminal differentiation of multiple cell types. This developmental role is independent of proteolytic activity, because the mutation of both catalytic aspartates does not affect presenilin ability to rescue development, and the ablation of nicastrin, a γ-secretase component that is crucial for proteolytic activity, does not block development. The role of presenilins during Dictyostelium development is therefore independent of their proteolytic activity. However, presenilin loss in Dictyostelium results in elevated cyclic AMP (cAMP) levels and enhanced stimulation-induced calcium release, suggesting that presenilins regulate these intracellular signalling pathways. Our data suggest that presenilin proteins perform an ancient non-proteolytic role in regulating intracellular signalling and development, and that Dictyostelium is a useful model for analysing human presenilin function

Inventarisatie lokstoffen : huidige en toekomstige trends in beheersing van plaaginsecten met signaalstoffen in combinatie met insecticiden t.b.v. de vollegrondsgroenteteelt

De effectiviteit van gewasbeschermingsmiddelen is sterk afhankelijk van de mate waarin het middel in contact komt met het insect (de raakkans). Insecten hebben de mogelijkheid om zich te verstoppen. Met lokstoffen zouden insecten uit hun verstopplek kunnen komen waarna ze beter geraakt kunnen worden. Internationaal zijn voorbeelden bekend waarbij lokmiddelen met bestrijdingsmiddel toegepast worden, o.a. tegen rupsen en als bait of als gel. Lokken/verstoren en daarna spuiten is een strategie die voor zover bekend nog weinig wordt toegepast. Wel zijn er veel lokstoffen van insecten op de markt. Onbekend is nu welke toepassingen er al zijn, in ontwikkeling zijn, of kansrijk ontwikkeld kunnen worden in de vollegrondsgroenteteelt. In dit verslag resultaten van onderzoek waarin een overzicht van de huidige stand van zaken en potentiële mogelijkheden van het gebruik van lokstoffen om insecten uit het gewas te lokken (om vervolgens gericht te bestrijden met een insecticide). Daarbij worden de volgende vragen beantwoord: o Welke lokstoffen zijn in gebruik (insecten – gewas)? o Welke lokstoffen zijn in ontwikkeling? o Hoe worden ze toegepast? o Wat is het effect / meerwaarde van de lokstof? o Wat zijn de voor% en nadelen van het gebruik van lokstoffen

Actief randenbeheer Drenthe lijkt effect te hebben

Via monitoring inzicht krijgen in het effect van actief randenbeheer op de oppervlaktewaterkwaliteit en de biodiversiteit in het landelijk gebied en op de inpasbaarheid op de agrarische bedrijven in een bepaald gebied. Dat was het doel van het pilotprogramma ‘Actief Randenbeheer Drenthe’: een initiatief van de Provincie Drenthe, LTO-Noord en de waterschappen Hunze en Aa’s en Velt en Vecht, in het zuidoostelijk deel van Drenthe. Uitvoerende partijen zijn Royal Haskoning, Praktijkonderzoek Plant & Omgeving van Wageningen UR en enkele agrarische bedrijven. Het programma begon in januari 2006 en is in november 2008 afgesloten. De totale duur van de meetperiode bedroeg 27 maande

Genomic and transcriptional analysis of protein heterogeneity of the honeybee venom allergen Api m 6

Several components of honeybee venom are known to cause allergenic responses in humans and other vertebrates. One such component, the minor allergen Api m 6, has been known to show amino acid variation but the genetic mechanism for this variation is unknown. Here we show that Api m 6 is derived from a single locus, and that substantial protein-level variation has a simple genome-level cause, without the need to invoke multiple loci or alternatively spliced exons. Api m 6 sits near a misassembled section of the honeybee genome sequence, and we propose that a substantial number of indels at and near Api m 6 might be the root cause of this misassembly. We suggest that genes such as Api m 6 with coding-region or untranslated region indels might have had a strong effect on the assembly of this draft of the honeybee genome

A new marker based on the avian spindlin gene that is able to sex most birds, including species problematic to sex with CHD markers

We have developed a new marker (Z43B) that can be successfully used to identify the sex of most birds (69%), including species difficult or impossible to sex with other markers. We utilized the zebra finch Taeniopygia guttata EST microsatellite sequence (CK309496) which displays sequence homology to the 5′ untranslated region (UTR) of the avian spindlin gene. This gene is known to be present on the Z and W chromosomes. To maximize cross-species utility, the primer set was designed from a consensus sequence created from homologs of CK309496 that were isolated from multiple distantly related species. Both the forward and reverse primer sequences were 100% identical to 14 avian species, including the Z chromosome of eight species and the chicken Gallus gallus W chromosome, as well as the saltwater crocodile Crocodylus porosus. The Z43B primer set was assessed by genotyping individuals of known sex belonging to 61 non-ratite species and a single ratite. The Z and W amplicons differed in size making it possible to distinguish between males (ZZ) and females (ZW) for the majority (69%) of non-ratite species tested, comprising 10 orders of birds. We predict that this marker will be useful for obtaining sex-typing data for ca 6,869 species of birds (69% of non-ratites but not galliforms). A wide range of species could be sex-typed including passerines, shorebirds, eagles, falcons, bee-eaters, cranes, shags, parrots, penguins, ducks, and a ratite species, the brown kiwi, Apteryx australis. Those species sexed include species impossible or problematic to sex-type with other markers (magpie, albatross, petrel, eagle, falcon, crane, and penguin species)

Clinical and genetic characterisation of dystrophin-deficient muscular dystrophy in a family of Miniature Poodle dogs

Four full-sibling intact male Miniature Poodles were evaluated at 4–19 months of age. One was clinically normal and three were affected. All affected dogs were reluctant to exercise and had generalised muscle atrophy, a stiff gait and a markedly elevated serum creatine kinase activity. Two affected dogs also showed poor development, learning difficulties and episodes of abnormal behaviour. In these two dogs, investigations into forebrain structural and metabolic diseases were unremarkable; electromyography demonstrated fibrillation potentials and complex repetitive discharges in the infraspinatus, supraspinatus and epaxial muscles. Histopathological, immunohistochemical and immunoblotting analyses of muscle biopsies were consistent with dystrophin-deficient muscular dystrophy. DNA samples were obtained from all four full-sibling male Poodles, a healthy female littermate and the dam, which was clinically normal. Whole genome sequencing of one affected dog revealed a >5 Mb deletion on the X chromosome, encompassing the entire DMD gene. The exact deletion breakpoints could not be experimentally ascertained, but we confirmed that this region was deleted in all affected males, but not in the unaffected dogs. Quantitative polymerase chain reaction confirmed all three affected males were hemizygous for the mutant X chromosome, while the wildtype chromosome was observed in the unaffected male littermate. The female littermate and the dam were both heterozygous for the mutant chromosome. Forty-four Miniature Poodles from the general population were screened for the mutation and were homozygous for the wildtype chromosome. The finding represents a naturally-occurring mutation causing dystrophin-deficient muscular dystrophy in the dog