26 research outputs found

    Search for jet extinction in the inclusive jet-pT spectrum from proton-proton collisions at s=8 TeV

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    Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published articles title, journal citation, and DOI.The first search at the LHC for the extinction of QCD jet production is presented, using data collected with the CMS detector corresponding to an integrated luminosity of 10.7  fb−1 of proton-proton collisions at a center-of-mass energy of 8 TeV. The extinction model studied in this analysis is motivated by the search for signatures of strong gravity at the TeV scale (terascale gravity) and assumes the existence of string couplings in the strong-coupling limit. In this limit, the string model predicts the suppression of all high-transverse-momentum standard model processes, including jet production, beyond a certain energy scale. To test this prediction, the measured transverse-momentum spectrum is compared to the theoretical prediction of the standard model. No significant deficit of events is found at high transverse momentum. A 95% confidence level lower limit of 3.3 TeV is set on the extinction mass scale

    Complex speech-language therapy interventions for stroke-related aphasia: the RELEASE study incorporating a systematic review and individual participant data network meta-analysis

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    Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting: Participant data were collected in research and clinical settings. Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data sources and participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted. Review methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were used to generate hypotheses. Results: We retrieved 5928 individual participant data from 174 data sets across 28 countries, comprising 75 electronic (3940 individual participant data), 47 randomised controlled trial (1778 individual participant data) and 91 speech and language therapy intervention (2746 individual participant data) data sets. The median participant age was 63 years (interquartile range 53–72 years). We identified 53 unavailable, but potentially eligible, randomised controlled trials (46 of these appeared to include speech and language therapy). Relevant individual participant data were filtered into each analysis. Statistically significant predictors of recovery included age (functional communication, individual participant data: 532, n = 14 randomised controlled trials) and sex (overall language ability, individual participant data: 482, n = 11 randomised controlled trials; functional communication, individual participant data: 532, n = 14 randomised controlled trials). Older age and being a longer time since aphasia onset predicted poorer recovery. A negative relationship between baseline severity score and change from baseline (p < 0.0001) may reflect the reduced improvement possible from high baseline scores. The frequency, duration, intensity and dosage of speech and language therapy were variously associated with auditory comprehension, naming and functional communication recovery. There were insufficient data to examine spontaneous recovery. The greatest overall gains in language ability [14.95 points (95% confidence interval 8.7 to 21.2 points) on the Western Aphasia Battery-Aphasia Quotient] and functional communication [0.78 points (95% confidence interval 0.48 to 1.1 points) on the Aachen Aphasia Test-Spontaneous Communication] were associated with receiving speech and language therapy 4 to 5 days weekly; for auditory comprehension [5.86 points (95% confidence interval 1.6 to 10.0 points) on the Aachen Aphasia Test-Token Test], the greatest gains were associated with receiving speech and language therapy 3 to 4 days weekly. The greatest overall gains in language ability [15.9 points (95% confidence interval 8.0 to 23.6 points) on the Western Aphasia Battery-Aphasia Quotient] and functional communication [0.77 points (95% confidence interval 0.36 to 1.2 points) on the Aachen Aphasia Test-Spontaneous Communication] were associated with speech and language therapy participation from 2 to 4 (and more than 9) hours weekly, whereas the highest auditory comprehension gains [7.3 points (95% confidence interval 4.1 to 10.5 points) on the Aachen Aphasia Test-Token Test] were associated with speech and language therapy participation in excess of 9 hours weekly (with similar gains notes for 4 hours weekly). While clinically similar gains were made alongside different speech and language therapy intensities, the greatest overall gains in language ability [18.37 points (95% confidence interval 10.58 to 26.16 points) on the Western Aphasia Battery-Aphasia Quotient] and auditory comprehension [5.23 points (95% confidence interval 1.51 to 8.95 points) on the Aachen Aphasia Test-Token Test] were associated with 20–50 hours of speech and language therapy. Network meta-analyses on naming and the duration of speech and language therapy interventions across language outcomes were unstable. Relative variance was acceptable (< 30%). Subgroups may benefit from specific interventions. Limitations: Data sets were graded as being at a low risk of bias but were predominantly based on highly selected research participants, assessments and interventions, thereby limiting generalisability. Conclusions: Frequency, intensity and dosage were associated with language gains from baseline, but varied by domain and subgroup. Future work: These exploratory findings require confirmatory study designs to test the hypotheses generated and to develop more tailored speech and language therapy interventions. Study registration: This study is registered as PROSPERO CRD42018110947. Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme and will be published in full in Health and Social Care Delivery Research; Vol. 10, No. 28. See the NIHR Journals Library website for further project information. Funding was also provided by The Tavistock Trust for Aphasia

    Consistent patterns of common species across tropical tree communities

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    Trees structure the Earth’s most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations1,2,3,4,5,6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia. We estimate that 2.2%, 2.2% and 2.3% of species comprise 50% of the tropical trees in these regions, respectively. Extrapolating across all closed-canopy tropical forests, we estimate that just 1,053 species comprise half of Earth’s 800 billion tropical trees with trunk diameters of at least 10 cm. Despite differing biogeographic, climatic and anthropogenic histories7, we find notably consistent patterns of common species and species abundance distributions across the continents. This suggests that fundamental mechanisms of tree community assembly may apply to all tropical forests. Resampling analyses show that the most common species are likely to belong to a manageable list of known species, enabling targeted efforts to understand their ecology. Although they do not detract from the importance of rare species, our results open new opportunities to understand the world’s most diverse forests, including modelling their response to environmental change, by focusing on the common species that constitute the majority of their trees

    Searches for electroweak neutralino and chargino production in channels with Higgs, Z, and W bosons in pp collisions at 8 TeV

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    Searches for supersymmetry (SUSY) are presented based on the electroweak pair production of neutralinos and charginos, leading to decay channels with Higgs, Z, and W bosons and undetected lightest SUSY particles (LSPs). The data sample corresponds to an integrated luminosity of about 19.5 fb(-1) of proton-proton collisions at a center-of-mass energy of 8 TeV collected in 2012 with the CMS detector at the LHC. The main emphasis is neutralino pair production in which each neutralino decays either to a Higgs boson (h) and an LSP or to a Z boson and an LSP, leading to hh, hZ, and ZZ states with missing transverse energy (E-T(miss)). A second aspect is chargino-neutralino pair production, leading to hW states with E-T(miss). The decays of a Higgs boson to a bottom-quark pair, to a photon pair, and to final states with leptons are considered in conjunction with hadronic and leptonic decay modes of the Z and W bosons. No evidence is found for supersymmetric particles, and 95% confidence level upper limits are evaluated for the respective pair production cross sections and for neutralino and chargino mass values

    Emergência e desenvolvimento de plântulas de maracujazeiro azedo oriundas de sementes tratadas com bioestimulante Emergence and development of passion fruit plant from seeds treated with bio stimulant

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    O objetivo do trabalho foi estudar os efeitos de bioestimulante na emergência e no desenvolvimento de plântulas de Passiflora edulis Sims.f. flavicarpa Deg. O experimento foi conduzido sob cultivo protegido, com temperatura controlada (25ºC), no Departamento de Botânica, Instituto de Biociências, UNESP, Câmpus de Botucatu-SP. As sementes receberam os tratamentos com as concentrações 0 (testemunha); 4; 8; 12; 16 e 20 ml de bioestimulante/kg de semente e foram semeadas em bandejas de isopor contendo substrato comercial. O bioestimulante empregado é constituído por 0,005% de ácido índolbutírico (auxina), 0,009% de cinetina (citocinina) e 0,005% de ácido giberélico (giberelina). O delineamento experimental foi inteiramente casualizado, com seis tratamentos e cinco repetições de 24 sementes. As avaliações de porcentagem de emergência de plântulas foram realizadas semanalmente, bem como o comprimento de caule e raiz, diâmetro do caule, número de folhas, área foliar e massa seca de raiz, caule e folha, aos 35 dias após a semeadura. Os dados foram submetidos à análise de variância e regressão polinomial, ao nível de 5% de probabilidade. As concentrações de 12 e 16 ml de bioestimulante/kg de semente aplicado às sementes promoveram as maiores porcentagens de emergência e desenvolvimento de plântulas.<br>The aim of this work was the study of the effects of bio stimulants in the emergence and development of Passiflora edulis Sims.f. flavicarpa Deg. plantlet. The experiment was performed under shelter with controlled temperature (25ºC), at the Dep. of Botanic, Bioscience's Institute, UNESP, Campus de Botucatu, state of Sao Paulo, Brazil. The seeds were treated with different concentrations: 0 (check), 4, 8, 12, 16 and 20 ml of bio stimulant/kg of seeds and were sowed on polystyrene trays containing commercial substratum. The employed bio stimulant is comprised of 0.005% of indolylbutyric (auxin), 0.009% of kinetin (cytokine), and 0.005% of gibberellic acid. It was used the completely randomized blocks delineation with six treatment and five replications of 24 seeds. The estimation of the emergence percentage of plantlets were performed weekly and the stem and root lengths, stem diameter, number of leaves, leaf area and root, stem and leaf dry matter were performed 35 days after sowing. The data were submitted to analysis of variance and polynomial regression at 5% of probability. The concentrations of 12 and 16 ml of bio stimulant/kg of seed applied to the seeds have promoted the highest percentage of emergence and development of the plantlets

    Padrões de floração e frutificação de árvores da Amazônia Maranhense Flowering and Fruiting Patterns of the Maranhense Amazon Rainforest Trees

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    Estudos fenológicos em nível de comunidades podem facilitar a compreensão do comportamento das espécies diante de alterações nos ecossistemas, além de refletir a distribuição anual de tipos específicos de recursos. Este trabalho buscou definir os padrões gerais e a sazonalidade de floração e frutificação de uma comunidade em duas áreas de floresta na Amazônia Maranhense, uma não perturbada e outra submetida a corte seletivo. A vegetação corresponde às matas de cipós das florestas amazônicas, alternando matas densas e abertas, de alta biomassa. Valores médios anuais de temperatura variam entre 24,5º C e 26,0º C, e entre 1400 mm e 1800 mm de precipitação, com um período seco de 5 a 6 meses, de junho a novembro. Foram analisadas a floração e a frutificação de 89 espécies arbóreas, de agosto de 1994 a junho de 1996. As espécies foram agrupadas em: árvores do sub-dossel, árvores do estrato superior e árvores que ocorrem em ambos os estratos. Foi feita comparação entre grupos (estratos, tipos de floresta e mecanismos de dispersão) e possíveis correlações com a precipitação foram investigadas. Quinze espécies estudadas foram exclusivas do estrato inferior e 63 do estrato superior da floresta; 17 espécies foram registradas apenas na mata nativa e 37 apenas na mata manejada. A maioria das espécies é zoocórica (62,9 %). A floração e a frutificação ocorreram durante todo o ano, com pico de floração de outubro a dezembro e picos de frutificação de março a julho e de outubro a dezembro. Os resultados obtidos demonstram uma grande sincronia na floração e frutificação dos indivíduos, e confirmam a relação entre esses processos e a variação na precipitação ao longo do ano, e que plantas de ambientes diferenciados exibem comportamentos fenológicos diferentes. Os padrões observados foram semelhantes entre as áreas e a outros estudos na Amazônia.<br>Community level phonological studies can facilitate the understanding of species behavior as a result of ecosystem changes, further reflecting on the annual allotment of specific resources. The aim of the present study was to define the general patterns, flowering and fruiting seasonality from a community in two forest areas of the Maranhense Amazon Rainforest: a non-disturbed area and another submitted to selective logging. The vegetation is composed of Amazon forest lianas alternating between dense and open high biomass forest. Average annual temperature varies between 24.5O C and 26.0O C, with precipitation ranging from 1400 mm to 1800 mm, and a dry season between June and November. Flowering and fruiting of 89 species were analyzed from August 1994 to June 1996. The species were grouped as follows: sub-dossal, upper strata, and trees occurring in both strata. Comparison was made between groups (strata, types of forest and mechanisms for dispersal) and possible correlations with rainfall were investigated. Fifteen studied species were solely from the lower strata, and 63 from the upper forest strata; 17 species were recorded only in native forest and 37 in managed forest. Most species (62.9 %) is zoochorous. Flowering and fruiting take place throughout the year with flowering peak from October to December and fruiting peaks from March to July and from October to December. The results showed a great synchrony in flowering and fruiting of individuals, and confirm the relationship between these cases and the variation in rainfall throughout the year, and that plants of different environments exhibit phonological behavior different. The observed flowering and fruiting patterns were similar between the areas and comparable to other studies in the Amazon Rainforest
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