15,142 research outputs found
Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells
Neural crest precursors to the autonomic nervous system form different derivatives depending upon their axial level of origin; for example, vagal, but not trunk, neural crest cells form the enteric ganglia of the gut. Here, we show that Slit2 is expressed at the entrance of the gut, which is selectively invaded by vagal, but not trunk, neural crest. Accordingly, only trunk neural crest cells express Robo receptors. In vivo and in vitro experiments demonstrate that trunk, not vagal, crest cells avoid cells or cell membranes expressing Slit2, thereby contributing to the differential ability of neural crest populations to invade and innervate the gut. Conversely, exposure to soluble Slit2 significantly increases the distance traversed by trunk neural crest cells. These results suggest that Slit2 can act bifunctionally, both repulsing and stimulating the motility of trunk neural crest cells
Modelling yarn balloon motion in ring spinning
Air-drag on a ballooning yarn and balloon shape affect the yarn tension and ends-down (yarn breakage), which in turn affects energy consumption and yarn productivity in ring spinning. In this article, a mathematical model of yarn ballooning motion in ring spinning is established. The model can be used to generate balloon shape and predict tension in the ballooning yarn under given spinning conditions. Yarn tension was measured using a computer data acquisition system and the balloon shapes were captured using a digital camera with video capability during the experiments using cotton and wool yarns at various balloon-heights and with varying yarn-length in the balloon. The air-drag coefficients on ballooning cotton and wool yarns in ring spinning were estimated by making a “best fit” between the theoretical and experimental turning points. The theoretical results were verified with experimental data. The effects of air-drag and balloon shape on yarn tension are discussed
Justice and conservation: The need to incorporate recognition
In light of the Aichi target to manage protected areas equitably by 2020, we ask how the conservation sector should define justice. We focus in particular on ‘recognition’, because it is the least well understood aspect of environmental justice, and yet highly relevant to conservation because of its concern with respect for local knowledge and cultures. In order to explore the meaning of recognition in the conservation context, we take four main steps. First, we identify four components of recognition to serve as our analytical framework: subjects of justice, the harms that constitute injustice, the mechanisms that produce injustices, and the responses to alleviate these. Secondly, we apply this framework to explore four traditions of thinking about recognition: Hegelian inter-subjectivity, critical theory, southern decolonial theory, and the capabilities approach. Thirdly, we provide three case studies of conservation conflicts highlighting how different theoretical perspectives are illustrated in the claims and practices of real world conservation struggles. Fourthly, we finish the paper by drawing out some key differences between traditions of thinking, but also important areas of convergence. The convergences provide a basis for concluding that conservation should look beyond a distributive model of justice to incorporate concerns for social recognition, including careful attention to ways to pursue equality of status for local conservation stakeholders. This will require reflection on working practices and looking at forms of intercultural engagement that, for example, respect alternative ways of relating to nature and biodiversity
Image patch analysis of sunspots and active regions. II. Clustering via matrix factorization
Separating active regions that are quiet from potentially eruptive ones is a
key issue in Space Weather applications. Traditional classification schemes
such as Mount Wilson and McIntosh have been effective in relating an active
region large scale magnetic configuration to its ability to produce eruptive
events. However, their qualitative nature prevents systematic studies of an
active region's evolution for example. We introduce a new clustering of active
regions that is based on the local geometry observed in Line of Sight
magnetogram and continuum images. We use a reduced-dimension representation of
an active region that is obtained by factoring the corresponding data matrix
comprised of local image patches. Two factorizations can be compared via the
definition of appropriate metrics on the resulting factors. The distances
obtained from these metrics are then used to cluster the active regions. We
find that these metrics result in natural clusterings of active regions. The
clusterings are related to large scale descriptors of an active region such as
its size, its local magnetic field distribution, and its complexity as measured
by the Mount Wilson classification scheme. We also find that including data
focused on the neutral line of an active region can result in an increased
correspondence between our clustering results and other active region
descriptors such as the Mount Wilson classifications and the value. We
provide some recommendations for which metrics, matrix factorization
techniques, and regions of interest to use to study active regions.Comment: Accepted for publication in the Journal of Space Weather and Space
Climate (SWSC). 33 pages, 12 figure
A Photoionization Coincidence Time-of-Flight Mass Spectrometer for Studies on Ionization and Dissociation Processes
Abstract Not Provided
Systematic review of economic evaluations of laparoscopic surgery for colorectal cancer
Objective Colorectal cancer is one of the most common cancers and the standard surgical treatment for this cancer is open resection (OS), but laparoscopic surgery (LS) may be an alternative treatment. In 2000, a Health Technology Assessment (HTA) review found little evidence on costs and cost-effectiveness in comparing the two methods. The evidence base has since expanded and this study systematically reviews the economic evaluations on the subject published since 2000.
Method Systematic review of studies reporting costs and outcomes of LS vs OS for colorectal cancer. National Health Service Economic Evaluation Database (NHS EED) methods for abstract writing were followed. Studies were summarized and incremental cost-effectiveness ratios (ICER) for common outcomes were calculated.
Results Five studies met the inclusion criteria. LS generally had higher healthcare costs. Most studies reported longer operational time and shorter length of stay and similar long-term outcomes with LS vs OS. Only one outcome, complications, was common across all studies but results lacked consistency (e.g. in two studies, OS was less costly but more effective; in another study, LS was less costly but more effective; and in the further two studies, LS could potentially be cost effective depending on the decision-makers' willingness to pay for the health gain).
Conclusion The evidence on cost-effectiveness is not consistent. LS was generally more costly than OS. However, the effectiveness data used in individual economic evaluation were imprecise and unreliable when compared with data from systematic reviews of effectiveness. Nevertheless, short-term benefits of LS (e.g. shorter recovery) may make LS appear less costly when productivity gains are considered.Department of Health, National Coordinating Centre for Health Technology Assessment, Chief Scientist Office of the Scottish Government Health DirectoratesPeer reviewedAuthor versio
Image patch analysis of sunspots and active regions. I. Intrinsic dimension and correlation analysis
The flare-productivity of an active region is observed to be related to its
spatial complexity. Mount Wilson or McIntosh sunspot classifications measure
such complexity but in a categorical way, and may therefore not use all the
information present in the observations. Moreover, such categorical schemes
hinder a systematic study of an active region's evolution for example. We
propose fine-scale quantitative descriptors for an active region's complexity
and relate them to the Mount Wilson classification. We analyze the local
correlation structure within continuum and magnetogram data, as well as the
cross-correlation between continuum and magnetogram data. We compute the
intrinsic dimension, partial correlation, and canonical correlation analysis
(CCA) of image patches of continuum and magnetogram active region images taken
from the SOHO-MDI instrument. We use masks of sunspots derived from continuum
as well as larger masks of magnetic active regions derived from the magnetogram
to analyze separately the core part of an active region from its surrounding
part. We find the relationship between complexity of an active region as
measured by Mount Wilson and the intrinsic dimension of its image patches.
Partial correlation patterns exhibit approximately a third-order Markov
structure. CCA reveals different patterns of correlation between continuum and
magnetogram within the sunspots and in the region surrounding the sunspots.
These results also pave the way for patch-based dictionary learning with a view
towards automatic clustering of active regions.Comment: Accepted for publication in the Journal of Space Weather and Space
Climate (SWSC). 23 pages, 11 figure
Antigen-driven T-cell turnover.
A mathematical model is developed to characterize the distribution of cell turnover rates within a population of T lymphocytes. Previous models of T-cell dynamics have assumed a constant uniform turnover rate; here we consider turnover in a cell pool subject to clonal proliferation in response to diverse and repeated antigenic stimulation. A basic framework is defined for T-cell proliferation in response to antigen, which explicitly describes the cell cycle during antigenic stimulation and subsequent cell division. The distribution of T-cell turnover rates is then calculated based on the history of random exposures to antigens. This distribution is found to be bimodal, with peaks in cell frequencies in the slow turnover (quiescent) and rapid turnover (activated) states. This distribution can be used to calculate the overall turnover for the cell pool, as well as individual contributions to turnover from quiescent and activated cells. The impact of heterogeneous turnover on the dynamics of CD4(+) T-cell infection by HIV is explored. We show that our model can resolve the paradox of high levels of viral replication occurring while only a small fraction of cells are infected
Acoustic oscillations in stars near the tip of the red giant branch
Small amplitude oscillations are observed in red giant branch (RGB) stars.
Data on such oscillations are a source of information about the objects,
notably about properties of convection in their envelopes and about the systems
these objects inhabit. The OGLE-III catalog contains data for about 80 thousand
small amplitude variable red giants (OSARGs) in the Large Magellanic Cloud.
We want to explain variability in OSARGs as the solar-like oscillation and to
associate the peaks in power spectra with frequencies of acoustic modes. We use
data on reddening-free magnitudes of the objects and interpret them in terms of
stellar physical parameters using tabulated isochrones calculated for ages and
composition parameters corresponding to the upper RGB of the LMC. Massive data
on the peak frequencies and amplitudes are compared with expectations for
stochastically excited oscillations. The frequencies are also compared with
those calculated for radial modes in envelope models with parameters taken from
the isochrones.
In stars close to the tip of the RGB, the peaks in power spectra are found in
the 0.1-1.0 Hz range, which is consistent with extrapolation of the
frequency-luminosity relation for the solar-like oscillation. The dominant
peaks occur close to the first two radial overtones. The increase in amplitude
with luminosity is slower than linear. The exponent s=0.9 is similar to what is
found from recent analysis of CoRoT data on less luminous red giants. Frequency
separations between dominant peaks are found to be smaller by about 20% than
calculated separations between these modes. After examining various
possibilities, we left this discrepancy unexplained.
The small amplitude variability of stars at the RGB tip is likely to be
caused by a stochastic excitation of acoustic oscillations, but interpreting of
individual peaks in power spectra presents a problem.Comment: Accepted for publication in Astronomy and Astrophysics, 6 pages, 6
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Population screening for colorectal cancer means getting FIT:the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT)
Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. Although these tests are being performed worldwide, why is this test different from its predecessors? What evidence supports its adoption? How can this evidence best be used? This review addresses these questions and provides an understanding of FIT theory and practices to expedite international efforts to implement the use of FIT in CRC screening
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