76 research outputs found
Scaling in Plasticity-Induced Cell-Boundary Microstructure: Fragmentation and Rotational Diffusion
We develop a simple computational model for cell boundary evolution in
plastic deformation. We study the cell boundary size distribution and cell
boundary misorientation distribution that experimentally have been found to
have scaling forms that are largely material independent. The cell division
acts as a source term in the misorientation distribution which significantly
alters the scaling form, giving it a linear slope at small misorientation
angles as observed in the experiments. We compare the results of our simulation
to two closely related exactly solvable models which exhibit scaling behavior
at late times: (i) fragmentation theory and (ii) a random walk in rotation
space with a source term. We find that the scaling exponents in our simulation
agree with those of the theories, and that the scaling collapses obey the same
equations, but that the shape of the scaling functions depend upon the methods
used to measure sizes and to weight averages and histograms
Forward pi^0 Production and Associated Transverse Energy Flow in Deep-Inelastic Scattering at HERA
Deep-inelastic positron-proton interactions at low values of Bjorken-x down
to x \approx 4.10^-5 which give rise to high transverse momentum pi^0 mesons
are studied with the H1 experiment at HERA. The inclusive cross section for
pi^0 mesons produced at small angles with respect to the proton remnant (the
forward region) is presented as a function of the transverse momentum and
energy of the pi^0 and of the four-momentum transfer Q^2 and Bjorken-x.
Measurements are also presented of the transverse energy flow in events
containing a forward pi^0 meson. Hadronic final state calculations based on QCD
models implementing different parton evolution schemes are confronted with the
data.Comment: 27 pages, 8 figures and 3 table
Search for Doubly-Charged Higgs Boson Production at HERA
A search for the single production of doubly-charged Higgs bosons H^{\pm \pm}
in ep collisions is presented. The signal is searched for via the Higgs decays
into a high mass pair of same charge leptons, one of them being an electron.
The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment
at HERA. No evidence for doubly-charged Higgs production is observed and mass
dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs
boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only
decays into an electron and a muon via a coupling of electromagnetic strength
h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the
H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged
Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3,
masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity
Jet production in ep collisions at high Q(2) and determination of alpha(s)
The production of jets is studied in deep-inelastic e(+/-) p scattering at large negative four momentum transfer squared 150 LT Q(2) LT 15000 GeV2 using HERA data taken in 1999-2007, corresponding to an integrated luminosity of 395 pb(-1). Inclusive jet, 2-jet and 3-jet cross sections, normalised to the neutral current deep-inelastic scattering cross sections, are measured as functions of Q(2), jet transverse momentum and proton momentum fraction. The measurements are well described by perturbative QCD calculations at next-to-leading order corrected for hadronisation effects. The strong coupling as determined from these measurement
Strain Mode Dependence of Deformation Texture Developments: Microstructural Origin
Fully recrystallized commercial-purity aluminum sheets were deformed by limiting dome height
tests, the following strain modes: uniaxial tension (US), near plane strain tension (PS), and
equibiaxial tension (BS) were identified using standard procedure. The deformation texture
developments differed significantly depending on the strain mode. Although the full constraints
Taylor (FCT) model captured the texture developments in US, it failed to reproduce deformation
textures in PS and especially in BS. The Advanced LAMEL (ALAMEL) model and the
crystal plasticity finite element method (CPFEM) were, however, successful with respect to all
three strain modes. Microtexture data brought out interesting observations of orientation
gradients. First, the orientation gradients increased from US to PS to BS. Second, such gradients
were mostly around initial (or prior deformation) grain boundary regions. A simple
algorithm, and an associated computer program, was developed to demarcate such near
boundary gradient zones (NBGZs). The area fraction and severity of NBGZ seemed to affect
the texture development; FCT was reasonably successful at low NBGZ, whereas high NBGZ
required the ALAMEL and the CPFEM models that are capable of addressing strain heterogeneity
and grain interactions
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