Building Shared Values in the Community: Culture of Health

The zip codes where patients live are stronger determinants of health outcomes than the frequency of visits with a primary care provider. Providers have a unique opportunity to extend health care beyond the clinic walls and engage in efforts to improve the communities where their patients grow, live, work, and age. In order to impact the health of patients, a culture of health needs to be developed. The Robert Wood Johnson Foundation culture of health action framework directed the build of a foundation of health as a shared value in a neighborhood with high morbidity and mortality rates in southwest San Antonio, Texas. This community quality improvement intervention was designed to equip participating community members with knowledge, skills, and supplies to be drivers for health as a shared value. Prior to implementation, community surveys assessed perceptions regarding health as a shared value. A one-time class offering opened discussion regarding the effects of stress on heart health. A 7-week class, Health to the Fourth Power, was developed to equip community stakeholders using healthful education, physical activity, community responsibility, and plant-based meal preparation. Post implementation survey results revealed moderate understanding of health interconnectedness. Health to the Fourth Power participants increased daily fruit and vegetable consumption, decreased body mass index, and decreased mean systolic blood pressures. It is imperative for medical providers to advocate for a culture of health in their patients’ communities

Photometry of comet 9P/Tempel 1 during the 2004/2005 approach and the Deep Impact module impact

The results of the 9P/Tempel 1 CARA (Cometary Archive for Amateur Astronomers) observing campaign is presented. The main goal was to perform an extended survey of the comet as a support to the Deep Impact (DI) Mission. CCD R, I and narrowband aperture photometries were used to monitor the $Af\rho$ quantity. The observed behaviour showed a peak of 310 cm 83 days before perihelion, but we argue that it could be distorted by the phase effect, too. The phase effect is roughly estimated around 0.0275 mag/degree, but we had no chance for direct determination because of the very similar geometry of the observed apparitions. The log-slope of $Af\rho$ was around -0.5 between about 180--100 days before the impact but evolved near the steady-state like 0 value by the impact time. The DI module impact caused an about 60%{} increase in the value of $Af\rho$ and a cloud feature in the coma profile which was observed just after the event. The expansion of the ejecta cloud was consistent with a fountain model with initial projected velocity of 0.2 km/s and $\beta$=0.73. Referring to a 25~000 km radius area centered on the nucleus, the total cross section of the ejected dust was 8.2/$A$ km$^2$ 0.06 days after the impact, and 1.2/$A$ km$^2$ 1.93 days after the impact ($A$ is the dust albedo). 5 days after the event no signs of the impact were detected nor deviations from the expected activity referring both to the average pre-impact behaviour and to the previous apparitions ones.Comment: 25 pages (including cover pages), 9 figures, 1 table, accepted by Icarus DI Special Issu

65 Cybele in the thermal infrared: Multiple observations and thermophysical analysis

We investigated the physical and thermal properties of 65 Cybele}, one of the largest main-belt asteroids. Based on published and recently obtained thermal infrared observations, including ISO measurements, we derived through thermophysical modelling (TPM) a size of 302x290x232 km (+/- 4 %) and an geometric visible albedo of 0.050+/-0.005. Our model of a regolith covered surface with low thermal inertia and "default" roughness describes the wavelengths and phase angle dependent thermal aspects very well. Before/after opposition effect and beaming behaviour can be explained in that way. We found a constant emissivity of 0.9 at wavelengths up to about 100 micron and lower values towards the submillimetre range, indicating a grain size distribution dominated by 200 micron particle sizes. The spectroscopic analysis revealed an emissivity increase between 8.0 and 9.5 micron. We compared this emissivity behaviour with the Christiansen features of carbonaceous chondrite meteorites, but a conclusive identification was not possible. A comparison between the Standard Thermal Model (STM) and the applied TPM clearly demonstrates the limitations and problems of the STM for the analysis of multi-epoch and -wavelengths observations. While the TPM produced a unique diameter/albedo solution, the calculated STM values varied by +/-30 % and showed clear trends with wavelength and phase angle. Cybele can be considered as a nice textbook case for the thermophysical analysis of combined optical and thermal infrared observations.Comment: 11 pages, 8 figures, accepted for publication by A&

The NICMOS Snapshot Survey of nearby Galaxies

We present ``snapshot'' observations with the NearInfrared Camera and MultiObject Spectrometer (NICMOS) on board the Hubble Space Telescope (HST) of 94 nearby galaxies from the Revised Shapley Ames Catalog. Images with 0.2 as resolution were obtained in two filters, a broad-band continuum filter (F160W, roughly equivalent to the H-band) and a narrow band filter centered on the Paschen alpha line (F187N or F190N, depending on the galaxy redshift) with the 51x51 as field of view of the NICMOS camera 3. A first-order continuum subtraction is performed, and the resulting line maps and integrated Paschen alpha line fluxes are presented. A statistical analysis indicates that the average Paschen alpha surface brightness {\bf in the central regions} is highest in early-type (Sa-Sb) spirals.Comment: Original contained error in flux calibration. Table 1 now has correct Paschen Alpha fluxes. 14 pages LaTeX with JPEG and PS figures. Also available at http://icarus.stsci.edu/~boeker/publications.htm

Aerodynamic investigations of ventilated brake discs.

The heat dissipation and performance of a ventilated brake disc strongly depends on the aerodynamic characteristics of the flow through the rotor passages. The aim of this investigation was to provide an improved understanding of ventilated brake rotor flow phenomena, with a view to improving heat dissipation, as well as providing a measurement data set for validation of computational fluid dynamics methods. The flow fields at the exit of four different brake rotor geometries, rotated in free air, were measured using a five-hole pressure probe and a hot-wire anemometry system. The principal measurements were taken using two-component hot-wire techniques and were used to determine mean and unsteady flow characteristics at the exit of the brake rotors. Using phase-locked data processing, it was possible to reveal the spatial and temporal flow variation within individual rotor passages. The effects of disc geometry and rotational speed on the mean flow, passage turbulence intensity, and mass flow were determined. The rotor exit jet and wake flow were clearly observed as characterized by the passage geometry as well as definite regions of high and low turbulence. The aerodynamic flow characteristics were found to be reasonably independent of rotational speed but highly dependent upon rotor geometry

Asteroids. From Observations to Models

We will discuss some specific applications to the rotation state and the shapes of moderately large asteroids, and techniques of observations putting some emphasis on the HST/FGS instrument.Comment: to appear in LNP; 28pages; written in 2003; Winter School "Dynamique des Corps Celestes Non Ponctuels et des Anneaux", Lanslevillard (FRANCE

High Diversity, Low Disparity and Small Body Size in Plesiosaurs (Reptilia, Sauropterygia) from the Triassic–Jurassic Boundary

Invasion of the open ocean by tetrapods represents a major evolutionary transition that occurred independently in cetaceans, mosasauroids, chelonioids (sea turtles), ichthyosaurs and plesiosaurs. Plesiosaurian reptiles invaded pelagic ocean environments immediately following the Late Triassic extinctions. This diversification is recorded by three intensively-sampled European fossil faunas, spanning 20 million years (Ma). These provide an unparalleled opportunity to document changes in key macroevolutionary parameters associated with secondary adaptation to pelagic life in tetrapods. A comprehensive assessment focuses on the oldest fauna, from the Blue Lias Formation of Street, and nearby localities, in Somerset, UK (Earliest Jurassic: 200 Ma), identifying three new species representing two small-bodied rhomaleosaurids (Stratesaurus taylori gen et sp. nov.; Avalonnectes arturi gen. et sp. nov) and the most basal plesiosauroid, Eoplesiosaurus antiquior gen. et sp. nov. The initial radiation of plesiosaurs was characterised by high, but short-lived, diversity of an archaic clade, Rhomaleosauridae. Representatives of this initial radiation were replaced by derived, neoplesiosaurian plesiosaurs at small-medium body sizes during a more gradual accumulation of morphological disparity. This gradualistic modality suggests that adaptive radiations within tetrapod subclades are not always characterised by the initially high levels of disparity observed in the Paleozoic origins of major metazoan body plans, or in the origin of tetrapods. High rhomaleosaurid diversity immediately following the Triassic-Jurassic boundary supports the gradual model of Late Triassic extinctions, mostly predating the boundary itself. Increase in both maximum and minimum body length early in plesiosaurian history suggests a driven evolutionary trend. However, Maximum-likelihood models suggest only passive expansion into higher body size categories

Visual adaptation enhances action sound discrimination

Prolonged exposure, or adaptation, to a stimulus in one modality can bias, but also enhance, perception of a subsequent stimulus presented within the same modality. However, recent research has also found that adaptation in one modality can bias perception in another modality. Here we show a novel crossmodal adaptation effect, where adaptation to a visual stimulus enhances subsequent auditory perception. We found that when compared to no adaptation, prior adaptation to visual, auditory or audiovisual hand actions enhanced discrimination between two subsequently presented hand action sounds. Discrimination was most enhanced when the visual action ‘matched’ the auditory action. In addition, prior adaptation to a visual, auditory or audiovisual action caused subsequent ambiguous action sounds to be perceived as less like the adaptor. In contrast, these crossmodal action aftereffects were not generated by adaptation to the names of actions. Enhanced crossmodal discrimination and crossmodal perceptual aftereffects may result from separate mechanisms operating in audiovisual action sensitive neurons within perceptual systems. Adaptation induced crossmodal enhancements cannot be explained by post-perceptual responses or decisions. More generally, these results together indicate that adaptation is a ubiquitous mechanism for optimizing perceptual processing of multisensory stimuli

The Herbicide Atrazine Activates Endocrine Gene Networks via Non-Steroidal NR5A Nuclear Receptors in Fish and Mammalian Cells

Atrazine (ATR) remains a widely used broadleaf herbicide in the United States despite the fact that this s-chlorotriazine has been linked to reproductive abnormalities in fish and amphibians. Here, using zebrafish we report that environmentally relevant ATR concentrations elevated zcyp19a1 expression encoding aromatase (2.2 µg/L), and increased the ratio of female to male fish (22 µg/L). ATR selectively increased zcyp19a1, a known gene target of the nuclear receptor SF-1 (NR5A1), whereas zcyp19a2, which is estrogen responsive, remained unchanged. Remarkably, in mammalian cells ATR functions in a cell-specific manner to upregulate SF-1 targets and other genes critical for steroid synthesis and reproduction, including Cyp19A1, StAR, Cyp11A1, hCG, FSTL3, LHß, INHα, αGSU, and 11ß-HSD2. Our data appear to eliminate the possibility that ATR directly affects SF-1 DNA- or ligand-binding. Instead, we suggest that the stimulatory effects of ATR on the NR5A receptor subfamily (SF-1, LRH-1, and zff1d) are likely mediated by receptor phosphorylation, amplification of cAMP and PI3K signaling, and possibly an increase in the cAMP-responsive cellular kinase SGK-1, which is known to be upregulated in infertile women. Taken together, we propose that this pervasive and persistent environmental chemical alters hormone networks via convergence of NR5A activity and cAMP signaling, to potentially disrupt normal endocrine development and function in lower and higher vertebrates

Epithelial cell polarity: a major gatekeeper against cancer?

The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation and excessive cell growth are hallmarks of cancer. In this review, we focus on identifying the stages of tumoural development that are affected by the loss or deregulation of epithelial cell polarity. Asymmetric division has recently emerged as a major regulatory mechanism that controls stem cell numbers and differentiation. Links between cell polarity and asymmetric cell division in the context of cancer will be examined. Apical–basal polarity and cell–cell adhesion are tightly interconnected. Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed. Altogether, we present the argument that loss of epithelial cell polarity may have an important role in both the initiation of tumourigenesis and in later stages of tumour development, favouring the progression of tumours from benign to malignancy