51 research outputs found
Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam
Introduction: Allostatic Load (AL) index proposes indicators for the functioningof the main potentially stress-affected systems. Sex differences instress response and stress-related diseases susceptibility have been describedfor the general population. In this observational study we describe the effectsof sex and age on allostatic load variables, in a cohort of patients with generalanxiety disorders and neuroticism treated with alprazolam during 12 weeks,before and after treatment. Methods: Patients with general (DSM IV) anxietydisorders with >6 in Hamilton scale, Allostatic load (>1 Crimmins and SeemanAL modified criteria) and neuroticism >18 (NEO-FFI inventory), wereincluded. All patients completed psychiatric assessment, allostatic load indexdetermination before (â1 week) and after 12 weeks of treatment with alprazolam(0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular,metabolic and inflammatory variables. Univariate analysis (two-wayANOVA), Student?s t-test (related variables) and Pearson correlations weredetermined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19males (44.2 ± 12.8 years) with general anxiety disorder were included; 28 patientswith <50 years (60.7% females), and 26 with â„50 years (69.2% females).Younger patients (<50 years) (two-way ANOVA, p = 0.02) were significantlyassociated with lower allostatic load index after treatment. However, womenshowed higher anxiety levels in both, before (Two-way ANOVA, p = 0.059)and after treatment (two-way ANOVA, p = 0.005), with a significantly betterprofile than men in many individual AL variables, particularly cardiovascular(systolic blood pressure), obesity (body mass index), and lipids (higher HDLlevels). After treatment a higher reduction of fibrinogen levels was found inmen (two-way ANOVA, p = 0.02). Conclusions: In this preliminary analysiswe described sex and age differences in psychiatry aspects and allostatic loadindexes in patients with general anxiety disorders in the short-term treatmentwith alprazolam. These considerations remark the need of pondering sex andage differences during the use of drugs for protracted periods.Fil: D`Alessio, Luciana. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. NĂ©stor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Soria, Carlos A.. Henri Laborit Institute Of Biosciences; ArgentinaFil: Remedi, Carolina. Henri Laborit Institute Of Biosciences; Argentina; ArgentinaFil: RoldĂĄn, Emilio J. A.. Instituto de NeurobiologĂa IDNEU; Argentin
Semantic and Phonemic Verbal Fluency Performance in Patients with General Anxiety Disorders and Allostatic Load under Alprazolam Treatment
Purpose: Anxiety disorders are frequently associated with chronic stress with possible cognitive consequences. The aim of this study was to determine the verbal fluency performance in a cohort of patients with anxiety disorders and allostatic load, treated with alprazolam during 12 weeks. Methods: Patients with GAD (general anxiety disorders, DSM IV), with >6 in Hamilton Anxiety Rating Scale (HAM-A), neuroticism > 18 (NEO-FFI inventory), and normal Mini-Mental State Examination were included. Clinical and Psychiatric examination, Allostatic Load Index and cognitive assessment were analyzed before and after 12 weeks of treatment. The phonemic and semantic verbal fluency tests were determined in all patients. The scoring for each fluency task was determined by counting the number of correct words. The total score from each semantic and phonemic verbal task was analyzed comparing the individual score with normal data controlled by age and sex. Patients with scores > â2 standard deviation (SD) from normative data were considered impaired. Results: Fifty-four patients completed the semantic verbal fluency test before treatment and fifty patients completed after treatment. According to the z-scores before treatment 7 patients of 54 (12.9%) had verbal fluency impairments. After treatment none patients showed semantic verbal fluency deficits but 3 patients of 50 (6%) showed phonemic impairments. Impaired group was significantly associated with an older age before treatment (p = 0.033) and with a similar tendency but not significant (p = 0.09) after treatment (Student t test). Conclusion: In this study older age factor was associated with verbal fluency impairment in GAD patients. Stratified treatments.Fil: Soria, Carlos Alberto. Institute of Biosciences Henri Laborit; ArgentinaFil: Remedi, Carolina. Institute of Biosciences Henri Laborit; ArgentinaFil: D`alessio, Luciana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: RoldĂĄn, Emilio J. A.. DirecciĂłn CientĂfica Gador S. A.; Argentin
Updated review on the diagnosis and primary management of psychogenic nonepileptic seizure disorders
Psychogenic nonepileptic seizures (PNES) are paroxystic and episodic events associated with motor, sensory, mental or autonomic manifestations, which resemble epileptic seizures (ES), but are not caused by epileptogenic activity. PNES affect between 20% and 30% of patients attending at epilepsy centers and constitute a serious mental health problem. PNES are often underdiagnosed, undertreated and mistaken with epilepsy. PNES are diagnosed after medical causes (epilepsy, syncope, stroke, etc.) have been ruled out, and psychological mechanisms are involved in their genesis and perpetuation. For psychiatry, there is not a single definition for PNES; the DSM-IV and ICD-10/11 describe the conversion and dissociative disorders, and the DSM-5 describes the functional neurological disorders. However, patients with PNES also have a high frequency of other comorbidities like depression, particularly trauma and post-traumatic stress disorder. It has been postulated that PNES are essentially dissociations that operate as a defensive psychological mechanism that use the mind as a defense to deal with traumas. With the advent of VEEG in the 90s, the recognition of PNES has significantly increased, and several psychological treatments have been developed. In this manuscript, we carried out a state-of-the-art review, with the aim to provide a critical approach to the extensive literature about PNES, focusing on diagnostic aspects, the primary management, and the available treatments that have been shown to be effective for the improvement of PNES.Fil: Lanzillotti, Alejandra InĂ©s. Universidad de Buenos Aires. Facultad de PsicologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Sarudiansky, Mercedes. Universidad de Buenos Aires. Facultad de PsicologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Lombardi, NicolĂĄs Robertino. Universidad de Buenos Aires. Facultad de PsicologĂa; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Centro Universitario de Neurologia "dr. Jose Maria Ramos Mejia".; ArgentinaFil: Korman, Guido Pablo. Universidad de Buenos Aires. Facultad de PsicologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: D`alessio, Luciana. Universidad de Buenos Aires. Facultad de Medicina. Centro Universitario de Neurologia "dr. Jose Maria Ramos Mejia".; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; Argentin
Reducing Allostatic Load in Depression and Anxiety Disorders: Physical Activity and Yoga Practice as Add-On Therapies
The allostatic load (AL) index constitutes a useful tool to objectively assess the biological aspects of chronic stress in clinical practice. AL index has been positively correlated with cumulative chronic stress (physical and psychosocial stressors) and with a high risk to develop pathological conditions (e.g., metabolic syndrome, cardiovascular pathology, inflammatory disorders) and the so-called stress-related psychiatric disorders, including anxiety and depressive disorders. Chronic stress has negative effects on brain neuroplasticity, especially on hippocampal neurogenesis and these effects may be reversed by antidepressant treatments. Several evidences indicate that non-pharmacological interventions based on physical activity and yoga practice may add synergizing benefits to classical treatments (antidepressant and benzodiazepines) for depression and anxiety, reducing the negative effects of chronic stress. The aim of this review is to provide a general overview of current knowledge on AL and chronic stress in relation to depression and anxiety, physical activity and yoga practice.Fil: D`alessio, Luciana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Korman, Guido Pablo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de PsicologĂa; Argentina. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Sarudiansky, Mercedes. Centro Argentino de EtnologĂa Americana; Argentina. Universidad de Buenos Aires. Facultad de PsicologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Centro de Estudios FarmacolĂłgicos y BotĂĄnicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios FarmacolĂłgicos y BotĂĄnicos; ArgentinaFil: ScĂ©vola, Maria Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Pastore, Alejandra. No especifĂca;Fil: ObregĂłn, Amilcar. No especifĂca;Fil: RoldĂĄn, Emilio J. A.. No especifĂca
Psychological interventions for psychogenic non epileptic seizures (pnes)
Las Crisis No EpilĂ©pticas PsicĂłgenas (CNEP) representan un desafĂo clĂnico, debido a la complejidadde sus manifestaciones, etiologĂa y comorbilidad. El objetivo de este artĂculo es presentarlos tratamientos psicolĂłgicos disponibles para abordar y tratar las CNEP. Se ha llevado a cabo unabĂșsqueda bibliogrĂĄfica en las bases de datos Medline, Latindex, Redalyc, Cochrane Collaboration,EBSCO y Lilacs. Dentro de los abordajes diseñados para el tratamiento de las CNEP, se destacantres modelos de intervenciĂłn psicoterapĂ©utica que han obtenido resultados favorables en la puestaa prueba de sus intervenciones: dos modelos cognitivo conductuales y el tratamiento aumentadode Terapia Interpersonal. Se discuten estos hallazgos en funciĂłn de las limitaciones, tantometodolĂłgicas como provenientes de los distintos estudios clĂnicos encontrados.Psychogenic Nonepileptic Seizures (PNES) pose a clinical challenge because of the diagnostic difficulty due to the complexity of their manifestations, etiology and comorbility. The aim of this paper is to outline the available psychological treatments developed to deal with PNES. To fulfill this purpose a literature search was carried out across the databases Medline, Latindex, Redalyc, Cochrane Collaboration EBSCO and Lilacs. Within the designs intended to deal with PNES, three models of psychotherapeutic approach stand out, due to the positive outcome measurements of their interventions: two cognitive-behavioral based interventions and the augmented model of Interpersonal Therapy. These findings are analyzed taking into account their methodological and clinical limitations.Fil: Korman, Guido Pablo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Sarudiansky, Mercedes. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Lanzillotti, Alejandra InĂ©s. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Areco Pico, Maria Marta. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Tenreyro, Cristina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: ScĂ©vola, Maria Laura. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Kochen, Sara Silvia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: D`Alessio, Luciana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires; Argentin
Report on a psychoeducational intervention for psychogenic non-epileptic seizures in Argentina
Purpose: To examine the effects of a three-session psychoeducational intervention on patients diagnosed with psychogenic non-epileptic seizures (PNES) in an Argentinian public hospital. It was hypothesized that patients would experience improvements in their understanding of PNES, illness perception and affective scores, but might not necessarily experience a significant change in post-traumatic and dissociative symptoms and in seizure frequency. Methods: This study included 12 patients (10 women, 2 men) who were invited to participate in a psychoeducational group after receiving a V-EEG confirmed diagnosis of PNES. The group consisted of 3 sessions lasting 2 h each. Pre and post measures included Psychoeducational Intervention Questionnaire, State-Trait Anxiety Inventory, Beck Depression Inventory-II, Brief Illness Perception Questionnaire, Posttraumatic Stress Disorder Diagnostic Scale 5, Dissociative Experiences Scale (DES-M). Results: This psychoeducational intervention produced results that were similar to interventions reported in US and European studies with regard to changes on psychological measures. Moreover, many patients also reported (on the final day of the intervention) a decrease in seizure frequency. All patients reported that participating in the intervention was a positive experience. Also, all but one patient referred that the participation in the group would have a positive impact on their quality of life. Conclusions: Psychoeducational interventions appear to have had positive results in Argentinian patients with PNES. This is initial step in the design of empirically based psychoeducational/supportive initiatives for patients in South America.Fil: Sarudiansky, Mercedes. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Korman, Guido Pablo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Lanzillotti, Alejandra InĂ©s. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Areco Pico, MarĂa Marta. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Tenreyro, Cristina. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Valdez Paolasini, Maria Gabriela. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Wolfzun, Camila. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Centro Argentino de EtnologĂa Americana; ArgentinaFil: Kochen, Sara Silvia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. NĂ©stor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: D`alessio, Luciana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; ArgentinaFil: Myers, Lorna. No especifĂca
La experiencia de pacientes con crisis no epilépticas psicógenas: marcos interpretativos y de acción
La perspectiva del paciente se presenta como algo importante a tener en cuenta para la comprensiĂłn del padecimiento y para lograr un tratamiento efectivo. El objetivo de la presente investigaciĂłn es indagar las trayectorias terapĂ©uticas y las experiencias durante el recorrido terapĂ©utico de pacientes con Crisis No EpilĂ©pticas PsicĂłgenas (CNEP) pertenecientes a un Hospital General de la Ciudad AutĂłnoma de Buenos Aires. Se realizaron entrevistas semiestructuradas a diez pacientes diagnosticados con CNEP. Para el anĂĄlisis de los datos se utilizĂł una metodologĂa cualitativa basada en los principios del anĂĄlisis temĂĄtico. Se ha identificado una categorĂa central: Itinerarios terapĂ©uticos dentro del sistema etnomĂ©dico y tres subcategorĂas: (1) DiagnĂłsticos Recibidos; (2) Recursos del sistema etnomĂ©dico y (3) Evaluaciones de los recursos utilizados. La dificultad de arribar a un diagnĂłstico y un tratamiento que permitiera mejorar las CNEP, asĂ como el uso de distintas medicinas, fue destacada por la totalidad de los pacientes
Altimetry for the future: Building on 25 years of progress
In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ââGreenâ Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instrumentsâ development and satellite missionsâ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion
Altimetry for the future: building on 25 years of progress
In 2018 we celebrated 25âŻyears of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology.
The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the âGreenâ Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instrumentsâ development and satellite missionsâ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion
Doublecortin (DCX) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis
Introduction: Status epilepticus increases the production of new neurons (hippocampal neurogenesis) and promotes aberrant migration. However chronic experimental models of epilepsy and studies performed in human epilepsy showed controversial results suggesting a reduction in hippocampal neurogenesis in late stages of the disease. Doublecortin (DCX) has been validated to determine alterations in the production of new neurons in the human hippocampus. Objectives: Determine DCX expression in human hippocampal sclerosis (HS) from patients who underwent epilepsy surgery for refractory temporal lobe epilepsy (TLE). Methods: Hippocampal sections of 9 patients with HS and TLE who underwent surgery, were processed using immunoperoxidase for DCX. Archival material from 5 normal post-mortem hippocampus were simultaneously processed. Results: Significantly lower staining intensity was observed in DCX-positive neurons localized in dentate gyrus (DG) and in CA1 of epileptic hippocampus; lower DCX reactive area was observed in pyramidal layers of CA1; and a reduced in the mean number of DCX-positive neurons were determined in DG compared to normal hippocampus (p < 0.05). Conclusions: This study found a decrease in DCX expression in hippocampus of patients with HS and chronic and refractory TLE suggesting alterations in NG and hippocampal synaptogenesis with potential cognitive and emotional repercussion.Fil: D`Alessio, Luciana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Konopka, Hector. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Lopez, Ester Maria. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; ArgentinaFil: Seoane, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; ArgentinaFil: Consalvo, Damian. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; ArgentinaFil: Oddo, Silvia Andrea. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; ArgentinaFil: Kochen, Sara Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos MejĂa"; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; ArgentinaFil: LĂłpez, Juan JosĂ©. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de BiologĂa Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de BiologĂa Celular y Neurociencia; Argentin
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