Knee Osteoarthritis and the Efficacy of Kinesthesia, Balance & Agility Exercise Training: A Pilot Study

Kinesthesia, balance and agility (KBA) neuromuscular exercises are commonly used for rehabilitation of lower extremity injuries. KBA combined with strength training (ST) reportedly improves function among persons with knee osteoarthritis (OA), but independent effects of KBA are unknown. The purpose of this study was to determine the efficacy of KBA exercises, independent of ST, to improve function among persons with knee OA. Twenty participants (69.3, SD 11.4 y) were randomized to 8 weeks, 3-days per week, instructor-lead KBA or ST groups. Self-reported physical function (difficulty with daily living activities such as walking, bending, stair climbing, etc.) was measured at baseline and every two weeks. Community physical activity level, negative and positive outcome expectancies for exercise, self-reported knee stability, and timed 10-stair climb, 10-stair descent, and ‘get up and go’ 15 m walk were measured at baseline and follow-up. Physical function improved 59% (p = 0.02) with KBA and 40% (p = 0.02) with ST at 8 weeks. Community physical activity level improved only in KBA (p = 0.04); knee stability improved in both KBA (p = 0.04) and ST (p = 0.01). There were no significant between-group differences (p \u3e 0.05). In conclusion, both interventions appear to improve function and knee stability among persons with symptomatic knee OA. As KBA has never been studied as an independent treatment program, our results indicate it is a promising stand-alone intervention worthy of further study

Subformula and separation properties in natural deduction via small Kripke models

Various natural deduction formulations of classical, minimal, intuitionist, and intermediate propositional and first-order logics are presented and investigated with respect to satisfaction of the separation and subformula properties. The technique employed is, for the most part, semantic, based on general versions of the Lindenbaum and Lindenbaum–Henkin constructions. Careful attention is paid (i) to which properties of theories result in the presence of which rules of inference, and (ii) to restrictions on the sets of formulas to which the rules may be employed, restrictions determined by the formulas occurring as premises and conclusion of the invalid inference for which a counterexample is to be constructed. We obtain an elegant formulation of classical propositional logic with the subformula property and a singularly inelegant formulation of classical first-order logic with the subformula property, the latter, unfortunately, not a product of the strategy otherwise used throughout the article. Along the way, we arrive at an optimal strengthening of the subformula results for classical first-order logic obtained as consequences of normalization theorems by Dag Prawitz and Gunnar Stalmarck

Studies of the Canadian Arctic Archipelago water transport and its relationship to basin-local forcings : results from AO-FVCOM

Author Posting. © American Geophysical Union, 2016. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 121 (2016): 4392–4415, doi:10.1002/2016JC011634.A high-resolution (up to 2 km), unstructured-grid, fully coupled Arctic sea ice-ocean Finite-Volume Community Ocean Model (AO-FVCOM) was employed to simulate the flow and transport through the Canadian Arctic Archipelago (CAA) over the period 1978–2013. The model-simulated CAA outflow flux was in reasonable agreement with the flux estimated based on measurements across Davis Strait, Nares Strait, Lancaster Sound, and Jones Sounds. The model was capable of reproducing the observed interannual variability in Davis Strait and Lancaster Sound. The simulated CAA outflow transport was highly correlated with the along-strait and cross-strait sea surface height (SSH) difference. Compared with the wind forcing, the sea level pressure (SLP) played a dominant role in establishing the SSH difference and the correlation of the CAA outflow with the cross-strait SSH difference can be explained by a simple geostrophic balance. The change in the simulated CAA outflow transport through Davis Strait showed a negative correlation with the net flux through Fram Strait. This correlation was related to the variation of the spatial distribution and intensity of the slope current over the Beaufort Sea and Greenland shelves. The different basin-scale surface forcings can increase the model uncertainty in the CAA outflow flux up to 15%. The daily adjustment of the model elevation to the satellite-derived SSH in the North Atlantic region outside Fram Strait could produce a larger North Atlantic inflow through west Svalbard and weaken the outflow from the Arctic Ocean through east Greenland.NSF Grant Numbers: OCE-1203393, PLR-1203643; National Natural Science Foundation of China Grant Number: 41276197; Shanghai Pujiang Program Grant Number: 12PJ1404100; Shanghai Shuguang Program2016-12-2

Campus Vol IX N 2

Tuttle, C. Cover. Picture. 1. Howard Studio. Miss Betsy Phelps . Picture. 2. Troelstrud. Untitled. Cartoon. 4. Anonymous. Campus Calender . Picture. 5. Aaybe, Nancy. By Any Other Name . Prose. 8. Sherman, Marj. Gone Today and Gone Tomorrow . Prose. 10. Martin, Lyn. Six Weeks Old . Prose. 11. Shaw, Ted. \u27Twas The Night Before Christmas . Cartoon. 12. Bogardus, Edna. On Human Pageants . Prose. 14. Swanson, Dru. Nineveh Disclaimed . Prose. 15. Dock. Untitled. Cartoon. 15.; Curry, Chuck. Varsity Basketball . Prose. 16. Shackelford, Duck. The Freshman Rushing Primer . Prose. 18. Anonymous. Untitled. Prose. 19. Hodge, Beth. Denison\u27s Menaces . Cartoon. 20. Kull, Shaw. Untitled. Cartoon. 10. Kull, Shaw. Untitled. Cartoon. 21. Clifford, Bob. Christmas is For Everyone . Prose.23. Anonymous. Untitled. Cartoon. 23. Kull, Shaw. Untitled . Cartoon. 23

Greenland freshwater pathways in the sub-Arctic Seas from model experiments with passive tracers

Author Posting. © American Geophysical Union, 2016. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 121 (2016): 877–907, doi:10.1002/2015JC011290.Accelerating since the early 1990s, the Greenland Ice Sheet mass loss exerts a significant impact on thermohaline processes in the sub-Arctic seas. Surplus freshwater discharge from Greenland since the 1990s, comparable in volume to the amount of freshwater present during the Great Salinity Anomaly events, could spread and accumulate in the sub-Arctic seas, influencing convective processes there. However, hydrographic observations in the Labrador Sea and the Nordic Seas, where the Greenland freshening signal might be expected to propagate, do not show a persistent freshening in the upper ocean during last two decades. This raises the question of where the surplus Greenland freshwater has propagated. In order to investigate the fate, pathways, and propagation rate of Greenland meltwater in the sub-Arctic seas, several numerical experiments using a passive tracer to track the spreading of Greenland freshwater have been conducted as a part of the Forum for Arctic Ocean Modeling and Observational Synthesis effort. The models show that Greenland freshwater propagates and accumulates in the sub-Arctic seas, although the models disagree on the amount of tracer propagation into the convective regions. Results highlight the differences in simulated physical mechanisms at play in different models and underscore the continued importance of intercomparison studies. It is estimated that surplus Greenland freshwater flux should have caused a salinity decrease by 0.06–0.08 in the sub-Arctic seas in contradiction with the recently observed salinification (by 0.15–0.2) in the region. It is surmised that the increasing salinity of Atlantic Water has obscured the freshening signal.NSERC. Grant Numbers RGPIN 227438-09, RGPIN 04357 and RGPCC 433898; RFBR. Grant Number 13-05-00480, 14-05-00730, and 15-05-02457; NSF Grant Number: PLR-0804010, PLR-1313614, and PLR-12037202016-07-2

Patterns and variability in ocean acidification conditions in Puget Sound and the Strait of Juan de Fuca

The Washington Ocean Acidification Center is working with NOAA and other partners to increase understanding of ocean acidification dynamics and spatial variability in the Salish Sea, and how these correlate with planktonic responses. These data are critical for assessing water quality, areas with higher or lower OA stress, and to understand effects on the food web. Two main strategies are employed; seasonal ship cruises provide spatial coverage and the ability to collect plankton, while mooring buoys provide information on mechanisms and the range of variation due to the high-resolution and constant coverage they provide. Results show a strong degree of depth, seasonal, and spatial variation in pH and aragonite saturation state. In general, the lowest pH and aragonite saturation state values are at depth, particularly in stratified areas, though this can shift during seasonal localized upwelling, e.g., Southern Hood Canal, and in mixed water columns, e.g., the Main Basin. Seasonal patterns are spatially diverse, with stratified areas exhibiting strong vertical gradients with depth during summer and more homogenous conditions during winter; well-mixed areas show less variation year-round. This implies that species encounter quite different OA conditions in various parts of the Salish Sea between the seasons. Mooring CO2 data reveal higher variation during late fall through early spring at sites within the Salish Sea, due to winter mixing of stratified waters, yet the reverse pattern off the Washington coast, due to summer upwelling. In both cases, these mechanisms (winter mixing and summer upwelling) operate across a gradient, bringing relatively deeper lower pH / aragonite saturation state waters in contact with surface waters with higher values. Such changes in the spatial and depth distribution of corrosive conditions have broad implications for sensitive marine life

The Arctic Ocean Seasonal Cycles of Heat and Freshwater Fluxes: Observation-Based Inverse Estimates

This paper presents the first estimate of the seasonal cycle of ocean and sea ice heat and freshwater (FW) fluxes around the Arctic Ocean boundary. The ocean transports are estimated primarily using 138 moored instruments deployed in September 2005–August 2006 across the four main Arctic gateways: Davis, Fram, and Bering Straits, and the Barents Sea Opening (BSO). Sea ice transports are estimated from a sea ice assimilation product. Monthly velocity fields are calculated with a box inverse model that enforces mass and salt conservation. The volume transports in the four gateways in the period (annual mean ± 1 standard deviation) are −2.1 ± 0.7 Sv in Davis Strait, −1.1 ± 1.2 Sv in Fram Strait, 2.3 ± 1.2 Sv in the BSO, and 0.7 ± 0.7 Sv in Bering Strait (1 Sv ≡ 106 m3 s−1). The resulting ocean and sea ice heat and FW fluxes are 175 ± 48 TW and 204 ± 85 mSv, respectively. These boundary fluxes accurately represent the annual means of the relevant surface fluxes. The ocean heat transport variability derives from velocity variability in the Atlantic Water layer and temperature variability in the upper part of the water column. The ocean FW transport variability is dominated by Bering Strait velocity variability. The net water mass transformation in the Arctic entails a freshening and cooling of inflowing waters by 0.62 ± 0.23 in salinity and 3.74° ± 0.76°C in temperature, respectively, and a reduction in density by 0.23 ± 0.20 kg m−3. The boundary heat and FW fluxes provide a benchmark dataset for the validation of numerical models and atmospheric reanalysis products

An assessment of the Arctic Ocean in a suite of interannual CORE-II simulations. Part III: Hydrography and fluxes

In this paper we compare the simulated Arctic Ocean in 15 global ocean–sea ice models in the framework of the Coordinated Ocean-ice Reference Experiments, phase II (CORE-II). Most of these models are the ocean and sea-ice components of the coupled climate models used in the Coupled Model Intercomparison Project Phase 5 (CMIP5) experiments. We mainly focus on the hydrography of the Arctic interior, the state of Atlantic Water layer and heat and volume transports at the gateways of the Davis Strait, the Bering Strait, the Fram Strait and the Barents Sea Opening. We found that there is a large spread in temperature in the Arctic Ocean between the models, and generally large differences compared to the observed temperature at intermediate depths. Warm bias models have a strong temperature anomaly of inflow of the Atlantic Water entering the Arctic Ocean through the Fram Strait. Another process that is not represented accurately in the CORE-II models is the formation of cold and dense water, originating on the eastern shelves. In the cold bias models, excessive cold water forms in the Barents Sea and spreads into the Arctic Ocean through the St. Anna Through. There is a large spread in the simulated mean heat and volume transports through the Fram Strait and the Barents Sea Opening. The models agree more on the decadal variability, to a large degree dictated by the common atmospheric forcing. We conclude that the CORE-II model study helps us to understand the crucial biases in the Arctic Ocean. The current coarse resolution state-of-the-art ocean models need to be improved in accurate representation of the Atlantic Water inflow into the Arctic and density currents coming from the shelves

Investigation of NRXN1 deletions: Clinical and molecular characterization

Deletions at 2p16.3 involving exons of NRXN1 are associated with susceptibility for autism and schizophrenia, and similar deletions have been identified in individuals with developmental delay and dysmorphic features. We have identified 34 probands with exonic NRXN1 deletions following referral for clinical microarray‐based comparative genomic hybridization. To more firmly establish the full phenotypic spectrum associated with exonic NRXN1 deletions, we report the clinical features of 27 individuals with NRXN1 deletions, who represent 23 of these 34 families. The frequency of exonic NRXN1 deletions among our postnatally diagnosed patients (0.11%) is significantly higher than the frequency among reported controls (0.02%; P  = 6.08 × 10 −7 ), supporting a role for these deletions in the development of abnormal phenotypes. Generally, most individuals with NRXN1 exonic deletions have developmental delay (particularly speech), abnormal behaviors, and mild dysmorphic features. In our cohort, autism spectrum disorders were diagnosed in 43% (10/23), and 16% (4/25) had epilepsy. The presence of NRXN1 deletions in normal parents and siblings suggests reduced penetrance and/or variable expressivity, which may be influenced by genetic, environmental, and/or stochastic factors. The pathogenicity of these deletions may also be affected by the location of the deletion within the gene. Counseling should appropriately represent this spectrum of possibilities when discussing recurrence risks or expectations for a child found to have a deletion in NRXN1 . © 2013 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97220/1/35780_ftp.pd