Mecanismos dinâmicos de segurança para redes softwarizadas e virtualizadas

The relationship between attackers and defenders has traditionally been asymmetric, with attackers having time as an upper hand to devise an exploit that compromises the defender. The push towards the Cloudification of the world makes matters more challenging, as it lowers the cost of an attack, with a de facto standardization on a set of protocols. The discovery of a vulnerability now has a broader impact on various verticals (business use cases), while previously, some were in a segregated protocol stack requiring independent vulnerability research. Furthermore, defining a perimeter within a cloudified system is non-trivial, whereas before, the dedicated equipment already created a perimeter. This proposal takes the newer technologies of network softwarization and virtualization, both Cloud-enablers, to create new dynamic security mechanisms that address this asymmetric relationship using novel Moving Target Defense (MTD) approaches. The effective use of the exploration space, combined with the reconfiguration capabilities of frameworks like Network Function Virtualization (NFV) and Management and Orchestration (MANO), should allow for adjusting defense levels dynamically to achieve the required security as defined by the currently acceptable risk. The optimization tasks and integration tasks of this thesis explore these concepts. Furthermore, the proposed novel mechanisms were evaluated in real-world use cases, such as 5G networks or other Network Slicing enabled infrastructures.A relação entre atacantes e defensores tem sido tradicionalmente assimétrica, com os atacantes a terem o tempo como vantagem para conceberem uma exploração que comprometa o defensor. O impulso para a Cloudificação do mundo torna a situação mais desafiante, pois reduz o custo de um ataque, com uma padronização de facto sobre um conjunto de protocolos. A descoberta de uma vulnerabilidade tem agora um impacto mais amplo em várias verticais (casos de uso empresarial), enquanto anteriormente, alguns estavam numa pilha de protocolos segregados que exigiam uma investigação independente das suas vulnerabilidades. Além disso, a definição de um perímetro dentro de um sistema Cloud não é trivial, enquanto antes, o equipamento dedicado já criava um perímetro. Esta proposta toma as mais recentes tecnologias de softwarização e virtualização da rede, ambas facilitadoras da Cloud, para criar novos mecanismos dinâmicos de segurança que incidem sobre esta relação assimétrica utilizando novas abordagens de Moving Target Defense (MTD). A utilização eficaz do espaço de exploração, combinada com as capacidades de reconfiguração de frameworks como Network Function Virtualization (NFV) e Management and Orchestration (MANO), deverá permitir ajustar dinamicamente os níveis de defesa para alcançar a segurança necessária, tal como definida pelo risco actualmente aceitável. As tarefas de optimização e de integração desta tese exploram estes conceitos. Além disso, os novos mecanismos propostos foram avaliados em casos de utilização no mundo real, tais como redes 5G ou outras infraestruturas de Network Slicing.Programa Doutoral em Engenharia Informátic

Service function chaining para NFV em ambientes cloud

Mestrado em Engenharia de Computadores e TelemáticaService Function Chaining, Virtual Network Functions e Cloud Computing são os conceitos chave para resolver (em “grande plano”) uma necessidade actual dos operadores de telecomunicações: a virtualização dos equipamentos na casa dos consumidores, particularmente o Home Gateway. Dentro deste contexto, o objetivo desta dissertação será providenciar as Funções Virtuais de Rede (tais como um vDHCP, Classificador de Tráfego e Shaper) assim como respectivas APIs necessárias para se atingir essa solução de “grande plano”. A solução utilizará tecnologias Open Source como OpenStack, OpenVSwitch e OpenDaylight (assim como contribuições anteriores do Instituto de Telecomunicações) para concretizar uma Prova-de-Conceito do Home Gateway virtual. Após o sucesso da primeira PdC iniciar-se-á a construção da próxima prova, delineando um caminho claro para trabalho futuro.Service Function Chaining, Network Function Virtualization and Cloud Computing are the key concepts to solve (in “big-picture”) one of today’s operator’s needs: virtual Customer Premises Equipments, namely the virtualization of the Home Gateway. Within this realm, it will be the purpose of this dissertation to provide the required Virtual Network Functions (such as a vDHCP, Traffic Classifier and Traffic Shaper) as well as their respective APIs to build that “big-picture” solution. Open Source technologies such as OpenStack, OpenVSwitch and OpenDaylight (along with prior work from Instituto de Telecomunicações) will be used to make a working Proof-of-Concept of the Virtual Home Gateway. After the success of the first PoC, starts the construction of the next PoC and a path for future work is laid-down

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research