19 research outputs found
An interface tracking model for droplet electrocoalescence.
This report describes an Early Career Laboratory Directed Research and Development (LDRD) project to develop an interface tracking model for droplet electrocoalescence. Many fluid-based technologies rely on electrical fields to control the motion of droplets, e.g. microfluidic devices for high-speed droplet sorting, solution separation for chemical detectors, and purification of biodiesel fuel. Precise control over droplets is crucial to these applications. However, electric fields can induce complex and unpredictable fluid dynamics. Recent experiments (Ristenpart et al. 2009) have demonstrated that oppositely charged droplets bounce rather than coalesce in the presence of strong electric fields. A transient aqueous bridge forms between approaching drops prior to pinch-off. This observation applies to many types of fluids, but neither theory nor experiments have been able to offer a satisfactory explanation. Analytic hydrodynamic approximations for interfaces become invalid near coalescence, and therefore detailed numerical simulations are necessary. This is a computationally challenging problem that involves tracking a moving interface and solving complex multi-physics and multi-scale dynamics, which are beyond the capabilities of most state-of-the-art simulations. An interface-tracking model for electro-coalescence can provide a new perspective to a variety of applications in which interfacial physics are coupled with electrodynamics, including electro-osmosis, fabrication of microelectronics, fuel atomization, oil dehydration, nuclear waste reprocessing and solution separation for chemical detectors. We present a conformal decomposition finite element (CDFEM) interface-tracking method for the electrohydrodynamics of two-phase flow to demonstrate electro-coalescence. CDFEM is a sharp interface method that decomposes elements along fluid-fluid boundaries and uses a level set function to represent the interface
Serum Zinc Correlates with Parent- and Teacher-Rated Inattention in Children with Attention-Deficit/Hyperactivity Disorder
Objective:
The aim of this study was to explore the relationship of zinc nutrition to the severity of attentiondeficit/
hyperactivity disorder (ADHD) symptoms in a middle-class American sample with well-diagnosed
ADHD. Previous reports of zinc in ADHD, including two positive clinical trials of supplementation, have
come mainly from countries and cultures with different diets and/or socioeconomic realities. Method:
Children 5–10 years of age with DISC- and clinician-diagnosed ADHD had serum zinc determinations and
parent and teacher ratings of ADHD symptoms. Zinc levels were correlated (Pearson’s and multiple
regression) with ADHD symptom ratings. Results: Forty-eight children (37 boys, 11 girls; 33 combined
type, 15 inattentive) had serum zinc levels with a median/mode at the lowest 30% of the laboratory
reference range; 44 children also had parent/teacher ratings. Serum magnesium levels were normal.
Nutritional intake by a parent-answered food frequency questionnaire was unremarkable. Serum zinc
correlated at r = -0.45 (p = 0.004) with parent-teacher-rated inattention, even after controlling for gender,
age, income, and diagnostic subtype, but only at r = -0.20 (p = 0.22) with CPT omission errors. In contrast,
correlation with parent-teacher-rated hyperactivity-impulsivity was nonsignificant in the opposite direction.
Conclusion: These findings add to accumulating evidence for a possible role of zinc in ADHD, even for
middle-class Americans, and, for the first time, suggest a special relationship to inattentive symptoms.
They do not establish either that zinc deficiency causes ADHD nor that ADHD should be treated with zinc.
Hypothesis-testing clinical trials are needed
Acetyl-L-Carnitine in Attention-Deficit/Hyperactivity Disorder: A Multi-Site, Placebo-Controlled Pilot Trial
Objective:
To determine whether acetyl-L-carnitine (ALC), a metabolite necessary for energy metabolism and
essential fatty acid anabolism, might help attention-deficit/hyperactivity disorder (ADHD). Trials in Down’s
syndrome, migraine, and Alzheimer’s disease showed benefit for attention. A preliminary trial in ADHD
using L-carnitine reported significant benefit.
Method:
A multi-site 16-week pilot study randomized 112 children (83 boys, 29 girls) age 5-12 with
systematically diagnosed ADHD to placebo or ALC in weight-based doses from 500 to 1500 mg b.i.d. The
2001 revisions of the Conners’ parent and teacher scales (including DSM-IV ADHD symptoms) were
administered at baseline, 8, 12, and 16 weeks. Analyses were ANOVA of change from baseline to 16 weeks
with treatment, center, and treatment-by-center interaction as independent variables.
Results:
The primary intent-to-treat analysis, of 9 DSM-IV teacher-rated inattentive symptoms, was not
significant. However, secondary analyses were interesting. There was significant (p = 0.02) moderation by
subtype: superiority of ALC over placebo in the inattentive type, with an opposite tendency in combined
type. There was also a geographic effect (p = 0.047). Side effects were negligible; electrocardiograms, lab
work, and physical exam unremarkable.
Conclusion:
ALC appears safe, but with no effect on the overall ADHD population (especially combined type).
It deserves further exploration for possible benefit specifically in the inattentive type
Vestibular Stimulation for ADHD: Randomized Controlled Trial of Comprehensive Motion Apparatus
Objective:
This research evaluates effects of vestibular stimulation by Comprehensive Motion Apparatus
(CMA) in ADHD.
Method:
Children ages 6 to 12 (48 boys, 5 girls) with ADHD were randomized to thrice-weekly 30-min
treatments for 12 weeks with CMA, stimulating otoliths and semicircular canals, or a single-blind control of
equal duration and intensity, each treatment followed by a 20-min typing tutorial.
Results:
In intent-to-treat analysis (n = 50), primary outcome improved significantly in both groups (p =
.0001, d = 1.09 to 1.30), but treatment difference not significant (p = .7). Control children regressed by
follow-up (difference p = .034, d = 0.65), but overall difference was not significant (p = .13, d = .47). No
measure showed significant treatment differences at treatment end, but one did at follow-up. Children with
IQ-achievement discrepancy ≥ 1 SD showed significantly more CMA advantage on three measures.
Conclusion:
This study illustrates the importance of a credible control condition of equal duration and intensity
in trials of novel treatments. CMA treatment cannot be recommended for combined-type ADHD without
learning disorder
Age Determination of Six Intermediate-age SMC Star Clusters with HST/ACS
We present a photometric analysis of the star clusters Lindsay 1, Kron 3,
NGC339, NGC416, Lindsay 38, and NGC419 in the Small Magellanic Cloud (SMC),
observed with the Hubble Space Telescope Advanced Camera for Surveys (ACS) in
the F555W and F814W filters. Our color magnitude diagrams (CMDs) extend ~3.5
mag deeper than the main-sequence turnoff points, deeper than any previous
data. Cluster ages were derived using three different isochrone models: Padova,
Teramo, and Dartmouth, which are all available in the ACS photometric system.
Fitting observed ridgelines for each cluster, we provide a homogeneous and
unique set of low-metallicity, single-age fiducial isochrones. The cluster CMDs
are best approximated by the Dartmouth isochrones for all clusters, except for
NGC419 where the Padova isochrones provided the best fit. The CMD of NGC419
shows several main-sequence turn-offs, which belong to the cluster and to the
SMC field. We thus derive an age range of 1.2-1.6 Gyr for NGC419.
Interestingly, our intermediate-age star clusters have a metallicity spread of
~0.6 dex, which demonstrates that the SMC does not have a smooth, monotonic
age-metallicity relation. We find an indication for centrally concentrated blue
straggler star candidates in NGC416, while for the other clusters these are not
present. Using the red clump magnitudes, we find that the closest cluster,
NGC419 (~50kpc), and the farthest cluster, Lindsay 38 (~67kpc), have a relative
distance of ~17kpc, which confirms the large depth of the SMC.Comment: 25 pages, 45 Figure
Hierarchical structures in the Large and Small Magellanic Clouds
We investigate the degree of spatial correlation among extended structures in
the LMC and SMC. To this purpose we work with sub-samples characterised by
different properties such as age and size, taken from the updated catalogue of
Bica et al. or gathered in the present work. The structures are classified as
star clusters or non-clusters (basically, nebular complexes and their stellar
associations). The radius distribution functions follow power-laws
() with slopes and maximum radius () that
depend on object class (and age). Non-clusters are characterised by
and R_{max}\la472 pc, while young clusters (age \la10
Myr) have and R_{max}\la15 pc, and old ones (age \ga600
Myr) have and R_{max}\la40 pc. Young clusters present a
high degree of spatial self-correlation and, especially, correlate with
star-forming structures, which does not occur with the old ones. This is
consistent with the old clusters having been heavily mixed up, since their ages
correspond to several LMC and SMC crossing times. On the other hand, with ages
corresponding to fractions of the respective crossing times, the young clusters
still trace most of their birthplace structural pattern. Also, small clusters
( pc), as well as small non-clusters ( pc), are spatially
self-correlated, while their large counterparts of both classes are not. The
above results are consistent with a hierarchical star-formation scenario for
the LMC and SMC.Comment: Accepted by MNRA
Integrated spectral analysis of 18 concentrated star clusters in the Small Magellanic Cloud
We present in this study flux-calibrated integrated spectra in the range
3600-6800A for 18 concentrated SMC clusters. Cluster reddening values were
estimated by interpolation between the extinction maps of Burstein & Heiles
(1982, AJ, 87, 1165) and Schlegel et al. (1998, ApJ, 500, 525). The cluster
parameters were derived from the template matching procedure by comparing the
line strengths and continuum distribution of the cluster spectra with those of
template cluster spectra with known parameters and from the equivalent width
(EW) method. In this case, new calibrations were used together with diagnostic
diagrams involving the sum of EWs of selected spectral lines. A very good
agreement between ages derived from both methods was found. The final cluster
ages obtained from the weighted average of values taken from the literature and
the present measured ones range from 15 Mr (e.g. L51) to 7 Gyr (K3). Metal
abundances have been derived for only 5 clusters from the present sample, while
metallicity values directly averaged from published values for other 4 clusters
have been adopted. Combining the present cluster sample with 19 additional SMC
clusters whose ages and metal abundances were put onto a homogeneous scale, we
analyse the age and metallicity distributions in order to explore the SMC star
formation history and its spatial extent. By considering the distances of the
clusters from the SMC centre instead of their projections onto the right
ascension and declination axes, the present age-position relation suggests that
the SMC inner disk could have been related to a cluster formation episode which
reached the peak ~2.5 Gyr ago. Evidence for an age gradient in the inner SMC
disk is also presented.Comment: 21 pages, 21 figures. Accepted for publication in A&
A general catalogue of extended objects in the Magellanic System
We update the SMC, Bridge, and LMC catalogues of extended objects that were
constructed by members of our group from 1995 to 2000. In addition to the rich
subsequent literature for the previous classes, we now also include HI shells
and supershells. A total of 9305 objects were cross-identified, while our
previous catalogues amounted to 7900 entries, an increase of . We
present the results in subcatalogues containing 1445 emission nebulae, 3740
star clusters, 3326 associations, and 794 HI shells and supershells. Angular
and apparent size distributions of the extended objects are analysed. We
conclude that the objects, in general, appear to respond to tidal effects
arising from the LMC, SMC, and Bridge. Number-density profiles extracted along
directions parallel and perpendicular to the LMC bar, can be described by two
exponential-disks. A single exponential-disk fits the equivalent SMC profiles.
Interestingly, when angular-averaged number-densities of most of the extended
objects are considered, the profiles of both Clouds do not follow an
exponential-disk. Rather, they are best described by a tidally-truncated,
core/halo profile, despite the fact that the Clouds are clearly disturbed
disks. On the other hand, the older star clusters taken isolately, distribute
as an exponential disk. The present catalogue is an important tool for the
unambiguous identification of previous objects in current CCD surveys and to
establish new findings.Comment: 15 pages, 10 figures, MNRAS, accepte
Recommended from our members
Multiscale models of nuclear waste reprocessing : from the mesoscale to the plant-scale.
Recommended from our members
An interface tracking model for droplet electrocoalescence.
This report describes an Early Career Laboratory Directed Research and Development (LDRD) project to develop an interface tracking model for droplet electrocoalescence. Many fluid-based technologies rely on electrical fields to control the motion of droplets, e.g. microfluidic devices for high-speed droplet sorting, solution separation for chemical detectors, and purification of biodiesel fuel. Precise control over droplets is crucial to these applications. However, electric fields can induce complex and unpredictable fluid dynamics. Recent experiments (Ristenpart et al. 2009) have demonstrated that oppositely charged droplets bounce rather than coalesce in the presence of strong electric fields. A transient aqueous bridge forms between approaching drops prior to pinch-off. This observation applies to many types of fluids, but neither theory nor experiments have been able to offer a satisfactory explanation. Analytic hydrodynamic approximations for interfaces become invalid near coalescence, and therefore detailed numerical simulations are necessary. This is a computationally challenging problem that involves tracking a moving interface and solving complex multi-physics and multi-scale dynamics, which are beyond the capabilities of most state-of-the-art simulations. An interface-tracking model for electro-coalescence can provide a new perspective to a variety of applications in which interfacial physics are coupled with electrodynamics, including electro-osmosis, fabrication of microelectronics, fuel atomization, oil dehydration, nuclear waste reprocessing and solution separation for chemical detectors. We present a conformal decomposition finite element (CDFEM) interface-tracking method for the electrohydrodynamics of two-phase flow to demonstrate electro-coalescence. CDFEM is a sharp interface method that decomposes elements along fluid-fluid boundaries and uses a level set function to represent the interface