Untreated hypertension in Russian 35-69 year olds – a cross-sectional study

Background - The Russian Federation has among the highest rates of cardiovascular disease (CVD) in the world and a high rate of untreated hypertension remains an important risk factor. Understanding who is at greatest risk is important to inform approaches to primary prevention. Methods - 2,353 hypertensive 35–69 year olds were selected from a population-based study, Know Your Heart, conducted in Arkhangelsk and Novosibirsk, Russian Federation, 2015–2018. The associations between untreated hypertension and a range of co-variates related to socio-demographics, health, and health behaviours were examined. Results - The age-standardised prevalence of untreated hypertension was 51.1% (95% CI 47.8–54.5) in males, 28.8% (25.4–32.5) in females, and 40.0% (37.5–42.5) overall. The factors associated with untreated hypertension relative to treated hypertension were younger ages, self-rated general health as very good-excellent, not being obese, no history of CVD events, no evidence of diabetes or chronic kidney disease, and not seeing a primary care doctor in the past year as well as problem drinking for women and working full time, lower education, and smoking for men. Conclusion - The study found relatively high prevalence of untreated hypertension, especially, in men. Recent initiatives to strengthen primary care provision and implementation of a general health check programme (dispansarisation) are promising, although further studies should evaluate other, potentially more effective strategies tailored to the particular circumstances of this population

Canopy nitrogen, carbon assimilation, and albedo in temperate and boreal forests: Functional relations and potential climate feedbacks

The availability of nitrogen represents a key constraint on carbon cycling in terrestrial ecosystems, and it is largely in this capacity that the role of N in the Earth\u27s climate system has been considered. Despite this, few studies have included continuous variation in plant N status as a driver of broad-scale carbon cycle analyses. This is partly because of uncertainties in how leaf-level physiological relationships scale to whole ecosystems and because methods for regional to continental detection of plant N concentrations have yet to be developed. Here, we show that ecosystem CO2 uptake capacity in temperate and boreal forests scales directly with whole-canopy N concentrations, mirroring a leaf-level trend that has been observed for woody plants worldwide. We further show that both CO2 uptake capacity and canopy N concentration are strongly and positively correlated with shortwave surface albedo. These results suggest that N plays an additional, and overlooked, role in the climate system via its influence on vegetation reflectivity and shortwave surface energy exchange. We also demonstrate that much of the spatial variation in canopy N can be detected by using broad-band satellite sensors, offering a means through which these findings can be applied toward improved application of coupled carbon cycle–climate models

Midwest Cancer Alliance: Partnership to Support Quality Cancer Care

Comparative Medicine - OneHealth and Comparative Medicine Poster SessionOver 85% of cancer patients nationwide receive care in the community setting (NCI, 2007). In 2008, the Midwest Cancer Alliance (MCA) launched with a vision of marshaling the exceptional cancer resources of the region to support the system of care provided to patients while keeping them “close to home”. With an emphasis on education and research, the MCA was developed to connect hospitals and physician groups across Kansas and western Missouri with the purpose of: Providing strong support to community cancer care professionals; Enhancing cancer care for patients across the region; Advancing access to innovative, investigator-initiated and cooperative group clinical trials; Advancing access to newly developed therapies and prevention strategies; Providing continuing professional and community education opportunities; Facilitating second opinion and consultation services; and Providing patient navigator technical assistance across the network. A membership-based organization, the MCA currently has 14 partners spanning the region including: Children's Mercy Hospital and Clinics; Goodland Regional Medical Center; Hays Medical Center; Kansas Bioscience Authority; Kansas State University; Mt. Carmel Regional Medical Center; Promise Regional Medical Center; Saint Luke's Health; Salina Regional Health Center; St. Francis Health Center; Stormont-Vail HealthCare; Stowers Institute for Medical Research; Truman Medical Center; The University of Kansas Hospital. Methods: In collaboration with members, the MCA facilitates a wide-array of cancer related services. Activities range from developing clinical trial infrastructure including, a centralized Institutional Review Board (IRB), online Velos clinical trials management software to facilitate enrollment and trial data management, and access to Southwest Oncology Group (SWOG), Clinical Trials Support Unit (CTSU) sponsored trials, and research initiated by The University of Kansas Cancer Center's Investigators. MCA provides professional and community education specific to the needs of the community. Members have access to The University of Kansas Cancer Center Tumor Boards as well as continuing education such as chemotherapy and oncology nurse certification curricula. Results: Numerous cancer-related activities have occurred since the inception of the MCA. Over 11,450 individuals attended MCA community education and screening events. 6,200 cancer screenings resulted in 470+ referrals back to local physicians for follow-up on abnormal results. Over 3,096 Continuing Nursing Education (CNE) credits and 296 Continuing Medical Education (CME) credits. Five members have capacity to enroll patients through MCA sponsored trials with access to SWOG and CTSU. 7 cases have been presented at tumor boards. 9 second opinion consultations occurred through the use of telemedicine technology. Discussion: Less than three percent of adult cancer patients participate in clinical trials (Christian & Trimble, 2003). The MCA was established, in part, to address disparities such as this, in an effort to enhance the excellent cancer care provided across the region. The MCA appears to hold great promise of achieving this vision, by leveraging region's collective cancer resources and cancer expertise

Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII

Five unrelated subjects with dysfunctional coagulation factor VII (FVII) were studied In order to Identify missense mutations affecting function. Exons 2 to 8 and the Intron-exon Junctions of their FVIl genes were amplified from peripheral white blood cell DNA by PCR and screened by SSCP analysis. DNA fragments showing aberrant mobility were sequenced. The following mutations were Identified: In case 1 (FVII: C <1%, FVIl:Ag 18%) a heterozygous A to G transltion at nucleotlde 8915 In exon 6 results In the amlno acid substitution Lys-137 to Glu near the C-termlnus of the FVlla llght chaln; In case 2 (FVII: C 7%, FVll:Ag 47%) a heterozygous A to G transltion at nucleotide 7834 In exon 5 results in the substitution of Gin-100 by Arg in the second EGF-like domain; In case 3 (FVll:C 20%, FVIl:Ag 76%) a homozygous G to A transition at nucleotide position 6055 in exon 4 was detected resulting in substitution of Arg-79 by Gin in the first EGF-like domain; in case 5 (FVIl:C 10%, FVIl:Ag 52%) a heterozygous C to T transition at nucleotide position 6054 in exon 4 also results in the substitution of Arg79, but in this case it is replaced by Trp; case 4 (FVll:C <1%, FVIl:Ag 100%) was homozygous for a previously reported mutation (G to A) at nucleotide position 10715 in exon 8, substituting Gin for Arg at position 304 in the protease domain. Cases 1,2 and 5 evidently have additional undetected mutation

Towards a Critical Understanding of Music, Emotion and Self-Identity

The article begins by outlining a dominant conception of these relations in sociologically informed analysis of music, which sees music primarily as a positive resource for active self-making. My argument is that this conception rests on a problematic notion of the self and also on an overly optimistic understanding of music, which implicitly sees music as highly independent of negative social and historical processes. I then attempt to construct a) a more adequately critical conception of personal identity in modern societies; and b) a more balanced appraisal of music-society relations. I suggest two ways in which relations between self, music and society may not always be quite so positive or as healthy as the dominant conception suggests: 1) Music is now bound up with the incorporation of authenticity and creativity into capitalism, and with intensified consumption habits. 2) Emotional self-realisation through music is now linked to status competition. Interviews are analysed

HiFLEx – a highly flexible package to reduce cross-dispersed Echelle spectra

© 2020 The Astronomical Society of the Pacific. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (https://creativecommons.org/licenses/by/3.0/). Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.We describe a flexible data reduction package for high resolution cross-dispersed echelle data. This open-source package is developed in Python and includes optional GUIs for most of the steps. It does not require any pre-knowledge about the form or position of the echelle-orders. It has been tested on cross-dispersed echelle spectrographs between 13k and 115k resolution (bifurcated fiber-fed spectrogaph ESO-HARPS and single fiber-fed spectrograph TNT-MRES). HiFLEx can be used to determine radial velocities and is designed to use the TERRA package but can also control the radial velocity packages such as CERES and SERVAL to perform the radial velocity analysis. Tests on HARPS data indicates radial velocities results within ±3ms−1 of the literature pipelines without any fine tuning of extraction parameters.Peer reviewe

Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): a study protocol for a randomised controlled trial of a Resource Kit.

BACKGROUND: Improving care at home for people with dementia is a core policy goal in the dementia strategies of many European countries. A challenge to effective home support is the occurrence of crises in the care of people with dementia which arise from changes in their health and social circumstances. Improving the management of these crises may prevent hospital admissions and facilitate better and longer care at home. This trial is part of a National Institute for Health Research funded programme, AQUEDUCT, which aims to improve the quality and effectiveness of teams working to manage crises in dementia. METHODS/DESIGN: It is a pragmatic randomised controlled trial of an online Resource Kit to enhance practice in teams managing crises in dementia care. Thirty teams managing mental health crises in dementia in community settings will be randomised between the Resource Kit intervention and treatment as usual. The primary outcome measure is psychiatric admissions to hospital for people with dementia in the teams' catchment area recorded 6 months after randomisation. Other outcomes include quality of life measures for people with dementia and their carers, practitioner impact measures, acute hospital admissions and costs. To enhance understanding of the Resource Kit intervention, qualitative work will explore staff, patient and carers' experience. DISCUSSION: The Resource Kit intervention reflects current policy to enable home-based care for people with dementia by addressing the management of crises which threaten the viability of care at home. It is based upon a model of best practice for managing crises in dementia designed to enhance the quality of care, developed in partnership with people with dementia, carers and practitioners. If the Resource Kit is shown to be clinically and cost-effective in this study, this will enhance the probability of its incorporation into mainstream practice. TRIAL REGISTRATION: ISRCTN 42855694 ; Registered on 04/03/2021; Protocol number: 127686/2020v9; Research Ethics Committee, 09/03/2021, Ref 21/WM/0004; IRAS ID: 289982

Time trends in smoking in Russia in the light of recent tobacco control measures: synthesis of evidence from multiple sources

Background - The study aims at identifying long-term trends and patterns of current smoking by age, gender, and education in Russia, including the most recent period from 2008 during which tobacco control policies were implemented, and to estimate the impact on mortality of any reductions in prevalence. We present an in-depth analysis based on an unprecedentedly large array of survey data. Methods - We examined pooled micro-data on smoking from 17 rounds of the Russian Longitudinal Monitoring Study of 1996–2016, 11 other surveys conducted in Russia in 1975–2017, and two comparator surveys from England and the USA. Standardization by age and education, regression and meta-analysis were used to estimate trends in the prevalence of current smoking by gender, age, and educational patterns. Results - From the mid-1970s to the mid-2000s smoking prevalence among men was relatively stable at around 60%, after which time prevalence declined in every age and educational group. Among women, trends in smoking were more heterogeneous. Prevalence more than doubled above the age of 55 years from very low levels ( Conclusions - The implementation of an effective tobacco control strategy in Russia starting in 2008 coincided with a decline in smoking prevalence among men from what had been stable, high levels over many decades regardless of age and education. Among women, the declines have been more uneven, with young women showing recent downturns, while the smoking prevalence in middle age has increased, particularly among those with minimal education. Among men, these positive changes will have made a small contribution to the reduction in mortality seen in Russia since 2005

Ga2.52V2.48O7.33(OH)0.67, a synthetic member of the nolanite/akdalaite-type family of oxyhydroxides containing trivalent vanadium

The oxyhydroxide Ga2.52V2·48O7·33(OH)0.67 is prepared by reaction between Ga metal and Na3VO4 in a 1:1 monoethanolamine:water mixture at 240 ​°C. Powder neutron diffraction shows the material to be isostructural with the minerals nolanite and akdalaite, with cations occupying tetrahedral and octahedral interstitial sites in a hexagonal close-packed array of oxide/hydroxide (P63mc, a ​= ​5.7906(2) Å, c ​= ​9.2550(5) Å). Rietveld refinement against the data shows that Ga preferentially occupies tetrahedral sites, as well as some octahedral sites, and hence all V is octahedrally coordinated. The oxidation state of vanadium is confirmed as close to V3+ using V K-edge X-ray absorption near-edge structure spectroscopy, consistent with the refined chemical composition. The material is metastable, dehydrating around 300 ​°C and then decomposing above 500 ​°C, as shown by thermogravimetric analysis and thermodiffraction. The oxide Ga2.52V2.48O8 produced after dehydration at 300 ​°C is shown to contain a larger proportion of V4+ than the parent oxyhydroxide, to ensure charge balance, but the essential hexagonal structure is maintained. Variable temperature magnetisation measurements show that although both materials appear to obey the Curie-Weiss law at high temperatures, at low temperatures the inverse susceptibility curves are non-linear. There is, however, no evidence for strong magnetic exchange and the extracted effective moments are consistent with the presence of more V3+ in the oxyhydroxide compared to the oxide

Epigenetic regulation of nuclear processes in fungal plant pathogens

AU Through: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly the association of protein complexes to DNA, the eukaryotic : nuclear genome is broadly organized into open euchromatin that is accessible for enzymes acting on DNA and condensed heterochromatin that is inaccessible. Chemical and physical alterations to chromatin may impact its organization and functionality and are therefore important regulators of nuclear processes. Studies in various fungal plant pathogens have uncovered an association between chromatin organization and expression of in planta-induced genes that are important for pathogenicity. This review discusses chromatin-based regulation mechanisms as determined in the fungal plant pathogen Verticillium dahliae and relates the importance of epigenetic transcriptional regulation and other nuclear processes more broadly in fungal plant pathogens