Understanding the origin of magnetic znomalies in Monte San Vincenzo (Southern Italy) archaeological Site: susceptibility measurements, PXRD, XRF and optical analysis

In the 2002 a multidisciplinary research project began studying the ancient landscapes of Tavoliere, an agricultural area located in Southern Italy that, as shown by historical and archaeological documentations, has been intensively populated from the Neolithic until the Middle Ages (e.g. Bradford, 1949; Jones, 1987; Volpe, 2001). Since the number and extent of the sites (villages, villas, farms, necropolis, etc.) render the planning of a systematic programme of excavations very difficult, a ..

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production

© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Surfactant Protein SP-D, a member of the collectin family, is a pattern recognition protein, secreted by mucosal epithelial cells and has an important role in innate immunity against various pathogens. In this study, we confirm that native human SP-D and a recombinant fragment of human SP-D (rhSP-D) bind to gp120 of HIV-1 and significantly inhibit viral replication in vitro in a calcium and dose-dependent manner. We show, for the first time, that SP-D and rhSP-D act as potent inhibitors of HIV-1 entry in to target cells and block the interaction between CD4 and gp120 in a dose-dependent manner. The rhSP-D-mediated inhibition of viral replication was examined using three clinical isolates of HIV-1 and three target cells: Jurkat T cells, U937 monocytic cells and PBMCs. HIV-1 induced cytokine storm in the three target cells was significantly suppressed by rhSP-D. Phosphorylation of key kinases p38, Erk1/2 and AKT, which contribute to HIV-1 induced immune activation, was significantly reduced in vitro in the presence of rhSP-D. Notably, anti-HIV-1 activity of rhSP-D was retained in the presence of biological fluids such as cervico-vaginal lavage and seminal plasma. Our study illustrates the multi-faceted role of human SPD against HIV-1 and potential of rhSP-D for immunotherapy to inhibit viral entry and immune activation in acute HIV infection. © 2014 Pandit et al.The work (Project no. 2011-16850) was supported by Medical Innovation Fund of Indian Council of Medical Research, New Delhi, India (www.icmr.nic.in/)

Interweaving Chiral Spirals

We elaborate how to construct interweaving chiral spirals in (2+1) dimensions, defined as a superposition of chiral spirals oriented in different directions. We divide a two-dimensional Fermi sea into distinct wedges, characterized by the opening angle 2Theta and depth Q ~ pF, where pF is the Fermi momentum. In each wedge, the energy is lowered by forming a single chiral spiral. The optimal values for Theta and Q are chosen by balancing this gain in energy versus the cost of deforming the Fermi surface (which dominates at large Theta) and patch-patch interactions (dominant at small Theta). Using a non-local four-Fermi interaction model, we estimate the gain and cost in energy by expanding in terms of 1/Nc (where Nc is the number of colors), lqcd/Q, and Theta. Due to a form factor in our non-local model, at small 1/Nc the mass gap (chiral condensate) is large, and the interaction among quarks and the condensate local in momentum space. Consequently, interactions between different patches are localized near their boundaries, and it is simple to embed many chiral spirals. We identify the dominant and subdominant terms at high density and categorize formulate an expansion in terms of lqcd/Q or Theta. The kinetic term in the transverse directions is subdominant, so that techniques from (1+1)-dimensional systems can be utilized. To leading order in 1/Nc and lqcd/Q, the total gain in energy is ~ pF lqcd^2 with Theta ~ (lqcd/pF)^{3/5}. Since Theta decreases with increasing pF, there should be phase transitions associated with the change in the wedge number. We also argue the effects of subdominant terms at lower density where the large-Nc approximation is more reliable.Comment: 54 pages, 21 figures, published versio

Phases of Dense Quarks at Large N_c

In the limit of a large number of colors, N_c, we suggest that gauge theories can exhibit several distinct phases at nonzero temperature and quark density. Two are familiar: a cold, dilute phase of confined hadrons, where the pressure is ~ 1, and a hot phase of deconfined quarks and gluons, with pressure ~ N_c^2. When the quark chemical potential mu ~ 1, the deconfining transition temperature, T_d, is independent of mu. For T < T_d, as mu increases above the mass threshold, baryons quickly form a dense phase where the pressure is ~ N_c. As illustrated by a Skyrme crystal, chiral symmetry can be both spontaneously broken, and then restored, in the dense phase. While the pressure is ~ N_c, like that of (non-ideal) quarks, the dense phase is still confined, with interactions near the Fermi surface those of baryons, and not of quarks. Thus in the chirally symmetric region, baryons near the Fermi surface are parity doubled. We suggest possible implications for the phase diagram of QCD.Comment: 23 pages, 2 figures, uses entcs macro. Minor changes in wordin

Conference highlights of the 15th international conference on human retrovirology: HTLV and related retroviruses, 4-8 june 2011, Leuven, Gembloux, Belgium

The June 2011 15th International Conference on Human Retrovirology: HTLV and Related Viruses marks approximately 30 years since the discovery of HTLV-1. As anticipated, a large number of abstracts were submitted and presented by scientists, new and old to the field of retrovirology, from all five continents. The aim of this review is to distribute the scientific highlights of the presentations as analysed and represented by experts in specific fields of epidemiology, clinical research, immunology, animal models, molecular and cellular biology, and virology