839 research outputs found
A Subgrid-scale Model for Deflagration-to-Detonation Transitions in Type Ia Supernova Explosion Simulations - Numerical implementation
A promising model for normal Type Ia supernova (SN Ia) explosions are delayed
detonations of Chandrasekhar-mass white dwarfs, in which the burning starts out
as a subsonic deflagration and turns at a later phase of the explosion into a
supersonic detonation. The mechanism of the underlying
deflagration-to-detonation transition (DDT) is unknown in detail, but necessary
conditions have been determined recently. The region of detonation initiation
cannot be spatially resolved in multi-dimensional full-star simulations of the
explosion. We develop a subgrid-scale (SGS) model for DDTs in thermonuclear
supernova simulations that is consistent with the currently known constraints.
The probability for a DDT to occur is calculated from the distribution of
turbulent velocities measured on the grid scale in the vicinity of the flame
and the fractal flame surface area that satisfies further physical constraints,
such as fuel fraction and fuel density. The implementation of our DDT criterion
provides a solid basis for simulations of thermonuclear supernova explosions in
the delayed detonation scenario. It accounts for the currently known necessary
conditions for the transition and avoids the inclusion of resolution-dependent
quantities in the model. The functionality of our DDT criterion is demonstrated
on the example of one three-dimensional thermonuclear supernova explosion
simulation.Comment: accepted for publication in Astronomy and Astrophysic
Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.
Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to be the sole conduit for postreceptor signaling. Here we challenge that paradigm and show that GIV/Girdin, a guanidine exchange factor (GEF) for the trimeric G protein Gαi, is another major hierarchical conduit for the metabolic insulin response. By virtue of its ability to directly bind InsR, IRS1, and phosphoinositide 3-kinase, GIV serves as a key hub in the immediate postreceptor level, which coordinately enhances the metabolic insulin response and glucose uptake in myotubes via its GEF function. Site-directed mutagenesis or phosphoinhibition of GIV-GEF by the fatty acid/protein kinase C-theta pathway triggers IR. Insulin sensitizers reverse phosphoinhibition of GIV and reinstate insulin sensitivity. We also provide evidence for such reversible regulation of GIV-GEF in skeletal muscles from patients with IR. Thus GIV is an essential upstream component that couples InsR to G-protein signaling to enhance the metabolic insulin response, and impairment of such coupling triggers IR. We also provide evidence that GIV-GEF serves as therapeutic target for exogenous manipulation of physiological insulin response and reversal of IR in skeletal muscles
Three-dimensional simulations of gravitationally confined detonations compared to observations of SN 1991T
The gravitationally confined detonation (GCD) model has been proposed as a
possible explosion mechanism for Type Ia supernovae in the single-degenerate
evolution channel. Driven by buoyancy, a deflagration flame rises in a narrow
cone towards the surface. For the most part, the flow of the expanding ashes
remains radial, but upon reaching the outer, low-pressure layers of the white
dwarf, an additional lateral component develops. This makes the deflagration
ashes converge again at the opposite side, where the compression heats fuel and
a detonation may be launched. To test the GCD explosion model, we perform a 3D
simulation for a model with an ignition spot offset near the upper limit of
what is still justifiable, 200 km. This simulation meets our deliberately
optimistic detonation criteria and we initiate a detonation. The detonation
burns through the white dwarf and leads to its complete disruption. We
determine nucleosynthetic yields by post-processing 10^6 tracer particles with
a 384 nuclide reaction network and we present multi-band light curves and
time-dependent optical spectra. We find that our synthetic observables show a
prominent viewing-angle sensitivity in UV and blue bands, which is in tension
with observed SNe Ia. The strong dependence on viewing-angle is caused by the
asymmetric distribution of the deflagration ashes in the outer ejecta layers.
Finally, we perform a comparison of our model to SN 1991T. The overall
flux-level of the model is slightly too low and the model predicts pre-maximum
light spectral features due to Ca, S, and Si that are too strong. Furthermore,
the model chemical abundance stratification qualitatively disagrees with recent
abundance tomography results in two key areas: our model lacks low velocity
stable Fe and instead has copious amounts of high-velocity 56Ni and stable Fe.
We therefore do not find good agreement of the model with SN 1991T.Comment: 11 pages, accepted for publication in Astronomy & Astrophysic
Gamma-ray diagnostics of Type Ia supernovae: Predictions of observables from three-dimensional modeling
Besides the fact that the gamma-ray emission due to radioactive decays is
responsible for powering the light curves of Type Ia supernovae (SNe Ia), gamma
rays themselves are of particular interest as a diagnostic tool because they
provide a direct way to obtain deeper insights into the nucleosynthesis and the
kinematics of these explosion events. Focusing on two of the most broadly
discussed SN Ia progenitor scenarios - a delayed detonation in a
Chandrasekhar-mass white dwarf (WD) and a violent merger of two WDs - we use
three-dimensional explosion models and perform radiative transfer simulations
to obtain synthetic gamma-ray spectra. Both chosen models produce the same mass
of 56Ni and have similar optical properties that are in reasonable agreement
with the recently observed supernova SN 2011fe. In contrast to the optical
regime, the gamma-ray emission of our two chosen models proves to be rather
different. The almost direct connection of the emission of gamma rays to
fundamental physical processes occuring in SNe Ia permits additional
constraints concerning several explosion model properties that are not easily
accessible within other wavelength ranges. Proposed future MeV missions such as
GRIPS will resolve all spectral details only for nearby SNe Ia, but hardness
ratio and light curve measurements still allow for a distinction of the two
different models at 10 and 16 Mpc for an exposure time of 10^6 s, respectively.
The possibility to detect the strongest line features up to the Virgo distance
will offer the opportunity to build up a first sample of SN Ia detections in
the gamma-ray energy range and underlines the importance of future space
observatories for MeV gamma rays.Comment: 10 pages, 8 figures, accepted for publication by A&
Combustion in thermonuclear supernova explosions
Type Ia supernovae are associated with thermonuclear explosions of white
dwarf stars. Combustion processes convert material in nuclear reactions and
release the energy required to explode the stars. At the same time, they
produce the radioactive species that power radiation and give rise to the
formation of the observables. Therefore, the physical mechanism of the
combustion processes, as reviewed here, is the key to understand these
astrophysical events. Theory establishes two distinct modes of propagation for
combustion fronts: subsonic deflagrations and supersonic detonations. Both are
assumed to play an important role in thermonuclear supernovae. The physical
nature and theoretical models of deflagrations and detonations are discussed
together with numerical implementations. A particular challenge arises due to
the wide range of spatial scales involved in these phenomena. Neither the
combustion waves nor their interaction with fluid flow and instabilities can be
directly resolved in simulations. Substantial modeling effort is required to
consistently capture such effects and the corresponding techniques are
discussed in detail. They form the basis of modern multidimensional
hydrodynamical simulations of thermonuclear supernova explosions. The problem
of deflagration-to-detonation transitions in thermonuclear supernova explosions
is briefly mentioned.Comment: Author version of chapter for 'Handbook of Supernovae,' edited by A.
Alsabti and P. Murdin, Springer. 24 pages, 4 figure
Constraining Type Ia supernova models: SN 2011fe as a test case
The nearby supernova SN 2011fe can be observed in unprecedented detail.
Therefore, it is an important test case for Type Ia supernova (SN Ia) models,
which may bring us closer to understanding the physical nature of these
objects. Here, we explore how available and expected future observations of SN
2011fe can be used to constrain SN Ia explosion scenarios. We base our
discussion on three-dimensional simulations of a delayed detonation in a
Chandrasekhar-mass white dwarf and of a violent merger of two white
dwarfs-realizations of explosion models appropriate for two of the most
widely-discussed progenitor channels that may give rise to SNe Ia. Although
both models have their shortcomings in reproducing details of the early and
near-maximum spectra of SN 2011fe obtained by the Nearby Supernova Factory
(SNfactory), the overall match with the observations is reasonable. The level
of agreement is slightly better for the merger, in particular around maximum,
but a clear preference for one model over the other is still not justified.
Observations at late epochs, however, hold promise for discriminating the
explosion scenarios in a straightforward way, as a nucleosynthesis effect leads
to differences in the 55Co production. SN 2011fe is close enough to be followed
sufficiently long to study this effect.Comment: Accepted for publication in The Astrophysical Journal Letter
Type Ia supernova diversity: white dwarf central density as a secondary parameter in three-dimensional delayed detonation models
Delayed detonations of Chandrasekhar-mass white dwarfs (WDs) have been very
successful in explaining the spectra, light curves, and the width-luminosity
relation of spectroscopically normal Type Ia supernovae (SNe Ia). The ignition
of the thermonuclear deflagration flame at the end of the convective carbon
"simmering" phase in the core of the WD is still not well understood and much
about the ignition kernel distribution remains unknown. Furthermore, the
central density at the time of ignition depends on the still uncertain screened
carbon fusion reaction rates, the accretion history and cooling time of the
progenitor, and the composition. We present the results of twelve
high-resolution three-dimensional delayed detonation SN Ia explosion
simulations that employ a new criterion to trigger the deflagration to
detonation transition (DDT). All simulations trigger our DDT criterion and the
resulting delayed detonations unbind the star. We find a trend of increasing
iron group element (IGE) production with increasing central density for bright,
faint, and intermediate SNe. The total 56Ni yield, however, remains more or
less constant, even though increased electron captures at high density result
in a decreasing 56Ni mass fraction of the IGE material. We attribute this to an
approximate balance of 56Ni producing and destroying effects. The deflagrations
that were ignited at higher density initially have a faster growth rate of
subgrid-scale turbulence. Hence, the effective flame speed increases faster,
which triggers the DDT criterion earlier, at a time when the central density of
the expanded star is higher. This leads to an overall increase of IGE
production, which off-sets the percental reduction of 56Ni due to
neutronization.Comment: 8 pages, 6 figures, 2 tables, accepted for publication in MNRAS. v2
now includes correct Fig. 6, which was missing from v
Ursolic acid and luteolin-7-glucoside improves rat plasma lipid profile and increases liver glycogen content through glycogen synthase kinase-3
In the present study, two phytochemicals - ursolic acid (UA) and luteolin-7-glucoside (L7G) - were assessed in vivo in healthy rats regarding effects on plasma glucose and lipid profile (total cholesterol, HDL and LDL), as well as liver glycogen content, in view of their importance in the aetiology of diabetes and associated complications. Both UA and L7G significantly decreased plasma glucose concentration. UA also significantly increased liver glycogen levels accompanied by phosphorylation of glycogen synthase kinase-3 (GSK3). The increase in glycogen deposition induced by UA (mediated by GSK3) could have contributed to the lower plasma glucose levels observed. Both compounds significantly lowered total plasma cholesterol and low-density lipoprotein levels, and, in addition, UA increased plasma high-density lipoprotein levels. Our results show that UA particularly may be useful in preventable strategies for people at risk of developing diabetes and associated cardiovascular complications by improving plasma glucose levels and lipid profile, as well as by promoting liver glycogen deposition.MFA and CMS were supported by the Foundation for Science and Technology, Portugal, through the grants SFRH/BD/12527/2003 and SFRH/BD/42566/2007, respectively. This work was supported by the Foundation for Science and Technology, Portugal, research grant POCI/AGR/62040/2004
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