Predicting Function Delay with a Machine Learning Model: Improve the Long-term Survival of Pancreatic Grafts

The impact of delayed graft function on outcomes following various solid organ transplants is well documented and addressed in the literature. Delayed graft function following various solid organ transplants is associated with both short- and long-term graft survival issues. In a retrospective cohort study including 106 patients we evaluated whether pancreas graft survival differs according to moment of insulin therapy following simultaneous pancreaskidney transplant. As a result, we aimed to identify possible risk factors and build a machine-learning-based model that predicts the likelihood of dysfunction following SPK transplant patients based on day zero data after transplant, allowing to enhance pancreatic graft survival. Feature selection by Relief algorithm yielded donor features, age, cause of death, hemoglobin, gender, ventilation days, days in ICU, length of cardiac respiratory arrest and recipient features, gender, long-term insulin, dialysis type, time of diabetes mellitus, vPRA pre-Tx, number of HLA-A mismatches and PRDI, all contributed to the models' strength.info:eu-repo/semantics/publishedVersio

WORKING GROUP ON NEPHROPS SURVEYS (WGNEPS ; outputs from 2020)

The Working Group on Nephrops Surveys (WGNEPS) is the international coordination group for Nephrops underwater television and trawl surveys within ICES. This report summarizes the na-tional contributions on the results of the surveys conducted in 2020 together with time series covering all survey years, problems encountered, data quality checks and technological improve-ments as well as the planning for survey activities for 2021.ICE

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Incidência de ácaros Brevipalpus sp. em pomares e frutos do Recôncavo Baiano.

No Estado de São Paulo, o maior dispêndio de recursos está relacionado ao controle fitossanitário, principalmente para o controle de vetores de doenças da citricultura, dentre eles, o ácaro Brevipalpus phoenicis, cujo controle onera a cadeia produtiva em U$80 milhões. Esta espécie de ácaro está associado à transmissão do Citrus Leprosis Virus (CiLV), agente causal da Leprose dos Citros, doença que acomete ramos, folhas e frutos de laranja. Na Bahia, a doença está restrita aos Territórios de Identidade do Agreste de Alagoinhas / Litoral Norte e Oeste. O objetivo deste trabalho foi verificar a incidência e flutuação populacional de ácaros Brevipalpus em pomares cítricos localizados no Recôncavo Baiano. esteve trabalho teve por objetivos verificar a incidência de ácaros Brevipalpus, agente disseminador do Citrus Leprosis Virus (CiLV), em pomares e frutos, assim como sua flutuação populacional mensal.PDF. 092

New monitoring technologies to produce ancillary data on Nephrops stock assessment

Working Group on Nephrops Surveys (WGNEPS), 6-8 November 2018, Lorient, France.-- 2 pages, 2 figuresCurrent stock assessment based on UWTV surveys counts of Nephrops burrows (and thus inhabiting individuals) based on the peculiar morphological traits of these structures within the substrate. Three major uncertainties have been identified in this methodology: i. burrow occupancy which is currently assumed to be of one individual >17mm carapace length per identifiable burrow system; ii. burrow system size and the “edge effect” which could bias the estimates of effective area surveyed; iii. Burrow identification because other sympatric fish and decapod species construct tunnels with morphology similar to those of Nephrops. It is therefore of relevance to produce data on burrow emergence to validate or improve the assumptions made in the UWTV assessment methodology. New in situ technological applications should be used to monitor burrowing behavior producing data on the following key aspects: i. Burrow persistence related to the death and opportunistic occupation by other species; ii. Burrow emergence rhythms at different time-scales which oblige to perform surveys in specific time windows (tidal, day and seasons); iii. Emergence duration that varies according to the hunger state (predation-scavenging), predator presence (visual contact, odor plumes, noise) and intraspecific interactions (territoriality); and finally, iv. emergence range, identifying how many holes belong to a single anima

New monitoring technologies assisting deep-water and deep-sea crustacean decapods stock assessment

The Crustacean Society Mid-Year Meeting (TSC 2019), 26-30 May 2019, Hong Kong.-- 1 pageThe stock assessment of Norway lobster (Nephrops norvegicus) is made by fishery-dependent (i.e. trawl catches) or fishery-independent (i.e. burrow counts) methods. In both cases, important methodological assumptions affect the validity of derived population demographic estimates. Here, we provide a description of cabled underwater sensor networks in relation to the production of ancillary data for stock assessment of deep-sea highly commercially exploited decapods, whose fishery is in decline in the Mediterranean Sea. Specifically, two 20 m depth cabled video-observatories belonging to the European Multidisciplinary Seafloor and water column Observations (EMSO) network (SmartBay, in Ireland and OBSEA in Spain) are being used for in situ high-frequency time-lapse video and oceanographic monitoring of the burrow emergence of individuals. This monitoring will be used to quantify inter-individual variability in frequency and duration of emergence as a product of ecological and environmental forcing, and inform population level estimates of emergence (and hence availability to trawling) and burrow occupancy. Obtained data will serve as cross validation for acoustic tagging trials (i.e. animals bearing frequency-specific emitters, operating in tandem with listening hydrophone stations). Emissions and silences will be proxy of emergence timing and duration. A shallow water trial performed at OBSEA will serve as test-bed for acoustic mooring placement at 350-400 m depth, in the no take zone off Blanes Canyon (Spain)The present work was supported by RESBIO (TEC2017-87861-R) and RESNEP (CTM201782991-C2-1-R) as well as TNAs: ADVANCE (H2020-INFRAIA-2014-2015 under the Grant Agreement no. 654410, JERICO-NEXT) and SmartLobster (EMSO-LINK)