532 research outputs found
The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
The use of immunotherapy to treat cancer is rapidly gaining momentum. Using pre-clinical mouse models, we have recently demonstrated potent and long lasting tumor regression can be elicited by immune-stimulating monoclonal antibodies (mAbs) when combined with histone deacetylase inhibitors (HDACi) and believe this therapy will have broad application in humans
A Class of Eccentric Binaries with Dynamic Tidal Distortions Discovered with Kepler
We have discovered a class of eccentric binary systems within the Kepler data
archive that have dynamic tidal distortions and tidally-induced pulsations.
Each has a uniquely shaped light curve that is characterized by periodic
brightening or variability at time scales of 4-20 days, frequently accompanied
by shorter period oscillations. We can explain the dominant features of the
entire class with orbitally-varying tidal forces that occur in close, eccentric
binary systems. The large variety of light curve shapes arises from viewing
systems at different angles. This hypothesis is supported by spectroscopic
radial velocity measurements for five systems, each showing evidence of being
in an eccentric binary system. Prior to the discovery of these 17 new systems,
only four stars, where KOI-54 is the best example, were known to have evidence
of these dynamic tides and tidally-induced oscillations. We perform preliminary
fits to the light curves and radial velocity data, present the overall
properties of this class and discuss the work required to accurately model
these systems.Comment: 13 pages, submitted to Ap
K2 Discovers a Busy Bee: An Unusual Transiting Neptune Found in the Beehive Cluster
Open clusters have been the focus of several exoplanet surveys but only a few
planets have so far been discovered. The \emph{Kepler} spacecraft revealed an
abundance of small planets around small, cool stars, therefore, such cluster
members are prime targets for exoplanet transit searches. Kepler's new mission,
K2, is targeting several open clusters and star-forming regions around the
ecliptic to search for transiting planets around their low-mass constituents.
Here, we report the discovery of the first transiting planet in the
intermediate-age (800 Myr) Beehive cluster (Praesepe). K2-95 is a faint
() dwarf from K2's Campaign 5
with an effective temperature of , approximately
solar metallicity and a radius of . We
detected a transiting planet with a radius of and an orbital period of 10.134 days. We combined photometry,
medium/high-resolution spectroscopy, adaptive optics/speckle imaging and
archival survey images to rule out any false positive detection scenarios,
validate the planet, and further characterize the system. The planet's radius
is very unusual as M-dwarf field stars rarely have Neptune-sized transiting
planets. The comparatively large radius of K2-95b is consistent with the other
recently discovered cluster planets K2-25b (Hyades) and K2-33b (Upper
Scorpius), indicating systematic differences in their evolutionary states or
formation. These discoveries from K2 provide a snapshot of planet formation and
evolution in cluster environments and thus make excellent laboratories to test
differences between field-star and cluster planet populations.Comment: 14 pages, 8 figues. Accepted for publication in A
3C236: Radio Source, Interrupted?
We present new HST STIS/MAMA near-UV images and archival WFPC2 V and R band
images which reveal the presence of four star forming regions in an arc along
the edge of the dust lane in the giant (4 Mpc) radio galaxy 3C236. Two of the
star forming regions are relatively young with ages of order 1E7 yr, while the
other two are older with ages of order 1E8 - 1E9 yr which is comparable to the
estimated age of the giant radio source. Based on dynamical and spectral aging
arguments, we suggest that the fuel supply to the AGN was interrupted for 1E7
yr and has now been restored, resulting in the formation of the inner 2 kpc
scale radio source. This time scale is similar to that of the age of the
youngest of the star forming regions. We suggest that the transport of gas in
the disk is non-steady and that this produces both the multiple episodes of
star formation in the disk as well as the multiple epochs of radio source
activity. If the inner radio source and the youngest star forming region are
related by the same event of gas transport, the gas must be transported from
the hundreds of pc scale to the sub-parsec scale on a time scale of 1E7 yr,
which is similar to the dynamical time scale of the gas on the hundreds of pc
scales
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Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR (N = 2,969 case and 4,096 control subjects) and severe DR (N = 1,277 case and 3,980 control subjects). Previously identified lipid-associated single nucleotide polymorphisms served as instrumental variables. Meta-analysis to combine the Mendelian randomization estimates from different cohorts was conducted. There was no statistically significant change in odds ratios of having any DR or severe DR for any of the lipid fractions in the primary analysis that used single nucleotide polymorphisms that did not have a pleiotropic effect on another lipid fraction. Similarly, there was no significant association in the Caucasian and Chinese subgroup analyses. This study did not show evidence of a causal role of the four lipid fractions on DR. However, the study had limited power to detect odds ratios less than 1.23 per SD in genetically induced increase in plasma lipid levels, thus we cannot exclude that causal relationships with more modest effect sizes exist
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Characterization of the Testicular Abnormality in 5a-Reductase Deficiency
The testes of five phenotypic women (from four families) with 5ª-reductase deficiency were studied. In one of the patients, the enzyme deficiency was similar in the testis and epididymis and in fibroblasts cultured from the labia majora. In testes from four of the patients, the concentrations of the 55ªreduced steroids dihydrotestosterone and 3ª-androstanediol were less than 10% of those in normal subjects. We conclude that the testis is involved in 55ª-reductase deficiency. Impaired spermatogenesis was evident in testicular biopsies from all five subjects, and in two, sperm production, as estimated in testicular homogenates, was less than 10% of normal. The extent to which spermatogenic arrest is due to 55ª-reductase deficiency or testicular maldescent is not clear
Planetary Candidates Observed by Kepler, III: Analysis of the First 16 Months of Data
New transiting planet candidates are identified in sixteen months (May 2009 -
September 2010) of data from the Kepler spacecraft. Nearly five thousand
periodic transit-like signals are vetted against astrophysical and instrumental
false positives yielding 1,091 viable new planet candidates, bringing the total
count up to over 2,300. Improved vetting metrics are employed, contributing to
higher catalog reliability. Most notable is the noise-weighted robust averaging
of multi-quarter photo-center offsets derived from difference image analysis
which identifies likely background eclipsing binaries. Twenty-two months of
photometry are used for the purpose of characterizing each of the new
candidates. Ephemerides (transit epoch, T_0, and orbital period, P) are
tabulated as well as the products of light curve modeling: reduced radius
(Rp/R*), reduced semi-major axis (d/R*), and impact parameter (b). The largest
fractional increases are seen for the smallest planet candidates (197% for
candidates smaller than 2Re compared to 52% for candidates larger than 2Re) and
those at longer orbital periods (123% for candidates outside of 50-day orbits
versus 85% for candidates inside of 50-day orbits). The gains are larger than
expected from increasing the observing window from thirteen months (Quarter 1--
Quarter 5) to sixteen months (Quarter 1 -- Quarter 6). This demonstrates the
benefit of continued development of pipeline analysis software. The fraction of
all host stars with multiple candidates has grown from 17% to 20%, and the
paucity of short-period giant planets in multiple systems is still evident. The
progression toward smaller planets at longer orbital periods with each new
catalog release suggests that Earth-size planets in the Habitable Zone are
forthcoming if, indeed, such planets are abundant.Comment: Submitted to ApJS. Machine-readable tables are available at
http://kepler.nasa.gov, http://archive.stsci.edu/kepler/results.html, and the
NASA Exoplanet Archiv
Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data
Background: Numerous randomised trials have compared coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) for patients with coronary artery disease. However, no studies have been powered to detect a difference in mortality between the revascularisation strategies. Methods: We did a systematic review up to July 19, 2017, to identify randomised clinical trials comparing CABG with PCI using stents. Eligible studies included patients with multivessel or left main coronary artery disease who did not present with acute myocardial infarction, did PCI with stents (bare-metal or drug-eluting), and had more than 1 year of follow-up for all-cause mortality. In a collaborative, pooled analysis of individual patient data from the identified trials, we estimated all-cause mortality up to 5 years using Kaplan-Meier analyses and compared PCI with CABG using a random-effects Cox proportional-hazards model stratified by trial. Consistency of treatment effect was explored in subgroup analyses, with subgroups defined according to baseline clinical and anatomical characteristics. Findings: We included 11 randomised trials involving 11 518 patients selected by heart teams who were assigned to PCI (n=5753) or to CABG (n=5765). 976 patients died over a mean follow-up of 3·8 years (SD 1·4). Mean Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score was 26·0 (SD 9·5), with 1798 (22·1%) of 8138 patients having a SYNTAX score of 33 or higher. 5 year all-cause mortality was 11·2% after PCI and 9·2% after CABG (hazard ratio [HR] 1·20, 95% CI 1·06–1·37; p=0·0038). 5 year all-cause mortality was significantly different between the interventions in patients with multivessel disease (11·5% after PCI vs 8·9% after CABG; HR 1·28, 95% CI 1·09–1·49; p=0·0019), including in those with diabetes (15·5% vs 10·0%; 1·48, 1·19–1·84; p=0·0004), but not in those without diabetes (8·7% vs 8·0%; 1·08, 0·86–1·36; p=0·49). SYNTAX score had a significant effect on the difference between the interventions in multivessel disease. 5 year all-cause mortality was similar between the interventions in patients with left main disease (10·7% after PCI vs 10·5% after CABG; 1·07, 0·87–1·33; p=0·52), regardless of diabetes status and SYNTAX score. Interpretation: CABG had a mortality benefit over PCI in patients with multivessel disease, particularly those with diabetes and higher coronary complexity. No benefit for CABG over PCI was seen in patients with left main disease. Longer follow-up is needed to better define mortality differences between the revascularisation strategies
Kepler-21b: A 1.6REarth Planet Transiting the Bright Oscillating F Subgiant Star HD 179070
We present Kepler observations of the bright (V=8.3), oscillating star HD
179070. The observations show transit-like events which reveal that the star is
orbited every 2.8 days by a small, 1.6 R_Earth object. Seismic studies of HD
179070 using short cadence Kepler observations show that HD 179070 has a
frequencypower spectrum consistent with solar-like oscillations that are
acoustic p-modes. Asteroseismic analysis provides robust values for the mass
and radius of HD 179070, 1.34{\pm}0.06 M{\circ} and 1.86{\pm}0.04 R{\circ}
respectively, as well as yielding an age of 2.84{\pm}0.34 Gyr for this F5
subgiant. Together with ground-based follow-up observations, analysis of the
Kepler light curves and image data, and blend scenario models, we
conservatively show at the >99.7% confidence level (3{\sigma}) that the transit
event is caused by a 1.64{\pm}0.04 R_Earth exoplanet in a 2.785755{\pm}0.000032
day orbit. The exoplanet is only 0.04 AU away from the star and our
spectroscopic observations provide an upper limit to its mass of ~10 M_Earth
(2-{\sigma}). HD 179070 is the brightest exoplanet host star yet discovered by
Kepler.Comment: Accepted to Ap
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