Influence of clamp-widening on the quality factor of nanomechanical silicon nitride resonators

Nanomechanical resonators based on strained silicon nitride (Si$_3$N$_4$) have received a large amount of attention in fields such as sensing and quantum optomechanics due to their exceptionally high quality factors ($Q$s). Room-temperature $Q$s approaching 1 billion are now in reach by means of phononic crystals (soft-clamping) and strain engineering. Despite great progress in enhancing $Q$s, difficulties in fabrication of soft-clamped samples limits their implementation into actual devices. An alternative means of achieving ultra-high $Q$s was shown using trampoline resonators with engineered clamps, which serves to localize the stress to the center of the resonator, while minimizing stress at the clamping. The effectiveness of this approach has since come into question from recent studies employing string resonators with clamp-tapering. Here, we investigate this idea using nanomechanical string resonators with engineered clampings similar to those presented for trampolines. Importantly, the effect of orienting the strings diagonally or perpendicularly with respect to the silicon frame is investigated. It is found that increasing the clamp width for diagonal strings slightly increases the $Q$s of the fundamental out-of-plane mode at small radii, while perpendicular strings only deteriorate with increasing clamp width. Measured $Q$s agree well with finite element method simulations even for higher-order resonances. The small increase cannot account for previously reported $Q$s of trampoline resonators. Instead, we propose the effect to be intrinsic and related to surface and radiation losses.Comment: 7 pages, 4 figure

Study on Doping Prevention: A map of Legal, Regulatory and Prevention Practice Provisions in EU 28

Historically, anti-doping efforts have focused on the detection and deterrence of doping in elite and competitive sport. There is, however, a growing concern that doping is occurring outside the organised sporting system; giving rise to the belief that the misuse of doping agents in recreational sport has become a societal problem and a public health issue that must be addressed. The EU Commission awarded a contract (EAC/2013/0617) to a Consortium to undertake this Study with the aim of developing the evidence-base for policies designed to combat doping in recreational sport. Fourteen internationally recognised experts shaped the Study which comprised (i) the collection of primary data through a structured survey, and (ii) secondary data through literature searches and website analysis. All 28 Member States participated in the information-gathering process. Specifically, this involved a systematic study of the ethical considerations, legal position, prevention research landscape, and current practise in relation to the prevention of doping in recreational sport. The Study provides a comprehensive overview of current practice and legislation as it applies to the prevention of doping and promotes and supports the sharing of best practices in the EU regarding the fight against doping in recreational sport. It concludes with seven recommendations for future action that focus on the need for a coordinated response in relation to the problems arising from doping in recreational sport

What asteroseismology can do for exoplanets

We describe three useful applications of asteroseismology in the context of exoplanet science: (1) the detailed characterisation of exoplanet host stars; (2) the measurement of stellar inclinations; and (3) the determination of orbital eccentricity from transit duration making use of asteroseismic stellar densities. We do so using the example system Kepler-410 (Van Eylen et al. 2014). This is one of the brightest (V = 9.4) Kepler exoplanet host stars, containing a small (2.8 Rearth) transiting planet in a long orbit (17.8 days), and one or more additional non-transiting planets as indicated by transit timing variations. The validation of Kepler-410 (KOI-42) was complicated due to the presence of a companion star, and the planetary nature of the system was confirmed after analyzing a Spitzer transit observation as well as ground-based follow-up observations.Comment: 4 pages, Proceedings of the CoRoT Symposium 3 / Kepler KASC-7 joint meeting, Toulouse, 7-11 July 2014. To be published by EPJ Web of Conference

Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

The burden of colorectal cancer (CRC) is considerable—approximately 1.8 million people are diagnosed each year with CRC and of these about half will succumb to the disease. In the case of CRC, there is strong evidence that an early diagnosis leads to a better prognosis, with metastatic CRC having a 5-year survival that is only slightly greater than 10% compared with up to 90% for stage I CRC. Clearly, biomarkers for the early detection of CRC would have a major clinical impact. We implemented a coherent gel-based proteomics biomarker discovery platform for the identification of clinically useful biomarkers for the early detection of CRC. Potential protein biomarkers were identified by a 2D gel-based analysis of a cohort composed of 128 CRC and site-matched normal tissue biopsies. Potential biomarkers were prioritized and assays to quantitatively measure plasma expression of the candidate biomarkers were developed. Those biomarkers that fulfilled the preset criteria for technical validity were validated in a case-control set of plasma samples, including 70 patients with CRC, adenomas, or non-cancer diseases and healthy individuals in each group. We identified 63 consistently upregulated polypeptides (factor of four-fold or more) in our proteomics analysis. We selected 10 out of these 63 upregulated polypeptides, and established assays to measure the concentration of each one of the ten biomarkers in plasma samples. Biomarker levels were analyzed in plasma samples from healthy individuals, individuals with adenomas, CRC patients, and patients with non-cancer diseases and we identified one protein, tropomyosin 3 (Tpm3) that could discriminate CRC at a significant level (p = 0.0146). Our results suggest that at least one of the identified proteins, Tpm3, could be used as a biomarker in the early detection of CRC, and further studies should provide unequivocal evidence for the real-life clinical validity and usefulness of Tpm3

Into the Lyα jungle: exploring the circumgalactic medium of galaxies at z ∼ 4 − 5 with MUSE

We present a study of the galaxy environment of 9 strong H I+C IV absorption line systems (16.2 < log(N(HI)) < 21.2) spanning a wide range in metallicity at z ∼ 4 − 5, using MUSE integral field and X-Shooter spectroscopic data collected in a z ≈ 5.26 quasar field. We identify galaxies within a 250 kpc and ±1000 km s−1 window for 6 out of the 9 absorption systems, with 2 of the absorption line systems showing multiple associated galaxies within the MUSE field of view. The space density of Lyα emitting galaxies (LAEs) around the H I and C IV systems is ≈10 − 20 times the average sky density of LAEs given the flux limit of our survey, showing a clear correlation between the absorption and galaxy populations. Further, we find that the strongest C IV systems in our sample are those that are most closely aligned with galaxies in velocity space, i.e. within velocities of ±500 km s−1. The two most metal poor systems lie in the most dense galaxy environments, implying we are potentially tracing gas that is infalling for the first time into star-forming groups at high redshift. Finally, we detect an extended Lyα nebula around the z ≈ 5.26 quasar, which extends up to ≈50 kpc at the surface brightness limit of 3.8 × 10−18 erg s−1 cm−2 arcsec−2. After scaling for surface brightness dimming, we find that this nebula is centrally brighter, having a steeper radial profile than the average for nebulae studied at z ∼ 3 and is consistent with the mild redshift evolution seen from z ≈ 2

Solar-like oscillations in the G2 subgiant beta Hydri from dual-site observations

We have observed oscillations in the nearby G2 subgiant star beta Hyi using high-precision velocity observations obtained over more than a week with the HARPS and UCLES spectrographs. The oscillation frequencies show a regular comb structure, as expected for solar-like oscillations, but with several l=1 modes being strongly affected by avoided crossings. The data, combined with those we obtained five years earlier, allow us to identify 28 oscillation modes. By scaling the large frequency separation from the Sun, we measure the mean density of beta Hyi to an accuracy of 0.6%. The amplitudes of the oscillations are about 2.5 times solar and the mode lifetime is 2.3 d. A detailed comparison of the mixed l=1 modes with theoretical models should allow a precise estimate of the age of the star.Comment: 13 pages, 14 figures, accepted by ApJ. Fixed minor typo (ref to Fig 14

HD 181068: A Red Giant in a Triply-Eclipsing Compact Hierarchical Triple System

Hierarchical triple systems comprise a close binary and a more distant component. They are important for testing theories of star formation and of stellar evolution in the presence of nearby companions. We obtained 218 days of Kepler photometry of HD 181068 (magnitude of 7.1), supplemented by groundbased spectroscopy and interferometry, which show it to be a hierarchical triple with two types of mutual eclipses. The primary is a red giant that is in a 45-day orbit with a pair of red dwarfs in a close 0.9-day orbit. The red giant shows evidence for tidally-induced oscillations that are driven by the orbital motion of the close pair. HD 181068 is an ideal target for studies of dynamical evolution and testing tidal friction theories in hierarchical triple systems.Comment: 22 pages, including supporting on-line material. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Vol. 332 no. 6026 pp. 216-218 (8 April 2011), doi:10.1126/science.1201762. http://www.sciencemag.org/content/332/6026/216.ful

MUSE Analysis of Gas around Galaxies (MAGG) - I: Survey design and the environment of a near pristine gas cloud at z ≈ 3.5

We present the design, methods, and first results of the MUSE Analysis of Gas around Galaxies (MAGG) survey, a large programme on the Multi Unit Spectroscopic Explorer (MUSE) instrument at the Very Large Telescope (VLT) which targets 28 z > 3.2 quasars to investigate the connection between optically-thick gas and galaxies at z ∼ 3 − 4. MAGG maps the environment of 52 strong absorption line systems at z ≳ 3, providing the first statistical sample of galaxies associated with gas-rich structures in the early Universe. In this paper, we study the galaxy population around a very metal poor gas cloud at z ≈ 3.53 towards the quasar J124957.23−015928.8. We detect three Lyα emitters within ≲200 km s−1 of the cloud redshift, at projected separations ≲185 kpc (physical). The presence of star-forming galaxies near a very metal-poor cloud indicates that metal enrichment is still spatially inhomogeneous at this redshift. Based on its very low metallicity and the presence of nearby galaxies, we propose that the most likely scenario for this LLS is that it lies within a filament which may be accreting onto a nearby galaxy. Taken together with the small number of other LLSs studied with MUSE, the observations to date show a range of different environments near strong absorption systems. The full MAGG survey will significantly expand this sample and enable a statistical analysis of the link between gas and galaxies to pin down the origin of these diverse environments at z ≈ 3 − 4

Influence of initial severity of depression on effectiveness of low intensity interventions: Meta-analysis of individual patient data

This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Objective To assess how initial severity of depression affects the benefit derived from low intensity interventions for depression. Design Meta-analysis of individual patient data from 16 datasets comparing low intensity interventions with usual care. Setting Primary care and community settings. Participants 2470 patients with depression. Interventions Low intensity interventions for depression (such as guided self help by means of written materials and limited professional support, and internet delivered interventions). Main outcome measures Depression outcomes (measured with the Beck Depression Inventory or Center for Epidemiologic Studies Depression Scale), and the effect of initial depression severity on the effects of low intensity interventions. Results Although patients were referred for low intensity interventions, many had moderate to severe depression at baseline. We found a significant interaction between baseline severity and treatment effect (coefficient −0.1 (95% CI −0.19 to −0.002)), suggesting that patients who are more severely depressed at baseline demonstrate larger treatment effects than those who are less severely depressed. However, the magnitude of the interaction (equivalent to an additional drop of around one point on the Beck Depression Inventory for a one standard deviation increase in initial severity) was small and may not be clinically significant. Conclusions The data suggest that patients with more severe depression at baseline show at least as much clinical benefit from low intensity interventions as less severely depressed patients and could usefully be offered these interventions as part of a stepped care model.UK National Institute of Health Research (NIHR) School for Primary Care ResearchMedical Research Counci