Bicycle Dynamics

Tato bakalářská práce se zabývá vybranými parametry ovlivňující dynamiku pohybu jízdního kola. První část práce je zaměřena na analýzu jednotlivých odporů ovlivňující jízdu kola. V další části jsou shrnuty možné postupy zjišťování jednotlivých parametrů. Některé z těchto postupů jsou v bakalářské práci použity pro určení vybraných parametrů ovlivňujících jízdu kola. V poslední části práce jsou naměřené parametry využity pro vypočítání potřebného výkonu cyklisty při jízdě v různých podmínkách.This bachelor thesis deals with parameters affecting the dynamics of bicycle movement. The first part of the thesis focuses on the analysis of individual resistance components which affect the bicycle movement. In the next section, possible approaches for determining individual parameters are summarized. In this bachelor thesis, some of those processes are used to determine selected parameters affecting bicycle movements. In the last section, measured parameters are used to calculate the performance of a cyclist riding in different conditions.342 - Institut dopravyvelmi dobř

"Cultural revitalization" in contemporary Basque Country

The article attemts to make an initial insight into the problematic of language and cultural revitalization process which has been carried out since 1975 to presence. The history of Basque country with a special stress on the circumsatncies of the origin of modern basque nationalism are briefly sketched in the paper. Political, economic and social trends of the period mentioned above are also described, the questions of language revitalization, bilingvism and political consequences are emphasized. The article is based on the fieldresearch which has been carried out in Gipuzkoa (Basque Autonomy) in the february-june period in 2009. The article aslo concerns Navarra and French-Basque regions.The article attemts to make an initial insight into the problematic of language and cultural revitalization process which has been carried out since 1975 to presence. The history of Basque country with a special stress on the circumsatncies of the origin of modern basque nationalism are briefly sketched in the paper. Political, economic and social trends of the period mentioned above are also described, the questions of language revitalization, bilingvism and political consequences are emphasized. The article is based on the fieldresearch which has been carried out in Gipuzkoa (Basque Autonomy) in the february-june period in 2009. The article aslo concerns Navarra and French-Basque regions

Power source supply for pulse magnetron sputtering

Předkládaná práce se zabývá teorií depozice velmi tenkých vrstev pomocí pulsního magnetronového naprašování a návrhem, realizací a testováním napájecího zdroje pro pulsní magnetronové naprašování.The delivered thesis deals with the theory of very thin layers deposition by means of pulse magnetron sputtering and the proposal, realization and testing of the power supply source for the pulse magnetron sputtering.

Reactive Oxygen Species Hydrogen Peroxide Mediates Kaposi's Sarcoma-Associated Herpesvirus Reactivation from Latency

Kaposi's sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the host following an acute infection. Reactivation from latency contributes to the development of KSHV-induced malignancies, which include Kaposi's sarcoma (KS), the most common cancer in untreated AIDS patients, primary effusion lymphoma and multicentric Castleman's disease. However, the physiological cues that trigger KSHV reactivation remain unclear. Here, we show that the reactive oxygen species (ROS) hydrogen peroxide (H2O2) induces KSHV reactivation from latency through both autocrine and paracrine signaling. Furthermore, KSHV spontaneous lytic replication, and KSHV reactivation from latency induced by oxidative stress, hypoxia, and proinflammatory and proangiogenic cytokines are mediated by H2O2. Mechanistically, H2O2 induction of KSHV reactivation depends on the activation of mitogen-activated protein kinase ERK1/2, JNK, and p38 pathways. Significantly, H2O2 scavengers N-acetyl-L-cysteine (NAC), catalase and glutathione inhibit KSHV lytic replication in culture. In a mouse model of KSHV-induced lymphoma, NAC effectively inhibits KSHV lytic replication and significantly prolongs the lifespan of the mice. These results directly relate KSHV reactivation to oxidative stress and inflammation, which are physiological hallmarks of KS patients. The discovery of this novel mechanism of KSHV reactivation indicates that antioxidants and anti-inflammation drugs could be promising preventive and therapeutic agents for effectively targeting KSHV replication and KSHV-related malignancies

Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance?

BACKGROUND: The global pattern of varying prevalence of diseases of affluence, such as obesity, cardiovascular disease and diabetes, suggests that some environmental factor specific to agrarian societies could initiate these diseases. PRESENTATION OF THE HYPOTHESIS: We propose that a cereal-based diet could be such an environmental factor. Through previous studies in archaeology and molecular evolution we conclude that humans and the human leptin system are not specifically adapted to a cereal-based diet, and that leptin resistance associated with diseases of affluence could be a sign of insufficient adaptation to such a diet. We further propose lectins as a cereal constituent with sufficient properties to cause leptin resistance, either through effects on metabolism central to the proper functions of the leptin system, and/or directly through binding to human leptin or human leptin receptor, thereby affecting the function. TESTING THE HYPOTHESIS: Dietary interventions should compare effects of agrarian and non-agrarian diets on incidence of diseases of affluence, related risk factors and leptin resistance. A non-significant (p = 0.10) increase of cardiovascular mortality was noted in patients advised to eat more whole-grain cereals. Our lab conducted a study on 24 domestic pigs in which a cereal-free hunter-gatherer diet promoted significantly higher insulin sensitivity, lower diastolic blood pressure and lower C-reactive protein as compared to a cereal-based swine feed. Testing should also evaluate the effects of grass lectins on the leptin system in vivo by diet interventions, and in vitro in various leptin and leptin receptor models. Our group currently conducts such studies. IMPLICATIONS OF THE HYPOTHESIS: If an agrarian diet initiates diseases of affluence it should be possible to identify the responsible constituents and modify or remove them so as to make an agrarian diet healthier

Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients

Background Patients with acute medical illnesses are at prolonged risk for venous thrombosis. However, the appropriate duration of thromboprophylaxis remains unknown. Methods Patients who were hospitalized for acute medical illnesses were randomly assigned to receive subcutaneous enoxaparin (at a dose of 40 mg once daily) for 10±4 days plus oral betrixaban placebo for 35 to 42 days or subcutaneous enoxaparin placebo for 10±4 days plus oral betrixaban (at a dose of 80 mg once daily) for 35 to 42 days. We performed sequential analyses in three prespecified, progressively inclusive cohorts: patients with an elevated d-dimer level (cohort 1), patients with an elevated d-dimer level or an age of at least 75 years (cohort 2), and all the enrolled patients (overall population cohort). The statistical analysis plan specified that if the between-group difference in any analysis in this sequence was not significant, the other analyses would be considered exploratory. The primary efficacy outcome was a composite of asymptomatic proximal deep-vein thrombosis and symptomatic venous thromboembolism. The principal safety outcome was major bleeding. Results A total of 7513 patients underwent randomization. In cohort 1, the primary efficacy outcome occurred in 6.9% of patients receiving betrixaban and 8.5% receiving enoxaparin (relative risk in the betrixaban group, 0.81; 95% confidence interval [CI], 0.65 to 1.00; P=0.054). The rates were 5.6% and 7.1%, respectively (relative risk, 0.80; 95% CI, 0.66 to 0.98; P=0.03) in cohort 2 and 5.3% and 7.0% (relative risk, 0.76; 95% CI, 0.63 to 0.92; P=0.006) in the overall population. (The last two analyses were considered to be exploratory owing to the result in cohort 1.) In the overall population, major bleeding occurred in 0.7% of the betrixaban group and 0.6% of the enoxaparin group (relative risk, 1.19; 95% CI, 0.67 to 2.12; P=0.55). Conclusions Among acutely ill medical patients with an elevated d-dimer level, there was no significant difference between extended-duration betrixaban and a standard regimen of enoxaparin in the prespecified primary efficacy outcome. However, prespecified exploratory analyses provided evidence suggesting a benefit for betrixaban in the two larger cohorts. (Funded by Portola Pharmaceuticals; APEX ClinicalTrials.gov number, NCT01583218. opens in new tab.

Otázky rozvoje osobnosti v rámci sociálního plánování v podnicích

Katedra psychologieFilozofická fakult

Use of chosen methods of production management in a certain plant

The thesis deals with logistic processes in a chosen brush company. The aim of this thesis is analysis of used methods of management of a material and information flow which are dependent on a production program and improvement.There were carried on analysis off lows and relations with suppliers and buyers. Next there were mentioned a relation between flows and logistic center.Evaluations and recommendations are included in all the chapters of the thesis