Sustainable Approaches to Food Production

Permaculture is a system of ecological design that aims to create more sustainable communities: its principles reinforce to participants understanding patterns of nature, learning food production, managing water catchment and storage, utilizing renewable energy, and building communities. A permaculture system is the exemplary sustainable approach to food production systems that the Campus Garden aims to bring to the University at Buffalo. The belief is that through the building of this garden, we have created a community at UB that has a heightened understanding of where its food comes from (fair share), how that food affects individuals’ bodies (people care), and how food production affects the environment (earth care). With the framework of “Grow better, not bigger” in mind, the ultimate goal of this research is to double the amount of food production to forty-pounds, in the same 20’x20’ plot of the UB Campus Garden. To advance the Garden’s vision and further emphasize the importance of sustainability, it is our goal to explore different gardening techniques for implementation during the growing season. The four components to this alternative growing research include: 1) Community engagement and education; 2) Permaculture and companion planning; 3) Container gardening; and, 4) Vertical gardening. This research allows us to utilize the Garden’s space as best possible and be a representation to the campus community of how food production can occur despite space constraints. Wholly, we aim to educate individuals on alternative gardening techniques, prove that implementation of these techniques is plausible at other sites, and expand the campus community’s understanding of the importance of food production processes

Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus litoralis

The hyperthermophilic archaea Pyrococcus furiosus and Thermococcus litoralis contain the tungstoenzymes aldehyde ferredoxin oxidoreductase, a homodimer, and formaldehyde ferredoxin oxidoreductase, a homotetramer. herein we report the cloning and sequencing of the P. furiosus gene aor (605 residues; M_r, 66,630) and the T. litoralis gene for (621 residues; M_r, 68,941)

Early Clinical Detection of Pharmacologic Response in Insulin Action in a Nondiabetic Insulin-Resistant Population

AbstractBackgroundInsulin resistance heightens the risk for type 2 diabetes mellitus and cardiovascular disease. Amelioration of insulin resistance may reduce this risk. The thiazolidinedone class of insulin sensitizers improves insulin action in individuals with insulin-resistant diabetes and nondiabetic individuals. However, there are few reports on the time of onset of such effects independent of reversal of glucotoxicity.ObjectiveThe goal of our study was to test whether the thiazolidinedione pioglitazone has prominent early metabolic effects that can be detected in an obese, nondiabetic, insulin-resistant population.MethodsWe conducted a randomized, double-blind, placebo-controlled, parallel-group trial in men with nondiabetic insulin resistance using a hyperinsulinemic euglycemic clamp technique (at low and high doses of insulin at 10 and 40 mU/m2/min, respectively). The patients were given 30 mg daily oral pioglitazone or placebo for 28 days. Patients underwent a baseline clamp before initiation of treatment, and again at 14 and 28 days of treatment.ResultsCompared with placebo, under high-dose hyperinsulinemia, pioglitazone led to significant increases in glucose disposal rates (GDR) of 1.29 mg/kg/min (90% CI, 0.43–2.15; 39%; P=0.008) that were detectable at 2 weeks of treatment and persisted at 4 weeks of treatment. Under low-dose hyperinsulinemia, significant increases in GDR of 0.40 mg/kg/min (90% CI, 0.17–0.62; 95%; P=0.003) were observed at 4 weeks of treatment. These responses were accompanied by robust suppression of free fatty acids under hyperinsulinemic conditions, and by significant increases in circulating basal total adiponectin at 2 and 4 weeks of treatment.ConclusionsSignificant changes in insulin action across multiple insulin-sensitive tissues can be detected within 2 weeks of initiation of insulin-sensitizing therapy with pioglitazone in obese patients with nondiabetic insulin resistance. ClinicalTrials.gov identifier: NCT01115712

Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation

Throughout pregnancy the cytotrophoblast, the stem cell of the placenta, gives rise to the differentiated forms of trophoblasts. The two main cell lineages are the syncytiotrophoblast and the invading extravillous trophoblast. A successful pregnancy requires extravillous trophoblasts to migrate and invade through the decidua and then remodel the maternal spiral arteries. Many invasive cells use specialised cellular structures called invadopodia or podosomes in order to degrade extracellular matrix. Despite being highly invasive cells, the presence of invadapodia or podosomes has not previously been investigated in trophoblasts. In this study these structures have been identified and characterised in extravillous trophoblasts. The role of specialised invasive structures in trophoblasts in the degradation of the extracellular matrix was compared with well characterised podosomes and invadopodia in other invasive cells and the trophoblast specific structures were characterised by using a sensitive matrix degradation assay which enabled visualisation of the structures and their dynamics. We show trophoblasts form actin rich protrusive structures which have the ability to degrade the extracellular matrix during invasion. The degradation ability and dynamics of the structures closely resemble podosomes, but have unique characteristics that have not previously been described in other cell types. The composition of these structures does not conform to the classic podosome structure, with no distinct ring of plaque proteins such as paxillin or vinculin. In addition, trophoblast podosomes protrude more deeply into the extracellular matrix than established podosomes, resembling invadopodia in this regard. We also show several significant pathways such as Src kinase, MAPK kinase and PKC along with MMP-2 and 9 as key regulators of extracellular matrix degradation activity in trophoblasts, while podosome activity was regulated by the rigidity of the extracellular matrix

Status of Superconducting RF Linac Development for APT

This paper describes the development progress of high current superconducting RF linacs in Los Alamos, performed to support a design of the linac for the APT (Accelerator Production of Tritium) Project. The APT linac design includes a CW superconducting RF high energy section, spanning an energy range of 211 to 1030 MeV, and operating at a frequency of 700 MHz with two constant beta sections (beta of 0.64 and 0.82). In the last two years, we have progressed towards build a cryomodule with beta of 0.64. We completed the designs of the 5 cell superconducting cavities and the 210 kW power couplers. We are scheduled to begin assembly of the cryomodule in September 2000. In this paper, we present an overview of the status of our development efforts and a report on the results of the cavity and coupler test program.Comment: LINAC2000 THD1

Racial and Ethnic Differences in End‐of‐Life Medicare Expenditures

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134292/1/jgs14263.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134292/2/jgs14263_am.pd

Seeing and holding baby: Systematic review of clinical management and parental outcomes following stillbirth

Background - In 2009 there were an estimated 2.6 million stillbirths worldwide. In the United States, a 2007 systematic review found little consensus about professional behaviours perceived by parents to be most helpful or most distressing. In the United Kingdom a bereaved parents’ organisation has highlighted discordance between parental views and clinical guidelines that recommend clinicians’ do not encourage parents to see and hold their baby. The objective of this review was to identify and synthesise available research reporting parental outcomes relating to seeing and holding. Method(s) - We undertook a systematic review. We included studies of any design, reporting parental experiences and outcomes. Electronic searches (PubMed, PsychINFO) were conducted in January 2014. Three authors independently screened and assessed the quality of the studies, before abstracting data and undertaking thematic analysis. Results - We reviewed 741 records and included 23 studies (10 quantitative,12 qualitative,1 mixed-method). Twenty-one studies suggested positive outcomes for parents who saw or held their baby. Increased psychological morbidity was associated with current pregnancy, choice not to see their baby, lack of time with their baby and/or insufficient mementos. Three themes were formulated “Positive effects of contact within a traumatic life event”, “Importance of role of health professionals”; and “Impact on Mothers and Fathers: Similarities and differences”. Conclusions - Stillbirth is a risk factor for increased psychological morbidity. Parents’ seeing and holding their stillborn baby can be beneficial to their future wellbeing. Since 2007, there has been a proliferation of studies that challenge clinical guidelines recommending clinicians do not encourage parental contact

Survival Among Patients With High-Risk Gastrointestinal Cancers During the COVID-19 Pandemic

Importance: Prior reports demonstrated that patients with cancer experienced worse outcomes from pandemic-related stressors and COVID-19 infection. Patients with certain malignant neoplasms, such as high-risk gastrointestinal (HRGI) cancers, may have been particularly affected. Objective: To evaluate disruptions in care and outcomes among patients with HRGI cancers during the COVID-19 pandemic, assessing for signs of long-term changes in populations and survival. Design, Setting, and Participants: This retrospective cohort study used data from the National Cancer Database to identify patients with HRGI cancer (esophageal, gastric, primary liver, or pancreatic) diagnosed between January 1, 2018, and December 31, 2020. Data were analyzed between August 23 and September 4, 2023. Main Outcome and Measures: Trends in monthly new cases and proportions by stage in 2020 were compared with the prior 2 years. Kaplan-Meier curves and Cox regression were used to assess 1-year mortality in 2020 compared with 2018 to 2019. Proportional monthly trends and multivariable logistic regression were used to evaluate 30-day and 90-day mortality in 2020 compared with prior years. Results: Of the 156 937 patients included in this study, 54 994 (35.0%) were aged 60 to 69 years and 100 050 (63.8%) were men. There was a substantial decrease in newly diagnosed HRGI cancers in March to May 2020, which returned to prepandemic levels by July 2020. For stage, there was a proportional decrease in the diagnosis of stage I (−3.9%) and stage II (−2.3%) disease, with an increase in stage IV disease (7.1%) during the early months of the pandemic. Despite a slight decrease in 1-year survival rates in 2020 (50.7% in 2018 and 2019 vs 47.4% in 2020), survival curves remained unchanged between years (all P > .05). After adjusting for confounders, diagnosis in 2020 was not associated with increased 1-year mortality compared with 2018 to 2019 (hazard ratio, 0.99; 95% CI, 0.97-1.01). The rates of 30-day (2.1% in 2018, 2.0% in 2019, and 2.1% in 2020) and 90-day (4.3% in 2018, 4.4% in 2019, and 4.6% in 2020) operative mortality also remained similar. Conclusions and Relevance: In this retrospective cohort study, a period of underdiagnosis and increase in stage IV disease was observed for HRGI cancers during the pandemic; however, there was no change in 1-year survival or operative mortality. These results demonstrate the risks associated with gaps in care and the tremendous efforts of the cancer community to ensure quality care delivery during the pandemic. Future research should investigate long-term survival changes among all cancer types as additional follow-up data are accrued.</p

Employee Attributions of the Why of HR Practices: Their Effects on Employee Attitudes and Behaviors, and Customer Satisfaction

The construct of Human Resource (HR) Attributions is introduced. We argue that the attributions that employees make about the reasons why management adopts the HR practices that it does have consequences for their attitudes and behaviors, and ultimately, unit performance. Drawing on the strategic HR literature, we propose a typology of five HR-Attribution dimensions. Utilizing data collected from a service firm, we show that employees make varying attributions for the same HR practices, and that these attributions are differentially associated with commitment and satisfaction. In turn, we show that these attitudes become shared within units and that they are related to unit-level organizational citizenship behaviors and customer satisfaction. Findings and implications are discussed