2,094 research outputs found
Towards Mott design by -doping of strongly correlated titanates
Doping the distorted-perovskite Mott insulators LaTiO and GdTiO with
a single SrO layer along the [001] direction gives rise to a rich correlated
electronic structure. A realistic superlattice study by means of the charge
self-consistent combination of density functional theory with dynamical
mean-field theory reveals layer- and temperature-dependent multi-orbital
metal-insulator transitions. An orbital-selective metallic layer at the
interface dissolves via an orbital-polarized doped-Mott state into an
orbital-ordered insulating regime beyond the two conducting TiO layers. We
find large differences in the scattering behavior within the latter. Breaking
the spin symmetry in -doped GdTiO results in blocks of
ferromagnetic itinerant and ferromagnetic Mott-insulating layers which are
coupled antiferromagnetically.Comment: 17 pages, 9 figures, final versio
Billiard knots in a cylinder
We define cylinder knots as billiard knots in a cylinder. We present a
necessary condition for cylinder knots: after dividing cylinder knots by
possible rotational symmetries we obtain ribbon knots. We obtain an upper bound
for the number of cylinder knots with two fixed parameters (out of three). In
addition we prove that rosette knots are cylinder knots.Comment: 14 pages, 10 figures, to appear in the Journal of Knot Theor
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Association of Clinical Characteristics With Variation in Emergency Physician Preferences for Patients.
Importance:Much of the wide variation in health care has been associated with practice variation among physicians. Physicians choosing to see patients with more (or fewer) care needs could also produce variations in care observed across physicians. Objective:To quantify emergency physician preferences by measuring nonrandom variations in patients they choose to see. Design, Setting, and Participants:This cross-sectional study used a large, detailed clinical data set from an electronic health record system of a single academic hospital. The data set included all emergency department (ED) encounters of adult patients from January 1, 2010, to May 31, 2015, as well as ED visits information. Data were analyzed from September 1, 2018, to March 31, 2019. Exposure:Patient assignment to a particular emergency physician. Main Outcomes and Measures:Variation in patient characteristics (age, sex, acuity [Emergency Severity Index score], and comorbidities) seen by emergency physicians before patient selection, adjusted for temporal factors (seasonal, weekly, and hourly variation in patient mix). Results:This study analyzed 294 915 visits to the ED seen by 62 attending physicians. Of the 294 915 patients seen, the mean (SD) age was 48.6 (19.8) years and 176 690 patients (59.9%) were women. Many patient characteristics, such as age (F = 2.2; P < .001), comorbidities (F = 1.7; P < .001), and acuity (F = 4.7; P < .001), varied statistically significantly. Compared with the lowest-quintile physicians for each respective characteristic, the highest-quintile physicians saw patients who were older (mean age, 47.9 [95% CI, 47.8-48.1] vs 49.7 [95% CI, 49.5-49.9] years, respectively; difference, +1.8 years; 95% CI, 1.5-2.0 years) and sicker (mean comorbidity score: 0.4 [95% CI, 0.3-0.5] vs 1.8 [95% CI, 1.7-1.8], respectively; difference, +1.3; 95% CI, 1.2-1.4). These differences were absent or highly attenuated during overnight shifts, when only 1 physician was on duty and there was limited room for patient selection. Compared with earlier in the shift, the same physician later in the shift saw patients who were younger (mean age, 49.7 [95% CI, 49.4-49.7] vs 44.6 [95 % CI, 44.3-44.9] years, respectively; difference, -5.1 years; 95% CI, 4.8-5.5) and less sick (mean comorbidity score: 0.7 [95% CI, 0.7-0.8] vs 1.1 [95% CI, 1.1-1.1], respectively; difference, -0.4; 95% CI, 0.4-0.4). Accounting for preference variation resulted in substantial reordering of physician ranking by care intensity, as measured by ED charges, with 48 of 62 physicians (77%) being reclassified into a different quintile and 9 of 12 physicians (75%) in the highest care intensity quintile moving into a lower quintile. A regression model demonstrated that 22% of reported ED charges were associated with physician preference. Conclusions and Relevance:This study found preference variation across physicians and within physicians during the course of a shift. These findings suggest that current efforts to reduce practice variation may not affect the variation associated with physician preferences, which reflect underlying differences in patient needs and not physician practice
N-terminal modification of proteins with o-aminophenols.
The synthetic modification of proteins plays an important role in chemical biology and biomaterials science. These fields provide a constant need for chemical tools that can introduce new functionality in specific locations on protein surfaces. In this work, an oxidative strategy is demonstrated for the efficient modification of N-terminal residues on peptides and N-terminal proline residues on proteins. The strategy uses o-aminophenols or o-catechols that are oxidized to active coupling species in situ using potassium ferricyanide. Peptide screening results have revealed that many N-terminal amino acids can participate in this reaction, and that proline residues are particularly reactive. When applied to protein substrates, the reaction shows a stronger requirement for the proline group. Key advantages of the reaction include its fast second-order kinetics and ability to achieve site-selective modification in a single step using low concentrations of reagent. Although free cysteines are also modified by the coupling reaction, they can be protected through disulfide formation and then liberated after N-terminal coupling is complete. This allows access to doubly functionalized bioconjugates that can be difficult to access using other methods
Scaling Nonparametric Bayesian Inference via Subsample-Annealing
We describe an adaptation of the simulated annealing algorithm to
nonparametric clustering and related probabilistic models. This new algorithm
learns nonparametric latent structure over a growing and constantly churning
subsample of training data, where the portion of data subsampled can be
interpreted as the inverse temperature beta(t) in an annealing schedule. Gibbs
sampling at high temperature (i.e., with a very small subsample) can more
quickly explore sketches of the final latent state by (a) making longer jumps
around latent space (as in block Gibbs) and (b) lowering energy barriers (as in
simulated annealing). We prove subsample annealing speeds up mixing time N^2 ->
N in a simple clustering model and exp(N) -> N in another class of models,
where N is data size. Empirically subsample-annealing outperforms naive Gibbs
sampling in accuracy-per-wallclock time, and can scale to larger datasets and
deeper hierarchical models. We demonstrate improved inference on million-row
subsamples of US Census data and network log data and a 307-row hospital rating
dataset, using a Pitman-Yor generalization of the Cross Categorization model.Comment: To appear in AISTATS 201
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A Comparison of Patient History- and EKG-based Cardiac Risk Scores.
Patient-specific risk scores are used to identify individuals at elevated risk for cardiovascular disease. Typically, risk scores are based on patient habits and medical history - age, sex, race, smoking behavior, and prior vital signs and diagnoses. We explore an alternative source of information, a patient's raw electrocardiogram recording, and develop a score of patient risk for various outcomes. We compare models that predict adverse cardiac outcomes following an emergency department visit, and show that a learned representation (e.g. deep neural network) of raw EKG waveforms can improve prediction over traditional risk factors. Further, we show that a simple model based on segmented heart beats performs as well or better than a complex convolutional network recently shown to reliably automate arrhythmia detection in EKGs. We analyze a large cohort of emergency department patients and show evidence that EKG-derived scores can be more robust to patient heterogeneity
Multi-Agent Deployment for Visibility Coverage in Polygonal Environments with Holes
This article presents a distributed algorithm for a group of robotic agents
with omnidirectional vision to deploy into nonconvex polygonal environments
with holes. Agents begin deployment from a common point, possess no prior
knowledge of the environment, and operate only under line-of-sight sensing and
communication. The objective of the deployment is for the agents to achieve
full visibility coverage of the environment while maintaining line-of-sight
connectivity with each other. This is achieved by incrementally partitioning
the environment into distinct regions, each completely visible from some agent.
Proofs are given of (i) convergence, (ii) upper bounds on the time and number
of agents required, and (iii) bounds on the memory and communication
complexity. Simulation results and description of robust extensions are also
included
Sustainable Prairie
Tallgrass prairie once blanketed approximately 170 million acres of North America, from Texas up into Canada and from Kentucky west into Kansas. Only about 4 percent of this once vast sea of grass remains, making tallgrass prairie the most altered ecosystem on the continent in terms of acres lost
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