L’influenza dei Tasso nella poesia amorosa di Francisco de Quevedo

La poesía amorosa de Francisco de Quevedo está diseminada por influencias de varios poetas italianos pospetrarquistas, entre los cuales encontramos a Bernardo y Torquato Tasso. Sobre todo en el caso de este último, podemos notar una cercanía en la consideración filosófica del amor, cantando a una dama cruel que deja solo al amante y a un sentimiento poderoso que mueve los planetas pero que ya no es motivo de esperanzaLa poesia amorosa di Francisco de Quevedo è disseminata d’influenze di vari poeti italiani post petrarchisti, tra i quali ritroviamo Bernardo e Torquato Tasso. Soprattutto per quanto riguarda quest’ultimo, possiamo notare una vicinanza nella considerazione filosofica dell’amore, cantando una dama crudele che lascia solo l’amante e un sentimento potente che riesce a muovere anche i pianeti, ma che non è già più motivo di speranz

Una versión expurgada de El Parnaso español de Francisco de Quevedo en la Biblioteca de la Universidad de Santiago de Compostela

El ejemplar expurgado de El Parnaso español de Francisco de Quevedo de la Biblioteca de la Universidad de Santiago de Compostela nos muestra dos diferentes actitudes de censura del siglo xviii: de un lado, la búsqueda de simples palabras sin tener en cuentra los dobles sentidos; del otro, la concepción de la censura como simple consejero del lector delante del conceptismo quevediano. Además, la importancia de este ejemplar en particular está en la menor presencia de pasajes tachado con respecto a otros, lo que pro-bablemente permitió un mejor conocimiento y una mayor accesibilidad a la posteridad.The censored copy of El Parnaso español by Francisco de Quevedo from the library of the University of Santiago de Compostela shows ys two different actitudes of the censorship in the xviii century: on one side, the search for concrete words without considering the doublé meanings; on the other, the conception of censorship like a simple advisor to the reading facing the conceptismo quevediano. In addition, this particular copy is important because it contains less crossedçout verses than others, fact that could possibily gave more access to posterity

La literatura italiana en la obra de Quevedo

Por lo que concierne la vida y la obra de Quevedo, Italia es probablemente la nación que más ha influido en su parábola tanto existencial como literaria. Tanto desde el punto de vista ideológico, como poético y lingüístico, esta tesis estudia la presencia de literatura italiana en el corpus quevediano, centrándose en autores muy conocidos así como en autores considerados secundarios. Mi estudio ofrece reflexiones desde un punto de vista teórico sobre las influencias a nivel temático y a la vez estilístico, subrayando sobre todo las diferencias e innovaciones, pero también tiene en cuenta los datos empíricos de reelaboración lingüística y filosófica, además de proponer una mirada más clara sobre la situación política y su consideración en la prosa de Quevedo

Sequential chemotherapy in nonsmall-cell lung cancer: cisplatin and gemcitabine followed by docetaxel

Background: Improving results in nonsmall-cell lung cancer (NSCLC) will require the development of new drugs and strategies to combine available agents. On the basis of data indicating the activity of docetaxel as second-line therapy, a Phase II study was conducted to evaluate the efficacy and toxicity of the sequential combination of chemotherapy consisting of cisplatin (P) and gemcitabine (G) followed by docetaxel (DOC) in patients with advanced NSCLC. Methods: Patients with 1997 TNM stage IIIB (pleural effusion)/stage IV NSCLC, performance status (PS) of 0-1, and normal organ function were eligible. Therapy consisted of P at 75 mg/m(2) on Day 1 and G 1200 mg/m(2) on Days 1 and 8 every 3 weeks for 3 cycles followed, in nonprogressive patients, by DOC 30 mg/m(2) every week for 6 consecutive weeks every 8 weeks for 2 cycles. Results: Fifty-two eligible patients were enrolled (M/F, 39/13; stage IIIB/IV, 8/44; PS 0, 73%, PS 1, 27%; median age, 58 years; range, 36-73). The overall response rate was 36.5% (95% confidence interval [CI]: 23-49). The median overall survival was 11 months (95% CI: 9-13); the median progression-free survival was 6 months (95% CI: 5-7); and the 1- and 2-year survivals were 48% and 25%, respectively. One- and 2-year progression-free survivals were 12% and 8%, respectively. Both phases of the treatment protocol were well tolerated. Conclusions: P/G followed by weekly DOC is well tolerated and active as first-line therapy for NSCLC patients and provides a feasible chemotherapeutic option in this clinical setting

Specific inhibition of NF-Y subunits triggers different cell proliferation defects

Regulated gene expression is essential for a proper progression through the cell cycle. The transcription factor NF-Y has a fundamental function in transcriptional regulation of cell cycle genes, particularly of G2/M genes. In order to investigate common and distinct functions of NF-Y subunits in cell cycle regulation, NF-YA, NF-YB and NF-YC have been silenced by shRNAs in HCT116 cells. NF-YA loss led to a delay in S-phase progression, DNA damage and apoptosis: we showed the activation of the replication checkpoint, through the recruitment of Δp53 and of the replication proteins PCNA and Mcm7 to chromatin. Differently, NF-YB depletion impaired cells from exiting G2/M, but did not interfere with S-phase progression. Gene expression analysis of NF-YA and NF-YB inactivated cells highlighted a common set of hit genes, as well as a plethora of uncommon genes, unveiling a different effect of NF-Y subunits loss on NF-Y binding to its target genes. Chromatin extracts and ChIP analysis showed that NF-YA depletion was more effective than NF-YB in hitting NF-Y recruitment to CCAAT-promoters. Our data suggest a critical role of NF-Y expression, highlighting that the lack of the single subunits are differently perceived by the cells, which activate diverse cell cycle blocks and signaling pathways

Amor constante : Quevedo más allá de la muerte

La col·lecció Studia Aurea Monográfica, coeditada por la Universitat Autònoma de Barcelona y la Universitat de Girona, es una colección auspiciada por Studia Aurea. Revista de Literatura Española y Teoría Literaria del Renacimiento y Siglo de Oro.Els capítols d'aquest llibre els trobareu també al Dipòsit digital de documents de la UAB en text complet.El estudio de la recepción de la obra de Quevedo como 'clásico contemporáneo' se enriquece hoy con la publicación de una serie de ensayos que, por su propia naturaleza específica y variedad del conjunto, proporcionan y confirman un dato incontrovertible: Quevedo no solo es un modelo literario, sino un arquetipo, de la cultura y del pensamiento; su obra no solo vale como antecedente o hipotexto, sino que funciona como verdadero sistema comunicativo, disponible al uso de las distintas formas de la expresión humana

Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study

Objectives. Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.Methods. SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.Results. The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP.AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].Conclusion. Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality

Neutralizing antibodies to Omicron after the fourth SARS-CoV-2 mRNA vaccine dose in immunocompromised patients highlight the need of additional boosters

IntroductionImmunocompromised patients have been shown to have an impaired immune response to COVID-19 vaccines.MethodsHere we compared the B-cell, T-cell and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus after the fourth dose of mRNA COVID-19 vaccines in patients with hematological malignancies (HM, n=71), solid tumors (ST, n=39) and immune-rheumatological (IR, n=25) diseases. The humoral and T-cell responses to SARS-CoV-2 vaccination were analyzed by quantifying the anti-RBD antibodies, their neutralization activity and the IFN-γ released after spike specific stimulation.ResultsWe show that the T-cell response is similarly boosted by the fourth dose across the different subgroups, while the antibody response is improved only in patients not receiving B-cell targeted therapies, independent on the pathology. However, 9% of patients with anti-RBD antibodies did not have neutralizing antibodies to either virus variants, while an additional 5.7% did not have neutralizing antibodies to Omicron BA.2, making these patients particularly vulnerable to SARS-CoV-2 infection. The increment of neutralizing antibodies was very similar towards Omicron BA.2 and WT virus after the third or fourth dose of vaccine, suggesting that there is no preferential skewing towards either virus variant with the booster dose. The only limited step is the amount of antibodies that are elicited after vaccination, thus increasing the probability of developing neutralizing antibodies to both variants of virus.DiscussionThese data support the recommendation of additional booster doses in frail patients to enhance the development of a B-cell response directed against Omicron and/or to enhance the T-cell response in patients treated with anti-CD20