Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index

Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts

Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index

Diagnosis and Management of Pemphigus: recommendations by an International Panel of Experts

International audienceSeveral European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management, OBJECTIVE: We now present results from a subsequent Delphi consensus to broaden the generalizability of recommendations

Diagnosis and Management of Pemphigus: recommendations by an International Panel of Experts.

BACKGROUND Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management, OBJECTIVE: We now present results from a subsequent Delphi consensus to broaden the generalizability of recommendations. METHODS A preliminary survey, based on the European Dermatology Forum (EDF) and the European Academy of Dermatology and Venereology (EADV) guidelines, was sent to a panel of international experts to determine the level of consensus. The results were discussed at the International Bullous Diseases Consensus Group in March 2016 during the annual American Academy of Dermatology (AAD) conference. A second survey was sent following the meeting to more experts to achieve greater international consensus. RESULTS The 39 experts participated in the first round of the Delphi-survey while 54 from 21 countries completed the second round. The number of statements in the survey was reduced from 175 topics in Delphi I to 24 topics in Delphi II based on Delphi results and meeting discussion. LIMITATIONS Each recommendation represents the majority opinion and therefore may not reflect all possible treatment options available. CONCLUSIONS We present here the recommendations resulting from this Delphi process. This international consensus includes intravenous CD20 inhibitors as a first line therapy option for moderate to severe pemphigus

French SKA White Book - The French Community towards the Square Kilometre Array

Editor in chief: C. Ferrari; Editors: M. Alves, S. Bosse, S. Corbel, A. Ferrari, K. Ferri\`ere, S. Gauffre, E. Josselin, G. Lagache, S. Lambert, G. Marquette, J.-M. Martin, M.-A. Miville-Desch\^enes, L. Montier, B. Semelin, G. Theureau, S. Vergani, N. Vilmer, P. Zarka; Original file with high resolution figures at SKA-France link: https://ska-france.oca.eu/images/SKA-France-Media/FWB_051017.pdfInternational audienceThe "Square Kilometre Array" (SKA) is a large international radio telescope project characterised, as suggested by its name, by a total collecting area of approximately one square kilometre, and consisting of several interferometric arrays to observe at metric and centimetric wavelengths. The deployment of the SKA will take place in two sites, in South Africa and Australia, and in two successive phases. From its Phase 1, the SKA will be one of the most formidable scientific machines ever deployed by mankind, and by far the most impressive in terms of data throughput and required computing power. With the participation of almost 200 authors from forty research institutes and six private companies, the publication of this French SKA white paper illustrates the strong involvement in the SKA project of the French astronomical community and of a rapidly growing number of major scientific and technological players in the fields of Big Data, high performance computing, energy production and storage, as well as system integration