962 research outputs found
The business of genomic testing: a survey of early adopters
Purpose: The practice of genomic (or personalized ) medicine requires the availability of appropriate diagnostic testing. Our study objective was to identify the reasons for health systems to bring next-generation Sequencing into their clinical laboratories and to understand the process by which such decisions were made. Such information may be of value to other health systems seeking to provide next-generation sequencing-testing to their patient populations. Methods: A standardized open-ended interview was conducted With the laboratory medical directors and/or department of pathology chairs of 13 different academic institutions in 10 different states. Results: Genomic testing for cancer dominated the institutional decision making, with three primary reasons: more effective delivery of cancer care, the perceived need for institutional leadership in the field of genomics, and the premise that genomics will eventually be cost-effective. Barriers to implementation included implementation cost; the time and effort needed to maintain this newer testing; challenges in interpreting genetic variants; establishing the bioinformatics infrastructure; and curating data from medical, ethical, and legal standpoints. Ultimate success depended on alignment with institutional strengths and priorities and working closely with institutional clinical programs. Conclusion: These early adopters uniformly viewed genomic analysis as an imperative for developing their expertise in the implementation and practice of genomic medicine
Measurement of Leptonic Asymmetries and Top Quark Polarization in ttbar Production
We present measurements of lepton (l) angular distributions in ttbar -> W+ b
W- b -> l+ nu b l- nubar bbar decays produced in ppbar collisions at a
center-of-mass energy of sqrt(s)=1.96TeV, where l is an electron or muon. Using
data corresponding to an integrated luminosity of 5.4fb^-1, collected with the
D0 detector at the Fermilab Collider, we find that the angular distributions of
l- relative to anti-protons and l+ relative to protons are in agreement with
each other. Combining the two distributions and correcting for detector
acceptance we obtain the forward-backward asymmetry A^l_FB = (5.8 +- 5.1(stat)
+- 1.3(syst))%, compared to the standard model prediction of A^l_FB (predicted)
= (4.7 +- 0.1)%. This result is further combined with the measurement based on
the analysis of the l+jets final state to obtain A^l_FB = (11.8 +- 3.2)%.
Furthermore, we present a first study of the top-quark polarization.Comment: submitted versio
Search for Decay
We have searched for the charmless hadronic decay of B0 mesons into two
neutral pions. Using 9.13fb^-1 taken at the Upsilon(4S) with the CLEO detector,
we obtain an improved upper limit for the branching fraction BR(B0-->pi0pi0) <
5.7*10^-6 at the 90% confidence level.Comment: pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Search for Zgamma events with large missing transverse energy in ppbar collisions at sqrt(s)=1.96 TeV
We present the first search for supersymmetry (SUSY) in Zgamma final states
with large missing transverse energy using data corresponding to an integrated
luminosity of 6.2 fb-1 collected with the D0 experiment in ppbar collisions at
sqrt(s)=1.96 TeV. This signature is predicted in gauge-mediated SUSY-breaking
models, where the lightest neutralino is the next-to-lightest supersymmetric
particle (NLSP) and is produced in pairs, possibly through decay from heavier
supersymmetric particles. The NLSP can decay either to a Z boson or a photon
and an associated gravitino that escapes detection. We exclude this model at
the 95% C.L. for SUSY breaking scales of Lambda < 87 TeV, corresponding to
neutralino masses of < 151 GeV.Comment: submitted to Phys. Rev. Let
Search for Neutral Higgs Bosons in Events with Multiple Bottom Quarks at the Tevatron
The combination of searches performed by the CDF and D0 collaborations at the
Fermilab Tevatron Collider for neutral Higgs bosons produced in association
with b quarks is reported. The data, corresponding to 2.6 fb-1 of integrated
luminosity at CDF and 5.2 fb-1 at D0, have been collected in final states
containing three or more b jets. Upper limits are set on the cross section
multiplied by the branching ratio varying between 44 pb and 0.7 pb in the Higgs
boson mass range 90 to 300 GeV, assuming production of a narrow scalar boson.
Significant enhancements to the production of Higgs bosons can be found in
theories beyond the standard model, for example in supersymmetry. The results
are interpreted as upper limits in the parameter space of the minimal
supersymmetric standard model in a benchmark scenario favoring this decay mode.Comment: 10 pages, 2 figure
Measurement of the semileptonic charge asymmetry using Bs^0 -> D_s mu X decays
We present a measurement of the time-integrated flavor-specific semileptonic
charge asymmetry in the decays of Bs mesons that have undergone flavor mixing,
a^s_ls, using B_s^0 (barB_s^0) -> D_s^-/+ mu^+/- X decays, with D_s^-/+ -> phi
pi^-/+ and phi K^+ K^-, using 10.4 fb^-1 of proton-antiproton collisions
collected by the D0 detector during Run II at the Fermilab Tevatron Collider. A
fit to the difference between the time-integrated D_s^-$ and D_s^+ mass
distributions of the B_s^0 and barB^0_s candidates yields the flavor-specific
asymmetry a^s_ls = [-1.12 pm 0.74 (stat) +/-0.17 (syst)]% which is the most
precise measurement and in agreement with the standard model prediction.Comment: 7 pages, 3 figures (updated with changes made in journal review
process
Measurement of the semileptonic charge asymmetry in B0 meson mixing with the D0 detector
We present a measurement of the semileptonic mixing asymmetry for B0 mesons,
a^d_{sl}, using two independent decay channels: B0 -> mu+D-X, with D- ->
K+pi-pi-; and B0 -> mu+D*-X, with D*- -> antiD0 pi-, antiD0 -> K+pi- (and
charge conjugate processes). We use a data sample corresponding to 10.4 fb^{-1}
of ppbar collisions at sqrt(s) = 1.96 TeV, collected with the D0 experiment at
the Fermilab Tevatron collider. We extract the charge asymmetries in these two
channels as a function of the visible proper decay length (VPDL) of the B0
meson, correct for detector-related asymmetries using data-driven methods, and
account for dilution from charge-symmetric processes using Monte Carlo
simulation. The final measurement combines four signal VPDL regions for each
channel, yielding a^d_{sl} = [0.68 \pm 0.45 \text{(stat.)} \pm 0.14
\text{(syst.)}]%. This is the single most precise measurement of this
parameter, with uncertainties smaller than the current world average of B
factory measurements.Comment: Version includes minor textual changes following peer review by
journal, most notably the updating of Ref. [21] to reflect the most recent
publicatio
Search for associated production in collisions at
This report describes a search for associated production of and Higgs
bosons based on data corresponding to an integrated luminosity of collected with the D0 detector at the Fermilab
Tevatron Collider. Events containing a
candidate (with corresponding to or ) are selected in
association with two or three reconstructed jets. One or two of the jets are
required to be consistent with having evolved from a quark. A multivariate
discriminant technique is used to improve the separation of signal and
backgrounds. Expected and observed upper limits are obtained for the product of
the production cross section and branching ratios and reported in terms of
ratios relative to the prediction of the standard model as a function of the
mass of the Higgs boson (). The observed and expected 95% C.L. upper
limits obtained for an assumed are, respectively, factors
of 4.5 and 4.8 larger than the value predicted by the standard model.Comment: 25 pages, 14 figure
Search for single vector-like quarks in ppbar collisions at sqrt(s) = 1.96 TeV
We present a search for hypothetical vector-like quarks in ppbar collisions
at sqrt(s) = 1.96 TeV. The data were collected by the D0 detector at the
Fermilab Tevatron Collider and correspond to an integrated luminosity of 5.4
fb^(-1). We select events with a final state composed of a W or Z boson and a
jet consistent with a heavy object decay. We observe no significant excess in
comparison to the background prediction and set limits on production cross
sections for vector-like quarks decaying to W+jet and Z+jet. These are the most
stringent mass limits for electroweak single vector-like quark production at
hadron colliders.Comment: submitted to Phys. Rev. Let
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