2,116 research outputs found
Scale Dependence of Dark Energy Antigravity
We investigate the effects of negative pressure induced by dark energy
(cosmological constant or quintessence) on the dynamics at various
astrophysical scales. Negative pressure induces a repulsive term (antigravity)
in Newton's law which dominates on large scales. Assuming a value of the
cosmological constant consistent with the recent SnIa data we determine the
critical scale beyond which antigravity dominates the dynamics () and discuss some of the dynamical effects implied. We show that
dynamically induced mass estimates on the scale of the Local Group and beyond
are significantly modified due to negative pressure. We also briefly discuss
possible dynamical tests (eg effects on local Hubble flow) that can be applied
on relatively small scales (a few ) to determine the density and equation
of state of dark energy.Comment: Contributed talk at the 2nd Hellenic Cosmology Workshop at NOA
(Athens) Jan. 2001.To appear in the proceedings. Based on work done in
collaboration with M. Axenides and E. Florato
Partners in Pediatric Palliative Care: A Program to Enhance Collaboration Between Hospital and Community Palliative Care Services
Eliminat-ing Transportation Barriers to Outpatient Therapy for Underserved Patients with Cancer
Abstract Background: The cancer patients of Bellevue Hospital (BH) and Woodhull Hospital (WH) represent an underserved community, and are referred to New York University Clinical Cancer Center (NYUCCC) for outpatient radiotherapy (RT). Commuting to NYUCCC poses a financial burden hindering treatment compliance
Do Observations Favour Galileon Over Quintessence?
We study the Galileon scalar field model arising as a decoupling limit of the
Dvali-Gababdaze-Porrati (DGP) construction for the late time acceleration of
the universe. The model has one extra Galileon correction term over and above
the standard kinetic and potential energy terms for a canonical quintessence
field. We aim to study whether the current observational data can distinguish
between this Galileon field and the quintessence field. Our study shows the
remarkable result that for potentials like linear, square or exponential, the
data prefers the Galileon model over quintessence field. It confirms that the
observable universe demands the inclusion of higher derivative Galileon
corrections in the standard quintessence scalar field models.Comment: 5 pages, Revtex style, three eps figures, revised version with new
comments added. Conclusion is unchange
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Genetic variation in the HLA region is associated with susceptibility to herpes zoster.
Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in childhood, can remain asymptomatically latent in nerve tissues for many years and often re-emerges as shingles. Although reactivation may be related to immune suppression, aging and female sex, most inter-individual variability in re-emergence risk has not been explained to date. We performed a genome-wide association analyses in 22,981 participants (2280 shingles cases) from the electronic Medical Records and Genomics Network. Using Cox survival and logistic regression, we identified a genomic region in the combined and European ancestry groups that has an age of onset effect reaching genome-wide significance (P>1.0 × 10(-8)). This region tags the non-coding gene HCP5 (HLA Complex P5) in the major histocompatibility complex. This gene is an endogenous retrovirus and likely influences viral activity through regulatory functions. Variants in this genetic region are known to be associated with delay in development of AIDS in people infected by HIV. Our study provides further suggestion that this region may have a critical role in viral suppression and could potentially harbor a clinically actionable variant for the shingles vaccine
The design-by-adaptation approach to universal access: learning from videogame technology
This paper proposes an alternative approach to the design of universally accessible interfaces to that provided by formal design frameworks applied ab initio to the development of new software. This approach, design-byadaptation, involves the transfer of interface technology and/or design principles from one application domain to another, in situations where the recipient domain is similar to the host domain in terms of modelled systems, tasks and users. Using the example of interaction in 3D virtual environments, the paper explores how principles underlying the design of videogame interfaces may be applied to a broad family of visualization and analysis software which handles geographical data (virtual geographic environments, or VGEs). One of the motivations behind the current study is that VGE technology lags some way behind videogame technology in the modelling of 3D environments, and has a less-developed track record in providing the variety of interaction methods needed to undertake varied tasks in 3D virtual worlds by users with varied levels of experience. The current analysis extracted a set of interaction principles from videogames which were used to devise a set of 3D task interfaces that have been implemented in a prototype VGE for formal evaluation
Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats
This study reports on a comprehensive comparison of the effects of soy and meat proteins given at the recommended level on physiological markers of metabolic syndrome and the hepatic transcriptome. Male rats were fed semi-synthetic diets for 1 wk that differed only regarding protein source, with casein serving as reference. Body weight gain and adipose tissue mass were significantly reduced by soy but not meat proteins. The insulin resistance index was improved by soy, and to a lesser extent by meat proteins. Liver triacylglycerol contents were reduced by both protein sources, which coincided with increased plasma triacylglycerol concentrations. Both soy and meat proteins changed plasma amino acid patterns. The expression of 1571 and 1369 genes were altered by soy and meat proteins respectively. Functional classification revealed that lipid, energy and amino acid metabolic pathways, as well as insulin signaling pathways were regulated differently by soy and meat proteins. Several transcriptional regulators, including NFE2L2, ATF4, Srebf1 and Rictor were identified as potential key upstream regulators. These results suggest that soy and meat proteins induce distinct physiological and gene expression responses in rats and provide novel evidence and suggestions for the health effects of different protein sources in human diets
Effective Theory Approach to the Spontaneous Breakdown of Lorentz Invariance
We generalize the coset construction of Callan, Coleman, Wess and Zumino to
theories in which the Lorentz group is spontaneously broken down to one of its
subgroups. This allows us to write down the most general low-energy effective
Lagrangian in which Lorentz invariance is non-linearly realized, and to explore
the consequences of broken Lorentz symmetry without having to make any
assumptions about the mechanism that triggers the breaking. We carry out the
construction both in flat space, in which the Lorentz group is a global
spacetime symmetry, and in a generally covariant theory, in which the Lorentz
group can be treated as a local internal symmetry. As an illustration of this
formalism, we construct the most general effective field theory in which the
rotation group remains unbroken, and show that the latter is just the
Einstein-aether theory.Comment: 45 pages, no figures
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