Eating related problems amongst Iberian female college students

The current survey descriptive study evaluates the prevalence of eating related problems amongst a sample of first-year female college students attending an university campus in one of two areas of the Northwest of the Iberian Peninsula in Europe. A total of 1079 students participated in the current study, 486 from a large university campus of the North of Portugal (Minho), and 595 from two large university campuses of the Northwest of Spain (Galicia). Participants responded to the Eating Disorder Inventory (EDI) and to a questionnaire designed at assessing eating related habits and problems. Results showed that a significant number of students scored high on the EDI and showed considerable prevalence of eating related problems. Based on this self reported data, it is estimated that the prevalence of eating disorders on these peripheral areas of both countries is not significantly different than what is common in other European areas or countries.El presente estudio evalúa la prevalencia de los trastornos de la alimentación en una muestra de alumnas universitarias de primer año que frecuentaban una Universidad de una de dos áreas del Noroeste de la Península Ibérica. Se trata de un estudio descriptivo, mediante observación. Un total de 1079 mujeres participaron en este estudio, 486 de una Universidad del Norte de Portugal (Minho) y 595 de dos Universidades del Noroeste de España (Galicia). Las participantes respondieron al Inventario de Trastornos Alimentarios (EDI) y a un cuestionario desarrollado para evaluar problemas relacionados con la alimentación. Los resultados mostraron que un número significativo de estudiantes obtuvo un resultado elevado en el EDI, presentando una prevalencia considerable de problemas relacionados con la alimentación. Basándonos en los datos auto referidos se estimó que la prevalencia de trastornos en el comportamiento alimentario en estas áreas periféricas de ambos países no es significativamente diferente de lo que resulta común en otros países y áreas de Europa.O presente estudo avalia a a prevalência de problemas alimentares numa amostra de alunas universitárias do primeiro ano que frequentavam uma universidade de uma de duas áreas do noroeste da Península Ibérica. Trata-se de um estudo descritivo, mediante observação. Um total de 1079 mulheres participaram neste estudo, 486 de uma universidade do Norte de Portugal (Minho) e 595 de duas universidades do Noroeste de Espanha (Galiza). Os participantes responderam ao Inventário de Perturbações Alimentares (EDI) e a um questionário desenvolvido para avaliar problemas relacionados com a alimentação. Os resultados mostraram que um número significativo de estudantes obtiveram um resultado elevado no EDI e apresentavam uma prevalência considerável de problemas relacionados com a alimentação. Com base nos dados de auto relato foi estimada que a prevalência de perturbações do comportamento alimentar nestas áreas periféricas de ambos os países não é significativamente diferente da que é comum noutros países e áreas da Europa.Fundação para a Ciência e a Tecnologia (FCT) - PRAXIS/PCSH/P/PSI/85/96, Pograma Operacional "Ciência, Tecnologia, Inocação (POCTI) - POCTI/33252/PSI/2000

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression

The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype is linked to protection from the development of type 1 diabetes (T1D). However, it is not known at which stages in the natural history of T1D development this haplotype affords protection. We examined a cohort of 3,358 autoantibody-positive relatives of T1D patients in the Pathway to Prevention (PTP) Study of the Type 1 Diabetes TrialNet. The PTP study examines risk factors for T1D and disease progression in relatives. HLA typing revealed that 155 relatives carried this protective haplotype. A comparison with 60 autoantibody-negative relatives suggested protection from autoantibody development. Moreover, the relatives with DRB1*15:01-DQA1*01:02-DQB1*06:02 less frequently expressed autoantibodies associated with higher T1D risk, were less likely to have multiple autoantibodies at baseline, and rarely converted from single to multiple autoantibody positivity on follow-up. These relatives also had lower frequencies of metabolic abnormalities at baseline and exhibited no overall metabolic worsening on follow-up. Ultimately, they had a very low 5-year cumulative incidence of T1D. In conclusion, the protective influence of DRB1*15:01-DQA1*01:02-DQB1*06:02 spans from autoantibody development through all stages of progression, and relatives with this allele only rarely develop T1D

Academic team formation as evolving hypergraphs

This paper quantitatively explores the social and socio-semantic patterns of constitution of academic collaboration teams. To this end, we broadly underline two critical features of social networks of knowledge-based collaboration: first, they essentially consist of group-level interactions which call for team-centered approaches. Formally, this induces the use of hypergraphs and n-adic interactions, rather than traditional dyadic frameworks of interaction such as graphs, binding only pairs of agents. Second, we advocate the joint consideration of structural and semantic features, as collaborations are allegedly constrained by both of them. Considering these provisions, we propose a framework which principally enables us to empirically test a series of hypotheses related to academic team formation patterns. In particular, we exhibit and characterize the influence of an implicit group structure driving recurrent team formation processes. On the whole, innovative production does not appear to be correlated with more original teams, while a polarization appears between groups composed of experts only or non-experts only, altogether corresponding to collectives with a high rate of repeated interactions

Economía, Sociedad y Procesos Hegemónicos en la Provincia de Misiones (ESOHE). 16H328

Actividades desarrolladas durante el período: Desde mediados de año se ha instalado un Taller Continuo que funciona los días viernes destinado a la puesta en común de información y la discusión de la marcha general del proyecto. El taller, se ha constituido en caja de resonancia de los avances y dificultades que se presentan y como el espacio donde se distribuyen tareas y responsabilices, se analizan las actividades y los aportes personales o de los integrantes de cada grupo responsable de alguna línea de investigación y se incorporan ideas y señalamientos. En este marco, se ha programado también un Ciclo de Lecturas teóricas y metodológicas que colaboran en la construcción de un lenguaje y una mirada común, necesaria para armonizar la labor de investigadores y becarios de postgrado con trayectorias disciplinares y experiencias muy disímiles; En la investigación sobre la historia económica de Misiones se ha avanzado en los siguientes puntos: Construcción de una periodización basada en ciclos económicos. Se trabaja en el reconocimiento y exploración de repositorios y fuentes escritas existentes a nivel local. exhaustivo relevamiento de las tesis de grado y postgrado, tanto en historia como en Antropología, existentes en las bibliotecas de la UNaM, referidas a temas empresariales y o al funcionamiento de las elites del poder. Se ha tomado contacto y accedido a ámbitos empresariales como las cámaras de la construcción, que en Misiones son 5, de PyMES y la Delegación Provincial de la Cámara Argentina de la Construcción que reúne a grandes empresas; Un grupo de investigadores y auxiliares del ESOHE está investigando los procesos de transformación del sistema educativo provincial (incluyendo tanto la componente pública como la privada), entendiendo que el sistema escolar es una de las instancias donde se socializa ideológicamente a la población y se promueven “sentidos de la realidad”; Entre las tareas en ejecución cabe mencionar: Lectura y fichaje de materia bibliográfico destinado a la actualización reajuste del encuadre teórico-metodológico. Identificación y caracterización de diferentes actores: funcionarios gubernamentales, empresas constructoras, e inmobiliarias, medios de comunicación, asociaciones civiles y otras organizaciones, grupos de interés y afectados por las obras que intervienen en la producción, disputa, apropiación y uso del espacio urbano en las ciudades de Encarnación y Posadas, Garupá y Candelaria. Elección y contacto de informantes calificados. Relevamiento de políticas y/o programas de intervención urbana a ambos lados de la frontera y sus procesos resultantes. Geo-referenciamiento de áreas de revalorización urbana, comerciales, de relegación y desplazamiento, así como de asentamientos precarios y zonas residenciales para sectores de alto poder adquisitivo. El trabajo realizado en esta primera etapa ha permitido avanzar en: Revisión bibliográfica; Redefinición del marco teórico de la investigación; Análisis de algunas relaciones concretas establecidas entre el estado y el sector civil organizado, en particular en el campo de las actividades económicas del tercer sector y en el marco de la implementación de planes y programas públicos; Análisis de las tensiones entre prácticas políticas y económicas que se desatan en el proceso de generación y funcionamiento de los emprendimientos productivos auto-gestionados y cooperativas de trabajo

The Reversal of Immune Exclusion Mediated by Tadalafil and an Anti-tumor Vaccine Also Induces PDL1 Upregulation in Recurrent Head and Neck Squamous Cell Carcinoma: Interim Analysis of a Phase I Clinical Trial

Myeloid Derived suppressor cells (MDSCs) play a key role in the progression and recurrence of human malignancies and in restraining the efficacy of adjuvant therapies. We have previously shown that Tadalafil lowers MDSCs and regulatory T cells (Treg) in the blood and in the tumor, primes a tumor specific immune response, and increases the number of activated intratumoral CD8+T cells in patients with primary Head and Neck Squamous Cell Carcinoma (HNSCC). However, despite these important immune modulatory actions, to date no clinically significant effects have been reported following PDE5 inhibition. Here we report for the first time interim results of our ongoing phase I clinical trial (NCT02544880) in patients with recurrent HNSCC to evaluate the safety of and immunological effects of combining Tadalafil with the antitumor vaccine composed of Mucin1 (MUC1) and polyICLC. The combined treatment of Tadalafil and MUC1/polyICLC vaccine was well-tolerated with no serious adverse events or treatment limiting toxicities. Immunologically, this trial also confirms the positive immunomodulation of Tadalafil in patients with recurrent HNSCC and suggests an adjuvant effect of the anti-tumor vaccine MUC1/polyICLC. Additionally, image cytometry analysis of scanned tumors indicates that the PDE5 inhibitor Tadalafil in conjunction with the MUC1/polyICLC vaccine effectively reduces the number of PDL1+macrophages present at the tumor edge, and increases the number of activated tumor infiltrating T cells, suggesting reversion of immune exclusion. However, this analysis shows also that CD163 negative cells within the tumor upregulate PDL1 after treatment, suggesting the instauration of additional mechanisms of immune evasion. In summary, our data confirm the safety and immunologic potential of PDE5 inhibition in HNSCC but also point to PDL1 as additional mechanism of tumor evasion. This supports the rationale for combining checkpoint and PDE5 inhibitors for the treatment of human malignancies

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011