42 research outputs found
Probing the nuclide 180W for neutrinoless double-electron capture exploration
The mass difference of the nuclides 180W and 180Hf has been measured with the
Penning-trap mass spectrometer SHIPTRAP to investigate 180W as a possible
candidate for the search for neutrinoless doubleelectron capture. The Q-value
was measured to 143.20(27)keV. This value in combination with the calculations
of the atomic electron wave functions and other parameters results in a
half-life of the 0+ \rightarrow 0+ ground-state to ground-state double-electron
capture transition of approximately 5\cdot10E27 years/^2
Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study
Introduction: Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs). Methods: We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients <18 years of age were screened, and 706 with severe sepsis defined either by physician diagnosis or on the basis of 2005 International Pediatric Sepsis Consensus Conference consensus criteria were enrolled. The primary endpoint was agreement of pediatric severe sepsis between physician diagnosis and consensus criteria as measured using Cohen's ?. Secondary endpoints included characteristics and clinical outcomes for patients identified using physician diagnosis versus consensus criteria. Results: Of the 706 patients, 301 (42.6 %) met both definitions. The inter-rater agreement (? ± SE) between physician diagnosis and consensus criteria was 0.57 ± 0.02. Of the 438 patients with a physician's diagnosis of severe sepsis, only 69 % (301 of 438) would have been eligible to participate in a clinical trial of pediatric severe sepsis that enrolled patients based on consensus criteria. Patients with physician-diagnosed severe sepsis who did not meet consensus criteria were younger and had lower severity of illness and lower PICU mortality than those meeting consensus criteria or both definitions. After controlling for age, severity of illness, number of comorbid conditions, and treatment in developed versus resource-limited regions, patients identified with severe sepsis by physician diagnosis alone or by consensus criteria alone did not have PICU mortality significantly different from that of patients identified by both physician diagnosis and consensus criteria. Conclusions: Physician diagnosis of pediatric severe sepsis achieved only moderate agreement with consensus criteria, with physicians diagnosing severe sepsis more broadly. Consequently, the results of a research study based on consensus criteria may have limited generalizability to nearly one-third of PICU patients diagnosed with severe sepsis
The quality of options in strategic decision making: a study about creativity and completeness in business decision making
A qualidade das decisões estratégicas dos empresários está diretamente relacionada
à capacidade que eles demonstram para encontrar alternativas criativas
quando enfrentam os problemas de suas empresas. Essas alternativas podem
ser geradas intuitivamente, utilizando heurÃsticas. As pesquisas sobre geração
de alternativas têm indicado consistentemente que as pessoas não são eficientes
nessa atividade. As explicações para esse fato, contidas na literatura sobre
decisão, não são conclusivas e permitem especulações a respeito. Para explorar
essa questão e relacioná-la ao administrador brasileiro, foi idealizado um experimento
com 174 alunos de quatro cursos de MBA para avaliar a originalidade
e a completude das alternativas. O experimento e a respectiva análise basearam-se
na confluência da pesquisa experimental, oriunda da psicologia cognitiva
da decisão, com as visões da ciência da decisão organizacional tradicional e o
novo campo de estudo das decisões intuitivas ou naturalÃsticas. Para mensurar a
criatividade das alternativas apresentadas durante o experimento, empregou-se
o conceito de árvore hierárquica, que demonstrou ser uma poderosa ferramenta
para a tipologia de alternativas. O resultado desse experimento confirmou o
baixo desempenho em geração de alternativas dos gerentes e, ao mesmo tempo,
indicou que, provavelmente, a etapa de geração de alternativas isolada da etapa
de escolha pode melhorar a qualidade das alternativas. A heurÃstica, por sua vez,
não demonstrou influenciar o conjunto de alternativas geradas. _________________________________________________________________________________________ ABSTRACT: The quality of strategic decisions of executives is directly related to the ability they
have to find creative alternatives when facing business problems. These alternatives could be generated intuitively, using heuristics. On the other hand, the
researches on alternatives generation have consistently indicated that people are
not efficient on this duty. The argument for that, contained in the decision’s literature,
is not conclusive and it allows speculation about it. To explore this issue
and relate it to the Brazilian Administration, an experiment was designed for 174
students of four courses of MBA. The experiment and the analysis were resulted
from the confluence between the experimental research from decision cognitive
psychology with science’s vision of the traditional organizational decision and the
new field of study on naturalistic or intuitive decisions. To measure the creativity
of the alternatives presented during the experiment, the concept of hierarchical
tree was utilized and it has proved a powerful tool to the typology of alternatives.
The result of this experiment confirmed the poor performance in alternatives
generation by managers and at the same time, indicated that probably, the generation
of options isolated of analysis can produce better quality of alternatives.
The heuristic, do not demonstrated any influence on options generated
Children and Their Parents: A Comparative Study of the Legal Position of Children with Regard to Their Intentional and Biological Parents in English and Dutch Law
This is a book about children and their parents. There are many different kinds of children and at least about as many different kinds of parents. In addition to the many different disciplines that study children and their parents, such as sociology, psychology, child studies and gender studies, to name but a few, this study concerns a legal question with regard to the parent-child relationship, namely how the law assigns parents to children. This subject is approached in a comparative legal perspective and covers England and The Netherlands. The book contains a detailed comparison and analysis of the manner in which the law in the two jurisdictions assigns the status of legal parent and/or attributes parental responsibility to the child’s biological and intentional parents. The concept ‘procreational responsibility’, which is introduced in the concluding chapter of the book, may be used as a tool to assess and reform existing regulations on legal parent-child relationships. The structure of the book, which is based on a categorisation of different family types in a ‘family tree’, enables the reader to have easy access to family-specific information.FdR – Publicaties zonder aanstelling Universiteit Leide
Effect of androgenic-anabolic steroids and heavy strength training on patellar tendon morphological and mechanical properties
Combined androgenic- anabolic steroids (AAS) and overloading affects tendon collagen metabolism and ultrastructure and is often associated with a higher risk of injury. The aim of this prospective study was to investigate whether such effects would be reflected in the patellar tendon properties of individuals with a history of long-term resistance training and AAS abuse (RTS group), compared with trained (RT) and untrained (CTRL) nonsteroids users. Tendon cross-sectional area (CSA), stiffness, Young's modulus, and toe limit strain were measured in vivo, from synchronized ultrasonography and dynamometry data. The patellar tendon of RT and RTS subjects was much stiffer and larger than in the CTRL group. However, stiffness and modulus were higher in the RTS group (26%, P < 0.05 and 30%, P < 0.01, respectively) than in the RT group. Conversely, tendon CSA was 15% (P < 0.05) larger in the RT group than in RTS, although differences disappeared when this variable was normalized to quadriceps maximal isometric torque. Yet maximal tendon stress was higher in RTS than in RT (15%, P < 0.05), without any statistical difference in maximal strain and toe limit strain between groups. The present lack of difference in toe limit strain does not substantiate the hypothesis of changes in collagen crimp pattern associated with AAS abuse. However, these findings indicate that tendon adaptations from years of heavy resistance training are different in AAS users, suggesting differences in collagen remodeling. Some of these adaptations (e.g., higher stress) could be linked to a higher risk of tendon injury. Copyright © 2013 the American Physiological Society