Inflationary universe in loop quantum cosmology

Loop quantum cosmology provides a nice solution of avoiding the big bang singularity through a big bounce mechanism in the high energy region. In loop quantum cosmology an inflationary universe is emergent after the big bounce, no matter what matter component is filled in the universe. A super-inflation phase without phantom matter will appear in a certain way in the initial stage after the bounce; then the universe will undergo a normal inflation stage. We discuss the condition of inflation in detail in this framework. Also, for slow-roll inflation, we expect the imprint from the effects of the loop quantum cosmology should be left in the primordial perturbation power spectrum. However, we show that this imprint is too weak to be observed.Comment: 21 pages, 4 figures; accepted for publication in JCA

UV stable, Lorentz-violating dark energy with transient phantom era

Phantom fields with negative kinetic energy are often plagued by the vacuum quantum instability in the ultraviolet region. We present a Lorentz-violating dark energy model free from this problem and show that the crossing of the cosmological constant boundary w=-1 to the phantom equation of state is realized before reaching a de Sitter attractor. Another interesting feature is a peculiar time-dependence of the effective Newton's constant; the magnitude of this effect is naturally small but may be close to experimental limits. We also derive momentum scales of instabilities at which tachyons or ghosts appear in the infrared region around the present Hubble scale and clarify the conditions under which tachyonic instabilities do not spoil homogeneity of the present/future Universe.Comment: 22 pages, 7 figures; Presentation modified substantially, results and conclusions unchanged. Journal versio

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Iron-oxide-supported nanocarbon in lithium-ion batteries, medical, catalytic, and environmental applications

Owing to the three different orbital hybridizations carbon can adopt, the existence of various carbon nanoallotropes differing also in dimensionality has been already affirmed with other structures predicted and expected to emerge in the future. Despite numerous unique features and applications of 2D graphene, 1D carbon nanotubes, or 0D fullerenes, nanodiamonds, and carbon quantum dots, which have been already heavily explored, any of the existing carbon allotropes do not offer competitive magnetic properties. For challenging applications, carbon nanoallotropes are functionalized with magnetic species, especially of iron oxide nature, due to their interesting magnetic properties (superparamagnetism and strong magnetic response under external magnetic fields), easy availability, biocompatibility, and low cost. In addition, combination of iron oxides (magnetite, maghemite, hematite) and carbon nanostructures brings enhanced electrochemical performance and (photo)catalytic capability due to synergetic and cooperative effects. This work aims at reviewing these advanced applications of iron-oxide-supported nanocarbon composites where iron oxides play a diverse role. Various architectures of carbon/iron oxide nanocomposites, their synthetic procedures, physicochemical properties, and applications are discussed in details. A special attention is devoted to hybrids of carbon nanotubes and rare forms (mesoporous carbon, nanofoam) with magnetic iron oxide carriers for advanced environmental technologies. The review also covers the huge application potential of graphene/iron oxide nanocomposites in the field of energy storage, biomedicine, and remediation of environment. Among various discussed medical applications, magnetic composites of zero-dimensional fullerenes and carbon dots are emphasized as promising candidates for complex theranostics and dual magneto-fluorescence imagingclose5

Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles

"Nanoscience" is recognized as an emerging science of objects that have at least one dimension ranging from a few nanometers to less than 100 nm. Through the manipulation of organic and inorganic materials at the atomic level, novel materials can be prepared with different thermal, optical, electrical, and mechanical properties, compared to the bulk state of the same materials. Nanoscale entities are abundant in biological systems and include diverse entities such as proteins, small-molecule drugs, metabolites, viruses, and antibodies. In the past 20 years, there has been a rapid expansion in the number of engineered nanosystems that have been developed for biological and medical applications. Nanotechnology is a demanding new field based on the convergence of technical disciplines such as physics, chemistry, engineering and computer sciences, cell biology, and neuroscience. Nanotechnology is recognized as the design, preparation, characterization, and applications of materials, where at least one dimension is on the nanometer scale. Engineered nanodevices are finding an ever-expanding range of applications by versatile modifications of their properties. These involve modifications of the shape, size, surface, and chemical properties. For instance, the surface of nanomaterials can be tailored to a desired use, e.g., to improve the biocompatibility of implantable materials or through the attachment of receptors for targeted analyte binding or enhanced adhesion to biological structures.Deposited by bulk impor