Soil sedimentology at Gusev Crater from Columbia Memorial Station to Winter Haven

A total of 3140 individual particles were examined in 31 soils along Spirit’s traverse. Their size, shape, and texture were quantified and classified. They represent a unique record of 3 years of sedimentologic exploration from landing to sol 1085 covering the Plains Unit to Winter Haven where Spirit spent the Martian winter of 2006. Samples in the Plains Unit and Columbia Hills appear as reflecting contrasting textural domains. One is heterogeneous, with a continuum of angular-to-round particles of fine sand to pebble sizes that are generally dust covered and locally cemented in place. The second shows the effect of a dominant and ongoing dynamic aeolian process that redistributes a uniform population of medium-size sand. The texture of particles observed in the samples at Gusev Crater results from volcanic, aeolian, impact, and water-related processes

Life in the Atacama — Year 2: Geologic reconnaissance through long-range roving and implications on the search for life

The Life in the Atacama-2004 project, which included geological, morphological, and mineralogical mapping through combined satellite, field-based, and microscopic perspectives and long-range roving, led to the localization of potential habitats

Abatement of styrene waste gas emission by biofilter and biotrickling filter: comparison of packing materials and inoculation procedures

The removal of styrene was studied using 2 biofilters packed with peat and coconut fibre (BF1-P and BF2-C, respectively) and 1 biotrickling filter (BTF) packed with plastic rings. Two inoculation procedures were applied: an enriched culture with strain Pseudomonas putida CECT 324 for biofilters and activated sludge from a municipal wastewater treatment plant for the BTF. Inlet loads (ILs) between 10 and 45 g m-3 h-1 and empty bed residence times (EBRTs) from 30 to 120 s were applied. At inlet concentrations ranging between 200 and 400 mg Nm-3, removal efficiencies between 70 and 95% were obtained in the 3 bioreactors. Maximum elimination capacities (ECs) of 81 and 39 g m-3 h-1 were obtained for the first quarter of the BF1-P and BF2-C, respectively (IL of 173 g m-3 h-1 and EBRT of 60 s in BF1-P; IL of 89 g m-3 h-1 and EBRT of 90 s in BF2-C). A maximum EC of 52 g m-3 h-1 was obtained for the first third of the BTF (IL of 116 g m-3 h-1, EBRT of 45 s). Problems regarding high pressure drop appeared in the peat biofilter, whereas drying episodes occurred in the coconut fibre biofilter. DGGE revealed that the pure culture used for biofilter inoculation was not detected by day 105. Although 2 different inoculation procedures were applied, similar styrene removal at the end of the experiments was observed. The use as inoculum of activated sludge from municipal wastewater treatment plant appears a more feasible option

PyATMOS: a scalable grid of hypothetical planetary atmospheres

Cloud computing offers an opportunity to run compute-resource intensive climate models at scale by parallelising model runs such that datasets useful to the exoplanet community can be produced efficiently. To better understand the statistical distributions and properties of potentially habitable planetary atmospheres we implemented a parallelised climate modelling tool to scan a range of hypothetical atmospheres.Starting with a modern day Earth atmosphere, we iteratively and incrementally simulated a range of atmospheres to infer the landscape of the multi-parameter space, such as the abundances of biological mediated gases (\ce{O2}, \ce{CO2}, \ce{H2O}, \ce{CH4}, \ce{H2}, and \ce{N2}) that would yield `steady state' planetary atmospheres on Earth-like planets around solar-type stars. Our current datasets comprises of \numatmospheres simulated models of exoplanet atmospheres and is available publicly on the NASA Exoplanet Archive. Our scalable approach of analysing atmospheres could also help interpret future observations of planetary atmospheres by providing estimates of atmospheric gas fluxes and temperatures as a function of altitude. Such data could enable high-throughput first-order assessment of the potential habitability of exoplanetary surfaces and sepcan be a learning dataset for machine learning applications in the atmospheric and exoplanet science domain

PyATMOS: A Scalable Grid of Hypothetical Planetary Atmospheres

Cloud computing offers an opportunity to run compute-resource intensive climate models at scale by parallelising model runs such that datasets useful to the exoplanet community can be produced efficiently. To better understand the statistical distributions and properties of potentially habitable planetary atmospheres we implemented a parallelised climate modelling tool to scan a range of hypothetical atmospheres.Starting with a modern day Earth atmosphere, we iteratively and incrementally simulated a range of atmospheres to infer the landscape of the multi-parameter space, such as the abundances of biological mediated gases (\ce{O2}, \ce{CO2}, \ce{H2O}, \ce{CH4}, \ce{H2}, and \ce{N2}) that would yield `steady state' planetary atmospheres on Earth-like planets around solar-type stars. Our current datasets comprises of \numatmospheres simulated models of exoplanet atmospheres and is available publicly on the NASA Exoplanet Archive. Our scalable approach of analysing atmospheres could also help interpret future observations of planetary atmospheres by providing estimates of atmospheric gas fluxes and temperatures as a function of altitude. Such data could enable high-throughput first-order assessment of the potential habitability of exoplanetary surfaces and sepcan be a learning dataset for machine learning applications in the atmospheric and exoplanet science domain.Comment: 9 pages, 6 figure

Searching for life with rovers: exploration methods and science results from the 2004 field campaign of the “Life in the Atacama” project and applications to future Mars Missions

LITA develops and field tests a long-range automated rover and a science payload to search for microbial life in the Atacama. The Atacama's evolution provides a unique training ground for designing and testing exploration strategies and life detection methods for the search for life on Mars

Spectroscopic results from the Life in the Atacama (LITA) project 2004 field season

Analysis of spectroscopy datasets from rover field tests in the Atacama Desert (Chile), focusing on the composition of the surface and identification of potential habitats for life

PDE4 as a target in preterm labour

Cyclic nucleotide phosphodiesterases (PDE) are the enzymes catalyzing the hydrolysis and inactivation of the second messengers, cAMP and cGMP. Eleven PDE families are described to date, and selective inhibitors of some PDEs families are currently used in clinic for treating cardiovascular disorders, erectile dysfunction, and pulmonary hypertension. Isoforms of the PDE4 family are involved in smooth muscle contraction and inflammation. PDE4 selective inhibitors are currently in clinical trials for the treatment of diseases related to inflammatory disorders. Because of their myorelaxant properties, we first examined their expression in human myometrium and uncover an increased expression of one specific isoform, PDE4B2, in the near-term myometrium as compared to myometrium in the nonpregnant state. Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upregulated by the proinflammatory cytokine IL-1β. Functionally, augmentation of global PDE4 activity decreases the ability of β-adrenergic agonists (the most commonly used tocolytic drugs) to inhibit myometrial contraction at the end of pregnancy and during pathophysiological situations, such as persistent intrauterine inflammation which is a major cause of very preterm delivery. Currently exploring the anti-inflammatory properties of PDE4 inhibitors in gestational tissues, we recently demonstrated the ability of these drugs to block a persistent inflammatory response of the foetal membranes in Humans and to prevent inflammation-driven preterm delivery and foetal demise in mice. These data open up a new therapeutical strategy to prevent inflammation-induced preterm delivery and its sequelae in very preterm infants