Popular Support for Trade Agreements and Partner Country Characteristics – Evidence from an Unexpected Election Outcome

Using quasi‐experimental data from a survey that was conducted immediately before and after the November 2016 presidential election, we analyze how the election of Donald Trump affected the willingness of Europeans to sign a trade and investment agreement with the United States. We find that the election outcome lead to an immediate and sizable negative effect on Europeans' image of the United States. But we do not find that, at the same time, there was a negative reaction in the willingness of Europeans to sign an agreement with the United States

X-ray He-like ions diagnostics: New Computations for Photoionized Plasmas: I. preliminary considerations

Using the new version of the photoionization code Titan designed for plane-parallel photoionized thick hot media, which is unprecedented from the point of view of line transfer, we have undertaken a study of the influence of different parameters on the He-like and H-like emission of a medium photoionized by an X-ray source. We explain why in modelling the emitting medium it is important to solve in a self-consistent way the thermal and ionization equilibria and to take into account the interconnection between the different ions. We give the equivalent widths of the sum of the He-like triplets and the triplet intensity ratios $G$ and $R$, for the most important He-like ions, for a range of density, column density, and ionization parameter, in the case of constant density media. We show that the line intensities from a given ion can be accounted for, either by small values of both the column density and of the ionization parameter, or by large values of both quantities, and it is necessary to take into account several ions to disentangle these possibilities. We show also that a "pure recombination spectrum" almost never exists in a photoionized medium: either it is thin, and resonance lines are formed by radiative excitation, or it is thick, and free-bound absorption destroys the resonance photons as they undergo resonant diffusion.Comment: 19 pages, 14 figures, accepted in A &

SoLid : Search for Oscillations with Lithium-6 Detector at the SCK-CEN BR2 reactor

Sterile neutrinos have been considered as a possible explanation for the recent reactor and Gallium anomalies arising from reanalysis of reactor flux and calibration data of previous neutrino experiments. A way to test this hypothesis is to look for distortions of the anti-neutrino energy caused by oscillation from active to sterile neutrino at close stand-off (similar to 6-8m) of a compact reactor core. Due to the low rate of anti-neutrino interactions the main challenge in such measurement is to control the high level of gamma rays and neutron background. The SoLid experiment is a proposal to search for active-to-sterile anti-neutrino oscillation at very short baseline of the SCK center dot CEN BR2 research reactor. This experiment uses a novel approach to detect anti-neutrino with a highly segmented detector based on Lithium-6. With the combination of high granularity, high neutron-gamma discrimination using 6LiF:ZnS(Ag) and precise localization of the Inverse Beta Decay products, a better experimental sensitivity can be achieved compared to other state-of-the-art technology. This compact system requires minimum passive shielding allowing for very close stand off to the reactor. The experimental set up of the SoLid experiment and the BR2 reactor will be presented. The new principle of neutrino detection and the detector design with expected performance will be described. The expected sensitivity to new oscillations of the SoLid detector as well as the first measurements made with the 8 kg prototype detector deployed at the BR2 reactor in 2013-2014 will be reported

Evolution of the X-ray spectrum in the flare model of Active Galactic Nuclei

Nayakshin & Kazanas (2002) have considered the time-dependent illumination of an accretion disc in Active Galactic Nuclei, in the lamppost model. We extend their study to the flare model, which postulates the release of a large X-ray flux above a small region of the accretion disc. A fundamental difference with the lamppost model is that the region of the disc below the flare is not illuminated before the onset of the flare. A few test models show that the spectrum which follows immediately the increase in continuum flux should display the characteristics of a highly illuminated but dense gas, i.e. very intense X-ray emission lines and ionization edges in the soft X-ray range. The behaviour of the iron line is different in the case of a "moderate" and a ``strong'' flare: for a moderate flare, the spectrum displays a neutral component of the Fe K$\alpha$ line at 6.4 keV, gradually leading to more highly ionized lines. For a strong flare, the lines are already emitted by FeXXV (around 6.7 keV) after the onset, and have an equivalent width of several hundreds of eV. We find that the observed correlations between $R$, $\Gamma$, and the X-ray flux, are well accounted by a combination of flares having not achieved pressure equilibrium, strongly suggesting that the observed spectrum is dominated by regions in non-pressure equilibrium, typical of the onset of the flares. Finally a flare being confined to a small region of the disc, the spectral lines should be narrow (except for a weak Compton broadening), Doppler shifted, and moving.Comment: 14 pages, 13 figures, accepted in A & A, english corrected versio

Mixed-Model Noise Removal in 3D MRI via Rotation-and-Scale Invariant Non-Local Means

Mixed noise is a major issue influencing quantitative analysis in different forms of magnetic resonance image (MRI), such as T1 and diffusion image like DWI and DTI. Using different filters sequentially to remove mixed noise will severely deteriorate such medical images. We present a novel algorithm called rotation-and-scale invariant nonlocal means filter (RSNLM) to simultaneously remove mixed noise from different kinds of three-dimensional (3D) MRI images. First, we design a new similarity weights, including rank-ordered absolute difference (ROAD), coming from a trilateral filter (TriF) that is obtained to detect the mixed and high-level noise. Then, we present a shape view to consider the MRI data as a 3D operator, with which the similarity between the patches is calculated with the rigid transformation. The translation, rotation and scale have no influence on the similarity. Finally, the adaptive parameter estimation method of ROAD is illustrated, and the effective proof that validates the proposed algorithm is presented. Experiments using synthetic data with impulse noise, Rician noise, and the real MRI data confirm that the proposed method yields superior performance compared with current state-of-the-art methods

Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis

Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and regulates food intake and energy expenditure. Deficient leptin neuronal signalling favours weight gain by affecting central homeostatic circuitry. The aim of this study was to determine if leptin resistance was programmed by perinatal nutritional environment and to decipher potential cellular mechanisms underneath

The X-ray spectrum of NGC 7213 and the Seyfert--LINER connection

We present an XMM-Newton observation of the Seyfert-LINER galaxy NGC 7213. The RGS soft X-ray spectrum is well fitted with a power law plus soft X-ray collisionally ionised thermal plasma (kT = 0.18 +0.03/-0.01 keV). We confirm the presence of Fe I, XXV and XXVI K-alpha emission in the EPIC spectrum and set tighter constraints on their equivalent widths of 82 +10/-13, 24 +9/-11 and 24 +10/-13 eV respectively. We compare the observed properties together with the inferred mass accretion rate of NGC 7213, to those of other Seyfert and LINER galaxies. We find that NGC 7213 has intermediate X-ray spectral properties lying between those of the weak AGN found in the LINER M81 and higher luminosity Seyfert galaxies. There appears to be a continuous sequence of X-ray properties from the Galactic Centre through LINER galaxies to Seyferts, likely determined by the amount of material available for accretion in the central regions.Comment: 8 pages, 3 figures. Accepted for MNRA

Benefit-Harm Analysis for Informed Decision Making on Participating in Colorectal Cancer Screening: A Modeling Study

OBJECTIVES To facilitate informed decision making on participating in colorectal cancer (CRC) screening, we assessed the benefit-harm balance of CRC screening for a wide range of subgroups over different time horizons. METHODS The study combined incidence proportions of benefits and harms of (not) participating in CRC screening estimated by the Adenoma and Serrated pathway to CAncer microsimulation model, a preference eliciting survey, and benefit-harm balance modeling combining all outcomes to determine the net health benefit of CRC screening over 10, 20, and 30 years. Probability of net health benefit was estimated for 210 different subgroups based on age, sex, previous participation in CRC screening, and lifestyle. RESULTS CRC screening was net beneficial in 183 of 210 subgroups over 30 years (median probability [MP] of 0.79, interquartile range [IQR] of 0.69-0.85) across subgroups. Net health benefit was greater for men (MP 0.82; IQR 0.69-0.89) than women (MP 0.76; IQR 0.67-0.83) and for those without history of participation in previous screenings (MP 0.84; IQR 0.80-0.89) compared with those with (MP 0.69; IQR 0.59-0.75). Net health benefit decreased with increasing age, from MP of 0.84 (IQR 0.80-0.86) at age 55 to 0.61 (IQR 0.56-0.71) at age 75. Shorter time horizons led to lower benefit, with MP of 0.70 (IQR 0.62-0.80) over 20 years and 0.54 (IQR 0.48-0.67) over 10 years. CONCLUSIONS Our benefit-harm analysis provides information about net health benefit of screening participation, based on important characteristics and preferences of individuals, which could assist screening invitees in making informed decisions on screening participation

Study protocol: Cost effectiveness of two strategies to implement the NVOG guidelines on hypertension in pregnancy: An innovative strategy including a computerised decision support system compared to a common strategy of professional audit and feedback, a randomized controlled trial

Background: Hypertensive disease in pregnancy remains the leading cause of maternal mortality in the Netherlands. Seventeen percent of the clinical pregnancies are complicated by hypertension and 2% by preeclampsia. The Dutch Society of Obstetrics and Gynaecology (NVOG) has developed evidence-based guidelines on the management of hypertension in pregnancy and chronic hypertension. Previous studies showed a low adherence rate to other NVOG guidelines and a large variation in usual care in the different hospitals. An explanation is that the NVOG has no general strategy of practical implementation and evaluation of its guidelines. The development of an effective and cost effective implementation strategy to improve adherence to the guidelines on hypertension in pregnancy is needed.Methods/Design: The objective of this study is to assess the cost effectiveness of an innovative implementation strategy of the NVOG guidelines on hypertension including a computerised decision support system (BOS) compared to a common strategy of professional audit and feedback. A cluster randomised controlled trial with an economic evaluation alongside will be performed. Both pregnant women who develop severe hypertension or pre-eclampsia and professionals involved in the care for these women will participate. The main outcome measures are a combined rate of major maternal complications and process indicators extracted from the guidelines. A total of 472 patients will be included in both groups. For analysis, descriptive as well as regression techniques will be used. A cost effectiveness and cost utility analysis will be performed according to the intention-to-treat principle and from a societal perspective. Cost effectiveness ratios will be calculated using bootstrapping techniques