2,255 research outputs found

    Sing Again that Sweet Refrain / music by Gussie L. Davis; words by Gussie L. Davis

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    Cover: drawing of an African American male carrying a full lobster trap; photo inset of Ozzie Nelson; Publisher: Calumet Music Co. (Chicago)https://egrove.olemiss.edu/sharris_e/1046/thumbnail.jp

    J. E. Davis to Messrs, Gunnison, Chapman and Co., Greenville, Mississippi, 5 August

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    https://egrove.olemiss.edu/ciwar_corresp/1032/thumbnail.jp

    The Horse Trot / words by Uriel Davis

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    Cover: drawing of a Caucasian couple dancing on a yellow carpet; Publisher: Jerome H. Remick and Co. (New York)https://egrove.olemiss.edu/sharris_c/1043/thumbnail.jp

    What a Wonderful World / words by George Davis Weiss and Bob Thiele

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    Cover: photograph of Louis Armstrong; Publisher: Music of the Times Publishing Co.https://egrove.olemiss.edu/sharris_e/1087/thumbnail.jp

    Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells

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    Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we demonstrate that the signal-dependent transcription factor (TF) STAT5 is critical for accumulation of all known ILC subsets in mice and reveal a hierarchy of STAT5 dependency for populating lymphoid and nonlymphoid tissues. We apply transcriptome and genomic distribution analyses to define a STAT5 gene signature in natural killer (NK) cells, the prototypical ILC subset, and provide a systems-based molecular rationale for its key functions downstream of IL-15. We also uncover surprising features of STAT5 behavior, most notably the wholesale redistribution that occurs when NK cells shift from tonic signaling to acute cytokine-driven signaling, and genome-wide coordination with T-bet, another key TF in ILC biology. Collectively, our data position STAT5 as a central node in the TF network that instructs ILC development, homeostasis, and function and provide mechanistic insights on how it works at cellular and molecular levels

    Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review.

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    Osteoarthritis (OA) is the most common form of arthritis worldwide. Pain and reduced function are the main symptoms in this prevalent disease. There are currently no treatments for OA that modify disease progression; therefore analgesic drugs and joint replacement for larger joints are the standard of care. In light of several recent studies reporting the use of bisphosphonates for OA treatment, our work aimed to evaluate published literature to assess the effectiveness of bisphosphonates in OA treatment

    Open Design, Inclusivity and the Intersections of Making

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    This paper presents insights from an ethnographic study with a diverse population of makers in the city of Newcastle upon Tyne, UK. By engaging individuals, groups and communities who 'make' in different contexts, we reveal under-explored perspectives on 'making' and highlight points of intersection between different kinds of making across the city. We reflect on the dynamics of these intersections and connect our observations to emerging discourses around 'open design'. In doing so, we argue for a renewed focus on 'inclusivity' and highlight a need for new infrastructure to support iterative, collaborative making within -- and across -- interconnected networks of makers
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