88 research outputs found
A STABLE ANALOG OF INDOLE-2,3-QUINODIMETHANE - SYNTHESIS AND DIELS-ALDER REACTION OF 2-METHOXYCARBONYL-4-[(PARA-METHOXYPHENYL)SULPHONYL]-2,4-DIHYDROPYRROLO-[3,4-B]INDOLE
- Author
- Publication venue
- Royal Society of Chemistry
- Publication date
- Field of study
[[abstract]]The 2,4-dihydropyrrolo[3,4-b]indole ring system, readily prepared from 1-[(p-methoxyphenyl)sulphonyl]-2-methyl-3,-formylindole, underwent DielsâAlder reaction with highly reactive dienophiles, e.g., benzyne and N-phenylmethoxy, to give cycloadducts in excellent yields.[[fileno]]2010328010011[[department]]ććž
Radical cyclization reactions of 4-bromo vinylogous-esters, vinylogous-amides and enones
- Author
- Publication venue
- Royal Society of Chemistry
- Publication date
- Field of study
[[abstract]]Radicals generated from 4-bromo vinylogous-esters, vinylogous-amides and enones cyclize to a tethered acetylene side-chain preferentially at the -position; theoretical calculations of the spin density of the radicals and the relative stability of the radical intermediates are performed to rationalize the experimental observations.[[fileno]]2010328010024[[department]]ććž
INTRAMOLECULAR 1,3-DIPOLAR CYCLOADDITION OF ALKYLAZIDE-ENONES AND REARRANGEMENTS OF THE TRIAZOLINE INTERMEDIATES
- Author
- Publication venue
- Royal Society of Chemistry
- Publication date
- Field of study
[[abstract]]The intramolecular 1,3-dipolar cycloaddition of alkylazide-enones is followed by several novel rearrangements.[[fileno]]2010328010017[[department]]ććž
Crystal Structure of the Heteromolecular Chaperone, AscE-AscG, from the Type III Secretion System in Aeromonas hydrophila
- Author
- AL Fink
- AT BrĂŒnger
- B Austin
- BB Finlay
- Chiradip Chatterjee
- CK Yip
- CM Weeks
- CR BĂŒttner
- E Krissinel
- EF Pettersen
- G Langer
- GR Cornelis
- HB Yu
- HB Yu
- HJ Dyson
- J Phan
- J Ruiz-Sanz
- J Sha
- J. Sivaraman
- JC Sierra
- JD Thompson
- JM Bourhis
- JM Janda
- Ka Yin Leung
- L Rodgers
- M Lunelli
- M Quinaud
- M Quinaud
- MJ Sippl
- MJ Sippl
- P Emsley
- P Sun
- P Tompa
- Paul Cobine
- PJ Edqvist
- RA Laskowski
- RL Thune
- S Birtalan
- S Vilches
- SC Birtalan
- Smarajit Chakraborty
- Sundramurthy Kumar
- T Pape
- TA Jones
- TF Moraes
- V Job
- WL DeLano
- Yih Wan Tan
- Yu-Keung Mok
- YW Tan
- YW Tan
- Z Gugolya
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
10.1371/journal.pone.0019208PLoS ONE64
Targeting tumor-associated macrophages by anti-tumor Chinese materia medica
- Author
- A Mantovani
- A Mantovani
- A Mantovani
- A Mantovani
- A Mantovani
- A Mantovani
- A Saccani
- A Schmieder
- A Sica
- A Sica
- B Ruffell
- B Shao
- BB Aggarwal
- BC Kennedy
- BK Sekhon
- C Jia
- C Liu
- C Steidl
- CE Lewis
- CK Mueller
- Curzio RĂŒegg
- D Ghosh
- DM Mosser
- E Bolli
- E Schutyser
- F Li
- F Zhao
- FO Martinez
- FR Zhao
- G Shu
- G Solinas
- H Diao
- H Fritz
- H Kurahara
- H Kurahara
- H Ouyang
- H Wang
- H Wang
- H Zhang
- H Zhao
- HYT Nguyen
- IA Schepetkin
- J Cook
- J Deng
- J Ding
- J Gao
- J Li
- J Li
- J Li
- J Rius
- J Wang
- J Yin
- J Zhang
- JB Mitchem
- JW Pollard
- JY Jang
- JY Shin
- Kun Zhou
- L Bingle
- L Sanchez-Martin
- L Varinska
- LI Partecke
- Li-kang Sun
- Lin Miao
- M Egeblad
- M Hong
- M Ito
- M Jinushi
- M Pesic
- MA Khan
- Margaret Gebauer
- Micheal O. Hottiger
- ML Taddei
- MR Galdiero
- Muriel Cuendet
- MY Kim
- P Allavena
- P Suboj
- P Sun
- P Yu
- PS Kyrn
- Q Dong
- Q Lin
- R Graziose
- R Noy
- R Ostuni
- R Zhu
- S Banerjee
- S Gao
- S Iwanowycz
- S Lunardi
- S Shi
- S Shimura
- S Ye
- SM Woo
- SR Hingorani
- SR Hyam
- T Kawanishi
- T Xu
- V Riabov
- W Lam
- W Shi
- Wei-ling Pu
- X Jia
- X Li
- X Lin
- X Nie
- X Qian
- X Sun
- X Tang
- X Wang
- X Zhan
- X Zhang
- X Zhang
- Xiu-mei Gao
- XL Zhu
- XW Yang
- Y Cai
- Y Kimura
- Y Lei
- Y Liu
- Y Song
- Y Tu
- Y Wang
- Y Wang
- Y Zhao
- YP Guo
- Yun-sha Zhang
- Z Cai
- Z Jiang
- Z Lin
- Z Liu
- Publication venue
- Publication date
- 16/11/2017
- Field of study
Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica (CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine (CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment (TME). Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis and immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy
Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus
- Author
- A Ahmann
- A Barnett
- A Bellomo Damato
- A Dornhorst
- A Garber
- A Garber
- A Gill
- A Maida
- A Merovci
- A Panelo
- A Ptaszynska
- A TrĂŒmper
- AA Tahrani
- AA Tahrani
- AA Tahrani
- AA Tahrani
- AA Tahrani
- AA Tahrani
- Abd A. Tahrani
- AD Hughes
- AG Egan
- AH Barnett
- AH Barnett
- AH Barnett
- AH Barnett
- AH Barnett
- AH Cincotta
- AI Palalau
- AJ Krentz
- AJ Mulherin
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AK Madiraju
- AL Peters
- AM Jacobson
- Anthony H. Barnett
- AV Schwartz
- AW Hitchings
- B Ahrén
- B Ahrén
- B Ahrén
- B Ahrén
- B Charbonnel
- B Charbonnel
- B ElbrĂžnd
- B Gallwitz
- B Jose
- B Marcheva
- B Neal
- B Thorens
- B Viollet
- B Zinman
- B Zinman
- BC Meier
- BD Green
- BM Scirica
- C Bonner
- C Day
- C Eng
- C Filozof
- C Wysham
- C Yu Pan
- CB Burness
- CB Giorda
- CB Juhl
- CF Deacon
- CF Deacon
- CF Deacon
- CF Deacon
- CH Wysham
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CK Lam
- CL Meinert
- Clifford J. Bailey
- CM Edwards
- CS Kovacs
- CS Kovacs
- CS Yang
- D Devineni
- D Raccah
- D Russell-Jones
- D Russell-Jones
- DC Klonoff
- DJ Drucker
- DJ Drucker
- DJ Drucker
- DJ Drucker
- DM Kendall
- DR Matthews
- DR Owens
- DT Eurich
- E Erdmann
- E Ferrannini
- E Ferrannini
- E Ferrannini
- E Jimenez-Solem
- E Klein
- E Mannucci
- E Mannucci
- EM Wright
- EM Wright
- EM Wright
- EO Billington
- ES Mearns
- F Giorgino
- F Sun
- F Sun
- F Sun
- FA van de Laar
- FM Ashcroft
- G Derosa
- G Ferrannini
- G Fulcher
- G Schernthaner
- G Umpierrez
- G Zhou
- GA Herman
- GB Bolli
- GS Meneilly
- H AgersĂž
- H Elrick
- H Hauner
- H Linnebjerg
- H Mulder
- H Park
- H Storgaard
- H Ueno
- H Yki-JĂ€rvinen
- H Zimdahl
- HC Fehmann
- HE Lebovitz
- HU Haering
- HU HĂ€ring
- HU HĂ€ring
- I Gantz
- I Tikkanen
- IW Campbell
- J Dupre
- J Eng
- J Farngren
- J Heaf
- J LĂžnborg
- J Reusch
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- JA Dormandy
- JA Udell
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Green
- JC Arjona Ferreira
- JC Arjona Ferreira
- JC Henquin
- JE Campbell
- JE Foley
- JE Matthews
- JE Potts
- JF Gautier
- JH Um
- JJ Meier
- JJ Meier
- JL Chiasson
- JL Chiasson
- JM Gaziano
- JM Trujillo
- JP Bilezikian
- JR Lindsay
- JR Ussher
- K Copley
- K Esposito
- K Esposito
- K McKeage
- K Winkler
- KB Harris
- KC Ferdinand
- KE Wellen
- KM Dungan
- KM Hurren
- KW Mahaffey
- L Blonde
- L Hansen
- L Li
- L Merker
- L Rui
- L Simonsen
- L van Gaal
- LA Leiter
- LC Groop
- LJ Schmidt
- LL Baggio
- LM Younk
- M Abe
- M Barnea
- M Brownlee
- M Christensen
- M Christensen
- M Chung
- M Davies
- M de Groot
- M Diamant
- M Diamant
- M Katout
- M Marre
- M Nauck
- M Nauck
- M Obermeier
- M Pinget
- M Reaney
- M Rendell
- M RidderstrÄle
- M Roden
- M Roden
- M Stumvoll
- MA Nauck
- MA Nauck
- MA Nauck
- MA Nauck
- MA Nauck
- MA Nauck
- MA Pfeffer
- MC Riddle
- MC Riddle
- N Erondu
- N Inagaki
- NB Amin
- NB Amin
- NB Watts
- NE Straznicky
- NM Maruthur
- OG Kolterman
- P Arnouts
- P Barrington
- P Home
- P Marchetti
- P Nyirjesy
- P Stein
- PD Home
- PJ Grant
- PN Weissman
- PS Roshanov
- Q Yang
- QA Altaf
- R Grempler
- R Guardado-Mendoza
- R Mentlein
- R Pfister
- R Toto
- R Wilcox
- RA Defronzo
- RA DeFronzo
- RA Hayward
- RE Pratley
- RE Ratner
- RF Carlson
- RG Yip
- RI Holt
- RM Bergenstal
- RR Henry
- RR Henry
- RR Henry
- RR Holman
- RR Holman
- RS Weinstock
- S Del Prato
- S Grandy
- S Hu
- S Kalra
- S Madsbad
- S Malmgren
- S Sha
- SC Gough
- SC Gough
- SC Hung
- SE Inzucchi
- SE Kahn
- SE Kahn
- SE Nissen
- SE Nissen
- SH Tella
- SL Schwarz
- SR Joshi
- SR Salpeter
- SS Lund
- T Biftu
- T Blevins
- T Dujic
- T Hach
- T Heise
- T Karagiannis
- T Karagiannis
- T Marbury
- T Mazzone
- T Seck
- T VilsbĂžll
- T Wang
- V Jahagirdar
- VA Fonseca
- VA Fonseca
- VR Aroda
- VT Samuel
- W Duckworth
- W Kothny
- W Liang
- W Meng
- W Yang
- WB White
- XP Yang
- Y Huang
- Y Ohkubo
- Y Seino
- Y Wang
- Y Zhang
- YG Kim
- YG Kim
- YK Loke
- YL He
- YM Cho
- YN Sun
- Z Punthakee
- Z Skrivanek
- Ă Ljunggren
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/06/2016
- Field of study
Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-care systems. Improving metabolic control to approach normal glycaemia (where practical) greatly benefits long-term prognoses and justifies early, effective, sustained and safety-conscious intervention. Improvements in the understanding of the complex pathogenesis of T2DM have underpinned the development of glucose-lowering therapies with complementary mechanisms of action, which have expanded treatment options and facilitated individualized management strategies. Over the past decade, several new classes of glucose-lowering agents have been licensed, including glucagon-like peptide 1 receptor (GLP-1R) agonists, dipeptidyl peptidase 4 (DPP-4) inhibitors and sodium/glucose cotransporter 2 (SGLT2) inhibitors. These agents can be used individually or in combination with well-established treatments such as biguanides, sulfonylureas and thiazolidinediones. Although novel agents have potential advantages including low risk of hypoglycaemia and help with weight control, long-term safety has yet to be established. In this Review, we assess the pharmacokinetics, pharmacodynamics and safety profiles, including cardiovascular safety, of currently available therapies for management of hyperglycaemia in patients with T2DM within the context of disease pathogenesis and natural history. In addition, we briefly describe treatment algorithms for patients with T2DM and lessons from present therapies to inform the development of future therapies
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
- Bazmandegan G
- Becker JS
- Bedi N
- Beghi E
- Behzadifar M
- Bejot Y
- Bekuma TTT
- Bell ML
- Bello AK
- Ben L
- Bender RG
- Bennett DA
- Bennitt FB
- Bensenor IM
- Benziger CP
- Berhe K
- Berman AE
- Bernabe E
- Bernstein RS
- Bertolacci GJ
- Bhagavathula AS
- Bhageerathy R
- Bhala N
- Bhandari D
- Bhardwaj P
- Bhat AG
- Bhattacharyya K
- Bhattarai S
- Bhutta ZA
- Bibi S
- Bicer BK
- Biehl MH
- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
- Bitew H
- Bjorge T
- Bockarie MJ
- Bohlouli S
- Bohluli M
- Bojia HA
- Bolla SR
- Boloor A
- Boon-Dooley AS
- Borges G
- Borzi AM
- Borzouei S
- Bose D
- Bosetti C
- Boston S
- Boufous S
- Bourne R
- Brady OJ
- Braithwaite D
- Brauer M
- Brayne C
- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
- Briant PS
- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
- Car LT
- Cardenas R
- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
- Chang J-C
- Chang K-L
- Charan J
- Charlson FJ
- Chattu VK
- Chaturvedi S
- Cherbuin N
- Chimed-Ochir O
- Chin KL
- Chirinos-Caceres JL
- Cho DY
- Choi J-YJ
- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
- Cicuttini FM
- Ciobanu LG
- Cirillo M
- Cislaghi B
- Classen TKD
- Cohen AJ
- Collins EL
- Comfort H
- Compton K
- Conti S
- Cooper OR
- Corso B
- Cortesi PA
- Costa VM
- Cousin E
- Cowden RG
- Cowie BC
- Cromwell EA
- Croneberger AJ
- Cross DH
- Cross M
- Crowe CS
- Cruz JA
- Cummins S
- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
- Dargan PI
- Darshan BB
- Darwesh AM
- Daryani A
- Das Gupta R
- Das Neves J
- Das JK
- Dash AP
- Davey G
- Davila-Cervantes CA
- Davis AC
- Davitoiu DV
- Davletov K
- De Leo D
- De Neve J-W
- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
- DeLang M
- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
- Denova-Gutierrez E
- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
- Eagan AW
- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
- Emamian MH
- Emmons-Bell S
- Erskine HE
- Eshrati B
- Eskandari K
- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
- Esteghamati A
- Esteghamati S
- Estep K
- Etemadi A
- Etisso AE
- Ezekannagha O
- Fanzo J
- Farag T
- Farahmand M
- Faraj A
- Faraon EJA
- Fareed M
- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
- Farzadfar F
- Fattahi N
- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
- Ferrara G
- Ferrara P
- Ferrari AJ
- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
- Fitzgerald R
- Flohr C
- Flor LS
- Foigt NA
- Folayan MO
- Fomenkov AA
- Force LM
- Fornari C
- Forooshani ZSD
- Foroutan M
- Fox JT
- Francis JM
- Frank TD
- Franklin RC
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- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
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- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Application guide for omics approaches to cell signaling
- Author
- A Birmingham
- A Franceschini
- A Koide
- A Wutz
- A Zuzuarregui
- AL Couzens
- AL Jackson
- AR Joyce
- B Berger
- B Bodenmiller
- B Neumann
- B Seed
- B Snijder
- BC Collins
- C Choudhary
- C Kasap
- C Tiede
- CK Kaufman
- D Kokel
- D Reyon
- DK Nomura
- DR Bandura
- E Jabbour
- E Stefan
- E Tchekanda
- F Ciruela
- F Grebien
- F Sha
- FC Gonsalves
- FD Bushman
- G Rigaut
- GJ Gu
- H Daub
- H Koike-Yusa
- I Lemmens
- I Lemmens
- I Stagljar
- Igor Stagljar
- IW Taylor
- J Heintze
- J Luo
- J Mercer
- J Moffat
- J Petschnigg
- J Petschnigg
- J Wojcik
- JN Savas
- JP Lambert
- JS Duncan
- Julia Petschnigg
- JV Olsen
- K Newton
- K Sharma
- KJ Leuchowius
- KJ Roux
- KM Specht
- KV Huber
- L Pelkmans
- LA Gilbert
- LC Gillet
- M Bantscheff
- M Deininger
- M Jinek
- MA Lemmon
- MA Smith
- MC Wehr
- MK Muellner
- MN Teruel
- MR Banko
- N Bisson
- O Shalem
- O Söderberg
- P Braun
- PJ Alaimo
- R Geiss-Friedlander
- R Ketteler
- RJ Lefkowitz
- Robin Ketteler
- S Fields
- S Lievens
- S Marine
- SA Hasson
- SC Bendall
- SE Mohr
- SE Ong
- SJ Campbell
- SW Michnick
- T Hart
- T Hunter
- T Pawson
- T Wang
- TK Kerppola
- TS Wehrman
- U Alon
- U Rix
- UH Weidle
- V Lange
- VN Kristensen
- W Kolch
- Y Smurnyy
- Y Zheng
- YL Deribe
- Z Serber
- Zhong Yao
- Publication venue
- Publication date
- 15/05/2015
- Field of study
Research in signal transduction aims to identify the functions of different signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made important contributions to our understanding of cellular signaling. However, the single-gene approach does not take into account the full complexity of cell signaling. With the availability of omics techniques, great progress has been made in understanding signaling networks. Omics approaches can be classified into two categories: 'molecular profiling', including genomic, proteomic, post-translational modification and interactome profiling; and 'molecular perturbation', including genetic and functional perturbations
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