796 research outputs found
Feelings in Literature
In this article it is argued that feelings are all important to the function of literature. In contradiction to music that is concerned with the inwardness of humankind, literature has, because of language, the capacity to create fictional worlds that in many respects are similar to and related to the life world within which we live. One of the most important reasons for our emotional engagement in literature is our empathy with others and our constant imagining and hypothesizing on possible developments in our interactions with them. Hence, we understand and engage ourselves in fictional worlds. It is further claimed and exemplified, how poetic texts are very good at rhetorically engage and manipulate our feelings. Finally, with reference to the important work of Ellen Dissanayake, it is pointed out that the first kind of communication in which we engage, that between mother and infant, is a kind of speech that positively engages the infant in a dialogue with the mother by means of poetic devices
Local threshold field for dendritic instability in superconducting MgB2 films
Using magneto-optical imaging the phenomenon of dendritic flux penetration in
superconducting films was studied. Flux dendrites were abruptly formed in a 300
nm thick film of MgB2 by applying a perpendicular magnetic field. Detailed
measurements of flux density distributions show that there exists a local
threshold field controlling the nucleation and termination of the dendritic
growth. At 4 K the local threshold field is close to 12 mT in this sample,
where the critical current density is 10^7 A/cm^2. The dendritic instability in
thin films is believed to be of thermo-magnetic origin, but the existence of a
local threshold field, and its small value are features that distinctly
contrast the thermo-magnetic instability (flux jumps) in bulk superconductors.Comment: 6 pages, 6 figures, submitted to Phys. Rev.
An improved model of the Edgeworth-Kuiper debris disk
(Abridged) We access the expected EKB dust disk properties by modeling. We
treat the debiased population of the known transneptunian objects (TNOs) as
parent bodies and generate the dust with our collisional code. The resulting
dust distributions are modified to take into account the influence of
gravitational scattering and resonance trapping by planets on migrating dust
grains as well as the effect of sublimation. A difficulty is that the amount
and distribution of dust are largely determined by sub-kilometer-sized bodies.
These are directly unobservable, and their properties cannot be accessed by
collisional modeling, because objects larger than 10...60m in the present-day
EKB are not in a collisional equilibrium. To place additional constraints, we
use in-situ measurements of the New Horizons spacecraft within 20AU. We show
that the TNO population has to have a break in the size distribution at s<70km.
However, even this still leaves us with several models that all correctly
reproduce a nearly constant dust impact rates in the region of giant planet
orbits and do not violate the constraints from the non-detection of the EKB
dust thermal emission by the COBE spacecraft. The modeled EKB dust disks, which
conform to the observational constraints, can either be transport-dominated or
intermediate between the transport-dominated and collision-dominated regime.
The in-plane optical depth of such disks is tau(r>10AU)~10^-6 and their
fractional luminosity is f_d~10^-7. Planets and sublimation are found to have
little effect on dust impact fluxes and dust thermal emission. The spectral
energy distribution of an EKB analog, as would be seen from 10pc distance,
peaks at wavelengths of 40...50\mum at F~0.5mJy, which is less than 1% of the
photospheric flux at those wavelengths. Therefore, exact EKB analogs cannot be
detected with present-day instruments such as Herschel/PACS.Comment: 10 pages, 8 figures, accepted for publication in Astronomy and
Astophysic
Prognostic implications of immunohistochemically detected YKL-40 expression in breast cancer
BACKGROUND: YKL-40 has been implicated as a mediator of collagen synthesis and extracellular matrix re-modeling as well as mitogenesis. Elevated serum levels of YKL-40 have been associated with worse survival in a variety of malignancies including breast cancer. We wished to determine if immunohistochemically detected expression had prognostic implications in breast cancer. METHODS: A prospectively collected database of breast cancer patients treated at the University Hospital of Newark was used for analysis. Immunohistochemistry was performed on archived tumor tissue from 109 patients for whom full clinical information and follow up was available. RESULTS: YKL-40 expression was noted in 37 patients (34%). YKL-40 immunoreactivity significantly correlated with larger tumor size, poorer tumor differentiation, and a greater likelihood of being estrogen and/or progesterone receptor negative. No significant correlation was demonstrated between YKL-40 status and nodal stage. At a mean follow up of 3.2 years, disease-free survival was significantly worse in the subset of patients whose tumors demonstrated YKL-40 expression compared to the non-expressors. In multivariate analysis, YKL-40 status was independent of T-stage and N-stage in predicting disease recurrence. CONCLUSION: Immunoreactivity for YKL-40 was a significant predictor of breast cancer relapse in this subset of patients. This was independent of T or N-stage and suggests that tumor immunohistochemistry for this protein may be a valuable prognostic marker in breast cancer
The Edgeworth-Kuiper debris disk
(Abridged) The Edgeworth-Kuiper belt with its presumed dusty debris is a
natural reference for extrsolar debris disks. We employ a new algorithm to
eliminate the inclination and the distance selection effects in the known TNO
populations to derive expected parameters of the "true" EKB. Its estimated mass
is M_EKB=0.12 M_earth, which is by a factor of \sim 15 larger than the mass of
the EKB objects detected so far. About a half of the total EKB mass is in
classical and resonant objects and another half is in scattered ones. Treating
the debiased populations of EKB objects as dust parent bodies, we then
"generate" their dust disk with our collisional code. Apart from accurate
handling of collisions and direct radiation pressure, we include the
Poynting-Robertson (P-R) drag, which cannot be ignored for the EKB dust disk.
Outside the classical EKB, the radial profile of the optical depth
approximately follows tau \sim r^-2 which is roughly intermediate between the
slope predicted analytically for collision-dominated (r^-1.5) and
transport-dominated (r^-2.5) disks. The cross section-dominating grain size
still lies just above the blowout size (\sim 1...2 \microm), as it would
without the P-R transport. However, if the EKB were by one order of magnitude
less massive, the optical depth profile would fall off as tau \sim r^-3, and
the cross section-dominating grain size would shift from \sim 1...2\microm to
~100 \microm. These properties are seen if dust is assumed to be generated only
by known TNOs. If the solar system were observed from outside, the thermal
emission flux from the EKB dust would be about two orders of magnitude lower
than for solar-type stars with the brightest known infrared excesses observed
from the same distance. Herschel and other new-generation facilities should
reveal extrasolar debris disks nearly as tenuous as the EKB disk. The
Herschel/PACS instrument should be able to detect disks at a \sim 1...2M_EKB
level.Comment: 18 pages, 14 figures, accepted for publication in A&
Interplay of dendritic avalanches and gradual flux penetration in superconducting MgB2 films
Magneto-optical imaging was used to study a zero-field-cooled MgB2 film at
9.6K where in a slowly increasing field the flux penetrates by abrupt formation
of large dendritic structures. Simultaneously, a gradual flux penetration takes
place, eventually covering the dendrites, and a detailed analysis of this
process is reported. We find an anomalously high gradient of the flux density
across a dendrite branch, and a peak value that decreases as the applied field
goes up. This unexpected behaviour is reproduced by flux creep simulations
based on the non-local field-current relation in the perpendicular geometry.
The simulations also provide indirect evidence that flux dendrites are formed
at an elevated local temperature, consistent with a thermo-magnetic mechanism
of the instabilityComment: 5 pages, 5 figures, submitted to Supercond. Sci. Techno
Metabolic design of macroscopic bioreaction models: application to Chinese hamster ovary cells
The aim of this paper is to present a systematic methodology to design macroscopic bioreaction models for cell cultures based upon metabolic networks. The cell culture is seen as a succession of phases. During each phase, a metabolic network represents the set of reactions occurring in the cell. Then, through the use of the elementary flux modes, these metabolic networks are used to derive macroscopic bioreactions linking the extracellular substrates and products. On this basis, as many separate models are obtained as there are phases. Then, a complete model is obtained by smoothly switching from model to model. This is illustrated with batch cultures of Chinese hamster ovary cells
Rupture by damage accumulation in rocks
The deformation of rocks is associated with microcracks nucleation and
propagation, i.e. damage. The accumulation of damage and its spatial
localization lead to the creation of a macroscale discontinuity, so-called
"fault" in geological terms, and to the failure of the material, i.e. a
dramatic decrease of the mechanical properties as strength and modulus. The
damage process can be studied both statically by direct observation of thin
sections and dynamically by recording acoustic waves emitted by crack
propagation (acoustic emission). Here we first review such observations
concerning geological objects over scales ranging from the laboratory sample
scale (dm) to seismically active faults (km), including cliffs and rock masses
(Dm, hm). These observations reveal complex patterns in both space (fractal
properties of damage structures as roughness and gouge), time (clustering,
particular trends when the failure approaches) and energy domains (power-law
distributions of energy release bursts). We use a numerical model based on
progressive damage within an elastic interaction framework which allows us to
simulate these observations. This study shows that the failure in rocks can be
the result of damage accumulation
Sequential Quasi-Monte Carlo
We derive and study SQMC (Sequential Quasi-Monte Carlo), a class of
algorithms obtained by introducing QMC point sets in particle filtering. SQMC
is related to, and may be seen as an extension of, the array-RQMC algorithm of
L'Ecuyer et al. (2006). The complexity of SQMC is , where is
the number of simulations at each iteration, and its error rate is smaller than
the Monte Carlo rate . The only requirement to implement SQMC is
the ability to write the simulation of particle given as a
deterministic function of and a fixed number of uniform variates.
We show that SQMC is amenable to the same extensions as standard SMC, such as
forward smoothing, backward smoothing, unbiased likelihood evaluation, and so
on. In particular, SQMC may replace SMC within a PMCMC (particle Markov chain
Monte Carlo) algorithm. We establish several convergence results. We provide
numerical evidence that SQMC may significantly outperform SMC in practical
scenarios.Comment: 55 pages, 10 figures (final version
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