2023 Updated MASCC/ESMO Consensus Recommendations: prevention of radiotherapy-and chemoradiotherapy-induced nausea and vomiting

Purpose Radiotherapy and chemoradiotherapy-induced nausea and vomiting (RINV and C-RINV) are common and distressing, and there is a need for guidance for clinicians to provide up to date optimal antiemetic prophylaxis and treatment. Through a comprehensive review of the literature concerning RINV and C-RINV, this manuscript aims to update the evidence for antiemetic prophylaxis and rescue therapy and provide a new edition of recommendations for the MASCC/ESMO antiemetic guidelines for RINV and C-RINV. Methods A systematic review of the literature including data published from May 1, 2015, to January 31, 2023, was performed. All authors assessed the literature. Results The searches yielded 343 references; 37 met criteria for full article review, and 20 were ultimately retained. Only one randomized study in chemoradiation had the impact to provide new recommendations for the antiemetic guideline. Based on expert consensus, it was decided to change the recommendation for the “low emetic risk” category from “prophylaxis or rescue” to “rescue” only, while the drugs of choice remain unchanged. Conclusion As for the previous guideline, the serotonin receptor antagonists are still the cornerstone in antiemetic prophylaxis of nausea and vomiting induced by high and moderate emetic risk radiotherapy. The guideline update provides new recommendation for the management of C-RINV for radiotherapy and concomitant weekly cisplatin. To avoid overtreatment, antiemetic prophylaxis is no longer recommended for the “low emetic risk” category

Two superluminous supernovae from the early universe discovered by the Supernova Legacy Survey

We present spectra and lightcurves of SNLS 06D4eu and SNLS 07D2bv, two hydrogen-free superluminous supernovae discovered by the Supernova Legacy Survey. At z = 1.588, SNLS 06D4eu is the highest redshift superluminous SN with a spectrum, at M_U = -22.7 is one of the most luminous SNe ever observed, and gives a rare glimpse into the restframe ultraviolet where these supernovae put out their peak energy. SNLS 07D2bv does not have a host galaxy redshift, but based on the supernova spectrum, we estimate it to be at z ~ 1.5. Both supernovae have similar observer-frame griz lightcurves, which map to restframe lightcurves in the U-band and UV, rising in ~ 20 restframe days or longer, and declining over a similar timescale. The lightcurves peak in the shortest wavelengths first, consistent with an expanding blackbody starting near 15,000 K and steadily declining in temperature. We compare the spectra to theoretical models, and identify lines of C II, C III, Fe III, and Mg II in the spectrum of SNLS 06D4eu and SCP 06F6, and find that they are consistent with an expanding explosion of only a few solar masses of carbon, oxygen, and other trace metals. Thus the progenitors appear to be related to those suspected for SNe Ic. A high kinetic energy, 10^52 ergs, is also favored. Normal mechanisms of powering core- collapse or thermonuclear supernovae do not seem to work for these supernovae. We consider models powered by 56Ni decay and interaction with circumstellar material, but find that the creation and spin-down of a magnetar with a period of 2ms, magnetic field of 2 x 10^14 Gauss, and a 3 solar mass progenitor provides the best fit to the data.Comment: ApJ, accepted, 43 pages, 15 figure

Техніка і технологія збагачення корисних копалин

Викладені теоретичні основи і технологія процесів збагачення корисних копалин. Розглянуті основні конструкції технологічного обладнання, його принцип дії і технологічні характеристики. Викладені методи контролю технологічного процесу і базисні положення охорони навколишнього середовища. Навчальний посібник відповідає програмі навчальної дисципліни "Техніка і технологія переробки гірських порід", призначений для здобувачів ступеня бакалавра за спеціальністю 184 "Гірництво" та буде корисним фахівцям з гірничо-видобувних підприємств

An Efficient Approach to Obtaining Large Numbers of Distant Supernova Host Galaxy Redshifts

We use the wide-field capabilities of the 2dF fibre positioner and the AAOmega spectrograph on the Anglo-Australian Telescope (AAT) to obtain redshifts of galaxies that hosted supernovae during the first three years of the Supernova Legacy Survey (SNLS). With exposure times ranging from 10 to 60 ksec per galaxy, we were able to obtain redshifts for 400 host galaxies in two SNLS fields, thereby substantially increasing the total number of SNLS supernovae with host galaxy redshifts. The median redshift of the galaxies in our sample that hosted photometrically classified Type Ia supernovae (SNe Ia) is 0.77, which is 25% higher than the median redshift of spectroscopically confirmed SNe Ia in the three-year sample of the SNLS. Our results demonstrate that one can use wide-field fibre-fed multi-object spectrographs on 4m telescopes to efficiently obtain redshifts for large numbers of supernova host galaxies over the large areas of sky that will be covered by future high-redshift supernova surveys, such as the Dark Energy Survey.Comment: 22 pages, 4 figures, accepted for publication in PAS

The Supernova Legacy Survey 3-year sample: Type Ia Supernovae photometric distances and cosmological constraints

We present photometric properties and distance measurements of 252 high redshift Type Ia supernovae (0.15 < z < 1.1) discovered during the first three years of the Supernova Legacy Survey (SNLS). These events were detected and their multi-colour light curves measured using the MegaPrime/MegaCam instrument at the Canada-France-Hawaii Telescope (CFHT), by repeatedly imaging four one-square degree fields in four bands. Follow-up spectroscopy was performed at the VLT, Gemini and Keck telescopes to confirm the nature of the supernovae and to measure their redshifts. Systematic uncertainties arising from light curve modeling are studied, making use of two techniques to derive the peak magnitude, shape and colour of the supernovae, and taking advantage of a precise calibration of the SNLS fields. A flat LambdaCDM cosmological fit to 231 SNLS high redshift Type Ia supernovae alone gives Omega_M = 0.211 +/- 0.034(stat) +/- 0.069(sys). The dominant systematic uncertainty comes from uncertainties in the photometric calibration. Systematic uncertainties from light curve fitters come next with a total contribution of +/- 0.026 on Omega_M. No clear evidence is found for a possible evolution of the slope (beta) of the colour-luminosity relation with redshift.Comment: (The SNLS Collaboration) 40 pages, 32 figures, Accepted in A&

Constraining Type Ia Supernovae progenitors from three years of SNLS data

While it is generally accepted that Type Ia supernovae are the result of the explosion of a carbon-oxygen White Dwarf accreting mass in a binary system, the details of their genesis still elude us, and the nature of the binary companion is uncertain. Kasen (2010) points out that the presence of a non-degenerate companion in the progenitor system could leave an observable trace: a flux excess in the early rise portion of the lightcurve caused by the ejecta impact with the companion itself. This excess would be observable only under favorable viewing angles, and its intensity depends on the nature of the companion. We searched for the signature of a non-degenerate companion in three years of Supernova Legacy Survey data by generating synthetic lightcurves accounting for the effects of shocking and comparing true and synthetic time series with Kolmogorov-Smirnov tests. Our most constraining result comes from noting that the shocking effect is more prominent in rest-frame B than V band: we rule out a contribution from white dwarf-red giant binary systems to Type Ia supernova explosions greater than 10% at 2 sigma, and than 20% at 3 sigma level.Comment: 14 pages, 15 figures, resubmitted to ApJ, figure 15 modifie

Photometric selection of Type Ia supernovae in the Supernova Legacy Survey

We present a sample of 485 photometrically identified Type Ia supernova candidates mined from the first three years of data of the CFHT SuperNova Legacy Survey (SNLS). The images were submitted to a deferred processing independent of the SNLS real-time detection pipeline. Light curves of all transient events were reconstructed in the g_M, r_M, i_M and z_M filters and submitted to automated sequential cuts in order to identify possible supernovae. Pure noise and long-term variable events were rejected by light curve shape criteria. Type Ia supernova identification relied on event characteristics fitted to their light curves assuming the events to be normal SNe Ia. The light curve fitter SALT2 was used for this purpose, assigning host galaxy photometric redshifts to the tested events. The selected sample of 485 candidates is one magnitude deeper than that allowed by the SNLS spectroscopic identification. The contamination by supernovae of other types is estimated to be 4%. Testing Hubble diagram residuals with this enlarged sample allows us to measure the Malmquist bias due to spectroscopic selections directly. The result is fully consistent with the precise Monte Carlo based estimate used to correct SN Ia distance moduli in the SNLS 3-year cosmological analyses. This paper demonstrates the feasibility of a photometric selection of high redshift supernovae with known host galaxy redshifts, opening interesting prospects for cosmological analyses from future large photometric SN Ia surveys.Comment: (The SNLS collaboration) 23 pages, 28 figures, Accepted in A&

Evolution in the Volumetric Type Ia Supernova Rate from the Supernova Legacy Survey

We present a measurement of the volumetric Type Ia supernova (SN Ia) rate (SNR_Ia) as a function of redshift for the first four years of data from the Canada-France-Hawaii Telescope (CFHT) Supernova Legacy Survey (SNLS). This analysis includes 286 spectroscopically confirmed and more than 400 additional photometrically identified SNe Ia within the redshift range 0.1<z<1.1. The volumetric SNR_Ia evolution is consistent with a rise to z~1.0 that follows a power-law of the form (1+z)^alpha, with alpha=2.11+/-0.28. This evolutionary trend in the SNLS rates is slightly shallower than that of the cosmic star-formation history over the same redshift range. We combine the SNLS rate measurements with those from other surveys that complement the SNLS redshift range, and fit various simple SN Ia delay-time distribution (DTD) models to the combined data. A simple power-law model for the DTD (i.e., proportional to t^-beta) yields values from beta=0.98+/-0.05 to beta=1.15+/-0.08 depending on the parameterization of the cosmic star formation history. A two-component model, where SNR_Ia is dependent on stellar mass (Mstellar) and star formation rate (SFR) as SNR_Ia(z)=AxMstellar(z) + BxSFR(z), yields the coefficients A=1.9+/-0.1 SNe/yr/M_solar and B=3.3+/-0.2 SNe/yr/(M_solar/yr). More general two-component models also fit the data well, but single Gaussian or exponential DTDs provide significantly poorer matches. Finally, we split the SNLS sample into two populations by the light curve width (stretch), and show that the general behavior in the rates of faster-declining SNe Ia (0.8<s<1.0) is similar, within our measurement errors, to that of the slower objects (1.0<s<1.3) out to z~0.8.Comment: Accepted in A

A Type II Supernova Hubble Diagram from the CSP-I, SDSS-II and SNLS Surveys

The coming era of large photometric wide-field surveys will increase the detection rate of supernovae by orders of magnitude. Such numbers will restrict spectroscopic follow-up in the vast majority of cases, and hence new methods based solely on photometric data must be developed. Here, we construct a complete Hubble diagram of Type II supernovae (SNe II) combining data from three different samples: the Carnegie Supernova Project-I, the Sloan Digital Sky Survey II SN, and the Supernova Legacy Survey. Applying the Photometric Color Method (PCM) to 73 SNe II with a redshift range of 0.01–0.5 and with no spectral information, we derive an intrinsic dispersion of 0.35 mag. A comparison with the Standard Candle Method (SCM) using 61 SNe II is also performed and an intrinsic dispersion in the Hubble diagram of 0.27 mag, i.e., 13% in distance uncertainties, is derived. Due to the lack of good statistics at higher redshifts for both methods, only weak constraints on the cosmological parameters are obtained. However, assuming a flat universe and using the PCM, we derive the universe's matter density: ${{\rm{\Omega }}}_{m}={0.32}_{-0.21}^{+0.30}$ providing a new independent evidence for dark energy at the level of two sigma