DESIGN OF ADVANCED SYSTEM DISPENSING CONCENTRATE FOR FISH IN CAPTIVITY

Este paper presenta el desarrollo del prototipo de un sistema dosificador de alimento para peces, observando las variables externas y regulando la cantidad de alimento según estas condiciones, se realizo todo desde el diseño mecánico, electrónico y eléctrico; hasta su construcción y pruebas de funcionamiento.This paper presents the development of a prototype for dispensing fish food, observing external variables and regulating the amount of food under these conditions, was performed everything from mechanical design, electronics and electrical, the construction and performance testing

What Matters Most to Patients and Rheumatologists? A Discrete Choice Experiment in Rheumatoid Arthritis

Introduction: To determine patient and rheumatologist preferences for rheumatoid arthritis (RA) treatment attributes in Spain and to evaluate their attitude towards shared decision-making (SDM). Methods: Observational, descriptive, exploratory and cross-sectional study based on a discrete choice experiment (DCE). To identify the attributes and their levels, a literature review and two focus groups (patients [P] = 5; rheumatologists [R] = 4) were undertaken. Seven attributes with 2–4 levels were presented in eight scenarios. Attribute utility and relative importance (RI) were assessed using a conditional logit model. Patient preferences for SDM were assessed using an ad hoc questionnaire. Results: Ninety rheumatologists [52.2% women; mean years of experience 18.1 (SD: 9.0); seeing an average of 24.4 RA patients/week (SD: 15.3)] and 137 RA patients [mean age: 47.5 years (SD: 10.7); 84.0% women; mean time since diagnosis of RA: 14.2 years (SD: 11.8) and time in treatment: 13.2 years (SD: 11.2), mean HAQ score 1.2 (SD: 0.7)] participated in the study. In terms of RI, rheumatologists and RA patients viewed: time with optimal QoL: R: 23.41%/P: 35.05%; substantial symptom improvement: R: 13.15%/P: 3.62%; time to onset of treatment action: R: 16.24%/P: 13.56%; severe adverse events: R: 10.89%/P: 11.20%; mild adverse events: R: 4.16%/P: 0.91%; mode of administration: R: 25.23%/P: 25.00%; and added cost: R: 6.93%/P: 10.66%. Nearly 73% of RA patients were involved in treatment decision-making to a greater or lesser extent; however, 27.4% did not participate at all. Conclusion: Both for rheumatologists and patients, the top three decision-making drivers are time with optimal quality, treatment mode of administration and time to onset of action, although in different ranking order. Patients were willing to be more involved in the treatment decision-making process

Factors determining access to oral health services among children aged less than 12 years in Peru

ABSTRACT Background: Understanding problems of access to oral health services requires knowledge of factors that determine access. This study aimed to evaluate factors that determine access to oral health services among children aged <12 years in Peru between 2014 and 2015. Methods: We performed a secondary data analysis of 71,614 Peruvian children aged <12 years and their caregivers. Data were obtained from the Survey on Demography and Family Health 2014-2015 (Encuesta Demográfica y de Salud Familiar - ENDES). Children’s access to oral health services within the previous 6 months was used as the dependent variable (i.e. Yes/No), and the Andersen and col model was used to select independent variables. Predisposing (e.g., language spoken by tutor or guardian, wealth level, caregivers’ educational level, area of residence, natural region of residence, age, and sex) and enabling factors (e.g. type of health insurance) were considered. Descriptive statistics were calculated, and multivariate analysis was performed using generalized linear models (Poisson family). Results: Of all the children, 51% were males, 56% were aged <5 years, and 62.6% lived in urban areas. The most common type of health insurance was Integral Health Insurance (57.8%), and most respondents were in the first quintile of wealth (31.6%). Regarding caregivers, the most common educational level was high school (43.02%) and the most frequently spoken language was Spanish (88.4%). Univariate analysis revealed that all variables, except sex and primary educational level, were statistically significant. After adjustment, sex, area of residence, and language were insignificant, whereas the remaining variables were statistically significant. Conclusions: Wealth index, caregivers’ education level, natural region of residence, age, and type of health insurance are factors that determine access to oral health services among children aged <12 years in Peru. These factors should be considered when devising strategies to mitigate against inequities in access to oral health services

DEVELOPMENT OF A TRAINNING MODULE FOR PARALLEL ROBOTIC AND ARTIFICIAL VISION WITH A UNIVERSAL GRIPPER SYSTEM

En este artículo se presenta de forma descriptiva el desarrollo de un módulo didáctico para el estudio de la UREytica paralela y algoritmos de YLVLyn artificial. Se integro un sistema de sujeción universal para la manipulación de objetos en movimiento.También se presenta el procedimiento para la estimación de la posición de los objetos, clasificación y transporte.This paper presents in adescriptive way the develop a training module for the study of parallel robotics and artificial vision algorithms. Was integrated a universal gripper system for handling moving objects. It also shows the procedure for estimating the position of objects, classification and transport

Coaching in clinical psychology: fundamental issues of possibilities and limits

En el texto se hace un abordaje de lo que es el Coaching, de las teorías dentro de la Psicología del que se basa éste y de su aplicabilidad en la Psicología clínica. Se podría definir el Coaching como el proceso interactivo y transparente mediante el cual el Coach o entrenador y la persona o grupo implicados en dicho proceso (Coachee) buscan el camino más eficaz para alcanzar los objetivos fijados usando sus propios recursos y habilidades. Esta definición se asemeja al rol que psicólogo y cliente adoptarían en las sesiones. Por lo cual, la psicología clínica ha empezado a interesarse por el proceso de Coaching en psicoterapia cómo una herramienta más a utilizar dentro de nuestro campo. De ahí la conveniencia de elaborar un modelo de intervención integrador con la inclusión del Coaching en población clínica. El “coaching” se hace interesante para la Psicología porque es una manera de intervenir con una persona. Esta manera de intervenir, propia del “coaching”, se aplica en los contextos naturales de la persona. En estos contextos naturales es donde se desarrolla e interacciona la persona con su medio. Es decir, que este modo de actuar con las técnicas adecuadas a cada caso se podría considerar muy positivo para aquellas personas que necesiten una intervención aplicada en sus contextos naturales.In this text we talk about Coaching, how it is based on psychological theories and its applicability in clinical psychology. The Coaching could be defined as the interactive and transparent process throught which the coach is the trainer and the coachee is the person that searches the better way to find his objective using its own resources and abilities. This definition is similar to the roll that psychologist and client would adopt in the sessions. Thus, clinical psychology has begun to be interested in the process of Coaching in psychotherapy, as one tool more to use within our field. Therefore, the convenience to ellaborate a model of intervention integrates coaching in clinical Psychology population. Coaching becomes interesting for psychologists because it is a way of intervention with the person. This way of intervention, own of coaching, it is applied in natural contexts of the person. In this natural contexts it is were the person with her atmosphere is developed and interacted. Therefore, this way to act with the techniques adapted to each case, it would be considered very positive for those people that they need an intervention applied in its natural contexts.peerReviewe

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine

Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior. We provide evidence for pharmacologically significant interactions between CRF and orexin-A that depend on oligomerization of CRF1 receptor (CRF1R) and orexin OX1 receptors (OX1R). CRF1R–OX1R heteromers are the conduits of a negative crosstalk between orexin-A and CRF as demonstrated in transfected cells and rat VTA, in which they significantly modulate dendritic dopamine release. The cocaine target σ1 receptor (σ1R) also associates with the CRF1R–OX1R heteromer. Cocaine binding to the σ1R–CRF1R–OX1R complex promotes a long-term disruption of the orexin-A–CRF negative crosstalk. Through this mechanism, cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces cocaine seeking

Consideraciones para una óptima salud en el puesto de trabajo

La ergonomía desempeña un papel creciente en la solución del problema de rehabilitación de personas que en una u otra medida han perdido la capacidad de trabajo; también se estudian las aptitudes y peculiaridades psíquicas y físicas de las personas de edad avanzada y de aquellos individuos considerados como trabajadores especialmente sensibles. Por ello los principios ergonómicos se aplican para optimizar las condiciones de trabajo en relación al bienestar de la persona, su salud y su seguridad, sin olvidar la eficiencia tecnológica y económica. El abordaje de los factores de riesgo que intervienen en la producción de problemas de espalda en los profesionales, incluye al ser humano en sentido integral, desde el punto de vista físico, psicológico y social. En nuestro trabajo nos vamos a centrar en los factores físicos principalmente, destacaremos la adopción de posturas forzadas, movimientos bruscos, así como la inadecuada preparación física y el sedentarismo en una profesión sanitaria, la del técnico en transporte sanitario. Pero no debemos dejar de hacer mención de los otros puntos de vista: el estrés laboral, el apremio de tiempo, que da lugar a que se trabaje con mayor ritmo y no precisamente adoptando posiciones correctas. Aspectos relacionados con la satisfacción laboral también acentúan el estrés y la tensión muscular. La ausencia de una formación preventiva adecuada respecto a técnicas de movilización de enfermos. La falta de personal en los centros de trabajo, que implican una sobrecarga; el deficiente o nulo uso de medios mecánicos adecuadamente diseñados desde el punto de vista ergonómico.Ergonomics plays an increasing role in solving the problem of rehabilitation of people have lost the ability to work, it also examines the skills and mental and physical peculiarities of the elderly and those individuals considered workers are particularly sensitive. Therefore apply ergonomic principles to optimize the conditions of work for the welfare of the person, their health and safety, not forgetting the technological and economic efficiency. The approach of the risk factors involved in the production of back problems in the professionals, including the human being in integral sense from the standpoint of physical, psychological and social. In our work we focus mainly on physical factors, we will highlight the adoption of awkward postures, sudden movements, as well as inadequate physical fitness and physical inactivity in a health profession, the technician in health transport. But we must not fail to mention the other points of view: work stress, time pressure, which leads you to work with greater pace and not just taking proper positions. Aspects related to job satisfaction also accentuate stress and muscle tension. The absence of adequate preventive training on techniques of mobilization of patients. The lack of staff in the workplace, resulting in an overload, the poor or no use of properly designed mechanical means from the ergonomic standpoint.peerReviewe

Modelo de negocios Los Ilusionistas para incrementar la seguridad en el hogar

Las empresas de seguridad dentro de la zona metropolitana de Guadalajara ofrecen básicamente lo mismo: un contrato de servicio y la renta de equipo. En ningún caso el equipo puede ser propiedad del cliente si no se acepta primero el contrato. En el presente proyecto, se propone un servicio diferenciado en conjunto con un equipo específico que será propiedad del cliente y que cumple con las funciones esperadas. Para esto, se realizó un análisis de mercado que considera estos proveedores locales. Una vez que se concluyó con 105 entrevistas dentro del segmento al cual va dirigido el proyecto, se completó el lienzo de modelo de negocios hasta llegar a la versión final. Se identificó una propuesta de valor diferenciada con la oferta existente, la cual fue validada con la tercera versión del Producto Mínimo Viable (MVP). La propuesta de negocio del proyecto consigue en la adecuación del equipo propuesto con el fin de poder ser monitoreado bajo demanda, es decir, solo en los periodos en que son requeridos por el cliente

Creación de bancos de germoplasma o “semillas” con algas laminarias para su conservación, restauración ecológica y/o cultivo comercial

Versión del edito

Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis

[Abstract] Osteosarcoma is the most common subtype of primary bone cancer, affecting mostly adolescents. In recent years, several studies have focused on elucidating the molecular mechanisms of this sarcoma; however, its molecular etiology has still not been determined with precision. Therefore, we applied a consensus strategy with the use of several bioinformatics tools to prioritize genes involved in its pathogenesis. Subsequently, we assessed the physical interactions of the previously selected genes and applied a communality analysis to this protein–protein interaction network. The consensus strategy prioritized a total list of 553 genes. Our enrichment analysis validates several studies that describe the signaling pathways PI3K/AKT and MAPK/ERK as pathogenic. The gene ontology described TP53 as a principal signal transducer that chiefly mediates processes associated with cell cycle and DNA damage response It is interesting to note that the communality analysis clusters several members involved in metastasis events, such as MMP2 and MMP9, and genes associated with DNA repair complexes, like ATM, ATR, CHEK1, and RAD51. In this study, we have identified well-known pathogenic genes for osteosarcoma and prioritized genes that need to be further explored.Instituto Carlos III; PI17/01826Xunta de Galicia; ED431C 2018/49Xunta de Galicia; ED431G/0