29 research outputs found
The association of APOE genotype and cognitive decline in interaction with risk factors in a 65–69 year old community sample
- Author
- A Baddeley
- A Smith
- AF Jorm
- AF Jorm
- AM Saunders
- American Psychiatric Association
- Andrew J Mackinnon
- Anthony F Jorm
- BJ Small
- D Wechsler
- DC Delis
- ER Peskind
- FC Crawford
- Helen Christensen
- Holly A Mack
- JA Schneider
- JB Saunders
- JE Hixson
- JM Johnston
- Kaarin J Anstey
- Karen A Mather
- KJ Anstey
- KJ Mukamal
- L Backman
- LG Nilsson
- M Albert
- MF Folstein
- MW Bondi
- N Ertekin-Taner
- N Nathoo
- P Butterworth
- Perminder S Sachdev
- Philip J Batterham
- PM Greenwood
- PM Greenwood
- R Kumar
- R Levy
- R Mayeux
- RC Petersen
- RS Wilson
- Simon Easteal
- SM Hofer
- T Crook
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>While the evidence of an association between the apolipoprotein E (<it>APOE</it>) <it>*E4 </it>allele and Alzheimer's disease is very strong, the effect of the <it>*E4 </it>allele on cognitive decline in the general population is more equivocal. A cross-sectional study on the lifespan effects of the <it>*E4 </it>allele <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> failed to find any effect of the <it>*E4 </it>allele on cognitive performance at ages 20–24, 40–44 or 60–64 years.</p> <p>Methods</p> <p>In this four year follow-up study, we reexamine the effect of <it>*E4 </it>in the sample of 2,021 individuals, now aged 65–69 years.</p> <p>Results</p> <p>Performance on the Mini-Mental State Examination (MMSE) was significantly poorer for <it>*E4 </it>homozygotes than heterozygotes or non-carriers. The effects of the <it>*E4 </it>genotype on cognitive decline over four years were found on the MMSE and Symbol-Digit Modalities test but only when controlling for risk factors such as head injury and education. Analyses were repeated with the exclusion of participants diagnosed with a mild cognitive disorder, with little change.</p> <p>Conclusion</p> <p>It is possible that <it>*E4 </it>carriers become vulnerable to greater cognitive decline in the presence of other risk factors at 65–69 years of age.</p
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
- Clarke Judith
- Clarke Natasha
- Clarke Rebecca
- Clarke Samantha
- Clarkson Emma
- Clay Caroline
- Clayton Susan
- Clayton-Evans Lisa
- Cluckie Gillian
- Cochrane Helen
- Codd Laura
- Cohen David
- Collins Kayleigh
- Connor Lynda
- Constantin Carmen
- Cook Angela
- Cooper Martin
- Copeland Claire
- Cosier Tracey
- Courtauld Gillian
- Couser Mandy
- Coward Lucy
- Cowie Linda
- Cox Chantel
- Cox Chloe
- Cox Penelope
- Crabtree Karen
- Crawford Pam
- Crawford Susan
- Creeden Robyn
- Crisp Sarah
- Cronin Julie
- Crook Luci
- Crosbie Caroline
- Crouch Nichola
- Crown Rachel
- Crowther Hannah
- Cuddy Sarah
- Cuenoud Larissa
- Cullen Claire
- Culmsee Charlotte
- Cunningham James
- Cunningham Mishell
- Cvoro Vera
- Dacey Lynne
- Dakin Katy
- Dallol Bander
- Dangri Puneet
- Datta Prabal
- Davey Richard
- David Anette
- David Owen
- Davies Caroline
- Davies Ruth
- Davies Silvie
- Davis Fiona
- Davis Michelle
- Day Nicola
- Dayal Nilofer
- De Berker Henry
- Deary Ann
- Denic Hayley
- Dennis Martin
- Dennis Martin S
- Denniss Carol
- Devine Joseph
- Devitt Nicola
- Dewar Richard
- Dhakal Mahesh
- Dhar Saikat
- Dickinson Christina
- Dickson Christine
- Dima Sofia
- Dinsmore Lynn
- Dixon Lynn
- Dobson Tracey
- Dodd Angela
- Dodd Emily
- Doherty Mandy
- Doherty Mandy
- Donaldson Denise
- Donnelly Richard
- Doubal Fergus
- Dow Lindsey
- Downham Susan
- Doyle Clare
- Doyle Donna
- Drever Jonathan
- du Plessis Johann C
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
- Dunn Linda
- Dunne Karen
- Durairaj Ramesh
- Durman Helen
- Dutta Dipankar
- Dynan Kevin
- Edwards Mandy
- Egerton Shuna
- Eglinton Charlotte
- Eglinton Charlotte
- El Tawil Salwa
- Elfandi Khaled
- Elliot Jennifer
- Elliott Emma
- Ellis Sam
- Emberson Jonathan
- Emsley Hedley
- England Timothy
- Epstein Daniel
- Erande Renuka
- Erumere Esther
- Esisi Bernard
- Esisi Bernard
- Esson Derek
- Esson Derek
- Evans Rachel
- Evans Sue
- Eveson David
- Ewing Jordan
- Fathima Razik
- Fawcett Michelle
- Feerick Shez
- Fennelly Ruth
- Ferdinand Phillip
- Findlay Paul
- Finlay Sarah
- Finney Kay
- Fitzell Pauline
- Fitzsimmons Paul
- Fletcher Glyn
- Fletcher Jo
- Fong Rosanna
- Foot Jayne
- Foote Leanne
- Ford Gary
- Foster Eliza
- Fotherby Ken
- Fox Charlotte
- Francia Nina
- Francis Jobbin
- Fraser Ruth
- Fraser Ruth
- Fuller Tracy
- Fulton Ailsa
- Furnace Jacqueline
- Gadapa Naveen
- Gainard Glyn
- Gainsborough Nicola
- Gallagher Jill
- Gallagher Louise
- Gallifent Rachel
- Gamble Ed
- Garcia Tatiana
- Gardener Léjeune
- Garfield-Smith Joanne
- Garside Mark
- Gartrell Imogen
- Gascoyne Rachel
- Gattringer Thomas
- Gautam Nikki
- Gaylard Jane
- Gbadamoshi Lukuman
- Geraghty Olivia
- Ghaly George
- Ghatala Rita
- Ghosh Sandip
- Giallombardo Elio
- Gilham Ellie
- Gilmour Danielle
- Gilzeane Nicola
- Glass Jon
- Gleave Laura
- Glover Rachel
- Godfrey Margi
- Goff Anita
- Goorah Neetish
- Gott Valerie
- Gow Heather
- Graham Carol
- Graham Ruth
- Gray Jane
- Green Carole
- Greenwood Richard
- Gregory Bindu
- Greig Jill
- Grimwood Gemma
- Grocott Jeanette
- Grue Rebecca
- Gulliver Diane
- Guo Fenglin
- Gupwell Karin
- Guthrie Lucy Belle
- Guy Helen
- Guyler Paul
- Hague Adam
- Haider Syed
- Hairsine Brigid
- Hakim Eluzai
- Hall Andrea
- Halse Omid
- Handley Dominic
- Hann Gail
- Hannon Niamh
- Hansen Christian
- Haque Mohammad
- Hardwick Anne
- Harkness Kirsty
- Harrington Frances
- Harrington-Davies Yasmin
- Harrison Louise
- Harrison Melanie
- Harrison Thomas
- Harston George
- Harvey Kirsten
- Harvey Miriam
- Hassan Ahamad
- Hassan Hardi
- Havard Diane
- Hayes Anne
- Hayhoe Helen
- Hayman Rachel
- Hays Carole
- Hazel Beth
- Hedstrom Amanda
- Hedstrom Amanda
- Hemsley Anthony
- Henry Margo
- Herman Jane
- Hervey Simon
- Hewitt Jonathan
- Hiden Joanne
- Hogan Caroline
- Hogg Valerie
- Holden Melinda
- Holmes Clare
- Homan Jane
- Hooley Michaela
- Horan Kathleen
- Horton Sarah
- Hostettler Isabel
- Hove Dionne
- Howaniec Laura
- Howard Gabriella
- Howard Joanne
- Howard Peter
- Howcroft Deborah
- Howe Jo
- Huang Xuya
- Huggett Isabel
- Hughes Chloe
- Hughes Claire
- Hughes Tom
- Humphreys Louise
- Humphries Fiona
- Hunt Benjamin
- Hunt Nicholas
- Hunter Annemarie
- Hunter Neil
- Hurford Frances
- Hurley Jennifer
- Hussain Malik
- Hutchison Aidan
- Hyams Benjamin
- Hyatt Lisa
- Imam Javed
- Ingham Andrea
- Ingram Tanya
- Innes Karen
- Iqbal Arshi
- Iqbal Mohammad Shazad
- Irvine Janice
- Ispoglou Sissy
- Ivatts Simone
- Jackson Benjamin
- Jackson Linda
- Jagger Jenny
- Jagpal Baljit
- James Ali
- James Claire
- James Martin
- Jarapa Rowilson
- Jarrett David
- Jeffs Carol
- Jelley Benjamin
- Jenkins Colin
- Jennings-Preece Karla
- Jeyaraj Naomi
- Jha Ratneshwari
- Jinks Emma
- Johnes Mary
- Johnson Sharon
- Jones Ifan
- Jones Ifan
- Jones Kirsty
- Jones Rachael
- Jones Stephanie
- Jones Terry
- Jones Val
- Jordan Carla
- Jose Deepa
- Jose Josin
- Joshi Yogish
- Joshi Yogish
- Joyson Anu
- Jupp Becky
- Justin Frances
- Kakar Puneet
- Kalathil Latheef
- Kalladka Dheeraj
- Kamara Christine
- Kambafwile Mary
- Kane Ingrid
- Kar Arindam
- Keegan Breffni
- Keeling Elizabeth
- Keenan Samantha
- Kelavkar Shyam
- Kelly Christine
- Kelly Debs
- Kelly Jim
- Kelly Siobhan
- Keltos Marketa
- Kennedy James
- Kennedy Kate
- Kenton Antony
- Kerin Lourda
- Kerr Enda
- Kerr Gillian
- Keshvara Rekha
- Khan Mohammad
- Khan Shagufta
- Khan Usman
- Khan Uzma
- Kibutu Faith
- King Sam
- Kingwell Hayley
- Kini Manohar
- Klaasen Katrina
- Knops Kerstin
- Krishnamoorthy Shrivakumar
- Krishnamurthy Ramesh
- Krishnamurthy Vinodh
- Krishnan Kailash
- Krishnan Manju
- Krommyda Magdalini
- Kullane Sagal
- Kumar Balakrishna
- Kumar Pradeep
- Kunhunny Swapna
- Lam Man Yee
- Lambert Caroline
- Landers Geraldine
- Langhorne Peter
- Lasserson Daniel
- Latter Laura
- Law Zhe
- Lawrence Tara
- Lawson Heidi
- Leason Sandra
- Lee Stephanie
- Leggett Jacqui
- Lenti Giulia
- Lerpiniere Christine
- Lerpiniere Christine
- Licenik Radim
- Lindert Ralf
- Little Victoria
- Littleton Edward
- Ljubez Anja
- Loganathan Thayalini
- Longland Barbara
- Lopez Paula
- Lovelock Caroline
- Lowe Gordon
- Lucas Linda
- Lucas Suzanne
- Luder Robert
- Lyjko Sue
- Maanoosi Mehran
- Maatouk Ahmad
- Macaden Ashish
- MacInnes Brian
- MacLennan Beverly
- Macleod Malcolm
- MacLeod Mary
- MacLiver Linda
- MacRaild Allan
- Maddula Mohana
- Madigan Barbara
- Maguire Holly
- Maguire Stuart
- Maiden Susan
- Majis Arshad
- Majmudar Nikhil
- Makawa Linetty
- Mangion David
- Manning Lisa
- Manoj Aravind
- Mardania Rina
- Marigold James Richard
- Markova Skarlet
- Marks Katherine
- Marsden Tracy
- Marshall Sally
- Martin Irene
- Mashate Sheila
- Mason Cathy
- Mate Abhijit
- Mathieson Philip
- Matias Oliver
- Matthews Christopher
- Maund Bev
- McAlpine Christine
- McArdle Damian
- Mcauley Sean
- McCann Stephanie
- McCarron Mark
- McClelland Beverley
- McCormick Katrina
- McCormick Katrina
- McDonald Shanni
- McDonald Susan
- Mcgee Joanne
- McGhee Caroline
- McGill Connor
- McGrath Aileen
- McIlmoyle James
- McKee Jacqueline
- McLoughlin Alison
- McVerry Ferghal
- Mead Denise
- Mead Gillian
- Meir Julie
- Menon Nisha
- Mercer Lily
- Metcalf Kneale
- Miller Keniesha
- Miller Richard
- Milligan Josette
- Minks David
- Minks David P.
- Miriam Skelton
- Mistri Amit
- Mitchell Jennifer
- Mitra Dipayan
- Mitra Dipayan
- Mohammed Niaz
- Mohd Nor Azlisham
- Mokoena Betty
- Moores Andrew
- Moqsith Mohammed
- Morell Jordi
- Moreton Fiona
- Morgan Debbie
- Moroney Helen
- Morse Bethan
- Moseley Sally
- Motherwell Nichola
- Moynihan Barry
- Mpelembue Mushiya
- Mudd Paul
- Muddegowda Girish
- Muir Keith
- Mukherjee Indranil
- Murali Elodie
- Murphy Peter
- Murray Gordon D
- Musarrat Kashif
- Myint Min
- Naeem Muhammad
- Naing Zin
- Nair Anand
- Nallasivan Arumugam
- Nasar Mohammad
- Nasim Ashraf
- Naylor Charde
- Needle Ann
- Nelson Sandra
- Newby David E
- Newton Sophie
- Ng Kheng Xiong
- Ngo David
- Nguyen Vinh
- Ngwako Mmua
- Ni Hlaing
- Nicholas Paul
- Nicolson Anne
- Niranchanan Rangah
- Nisar Nabeela
- Njoku Kelechi
- Nott Claire
- Nott Claire
- Nozedar Tarn
- Nyabadza Sheila
- O'Brien Eoin
- O'Brien Richard
- O'Brien Richard
- O'Connell Susan
- O'Loughlin Victoria
- O'Reilly Joanna
- O'Toole Sarah
- OConnell Janice
- Oji Nnebuife
- Orath Prabakaran Rajalakshmi
- Orefo Chukwuka
- Orugun Enoch
- Osborn Mairead
- Osborne Emily
- Oshodi Anne
- Osman Ahmed
- Ovington Catherine
- Owings Paula
- Owoyele Emmanuelle
- Owusu-Agyei Peter
- Pai Yogish
- Palmer Jeb
- Papavasileiou Vasileios
- Parakramawansha Ruwan
- Parker Richard
- Parry Anthea
- Parry-Jones Adrian
- Pasco Kath
- Patel Bhavini
- Patel Champa
- Patel Farzana
- Patel Krishna
- Patterson Chris
- Paulton Ruth
- Pawley Corinne
- Peixoto Cassilda
- Penge Justin
- Perez Jane
- Perfitt Rebekah
- Perkins Charlotte
- Perry David
- Perry Jack
- Persad Nicola
- Peters Jenny
- Pettitt Kerry
- Phiri Duke
- Pitt-Ford Alexandra
- Pitt-Kerby Tressy
- Plewa Catherine
- Poku Philip
- Ponnambath Suheil
- Poultney Una
- Pound Susan
- Power Michael
- Pressly Vanessa
- Price Fiona
- Proeschel Harald
- Punekar Shuja
- Punter Martin
- Pusalkar Aparna
- Putterill Janet
- Quinn Leanne
- Quinn Outi
- Qureshi Sammie
- Ragab Suzanne
- Raghunathan Senthil
- Rahman Bithi
- Rai Baljinder
- Raj Sonia
- Rajapakse Anoja
- Rajkumar Chakravarthi
- Ramachandran Sankaranarayana
- Ramadan Hawraman
- Ramshaw Alex
- Rana Pratap
- Randall Marc
- Rashed Khalid
- Rashmi Sindhu
- Ravenhill Garth
- Rayessa Rayessa
- Reckless Ian
- Reddan Julie
- Reddan Julie
- Redgrave Jessica
- Redjep Ozlem
- Remegoso Alda
- Richard Bella
- Richards Emma
- Rinkel Gabriel
- Roberts Josh
- Robinson Matthew
- Robinson Naomi
- Rodgers Alicia
- Rodrigues Mark A
- Rodriguez Aryelly
- Roffe Christine
- Roffe Jack
- Roganova Tatjana
- Rogers Emily
- Rogers Gill
- Rojas Javier
- Ross Sarah
- Roughan Caroline
- Rudd Tony
- Rudenko Hannah
- Saada Janak
- Saastamoinen Kari
- Sajid Mahmud
- Sakka Eleni
- Salehin Maqsud
- Salek-Haddadi Afraim
- Salih Isam
- Sally Moore
- Sandercock Peter A G
- Sangombe Mirriam
- Sangster Graeme
- Sanyal Ranjan
- Sarah Procter
- Sarah Procter
- Sattar Naweed
- Sattar Saira
- Saulat Afaq
- Saulat Afaq
- Schofield Christine
- Schulz Ursula
- Schumacher Natasha
- Schwarz Stefan
- Seagrave Samantha
- Sekaran Lakshmanan
- Sesay Juliana
- Sethuraman Sakthivel
- Shackcloth Daniela
- Shah Alex
- Shah Sweni
- Shahmehri Shahrzad
- Sharma Nikhil
- Sharpe Simon
- Shaw Kelly Marie
- Shaw Louise
- Sheikh Saima
- Shekhar Raj
- Shelton Faye
- Shinh Naval
- Shread Ian
- Shukla Avani
- Siddegowda Prasad
- Siddiq Muhammad
- Siddiqui Amber
- Siddiqui Anwer
- Sigsworth Andrew
- Simon Rohan
- Sims Don
- Singh Arun
- Sinha Devesh
- Skinner Helen
- Slade Peter
- Smart Amanda
- Smith Andrew
- Smith Fiona
- Smith Gemma Marie
- Smith Simon
- Smith Wilma
- Smyth Nigel
- Spencer Jayne
- Sprigg Nikola
- Sprigg Nikola
- Srinivasan Meena
- Stafford Samantha
- Stafford Samantha
- Stanners Andrew
- Steele Amy
- Stephen Jacqueline
- Stephens Claire
- Stevens Angela
- Stevens Stephanie
- Stevenson Sarah
- Stewart Kelvin
- Stocks Kathy
- Stone Andrew
- Storton Sharon
- Strain David
- Subramonian Santhosh
- Sudlow Cathie
- Sudlow Cathie L M
- Sukdeo Varthi
- Sullivan Frank
- Sultan Sulaiman
- Suttling Anne
- Sutton Claire
- Sutton Patrick
- Sutton Victoria
- Sword Jane
- Sykes Lucy
- Symonds Stuart
- Szabo Susan
- Tallantyre Emma
- Tanate Alfonso
- Tandy Jane
- Tate Margaret
- Tauro Suzanne
- Tayler Michelle
- Taylor Pat
- Taylor Vicky
- Teal Rachel
- Temple Natalie
- Thant Hlaing
- Thavanesan Kamy
- Thomas Isobel
- Thomas Kelly
- Thomas Philip
- Thomas Sarah
- Thompson Philip
- Thompson Susan
- Thompson Teresa
- Thompson-Jones Helen
- Thomson Audrey
- Thornthwaite Sarah
- Thorpe Kevin
- Tilley Victoria
- Tiwari Divya
- Tomlin Dawn
- Tomlinson Benjamin
- Treadwell Shelley
- Tribbeck Michele
- Trippier Sarah
- Triscott Claire
- Triscott Claire
- Tryambake Dinesh
- Tucker Laura
- Tucker Susan
- Turfrey Jennifer
- Tysoe Sharon
- Ullah Khalil
- Valentine Stacey
- van Someren Chloe
- Varquez Resti
- Vasileiadis Evangelos
- Vassallo Joseph
- Venter Marius
- Veraque Emelda
- Verrion Anna
- Vettimootal Johnson Venetia
- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
- Walker Pauli
- Walker Susannah
- Wallace Aine
- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw Joanna M
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- Author
- Akilesh Shreeram
- Bakker Stephan J. L.
- Bansal Nisha
- Baptista Daniela
- Biggs Mary L.
- Bochud Murielle
- Boerwinkle Eric
- Brenner Hermann
- Burkhardt Ralph
- Butterworth Adam S.
- Böger Carsten A.
- Carroll Robert J.
- Chai Jin-Fang
- Chee Miao-Li
- Chee Miao-Ling
- Chen Mengmeng
- Cheng Ching-Yu
- Chu Audrey Y.
- Cocca Massimiliano
- Connell Jeffrey O’
- Cook James P.
- Coresh Josef
- Corre Tanguy
- Danesh John
- de Borst Martin H.
- De Grandi Alessandro
- de Mutsert Renée
- de Vries Aiko P. J.
- Degenhardt Frauke
- Devuyst Olivier
- Dittrich Katalin
- Divers Jasmin
- Eckardt Kai-Uwe
- Edwards Todd L.
- Ehret Georg
- Endlich Karlhans
- Feitosa Mary F.
- Felix Janine F.
- Foo Valencia Hui Xian
- Franco Oscar H.
- Franke Andre
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Gansevoort Ron T.
- Gerstner Lea
- Ghasemi Sahar
- Giedraitis Vilmantas
- Giri Ayush
- Gorski Mathias
- Grundner-Culemann Franziska
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Gögele Martin
- Hamet Pavel
- Harris Tamara B.
- Heid Iris M.
- Hermle Tobias
- Hicks Andrew A.
- Ho Kevin
- Holm Hilma
- Hoppmann Anselm
- Horn Katrin
- Hung Adriana M.
- Hwang Shih-Jen
- Ikram M. Arfan
- Ingelsson Erik
- Jaddoe Vincent W. V.
- Jakobsdottir Johanna
- Josyula Navya Shilpa
- Jung Bettina
- Khor Chiea-Chuen
- Kiess Wieland
- Kirsten Holger
- Koenig Wolfgang
- Kovacs Peter
- Kramer Holly
- Kronenberg Florian
- Krämer Bernhard K.
- Kähönen Mika
- Körner Antje
- Köttgen Anna
- Lange Leslie A.
- Langefeld Carl D.
- Lee Jeannette Jen-Mai
- Lehtimäki Terho
- Li Man
- Li Yong
- Lieb Wolfgang
- Lim Su-Chi
- Lind Lars
- Lindgren Cecilia M.
- Liu Jianjun
- Loeffler Markus
- Lyytikäinen Leo-Pekka
- Mahajan Anubha
- Maranville Joseph C.
- Marten Jonathan
- Mascalzoni Deborah
- McMullen Barbara
- Meisinger Christa
- Meitinger Thomas
- Miliku Kozeta
- Mook-Kanamori Dennis O.
- Morris Andrew P.
- Mychaleckyj Josyf C.
- Müller-Nurasyid Martina
- Nauck Matthias
- Nikus Kjell
- Ning Boting
- Noce Damia
- Noordam Raymond
- Nutile Teresa
- Olafsson Isleifur
- Palmer Nicholette D.
- Parsa Afshin
- Pattaro Cristian
- Pendergrass Sarah A.
- Peters Annette
- Podgornaia Anna I.
- Ponte Belen
- Poulain Tanja
- Pramstaller Peter P.
- Prins Bram P.
- Psaty Bruce M.
- Qiu Chengxiang
- Rabelink Ton J.
- Raffield Laura M.
- Reilly Dermot F.
- Rettig Rainer
- Rheinberger Myriam
- Rice Kenneth M.
- Rivadeneira Fernando
- Rotter Jerome I.
- Runz Heiko
- Ryan Kathleen A.
- Sabanayagam Charumathi
- Saum Kai-Uwe
- Scholz Markus
- Schöttker Ben
- Sedaghat Sanaz
- Shaffer Christian M.
- Shi Yuan
- Sieber Karsten B.
- Smith Albert V.
- Snieder Harold
- Stefansson Kari
- Strauch Konstantin
- Stumvoll Michael
- Sun Benjamin B.
- Susztak Katalin
- Sveinbjornsson Gardar
- Szymczak Silke
- Tai E-Shyong
- Tan Nicholas Y. Q.
- Taylor Kent D.
- Tayo Bamidele O.
- Teren Andrej
- Teumer Alexander
- Tham Yih-Chung
- Thiery Joachim
- Thio Chris H. L.
- Thomsen Hauke
- Thorsteinsdottir Unnur
- Tin Adrienne
- Tremblay Johanne
- Tönjes Anke
- Uitterlinden André G.
- van der Harst Pim
- van der Most Peter J.
- Verweij Niek
- Vogelezang Suzanne
- Völker Uwe
- Waldenberger Melanie
- Wang Chaolong
- Wang Lihua
- Wilson James G.
- Wilson Otis D.
- Wong Charlene
- Wong Tien-Yin
- Wuttke Matthias
- Xu Yizhe
- Yang Qiong
- Yasuda Masayuki
- Yu Zhi
- Ärnlöv Johan
- Publication venue
- Nature Communications
- Publication date
- 01/01/2019
- Field of study
Abstract: Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria
A horizon scan of global biological conservation issues for 2024
- Author
- Bennett Craig
- Brotherton Peter N.M.
- Butchart Stuart H.M.
- Butterworth Holly M.
- Clarke Stewart J.
- Esmail Nafeesa
- Fleishman Erica
- Gaston Kevin J.
- Herbert-Read James E.
- Hughes Alice C.
- James Jennifer
- Kaartokallio Hermanni
- Le Roux Xavier
- Lickorish Fiona A.
- Newport Sarah
- Palardy James E.
- Pearce-Higgins James W.
- Peck Lloyd S.
- Pettorelli Nathalie
- Primack Richard B.
- Primack Willow E.
- Schloss Irene R.
- Spalding Mark D.
- Sutherland William J.
- ten Brink Dirk
- Tew Eleanor
- Thornton Ann
- Timoshyna Anastasiya
- Tubbs Nicolas
- Watson James E.M.
- Wentworth Jonathan
- Wilson Jeremy D.
- Publication venue
- Cell Press/Elsevier
- Publication date
- 01/01/2024
- Field of study
We present the results of our 15th horizon scan of novel issues that could influence biological conservation in the future. From an initial list of 96 issues, our international panel of scientists and practitioners identified 15 that we consider important for societies worldwide to track and potentially respond to. Issues are novel within conservation or represent a substantial positive or negative step-change with global or regional extents. For example, new sources of hydrogen fuel and changes in deep-sea currents may have profound impacts on marine and terrestrial ecosystems. Technological advances that may be positive include benchtop DNA printers and the industrialisation of approaches that can create high-protein food from air, potentially reducing the pressure on land for food production
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
- Angelis Fragkiskos
- Angeslis Fragkiskos
- Aqeel Syed Talha Bin
- Aral Canan
- Arebi Jaber
- Arnaoutoglou Eleni
- Arslangilay Mert
- Arvanitaki Alexandra
- Asadyari-Lupo Shadie
- Ashar Nur Ayuni Khirul
- Ashour Amira
- Ashraf Hamza
- Ashur Abir Ben
- Asjad Imran
- Askar Aamal
- Askin Abdullah Emre
- Aslam Muhammad Nadeem
- Aslan Merve
- Aslangilay Mert
- Astal Mohammed
- Asudo Felicia
- Atadag Yildiz Buyukdereli
- Atef Dina
- Athamneh Tayseer
- Athanasiadis Apostolos
- Ather M Hammad
- Atherton Kristy
- Atia Ahmed
- Atici Semra Demirli
- Atilhan Ridvan
- Atim Terkaa
- Atiq Tabish
- Atta Raneem
- Attia Mohamed
- Attiya Omar
- Awad Hasan
- Awadallah Safaa
- Awoyinka Babatunde
- Ayasrah Salem
- Aydin Cemil
- Aydoğdu Erhan Onur
- Ayogu Emeka
- Ayoub Kerillos
- Ayyad Alaa
- Azboy Ibrahim
- Azer Armia
- Azhari Malaz
- Aziz Aliya Begum
- Babalola Olakunle
- Babar Daniyal
- Babekir Enas Mohammedtom Abdulhameed
- Babiker Afra
- Bacariza Loreto
- Baccar Marwen
- Badawy Asmaa
- Badi Hussameddin
- Badr Karim
- Badri Danniel
- Bagazi Doaa
- Bailey Ashley
- Bakare Adewumi
- Bakari Maisaratu A
- Bakeer Hibah Bileid
- Bakeer Mohammed
- Balciscueta Zutoia
- Ballah Shirahn
- Balogh Zsolt
- Baltacı Zeynep Hazal
- Banaga Essam Eldien Abuobaida
- Banerjee Arnab
- Banihani Farah
- Barbara Silvia Jasmine
- Barbaro Antonio
- Bareka Metaxia
- Bariun Yara
- Barka Sharf
- Barker John
- Barker Sally
- Barsoum Fady
- Basam Aya
- Basam Aya
- Bassam Ahmad
- Bassey Asi-oqua
- Bataineh Saad
- Bature Stephen Bodam
- Bayram Cigdem
- Baysallar Duygu
- Baziotis-Kalfas Kristian
- Beatson Nicholas
- Bei Michael
- Bektas Sebnem
- Bell David
- Benamor Oumayma
- Benek Duygu Ece
- Benham Emily
- Benismai Israa
- Bensalem Marya
- Bensalem Serien Hossain
- Benyani Simran Vinod
- Bernabei Massimiliano
- Betts Aisling
- Bezweek Adel
- Bhikha Jainey
- Bindra Randipsingh
- Binnawara Muhannud
- Bird Katie
- Bisgin Tayfun
- Bitsianis Stefanos
- Blake Jessica
- Bland Laura
- Blassey Aneel
- Blundell Jian
- Bobba Sriya
- Bockxmeer John Van
- Bolam Scott Matthew
- Bolton Damien
- Bosi Simone
- Bouaoud Souad
- Bouchenak Kamel
- Boussahel Ikram Fatima Zohra
- Bowman Sarah
- Boyd Theresa
- Boyes Hamish
- Boyley Jessica
- Bozhko Maxim
- Bozkir Haktan Ovul
- Bozkurt Mehmet Abdussamet
- Bresadola Vittorio
- Brewster Dani
- Brooke Kenya
- Brown Georgia
- Brown Matthew
- Buari Taiwo
- Buhavac Milos
- Bunjo Zachary
- Burrows Emalee
- Burruso Luca
- Busaidi Ibrahim S Al
- Bushaala Hassan
- Butterworth Yasmine
- Butyrskii Aleksandr
- Cabalag Carlos
- Cade Richard
- Cakcak Ibrahim Ethem
- Cakir Niyazi
- Calini Giacomo
- Calini Giacomo
- Camkıran Elifsu
- Canavese Anna
- Candan Mert
- Canny Mitch
- Canton Joshua
- Capar Mehmet Ali
- Cardelli Stefano
- Carlos Angela
- Carnuccio Emma
- Carre Xenia
- Casciola Francesca
- Castagnini Francesco
- Catalioto Caterina
- Cepe Hale
- Cerinic Pietro Matucci
- Certel Alperen Taha
- Cetınkaya Zeynep Sahan
- Chakroun Sawssen
- Chambers Jessica
- Champipis Apostolos
- Chan Alex
- Chan Ashley
- Chan Juliet
- Chan Justin
- Chan Nicholas
- Chand Namisha
- Chandiok Karan
- Chandler Callum
- Chandra Pooja
- Chang Jared
- Chang Kelvin
- Changati Varun
- Chao Phoebe
- Chau Michelle
- Chau Michelle
- Chauhan Karanjeet
- Chawla Tabish
- Chen Andrew
- Chen Brian
- Chen Paul
- Chen Yan
- Chene Danielle
- Cheng Felicity
- Cheng Felicity
- Cheung Aiden
- Cheung King Tung
- Chiappe Caterina
- Chidambaram Seevakan
- Chilaka Lalitya
- Chlebicka Tara
- Choi Colin Chan-Min
- Choi Horim
- Choong Zhi Shyuan
- Chou Justin
- Chowdhury Nebula
- Chowdhury Sharfuddin
- Chua Alan
- Chua Alyssa
- Chua Anne Qi
- Chua Matthew
- Chye David
- Cianci Pasquale
- Ciranni Dominico
- Clair Sophie St
- Clanfield Matthew
- Clarnette Nick
- Clemente-Navarro Pablo
- Cobden Andrew
- Colaco Ashley
- Collins A-J
- Collins Josh
- Conlon Niamh
- Conversano Ivana
- Cook Holly
- Coomber Grace
- Copertino Nicolas
- Cordingley Timothy
- Cornwell Charlotte
- Cornwell Charlotte
- Corrigan Angela
- Cover Jacinta
- Craig-Lucas Alayna
- Crossman Mason
- Crostella
- Crotty Anna
- Cuneo Beatriz
- Currie William
- Cuthbert Mitchell
- Cyr Kathryn
- Çolak Eli ̇f
- Dabas Ayman Arhuma
- Dagklis Themistoklis
- Dagsali Alara Ece
- Dahshan Shaimaa
- Dajti Gerti
- Dang Jennifer
- Das Ankita
- Das Ankita
- Daud Mohamed Ashraf Mohamed
- Daudu Davina
- Davies Lily
- Dawod Nimatee
- Dawood Ali
- Dawson Abby
- Dawson Amanda
- Dawson Amanda
- Deafallah Asmaa
- Demirkiran Mehmet Ali
- Denby Hannah
- Dennaoui Rami
- Derwish Khawla
- Dharmaratne Isini
- Diab Menna
- Dimofte Mihail Gabriel
- Dindar Arzu
- Ding George
- Divekar Tanya
- Divinagracia Janelle
- Dogan Tugce
- Domenech Julio
- Donaldson Olivia
- Dong Isabella
- Dong Jason
- Donia Mohamed
- Dorovinis Panagiotis
- Douglas Rebecca Indiana
- Doulami Georgia
- Dowdle Benjamin
- Duart Mireia
- Dudi-Venkata Nagendra
- Duffield Jaime
- Durdu Beyza
- Durmus Elif
- Düzyol Zeynep
- Dzator Stephen
- Ebrahim Alshymaa
- Edwards Elton
- Edwards Liam
- Edwards Liam
- Egerton James
- Egzait Raneem
- Eid Ahmed
- Eismontas Vitalijus
- Ejaz Adya
- Ejembi Peter
- Ekwebelam Jennifer
- El-Masry Mariam
- el-mola Amira Gad
- El-Sakka Ahmed
- El-Taher Ahmed Kamal
- Elaagib Amna
- Eldaim Khalid Nour
- Eldarat Tarik Ahmed
- Eldomiaty Donia
- Elessi Khamis
- Elewa Ahmed
- Elfadli Mustafa
- Elfallah Sara
- Elfeki Hossam
- Elferis Donia
- Elgadi Tahani
- Elghamry Ahmed
- Elgharib Asmaa Moatasem
- Elghazy Mohamed Abdelaziz
- Elgherwi Laila
- Elghoul Youssef
- Elgindy Yara
- Elhadi Muhammed
- Elhadi Muhammed
- Elhadi Muhammed
- Elhadi Rawan Elnoman Hamadelniel
- Elhassan Baraa
- Elia Michael
- Elieyioğlu Güşta
- Elizabeth
- Elkenawi Karim
- Elkharaz Omar A
- Elkheshebi Ahlam
- Elkhodary Ahmed
- Ellepola Hasthika
- Ellilly Ahmed
- Elmaghrabey Abdallah
- Elmehdawi Haitham
- Elmubark Abdelhadi
- Elnagar Rahma
- Elporgay Aya
- Elreaid Fadwa
- Elreaid Fatma Fathi
- Elrishi Fatheia
- Elsaied Mostafa
- Elsawy Amr
- Eltaib Ibrahim
- Eltayeb Mohammed Omer Mohammed
- Elyan Basel
- Elzoubia Joma
- Emad Humam
- Emam Asmaa
- Emhimmed David
- Enaami Husam
- English Tessa
- Eniola Bolarinwa
- Erginoz Ergin
- Esaiti Salma
- Esho Adriana
- Evans Natalie
- Ezeoke Grace
- Fabbri Nicolò
- fadalah Bader Abo
- Fadlalmola Hammad
- Faisal Arwa
- Fang Carol
- Farag Abdelrahman
- Fares Gamal Elsayed
- Faris Farah
- Fariyike Bunmi
- Farre Joan
- Farrell Michael
- Farrell Michael
- Fasiku Olushola
- Fatima Aleeza
- Fearnley-Fitzgerald Chekodi
- Febre Jorge
- Feierdaiweisi Xireaili
- Feo Carlo V
- Fergar Cem
- Ferguson Liam
- Ferguson Neil
- Fernando Isuru
- Figgitt Ethan
- Filikus Abraham L
- Flame Aki
- Fletcher Joseph
- Flintoft Sean
- Flores-González Ana Karina
- Fong Bryan
- Fong Hakim
- Fong Pei Jun
- Foo Jonathon
- Forbes Clara
- Forsythe Jack
- Fotheringham Penelope
- Fouda Mohamed Fayez
- Fradelos Evangelos
- Franks Angus
- Fraser Calvin
- Frost Taylor
- Fu Jeff
- Fu Yangzirui
- Fuentes Stephie Oyervides
- Fufore Mohammed Bello
- Fujihara Asuka
- Fung James
- Furey Joseph
- Gaafar Mohammed
- Gaarour Osama Samir
- Gaborit Lorane
- Gaborit Lorane
- Gahwagi Milad
- Galal Adham
- Galal-Eldin Sami
- Gallert Kayla
- Gamage Tharushi
- Gan Christine
- Gan Kathy
- Gan Siang Wei
- Gara Mouna
- Garba Mohammad Albuhari
- Garcia Sara
- García Patricia Ludivina González
- Garton Briar
- Garza Alejandro Quiroga
- Garza Francisco Javier Arrambide
- Gattesco Davide
- Gattulli Domenico
- Gebeh Alpha
- Gecici Mehmet Emre
- Gemici Aylin
- Geng Ruxi
- Gentle Juliette
- George Akhita
- George Ria
- Gera Sahil
- Gernhoefer Erin
- Ghaly Moheb
- Ghandi Kushan
- Ghanem Sohila
- Ghemmied Malak
- Ghmagh Rawia
- Ghmagh Reem
- Giannakopoulos Konstantinos S
- Gidiem Doaa
- Gill Sonia
- Gilmore Paul
- Gineeb Hana Yousef
- Giurgius Mary
- Giuzzardi Giulia
- Glyn Tamara
- Glynatsis John
- Glynatsis John
- Goddard Kim
- Goh Sarah
- Goh Sarah
- Goh Sarah
- Gojnich Amy
- Golani Shalni
- Goldfinch Elisabeth
- Goldsmith Oliver
- Golja Damian
- Goonawardena Janindu
- Gopal Hemashree
- Gorgone Mara
- Gould Madeline
- Gover Tolga
- Grada Maren
- Grandi Alyssia De
- Graziadei Vivien
- Green Jemma
- Greenwood Emily
- Greig Hannah
- Grillea Giorgia
- Groot Julia De
- Gross Hannah
- Guerra Ethel Valeria Orta
- Guerra-Juárez Yesika Alejandra
- Guizzardi Giulia
- Gunasekara Aashrinee De Silva Abeweera
- Gundara Justin
- Guner Ali
- Gunn Emma
- Guo Oscar
- Gündoğdu Adnan
- Gweder Rima
- Gyftopoulos Argyrios
- Hadi Arwa
- Hadi Arwa
- Haege Emma
- Haggag Zeyad
- Hakak Fatima
- Halawa Mohamed
- Hamad Huda
- Hamdy Ahmed
- Hamdy Omar
- Hamer Peter
- Hamid Hytham K S
- Hammouri Ibraheem
- Hamoda Esraa
- hamoud Mohammad Al
- Hamza Alla Aldeen
- Hana Kerolous
- Hanan Aishath
- Hantes Michael
- Harb Fatma
- Hardidge Andrew
- Hares Mohamed M
- Hariharan Shubhang
- Harmston Christopher
- Haroon Ola
- Harris Alasdair
- Harrison Ella
- Hasan Najat Ben
- Hashem Ahmed Mohamed
- Hashem Boshra
- Hassan Majd
- Hassan Mohamed
- Hassan Muaz
- Hassan Shimaa Abbas
- Hassan Suhaib
- Hassan Tawfieg
- Hassan Yusuf
- Hassanein Mahmoud
- Hau Yin Chi Hebe
- Hauptman Samantha
- Hauptman Samantha
- Haximolla Hodo
- Hazaymeh Omar
- Healy Tom
- Heaney Emily
- Heard Matthew
- Hegazy Dana
- Heigan Rachael
- Hemaida Tarek
- Hendawy Hamdy
- Henes Kerollos
- Hernandez Gilmer Omar Perez
- Hewton Lewis
- Hezam Abdulhakim
- Hilail Ihab Abu
- Hilal Nadir
- Hilder Amie
- Hilder Amie
- Hill Terrence
- Ho Annie
- Ho Jess
- Ho Jess
- Hobbs Katie
- Hodgson Russell
- Hogan Lucinda
- Hokelekli Furkan
- Hong Jonathan
- Honore Elodie
- Hoosenally Mariyah
- Hopping Eve
- Horsburgh Eleanor
- Hou Lachlan
- Hou Zhen
- House Colin
- How Ming Zhou
- Hsieh Justin
- Hu Nelson
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- Hussien Aya
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- Ibiyemi Femi
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- Ifoto Oghenekaro
- Iftikhar Hareem
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- Jaffry Kumail
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- Jamil Muhammad Badrul Hisyam Mohamad
- Jangam Aishwarya
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- Jeffery Fraser
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- Ramlee Afiq Aizat
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- Rashed Osama Fathy Ali Ali
- Rasheed Ayat
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- Rasslan Esraa
- Rathnayake Athulya
- Ratnayake Milidu
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- Raubenheimer Kyle
- Raubenheimer Kyle
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- Rauf Abdul
- Ravi Anjana
- Rawal Alisha
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- Rusli Siti Mayuha
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- Saad Mahmoud M
- Saada Hind
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- Sabry Ahmed Abdelfatah
- Sabuncu Kubilay
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- Salawu Adedayo
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- Salih Alaa A
- Salihu Makama Baje
- Sallam Abdelaziz
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- Saraçoğlu Ayten
- Sarafi Aikaterini
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- Sawaftah Khaled
- Sayed Ahmed M
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- Saylar Alparslan
- Saylar Alparslan
- Sánchez Luis Antonio Heredia
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- Segaran Sharrada
- Seldon Alexandra
- Selim Kamar
- Selim Osama
- Seneviratne Dharani
- Sengupta Shomik
- Senthilrajan Rahavi
- Seow Warren
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- Tariq
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- Tasi Zoya
- Taşcı Muhammed Enes
- Taufiq Maliha
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- Tsakiridis Ioannis
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- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
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- Ugool Mahmoud
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- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
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- Vanguardia Maria Kristina
- Vanzuylekom Katie
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- Velenciuc Natalia
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- Vidanagama Sasini
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- Vu Jennifer
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- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- Author
- Akilesh S. (Shreeram)
- Bakker S.J.L. (Stephan)
- Bansal N. (Nisha)
- Baptista D. (Daniela)
- Biggs M.L. (M.)
- Bochud M. (Murielle)
- Boerwinkle E.A. (Eric)
- Brenner H. (Hermann)
- Burkhardt R. (Ralph)
- Butterworth A.S. (Adam S.)
- Böger C.A. (Carsten)
- Carroll R.J. (Robert J.)
- Chai J.-F. (Jin-Fang)
- Chee M.-L. (Miao-Li)
- Chee M.-L. (Miao-Ling)
- Chen M. (Mengmeng)
- Cheng C.-Y. (Ching-Yu)
- Chu A.Y. (Audrey Y)
- Cocca M. (Massimiliano)
- Connell J.O. (Jeffrey O')
- Cook J.P. (James P.)
- Coresh J. (Josef)
- Corre T. (Tanguy)
- Danesh J. (John)
- de Borst M.H. (Martin H.)
- de Vries A.P.J. (Aiko P J)
- Degenhardt F. (Frauke)
- Devuyst O. (Olivier)
- Dittrich K. (Katalin)
- Divers J. (Jasmin)
- Eckardt K.-U. (Kai-Uwe)
- Edwards T.L. (Todd L.)
- Ehret G.B. (Georg)
- Endlich K. (Karlhans)
- Feitosa M.F. (Mary Furlan)
- Felix J.F. (Janine)
- Foo V.H.X. (Valencia Hui Xian)
- Franco O.H. (Oscar)
- Franke A. (Andre)
- Freedman B.I. (Barry)
- Freitag-Wolf S. (Sandra)
- Fuchsberger C. (Christian)
- Gansevoort R.T. (Ron)
- Gerstner L. (Lea)
- Ghasemi S. (Sahar)
- Giedraitis V. (Vilmantas)
- Giri A. (Ayush)
- Gorski M. (Mathias)
- Grandi A. (Alessandro) de
- Grundner-Culemann F. (Franziska)
- Gudbjartsson D.F. (Daniel)
- Gudnason V. (Vilmundur)
- Gögele M. (Martin)
- Hamet P. (Pavel)
- Harris T.B. (Tamara)
- Harst P. (Pim) van der
- Heid I.M. (Iris)
- Hermle T. (Tobias)
- Hicks A.A. (Andrew A.)
- Ho K. (Kevin)
- Holm H. (Hilma)
- Hoppmann A. (Anselm)
- Horn K. (Katrin)
- Hung A.M. (Adriana M.)
- Hwang S.-J. (Shih-Jen)
- Ikram M.A. (Arfan)
- Ingelsson E. (Erik)
- Jaddoe V.W.V. (Vincent)
- Jakobsdottir M. (Margret)
- Josyula N.S. (Navya Shilpa)
- Jung B. (Bettina)
- Kao W.H.L. (Wen)
- Khor C.C.
- Kieß W. (Wieland)
- Kirsten H. (Holger)
- Koenig W. (Wolfgang)
- Kovacs P. (Peter)
- Kramer H. (Holly)
- Kronenberg F. (Florian)
- Krämer B.K. (Bernhard)
- Kähönen M. (Mika)
- Körner A. (Antje)
- Köttgen A. (Anna)
- Lange L.A. (Leslie)
- Langefeld C.D. (Carl)
- Lee J.J.-M. (Jeannette Jen-Mai)
- Lehtimäki T. (Terho)
- Li M. (Man)
- Li Y. (Yong)
- Lieb W. (Wolfgang)
- Lim S.-C. (Su-Chi)
- Lindgren C.M. (Cecilia M.)
- Liu J. (Jianjun)
- Loeffler M. (Markus)
- Lyytikäinen L.-P. (Leo-Pekka)
- Mahajan A. (Anubha)
- Maranville J.C. (Joseph C.)
- Marten J. (Jonathan)
- Mascalzoni D. (Deborah)
- McMullen B. (Barbara)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Miliku K. (Kozeta)
- Mook-Kanamori D.O. (Dennis O.)
- Morris A.P. (Andrew)
- Most P.J. (Peter) van der
- Mutsert R. (Reneé) de
- Mychaleckyj J.C. (Josyf)
- Müller-Nurasyid M. (Martina)
- Nauck M. (Matthias)
- Nikus K. (Kjell)
- Ning B. (Boting)
- Noce D. (Damia)
- Noordam R. (Raymond)
- Nutile T. (Teresa)
- Olafsson I. (Isleifur)
- Palmer N.D. (Nicholette)
- Parsa A. (Afshin)
- Pendergrass S.A. (Sarah)
- Penninx B.W.J.H.
- Peters A. (Annette)
- Podgornaia A.I. (Anna I.)
- Ponte B. (Belen)
- Poulain T. (Tanja)
- Pramstaller P.P. (Peter Paul)
- Prins B.P. (Bram Peter)
- Psaty B.M. (Bruce)
- Qiu C. (Chengxiang)
- Rabelink T. (Ton)
- Raffield L.M. (Laura M.)
- Reilly D.F. (Dermot F.)
- Rettig R. (Rainer)
- Rheinberger M. (Myriam)
- Rice K.M. (Kenneth)
- Rivadeneira F. (Fernando)
- Rotter J.I. (Jerome I.)
- Runz H. (Heiko)
- Ryan K.A. (Kathleen A.)
- Sabanayagam C. (Charumathi)
- Saum K.-U. (Kai-Uwe)
- Scholz M. (Markus)
- Schöttker B. (Ben)
- Sedaghat S. (Sanaz)
- Shaffer C.M. (Christian M.)
- Shi Y. (Yuan)
- Sieber K.B. (Karsten B.)
- Smith A.V. (Albert)
- Snieder H. (Harold)
- Strauch K. (Konstantin)
- Stumvoll M. (Michael)
- Sun B.B. (Benjamin B.)
- Susztak K. (Katalin)
- Sveinbjornsson G. (Gardar)
- Szymczak S. (Silke)
- Tai E.-S. (E-Shyong)
- Tan N.Y.Q. (Nicholas Y Q)
- Taylor K.D. (Kent)
- Tayo B. (Bamidele)
- Teren A. (Andrej)
- Teumer A. (Alexander)
- Tham Y.-C. (Yih-Chung)
- Thiery J. (Joachim)
- Thio C.H.L. (Chris H L)
- Thomsen H. (Hauke)
- Thorsteinsdottir U. (Unnur)
- Tin A. (Adrienne)
- Tremblay J. (Johanne)
- Tönjes A. (Anke)
- Uitterlinden A.G. (André)
- Verweij N. (Niek)
- Vogelezang S.
- Völker U. (Uwe)
- Waldenberger M. (Melanie)
- Wang C. (Chunliang)
- Wang L. (Lihua)
- Wilson J.F. (James)
- Wilson O.D. (Otis D.)
- Wong C. (Charlene)
- Wong T.-Y. (Tien-Yin)
- Wuttke M. (Matthias)
- Xu Y. (Yizhe)
- Yang Q. (Qiong)
- Yasuda M. (Masayuki)
- Yu Z. (Zhi)
- Zwart J-A. (John-Anker)
- Ärnlöv J. (Johan)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 11/09/2019
- Field of study
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- Author
- Akilesh Shreeram
- Bakker Stephan J.L.
- Bansal Nisha
- Baptista Daniela
- Biggs Mary L.
- Bochud Murielle
- Boerwinkle Eric
- Brenner Hermann
- Burkhardt Ralph
- Butterworth Adam S.
- Böger Carsten A.
- Carroll Robert J.
- Chai Jin Fang
- Chee Miao Li
- Chee Miao Ling
- Chen Mengmeng
- Cheng Ching Yu
- Chu Audrey Y.
- Cocca Massimiliano
- Connell Jeffrey O’
- Cook James P.
- Coresh Josef
- Corre Tanguy
- Danesh John
- de Borst Martin H.
- De Grandi Alessandro
- de Mutsert Renée
- de Vries Aiko P.J.
- Degenhardt Frauke
- Devuyst Olivier
- Dittrich Katalin
- Divers Jasmin
- Eckardt Kai Uwe
- Edwards Todd L.
- Ehret Georg
- Endlich Karlhans
- Feitosa Mary F.
- Felix Janine F.
- Foo Valencia Hui Xian
- Franco Oscar H.
- Franke Andre
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Gansevoort Ron T.
- Gerstner Lea
- Ghasemi Sahar
- Giedraitis Vilmantas
- Giri Ayush
- Gorski Mathias
- Grundner-Culemann Franziska
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Gögele Martin
- Hamet Pavel
- Harris Tamara B.
- Heid Iris M.
- Hermle Tobias
- Hicks Andrew A.
- Ho Kevin
- Holm Hilma
- Hoppmann Anselm
- Horn Katrin
- Hung Adriana M.
- Hwang Shih Jen
- Ikram M. Arfan
- Ingelsson Erik
- Jaddoe Vincent W.V.
- Jakobsdottir Johanna
- Josyula Navya Shilpa
- Jung Bettina
- Khor Chiea Chuen
- Kiess Wieland
- Kirsten Holger
- Koenig Wolfgang
- Kovacs Peter
- Kramer Holly
- Kronenberg Florian
- Krämer Bernhard K.
- Kähönen Mika
- Körner Antje
- Köttgen Anna
- Lange Leslie A.
- Langefeld Carl D.
- Lee Jeannette Jen Mai
- Lehtimäki Terho
- Li Man
- Li Yong
- Lieb Wolfgang
- Lim Su Chi
- Lind Lars
- Lindgren Cecilia M.
- Liu Jianjun
- Loeffler Markus
- Lyytikäinen Leo Pekka
- Mahajan Anubha
- Maranville Joseph C.
- Marten Jonathan
- Mascalzoni Deborah
- McMullen Barbara
- Meisinger Christa
- Meitinger Thomas
- Miliku Kozeta
- Mook-Kanamori Dennis O.
- Morris Andrew P.
- Mychaleckyj Josyf C.
- Müller-Nurasyid Martina
- Nauck Matthias
- Nikus Kjell
- Ning Boting
- Noce Damia
- Noordam Raymond
- Nutile Teresa
- Olafsson Isleifur
- Palmer Nicholette D.
- Parsa Afshin
- Pattaro Cristian
- Pendergrass Sarah A.
- Peters Annette
- Podgornaia Anna I.
- Ponte Belen
- Poulain Tanja
- Pramstaller Peter P.
- Prins Bram P.
- Psaty Bruce M.
- Qiu Chengxiang
- Rabelink Ton J.
- Raffield Laura M.
- Reilly Dermot F.
- Rettig Rainer
- Rheinberger Myriam
- Rice Kenneth M.
- Rivadeneira Fernando
- Rotter Jerome I.
- Runz Heiko
- Ryan Kathleen A.
- Sabanayagam Charumathi
- Saum Kai Uwe
- Scholz Markus
- Schöttker Ben
- Sedaghat Sanaz
- Shaffer Christian M.
- Shi Yuan
- Sieber Karsten B.
- Smith Albert V.
- Snieder Harold
- Stefansson Kari
- Strauch Konstantin
- Stumvoll Michael
- Sun Benjamin B.
- Susztak Katalin
- Sveinbjornsson Gardar
- Szymczak Silke
- Tai E. Shyong
- Tan Nicholas Y.Q.
- Taylor Kent D.
- Tayo Bamidele O.
- Teren Andrej
- Teumer Alexander
- Tham Yih Chung
- Thiery Joachim
- Thio Chris H.L.
- Thomsen Hauke
- Thorsteinsdottir Unnur
- Tin Adrienne
- Tremblay Johanne
- Tönjes Anke
- Uitterlinden André G.
- van der Harst Pim
- van der Most Peter J.
- Verweij Niek
- Vogelezang Suzanne
- Völker Uwe
- Waldenberger Melanie
- Wang Chaolong
- Wang Lihua
- Wilson James G.
- Wilson Otis D.
- Wong Charlene
- Wong Tien Yin
- Wuttke Matthias
- Xu Yizhe
- Yang Qiong
- Yasuda Masayuki
- Yu Zhi
- Ärnlöv Johan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2019
- Field of study
Publisher Copyright: © 2019, The Author(s).Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.Peer reviewe
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Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abud A Abed
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Addepalli SV
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo P Martinez
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Aizenberg I
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FL Lucio
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andana RY Gonzalez
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
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- Argyropoulos S
- Arling J-H
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- Armstrong A
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- Arnold H
- Artoni G
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- Asai K
- Asai S
- Asbah NA
- Asimakopoulou EM
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- Assahsah J
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- Austrup VA
- Avner G
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- Azuelos G
- Babal D
- Bachacou H
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- Backman F
- Badea A
- Bagnaia P
- Bahilo JJ Lozano
- Bahrasemani H
- Bailey AJ
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- Bakalis C
- Baker OK
- Bakker PJ
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- Baldin EM
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- Balunas WK
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- Bandyopadhyay A
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- Barberio EL
- Barberis D
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- Zimmermann S
- Zinsser J
- Ziolkowski M
- Zivkovic L
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 03/02/2022
- Field of study
This paper presents the measurement of the electroweak production of two jets
in association with a Zγ pair with the Z boson decaying into two
neutrinos. It also presents the search for invisible or partially invisible
decays of a Higgs boson with a mass of 125 GeV produced through vector-boson
fusion with a photon in the final state. These results use data from LHC
proton-proton collisions at s = 13 TeV collected with the ATLAS
detector corresponding to an integrated luminosity of 139 fb−1. The event
signature, shared by all benchmark processes considered for measurements and
searches, is characterized by a significant amount of unbalanced transverse
momentum and a photon in the final state, in addition to a pair of forward
jets. For electroweak production of Zγ in association with two jets, the
background-only hypothesis is rejected with an observed (expected) significance
of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this
process is 1.31±0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at
95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to
invisible particles, assuming the Standard Model production cross-section. The
signature is also interpreted in the context of decays of a Higgs boson to a
photon and a dark photon. An observed (expected) 95% CL upper limit on the
branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV
Standard Model Higgs boson production cross-section
Recommended from our members
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud A Abed
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo P Martinez
- Ahmad A
- Ahmadov F
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- Ai X
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- Akesson TPA
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- Alberghi GL
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- Aleksa M
- Aleksandrov IN
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- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 08/03/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
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- Zhemchugov A
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- Zimine NI
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- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 01/01/2022
- Field of study
The design and performance of the inner detector trigger for the high level
trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18
data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector
recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of
proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to
deal with the very high interaction multiplicities per bunch crossing expected
with the 13 TeV collisions the inner detector trigger was redesigned during the
long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of
these developments is provided and the performance of the tracking in the
trigger for the muon, electron, tau and b-jet signatures is discussed. The
high performance of the inner detector trigger with these extreme interaction
multiplicities demonstrates how the inner detector tracking continues to lie at
the heart of the trigger performance and is essential in enabling the ATLAS
physics programme