Emotion work and musculoskeletal pain in supermarket cashiers: a test of a sleep-mediation model

Repetitive movement and a lack of postural change are known risk factors for musculoskeletal pain in cashiers. This study tests emotional dissonance – the demand to keep being polite to impolite customers – as an additional risk factor. Furthermore, sleep problems are expected to mediate the link between emotion work and musculoskeletal pain. Data contains 103 female supermarket cashiers from three supermarkets of a large retailer responded to a questionnaire (participation rate 60.6%). An open question asked for the most negative job facets in daily work. Standardized questionnaire were used to assess emotional dissonance, sleep problems and musculoskeletal pain. Responses to the open question showed experience of unkind customers as the most prevalent negative experience at work reported by 47.6% of cashiers, followed by prolonged sitting (8.7%). Emotional dissonance was a significant predictor of neck and back pain when BMI, age, part-time work, and change of hand function during their shift (work rotation) were controlled (β = .30, p < .01). Moreover, sleep problems were confirmed as a mediator with respect to neck and back pain (B = .21, SE = .10, CI = 02–.22). No mediation was found in prediction of pain in arms and shoulders or hips, legs, and feet. Emotional dissonance in work of cashiers appeared as a unique risk factor of neck and back pain. Work design should pay more attention to the social demands of cashier work

Microglia toxicity in preterm brain injury

AbstractMicroglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments

Diagnosis of acute myocardial infarction in the presence of left bundle branch block

Objective Patients with suspected acute myocardial infarction (AMI) in the setting of left bundle branch block (LBBB) present an important diagnostic and therapeutic challenge to the clinician. Methods We prospectively evaluated the incidence of AMI and diagnostic performance of specific ECG and high-sensitivity cardiac troponin (hs-cTn) criteria in patients presenting with chest discomfort to 26 emergency departments in three international, prospective, diagnostic studies. The final diagnosis of AMI was centrally adjudicated by two independent cardiologists according to the universal definition of myocardial infarction. Results Among 8830 patients, LBBB was present in 247 (2.8%). AMI was the final diagnosis in 30% of patients with LBBB, with similar incidence in those with known LBBB versus those with presumably new LBBB (29% vs 35%, p=0.42). ECG criteria had low sensitivity (1%-12%) but high specificity (95%-100%) for AMI. The diagnostic accuracy as quantified by the receiver operating characteristics (ROC) curve of hs-cTnT and hs-cTnI concentrations at presentation (area under the ROC curve (AUC) 0.91, 95% CI 0.85 to 0.96 and AUC 0.89, 95% CI 0.83 to 0.95), as well as that of their 0/1-hour and 0/2-hour changes, was very high. A diagnostic algorithm combining ECG criteria with hs-cTnT/I concentrations and their absolute changes at 1 hour or 2 hours derived in cohort 1 (45 of 45(100%) patients with AMI correctly identified) showed high efficacy and accuracy when externally validated in cohorts 2 and 3 (28 of 29 patients, 97%). Conclusion Most patients presenting with suspected AMI and LBBB will be found to have diagnoses other than AMI. Combining ECG criteria with hs-cTnT/I testing at 0/1 hour or 0/2 hours allows early and accurate diagnosis of AMI in LBBB. Trial registration number APACE: NCT00470587; ADAPT: ACTRN12611001069943; TRAPID-AMI: RD001107;Results.</p