Endogenous estrogens increase postischemic hyperemia in the skin microcirculation

Estrogens have been recognized as a major regulator of vascular tone and structure, particularly in the skin. The objective of this study was to investigate the effects of endogenous estrogens on the skin microcirculation. Skin blood flow was measured at the forearm at rest and during postischemic hyperemia using laser Doppler flowmetry in 32 healthy women (mean age 34.5 +/- 3.9 years) involved in an in-vitro fertilization program. Women were treated for 10 to 12 days with gonadotropin-releasing hormone agonist (total dose 40.3 +/- 3.3 mg) and human menopausal gonadotropin (1942 +/- 801 IE) or follicle-stimulating hormone (2544 +/- 1071 IE) according to individual estrogen levels. Plasma estrogen levels increased from 132 +/- 90 pmol/L (36 +/- 25 pg/mL) to 8471 +/- 4386 pmol/L (2308 +/- 1195 pg/mL) during treatment (P < 0.0001). Maximal hyperemic blood flow increased from 353 +/- 81% before treatment to 516 +/- 144% after hormonal stimulation (P < 0.0001), whereas basal skin flow was not altered. This study shows that endogenous estrogens enhance the postischemic hyperemic response of the skin microcirculation

An empirical prediction for stellar metallicity distributions in nearby galaxies

We combine star-formation histories derived from observations of high redshift galaxies with measurements of the z~0 relation between gas-phase metallicity, stellar mass, and star formation rate to make an explicit and completely empirical connection between near-field and distant galaxy observations. Our approach relies on two basic assumptions: 1) galaxies' average paths through time in stellar mass vs. star formation rate space are represented by a family of smooth functions that are determined by the galaxies' final stellar mass, and 2) galaxies grow and become enriched with heavy elements such that they always evolve along the mass--metallicity--star formation rate relation. By integrating over these paths, we can track the chemical evolution of stars in galaxies in a model independent way, without the need for explicit assumptions about gas inflow, outflow, or star formation efficiency. Using this approach, we present predictions of stellar metallicity (i.e., O/H) distribution functions for present day star-forming galaxies of different stellar masses and the evolution of the alpha-element stellar metallicity-mass relation since z~1. The metallicity distribution functions are fairly well described as Gaussians, truncated at high metallicity, with power-law tails to low metallicity. We find that the stellar metallicity distribution for Milky Way mass galaxies is in reasonable agreement with observations for our Galaxy, and that the predicted stellar mass vs. mean stellar metallicity relation at z=0 agrees quite well with results derived from galaxy surveys. This validates the assumptions that are implicit in our simple approach. Upcoming observations will further test these assumptions and their range of validity, by measuring the mean stellar mass-metallicity relation up to z~1, and by measuring the stellar metallicity distributions over a range of galaxy masses.Comment: 8 pages, 2 figures, 2 tables. MNRAS, in pres

The metallicity gradient of M 33: chemical abundances of HII regions

We present spectroscopic observations of a sample of 72 emission-line objects, including mainly HII regions, in the spiral galaxy M 33. Spectra were obtained with the multi-object, wide field spectrograph AF2/WYFFOS at the 4.2m WHT telescope. Line intensities, extinction, and electron density were determined for the whole sample of objects. The aim of the present work was to derive chemical and physical parameters of a set of HII regions, and from them the metallicity gradient. Electron temperatures and chemical abundances were derived for the 14 HII regions where both [OII] and [OIII] emission line fluxes were measured, including the electron temperature sensitive emission line [OIII] 436.3 nm and in a few cases [NII] 575.5 nm. The ionization correction factor (ICF) method was used to derive the total chemical abundances. The presence of abundance gradients was inferred from the radial behaviour of several emission-line ratios, and accurately measured from chemical abundances directly derived in 14 HII regions. The oxygen abundances of our HII regions, located in the radial region from ~2 to ~7.2 kpc, gave an oxygen gradient -0.054+/-0.011 dex/kpc The overall oxygen gradient for M 33 obtained using ours and previous oxygen determinations in a large number of HII regions with direct electron temperature determination as well as abundance in young stars presented a two slope shape: -0.19 dex/kpc for the central regions (R<3kpc), and -0.038dex/kpc for the outer regions (R>=3kpc).Comment: 16 pages, 14 figures, A&A accepted 10/05/200

Phase Ib study of unesbulin (PTC596) plus dacarbazine for the treatment of locally recurrent, unresectable or metastatic, relapsed or refractory leiomyosarcoma

PURPOSE: This multicenter, single-arm, open-label, phase Ib study was designed to determine the recommended phase II dose (RP2D) and to evaluate the safety and preliminary efficacy of unesbulin plus dacarbazine (DTIC) in patients with advanced leiomyosarcoma (LMS). PATIENTS AND METHODS: Adult subjects with locally advanced, unresectable or metastatic, relapsed or refractory LMS were treated with escalating doses of unesbulin orally twice per week in combination with DTIC 1,000 mg/m RESULTS: Unesbulin 300 mg administered orally twice per week in combination with DTIC 1,000 mg/m CONCLUSION: Unesbulin 300 mg twice per week plus DTIC 1,000 mg/

The relation between metallicity, stellar mass and star formation in galaxies: an analysis of observational and model data

We study relations between stellar mass, star formation and gas-phase metallicity in a sample of 177,071 unique emission line galaxies from the SDSS-DR7, as well as in a sample of 43,767 star forming galaxies at z=0 from the cosmological semi-analytic model L-GALAXIES. We demonstrate that metallicity is dependent on star formation rate at fixed mass, but that the trend is opposite for low and for high mass galaxies. Low-mass galaxies that are actively forming stars are more metal-poor than quiescent low-mass galaxies. High-mass galaxies, on the other hand, have lower gas-phase metallicities if their star formation rates are small. Remarkably, the same trends are found for our sample of model galaxies. We find that massive model galaxies with low gas-phase metallicities have undergone a gas-rich merger in the past, inducing a starburst which exhausted their cold gas reservoirs and shut down star formation. This led to a gradual dilution in the gas-phase metallicities of these systems via accretion of gas. These model galaxies have lower-than-average gas-to-stellar mass ratios and higher-than-average central black hole masses. We confirm that massive galaxies with low gas-phase metallicities in our observational sample also have very massive black holes. We propose that accretion may therefore play a significant role in regulating the gas-phase metallicities of present-day massive galaxies.Comment: 18 pages, 18 figures, 2 tables. Submitted to MNRA

The effect of the regular solution model in the condensation of protoplanetary dust

We utilize a chemical equilibrium code in order to study the condensation process which occurs in protoplanetary discs during the formation of the first solids. The model specifically focuses on the thermodynamic behaviour on the solid species assuming the regular solution model. For each solution, we establish the relationship between the activity of the species, the composition and the temperature using experimental data from the literature. We then apply the Gibbs free energy minimization method and study the resulting condensation sequence for a range of temperatures and pressures within a protoplanetary disc. Our results using the regular solution model show that grains condense over a large temperature range and therefore throughout a large portion of the disc. In the high temperature region (T > 1400 K) Ca-Al compounds dominate and the formation of corundum is sensitive to the pressure. The mid-temperature region is dominated by Fe(s) and silicates such as Mg2SiO4 and MgSiO3 . The chemistry of forsterite and enstatite are strictly related, and our simulations show a sequence of forsterite-enstatite-forsterite with decreasing temperature. In the low temperature regions (T < 600 K) a range of iron compounds and sulfides form. We also run simulations using the ideal solution model and see clear differences in the resulting condensation sequences with changing solution model In particular, we find that the turning point in which forsterite replaces enstatite in the low temperature region is sensitive to the solution model. Our results show that the ideal solution model is often a poor approximation to experimental data at most temperatures important in protoplanetary discs. We find some important differences in the resulting condensation sequences when using the regular solution model, and suggest that this model should provide a more realistic condensation sequence.Comment: MNRAS: Accepted 2011 February 16. Received 2011 February 14; in original form 2010 July 2

Nitrogen enrichment, boron depletion and magnetic fields in slowly-rotating B-type dwarfs

Evolutionary models for massive stars, accounting for rotational mixing effects, do not predict any core-processed material at the surface of B dwarfs with low rotational velocities. Contrary to theoretical expectations, we present a detailed and fully-homogeneous, NLTE abundance analysis of 20 early B-type dwarfs and (sub)giants that reveals the existence of a population of nitrogen-rich and boron-depleted, yet intrinsically slowly-rotating objects. The low-rotation rate of several of these stars is firmly established, either from the occurrence of phase-locked UV wind line-profile variations, which can be ascribed to rotational modulation, or from theoretical modelling in the pulsating variables. The observational data presently available suggest a higher incidence of chemical peculiarities in stars with a (weak) detected magnetic field. This opens the possibility that magnetic phenomena are important in altering the photospheric abundances of early B dwarfs, even for surface field strengths at the one hundred Gauss level. However, further spectropolarimetric observations are needed to assess the validity of this hypothesis.Comment: Accepted by A&A. 11 pages, 4 figures (some in colour

The metallicity gradient as a tracer of history and structure : the Magellanic Clouds and M33 galaxies

Original article can be found at: http://www.aanda.org/ Copyright The European Southern Observatory (ESO) DOI: 10.1051/0004-6361/200912138Context. The stellar metallicity and its gradient place constraints on the formation and evolution of galaxies. Aims. This is a study of the metallicity gradient of the LMC, SMC and M33 galaxies derived from their asymptotic giant branch (AGB) stars. Methods. The [Fe/H] abundance was derived from the ratio between C- and M-type AGB stars and its variation analysed as a function of galactocentric distance. Galaxy structure parameters were adopted from the literature. Results. The metallicity of the LMC decreases linearly as −0.047±0.003 dex kpc−1 out to ∼8 kpc from the centre. In the SMC, [Fe/H] has a constant value of ∼−1.25 ± 0.01 dex up to ∼12 kpc. The gradient of the M33 disc, until ∼9 kpc, is −0.078 ± 0.003 dex kpc−1 while the outer disc/halo, out to ∼25 kpc, has [Fe/H] ∼ −1.7 dex. Conclusions. The metallicity of the LMC, as traced by different populations, bears the signature of two major star forming episodes: the first one constituting a thick disc/halo population and the second one a thin disc and bar due to a close encounter with the Milky Way and SMC. The [Fe/H] of the recent episode supports an LMC origin for the Stream. The metallicity of the SMC supports star formation, ∼3 Gyr ago, as triggered by LMC interaction and sustained by the bar in the outer region of the galaxy. The SMC [Fe/H] agrees with the present-day abundance in the Bridge and shows no significant gradient. The metallicity of M33 supports an “insideout” disc formation via accretion of metal poor gas from the interstellar medium.Peer reviewe

The Star Formation History in The Far Outer Disc of M33

The outer regions of disc galaxies are becoming increasingly recognized as key testing sites for models of disc assembly and evolution. Important issues are the epoch at which the bulk of the stars in these regions formed and how discs grow radially over time. To address these issues, we use Hubble Space Telescope Advanced Camera for Surveys imaging to study the star formation history (SFH) of two fields at 9.1 and 11.6 kpc along M33's northern major axis. These fields lie at ~ 4 and 5 V-band disc scale-lengths and straddle the break in M33's surface brightness profile. The colour-magnitude diagrams (CMDs) reach the ancient main sequence turnoff with a signal-to-noise ratio of ~ 5. From detailed modelling of the CMDs, we find that the majority of stars in both fields combined formed at z < 1. The mean age in the inner field, S1, is ~ 3 +/- 1 Gyr and the mean metallicity is [M/H] ~ -0.5 +/- 0.2 dex. The star formation history of S1 unambiguously reveals how the inside-out growth previously measured for M33's inner disc out to ~ 6 kpc extends out to the disc edge at ~ 9 kpc. In comparison, the outer field, S2, is older (mean age ~ 7 +/- 2 Gyr), more metal-poor (mean [M/H] ~ -0.8 +/- 0.3 dex), and contains ~ 30 times less stellar mass. These results provide the most compelling evidence yet that M33's age gradient reverses at large radii near the disc break and that this reversal is accompanied by a break in stellar mass surface density. We discuss several possible interpretations of this behaviour including radial stellar mixing, warping of the gaseous disc, a change in star formation efficiency, and a transition to another structural component. These results offer one of the most detailed views yet of the peripheral regions of any disc galaxy and provide a much-needed observational constraint on the last major epoch of star formation in the outer disc.Comment: 15 pages, 9 figures, accepted to MNRAS, hi-res version available at http://www.roe.ac.uk/~mkb/astroph/m33hires.pd

The planetary nebula population of M33 and its metallicity gradient: A look into the galaxy's distant past

The Planetary Nebula (PN) population of M33 is studied via multi-fiber spectroscopy with Hectospec at the MMT. In this paper we present the spectra of 102 PNe, whereas plasma diagnostic and chemical abundances were performed on the 93 PNe where the necessary diagnostic lines were measured. About 20% of the PNe are compatible with being Type I; the rest of the sample is the progeny of an old disk stellar population, with main sequence masses M<3M${_\odot}$ and ages t$>$0.3 Gyr. By studying the elemental abundances of the PNe in the M33 disk we were able to infer that: (1) there is a tight correlation between O/H and Ne/H, broadly excluding the evolution of oxygen; (2) the average abundances of the $\alpha$-elements are consistent with those of \hii regions, indicating a negligible global enrichment in the disk of M33 from the epoch of the formation of the PN progenitors to the present time; (3) the radial oxygen gradient across the M33 disk has a slope of -0.031$\pm$0.013 dex kpc$^{-1}$, in agreement, within the errors, with the corresponding gradient derived from HII regions. Our observations do not seem to imply that the metallicity gradient across the M33 disk has flattened considerably with time. We report also the discovery of a PN with Wolf-Rayet features, PN039, belonging the class of late [WC] starsComment: 25 pages, 12 figures, ApJ submitte