Age at first birth in women is genetically associated with increased risk of schizophrenia

Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe

Connecting seismically active normal faults with Quaternary geological structures in a complex extensional environment: The Colfiorito 1997 case history (northern Apennines, Italy)

The northern Apennines of Italy are characterized by a complex Tertiary tectonic history, where superposed compressional and extensional deformation occurred. In such regions, characterized by low active extensional strain rate, the coseismic surface ruptures are rare and often a matter of much debate resulting in a difficult connection between ‘‘geological’’ faults (i.e., faults which can be mapped at the surface) and ‘‘seismological’’ faults (i.e., faults which actually generate earthquakes). The availability of detailed geological mapping and high-resolution seismological data for the Colfiorito area, struck in 1997 by a sequence of six 5 < Mw 6 normal faulting earthquakes, allow us to compare and verify the existence of geometric and kinematic correspondence between the mapped geological Quaternary faults and the activated structures. In map view, the earthquakes distribution reflects the fault pattern mapped at the surface, the length of activated and mapped faults is quite similar (7–10 km), the coseismic subsided region imaged by interferometric synthetic aperture radar data, is located in the hanging wall of the mapped normal faults that bound the Quaternary basins. In section view, there is a geometric connection between mapped normal faults and the aftershock alignments used to image fault geometry at depth. Comparison of striated fault planes and aftershock focal mechanism solutions show a strong kinematic consistency. This study points out that the Quaternary tectonosedimentary evolution and the present-day geological and geomorphologic setting of the Colfiorito area can be interpreted as the result of repeated, extensional earthquakes, similar to the 1997 events, occurring on NW-SE trending normal faults. Our data also show that the main shocks of the Colfiorito sequence nucleated close to the intersections between the normal faults and the preexisting compressional/transpressional structures, which in 1997 acted as lateral barriers to rupture propagation and consequently constrained the fault size

New Methodologies for the Reliability-Based Analysis and Design of Water Distribution Systems

National Science Foundation Grant No. ECE-8511399Center for Water and the Environmen

New Methodologies for the Reliability-Based Analysis and Design of Water Distribution Systems

National Science Foundation Grant No. ECE-8511399Center for Water and the Environmen

Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study.

Background:  Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems. Aim:  We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect. Methods:  This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire. Results:  In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child. Conclusions:  The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association