Analysis Of The Histologic Features In The Differential Diagnosis Of Intrahepatic Neonatal Cholestasis.

To compare the histologic features of the liver in intrahepatic neonatal cholestasis (IHNC) with infectious, genetic-endocrine-metabolic, and idiopathic etiologies. Liver biopsies from 86 infants with IHNC were evaluated. The inclusion criteria consisted of jaundice beginning at 3 mo of age and a hepatic biopsy during the 1st year of life. The following histologic features were evaluated: cholestasis, eosinophilia, giant cells, erythropoiesis, siderosis, portal fibrosis, and the presence of a septum. Based on the diagnosis, patients were classified into three groups: group 1 (infectious; n=18), group 2 (genetic-endocrine-metabolic; n=18), and group 3 (idiopathic; n=50). There were no significant differences with respect to the following variables: cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and presence of a septum. A significant difference was observed with respect to erythropoiesis, which was more severe in group 1 (Fisher's exact test, P=0.016). A significant difference was observed in IHNC of infectious etiology, in which erythropoiesis was more severe than that in genetic-endocrine-metabolic and idiopathic etiologies, whereas there were no significant differences among cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and the presence of a septum.15478-8

Relação entre antropometria, gordura corporal e autoconceito de adolescentes do sexo feminino

  Obesity poses future metabolic risks, as well as contributing to the development of early psychosocial problems and to the reduction of adolescent quality of life. Self-concept is an important indicator of psychological well-being, especially in the young age, however, several factors can contribute to the perception of self-concept, among them is the nutritional status, which is constantly modified in this phase of life. In this sense, the nutritional status variables may be associated with positive or negative concepts about themselves, favoring the understanding of psychosocial factors of the young population in favor of healthy behaviors. Thus, this study sought to analyze the relationship of waist circumference, fat percentage and the physical and global self-concept of female adolescents. For that, a cross-sectional study was carried out with the participation of 101 female adolescents, students of the High School of a State Technical School of the city of São Paulo. The Harter self - perception scale for adolescents was validated for Brazilian adolescents, in the dimensions of the physical and global self - concept, and anthropometric measures of body mass and height were checked for BMI, skin folds for fat percentage and waist circumference. The data were categorized and correlated with each other. An inverse correlation was found between the variables physical self-concept and waist circumference corroborating with other studies. Keywords: self-concept; physical self-concept; adolescent; anthropometry.    La obesidad trae riesgos metabólicos futuros, además de contribuir en el desarrollo de problemas psicosociales precoces y en la reducción de la calidad de vida del adolescente. El autoconcepto es un importante indicador de bienestar psicológico, principalmente en la edad joven, sin embargo, diversos factores pueden contribuir a la percepción del autoconcepto, entre ellos, está el estado nutricional, que es constantemente modificado en esa fase de la vida. En este sentido, las variables del estado nutricional pueden estar asociadas a conceptos positivos o negativos sobre sí mismo, favoreciendo el entendimiento de factores psicosociales de la población joven en pro de comportamientos saludables. Así, ese trabajo buscó analizar la relación de la circunferencia de cintura, el porcentaje de grasa y el autoconcepto físico y global de adolescentes del sexo femenino. Para ello, se realizó un estudio transversal con la participación de 101 adolescentes del sexo femenino, estudiantes de la Enseñanza Media de una Escuela Técnica Estadual de la ciudad de São Paulo. Se utilizó la escala de Autopercepción de Harter para Adolescentes validada para adolescentes brasileños, en las dimensiones del autoconcepto físico y global, y medidas medidas antropométricas de masa corporal y estatura para la verificación del IMC, pliegues cutáneos para el porcentaje de grasa y circunferencia de cintura. Los datos fueron categorizados y correlacionados entre sí. Se encontró correlación inversa entre las variables autoconcepto físico y circunferencia de cintura corroborando con otros estudios. Palabras clave: autoconcepto; autoconcepto físico; adolescente; antropometría.  A obesidade traz futuras cãibras metabólicas, além de contribuir não para o desenvolvimento de problemas psicossociais e precários na redução da qualidade de vida do adolescente. O e Um autoconceito importante indicador de bem-estar psicológico, Jovem principalmente na Idade, não entanto, vários Fatores PODEM contribuir para uma Percepção fazer autoconceito entre ELES é ou estado nutricional, que E nessa fase constantemente modificado dá vida. Nesse sentido, como fazem Variáveis ​​PODEM estado nutricional ser positivo OU Associated negativo para se MESMO CONCEITOS, favorecendo ou Entendimento de psicossociais Fatores Jovem em Prol da População de comportamentos Saudáveis. Assim, esse trabalho buscou analisar a relação da circunferência da cintura, ou percentual de gordura e autoconceito físico e global de adolescentes do sexo feminino. Por isso, Foi realizado um estudo transversal com a participação de 101 adolescentes do sexo feminino, estudantes do Ensino Médio de uma Escola Técnica Estadual de São Paulo. Foi usado para dimensionar Autopercepção Harter adolescente validado para adolescentes Brasileiros, NAS fazer Dimensões autoconceito físico e, em geral, e aferidas medidas antropométricas de massa corporal e estatura para a verificação do IMC, pele para ou percentual de pregas de gordura e circunferência da cintura. Os foram foram categorizados e correlacionados entre si. Foi encontrada uma correlação inversa entre autoconceito físico variado e circunferência de cintura, corroborando com outros estudos. Foi usado para dimensionar Autopercepção Harter adolescente validado para adolescentes Brasileiros, NAS fazer Dimensões autoconceito físico e, em geral, e aferidas medidas antropométricas de massa corporal e estatura para a verificação do IMC, pele para ou percentual de pregas de gordura e circunferência da cintura. Os foram foram categorizados e correlacionados entre si. Foi encontrada uma correlação inversa entre autoconceito físico variado e circunferência de cintura, corroborando com outros estudos. Foi usado para dimensionar Autopercepção Harter adolescente validado para adolescentes Brasileiros, NAS fazer Dimensões autoconceito físico e, em geral, e aferidas medidas antropométricas de massa corporal e estatura para a verificação do IMC, pele para ou percentual de pregas de gordura e circunferência da cintura. Os foram foram categorizados e correlacionados entre si. Foi encontrada uma correlação inversa entre autoconceito físico variado e circunferência de cintura, corroborando com outros estudos. Os foram foram categorizados e correlacionados entre si. Foi encontrada uma correlação inversa entre autoconceito físico variado e circunferência de cintura, corroborando com outros estudos. Os foram foram categorizados e correlacionados entre si. Foi encontrada uma correlação inversa entre autoconceito físico variado e circunferência de cintura, corroborando com outros estudos. Palavras-chave: autoconceito; autoconceito físico; adolescente antropometria   &nbsp

Behaviour of the foramen ovale flow in fetuses with intrauterine growth restriction

Foramen ovale (FO) flow may be altered in IUGR. .is study was designed to test this hypothesis. Methods. Forty pregnant women (24–38 weeks) were divided into 3 groups: group I (IUGR), group II (adequate growth and maternal hypertension), and group III (normal controls). Impedance across the FO was assessed by the FO pulsatility index (FOPI): (systolic velocity − presystolic velocity)/mean velocity. Statistical analysis utilized ANOVA, Tukey test, and ROC curves. Results. Mean FOPI in IUGR fetuses (n=15) was 3.70 ± 0.99 (3.15–4.26); in the group II (n=12), it was 2.84 ± 0.69 (2.40–3.28), and in the group III (n=13), it was 2.77 ± 0.44 (2.50–3.04) (p=0.004). FOPI and UtA RI were correlated (r= 0.375, p= 0.017), as well as FOPI and UA RI (r= 0.356, p= 0.024) and, inversely, FOPI and MCA RI (r= −0.359, p= 0.023). Conclusions. .e FO flow pulsatility index is increased in fetuses with IUGR, probably as a result of impaired left ventricular diastolic functio

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe

Measurement of B-c(2S)(+) and B-c*(2S)(+) cross section ratios in proton-proton collisions at root s=13 TeV

Peer reviewe

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements

This paper presents new sets of parameters (“tunes”) for the underlying-event model of the HERWIG7 event generator. These parameters control the description of multiple-parton interactions (MPI) and colour reconnection in HERWIG7, and are obtained from a fit to minimum-bias data collected by the CMS experiment at s=0.9, 7, and 13Te. The tunes are based on the NNPDF 3.1 next-to-next-to-leading-order parton distribution function (PDF) set for the parton shower, and either a leading-order or next-to-next-to-leading-order PDF set for the simulation of MPI and the beam remnants. Predictions utilizing the tunes are produced for event shape observables in electron-positron collisions, and for minimum-bias, inclusive jet, top quark pair, and Z and W boson events in proton-proton collisions, and are compared with data. Each of the new tunes describes the data at a reasonable level, and the tunes using a leading-order PDF for the simulation of MPI provide the best description of the dat