17 research outputs found
Optimization of halopemide for phospholipase D2 inhibition.
Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2
Young people's perspectives on the use of reverse discourse in web-based sexual-health interventions
Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin
UI - 98221176NRC publication: Ye