The Effects of an Energy Increasing Supplement on Markers of V02 max, Body Composition, and Anaerobic Power

Research suggests that energy increasing supplement ingestion prior to prolonged aerobic exercise (\u3e60minutes) can improve aerobic capacity (VO2 Max). Energy increasing supplements affect on reduced aerobic training periods (\u3c60\u3eminutes) lack definitive empirical evidence. PURPOSE: To investigate the potential impact of an energy increasing supplement on aerobic training, body composition and anaerobic power. METHODS: Thirty-three healthy male and female subjects (18-30yrs) participated in an equated volume supervised running workout for six weeks utilizing long slow distance. Group one (N = 17, 21 ± 3 yr) participated in long slow distance training as a Placebo group void of any dietary instructions or interventions. Group two (N = 16, 21 ± 3 yr) participated in long slow distance training and was provided with a GU Energy Gel packet and 8 oz. of water fifteen minutes prior to the workout. All subjects participated in a familiarity session (FAM), a Pre-Test (T1) and a Post-Test (T2). Each testing session consisted of a V02 Max, a 30 second Wingate and body composition assessment. Data were analyzed by a two-way ANOVA with repeated measures. Significance was set at p \u3c 0.05 and adopted throughout. RESULTS: The GU and Placebo groups experienced significant increases (p \u3c 0.001), in VO2 max, with 9.71% (4.06 ± 2.68 ml/kg/min) and 2.81% (1.26 ± 2.25 ml/kg/min) increases respectively. A significant interaction (p \u3c 0.005) in VO2 max occurred between groups, as the GU group displayed a 322% greater increase when compared to the Placebo group. Body fat percentage significantly decreased (p \u3c 0.05) in the GU (0.76 ± 2.47%) and Placebo (1.55 ± 3.21%) groups without a significant reduction in total body weight at a p \u3c 0.05 significant level. No change was observed in Wingate peak or mean power (p \u3c 0.05). CONCLUSION: The findings of this study suggest GU Energy Gel supplementation has a more profound impact on aerobic capacity when compared to a Placebo under identical training protocols. However, both GU Energy Gel and Placebo supplementation had a significant effect on aerobic capacity and body fat percentage

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

European Cystic Fibrosis Society Standards of Care: Framework for the Cystic Fibrosis Centre

A significant increase in life expectancy in successive birth cohorts of people with cystic fibrosis (CF) is a result of more effective treatment for the disease. It is also now widely recognized that outcomes for patients cared for in specialist CF Centres are better than for those who are not. Key to the effectiveness of the specialist CF Centre is the multidisciplinary team (MDT), which should include consultants, clinical nurse specialist, microbiologist, physiotherapist, dietitian, pharmacist, clinical psychologist, social worker, clinical geneticist and allied healthcare professionals, all of whom should be experienced in CF care. Members of the MDT are also expected to keep up to date with developments in CF through continued professional development, attendance at conferences, auditing and involvement in research. Specialists CF Centres should also network with other Centres both nationally and internationally, and feed Centre data to registries in order to further the understanding of the disease. This paper provides a framework for the specialist CF Centre, including the organisation of the Centre and the individual roles of MDT members, as well as highlighting the value of CF organisations and disease registries

Miocene lateral extrusion in the inner western Alps revealed by dynamic fault analysis

International audienceFrom Early Miocene to the present-day the core parts of the western European Alps experienced brittle extensional deformations, mostly in a strike-parallel direction. Here we present new data constraining the brittle deformation of the Vanoise area (French Alps) and a synthesis of 312 paleostress tensors in the whole arc of the internal Western Alps. The data show a continuous change in the direction of extension, from N065° (Simplon area), to N-S (Vanoise area) and to NNW-SSE (Briançon area). The aboundance of orogen-perpendicular σ3 axes increases from the North to the South. In the Briançonnais area, an extensional reactivation of the Basal Penninic Thrust seems to be the origin of the E-W to NE-SW oriented σ3. In light of these new data and the regional paleostress synthesis, we propose a predominant orogen-parallel extension in the internal zone as a whole. This orogenparallel extension is related to the indentation/rotation of the Apulian microplate and to the opening of the Ligurian Sea during the Lower-Middle Miocene. The locally observed orogen-perpendicular extension is interpreted as an effect of the exhumation of the Internal Crystalline Massifs, the uplift of the External Crystalline Massifs and/or the present-day geodynamics (post-orogenic gravitational collapse). Some transcurrent tectonics, older than the extension in the Valais area, and younger than the extension further South is observed in the entire inner Western Alps; strike-slip movements are correlated with the Apulian rotation and local permutation of stress axes