Pengembangan Sistem Authority Control Terintegrasi Dalam Proses Bisnis Perpustakaan

Authority control  adalah kegiatan menetapkan, membuat, dan menggunakan istilah standar yang dipakai dalam katalog perpustakaan beserta acuannya. Sampai saat ini authority control belum banyak digunakan, padahal  authority control merupakan hal yang penting bagi perpustakaan sebagai bentuk kontrol bibliografi. Oleh karena itulah, perlu dikembangkan sebuah sistem authority control yang efektif, yang dapat dijadikan alat atau sarana bagi pustakawan dalam menentukan keseragaman akses pada katalog sehingga terdapat konsistensi dalam penentuan titik akses informasi dan untuk meningkatkan hasil temu kembali informasi. Rancangan sistem authority control dalam penelitian ini menggunakan metode SDLC (System Development Life Cycle)  yang meliputi studi kelayakan, investigasi sistem,  analisis sistem, desain sistem, implementasi, serta review dan maintenance (Avison dan Fitsgerald (2006). Penelitian ini dilakukan  sampai tahap pembuatan prototipe. Fasilitas yang disediakan dalam rancangan sistem ini adalah fasilitas penelusuran dan input data yang terdiri dari tajuk subjek, tajuk nama pengarang,  dan tajuk badan korporasi.Kata Kunci: Authority Control, Perpustakaan Nasional RI, Titik Akses Informasi, Referensi Silang, Tajuk Subjek, Tajuk Nama Pengarang, Tajuk Badan Korporas

The solar wind from a stellar perspective: how do low-resolution data impact the determination of wind properties?

Alfv\'en-wave-driven 3D magnetohydrodynamic (MHD) models, which are increasingly used to predict stellar wind properties, contain unconstrained parameters and rely on low-resolution stellar magnetograms. We explore the effects of the input Alfv\'en wave energy flux and the surface magnetogram on the wind properties predicted by the Alfv\'en Wave Solar Model (AWSoM). We lowered the resolution of two solar magnetograms during solar cycle maximum and minimum using spherical harmonic decomposition. The Alfv\'en wave energy was altered based on non-thermal velocities determined from a far ultraviolet (FUV) spectrum of the solar twin 18 Sco. Additionally, low-resolution magnetograms of three solar analogues were obtained using Zeeman Doppler imaging (ZDI). Finally, the simulated wind properties were compared to Advanced Composition Explorer (ACE) observations. AWSoM simulations using well constrained input parameters taken from solar observations can reproduce the observed solar wind mass and angular momentum loss rates. The resolution of the magnetogram has a small impact on the wind properties and only during cycle maximum. However, variation in Alfv\'en wave energy influences the wind properties irrespective of the solar cycle activity level. Furthermore, solar wind simulations carried out using the low-resolution magnetogram of the three stars instead of the solar magnetogram could lead to an order of a magnitude difference in the simulated wind properties. The choice in Alfv\'en energy has a stronger influence on the wind output compared to the magnetogram resolution. The influence could be even stronger for stars whose input boundary conditions are not as well constrained as those of the Sun. Unsurprisingly, replacing the solar magnetogram with a stellar magnetogram could lead to completely inaccurate solar wind properties, and should be avoided in solar and stellar wind simulations.Comment: accepted for publication in A&

The connection between stellar activity cycles and magnetic field topology

Zeeman–Doppler imaging (ZDI) has successfully mapped the large-scale magnetic fields of stars over a large range of spectral types, rotation periods and ages. When observed over multiple epochs, some stars show polarity reversals in their global magnetic fields. On the Sun, polarity reversals are a feature of its activity cycle. In this paper, we examine the magnetic properties of stars with existing chromospherically determined cycle periods. Previous authors have suggested that cycle periods lie on multiple branches, either in the cycle period–Rossby number plane or the cycle period–rotation period plane. We find some evidence that stars along the active branch show significant average toroidal fields that exhibit large temporal variations while stars exclusively on the inactive branch remain dominantly poloidal throughout their entire cycle. This lends credence to the idea that different shear layers are in operation along each branch. There is also evidence that the short magnetic polarity switches observed on some stars are characteristic of the inactive branch while the longer chromospherically determined periods are characteristic of the active branch. This may explain the discrepancy between the magnetic and chromospheric cycle periods found on some stars. These results represent a first attempt at linking global magnetic field properties obtained from ZDI and activity cycles.Publisher PDFPeer reviewe

The energy budget of stellar magnetic fields

Spectropolarimetric observations have been used to map stellar magnetic fields, many of which display strong bands of azimuthal fields that are toroidal. A number of explanations have been proposed to explain how such fields might be generated though none are definitive. In this paper, we examine the toroidal fields of a sample of 55 stars with magnetic maps, with masses in the range 0.1-1.5 M⊙. We find that the energy contained in toroidal fields has a power-law dependence on the energy contained in poloidal fields. However the power index is not constant across our sample, with stars less and more massive than 0.5 M⊙ having power indices of 0.72±0.08 and 1.25±0.06, respectively. There is some evidence that these two power laws correspond to stars in the saturated and unsaturated regimes of the rotation-activity relation. Additionally, our sample shows that strong toroidal fields must be generated axisymmetrically. The latitudes at which these bands appear depend on the stellar rotation period with fast rotators displaying higher latitude bands than slow rotators. The results in this paper present new constraints for future dynamo studie

Stellar Coronal and Wind Models: Impact on Exoplanets

Surface magnetism is believed to be the main driver of coronal heating and stellar wind acceleration. Coronae are believed to be formed by plasma confined in closed magnetic coronal loops of the stars, with winds mainly originating in open magnetic field line regions. In this Chapter, we review some basic properties of stellar coronae and winds and present some existing models. In the last part of this Chapter, we discuss the effects of coronal winds on exoplanets.Comment: Chapter published in the "Handbook of Exoplanets", Editors in Chief: Juan Antonio Belmonte and Hans Deeg, Section Editor: Nuccio Lanza. Springer Reference Work

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family

Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions. However, some IDPs remain disordered in the bound state, a phenomenon coined "fuzziness", often characterized by IDP polyvalency, sequence-insensitivity and a dynamic ensemble of disordered bound-state conformations. Besides the above general features, specific biophysical models for fuzzy interactions are mostly lacking. The transcriptional activation domain of the Ewing's Sarcoma oncoprotein family (EAD) is an IDP that exhibits many features of fuzziness, with multiple EAD aromatic side chains driving molecular recognition. Considering the prevalent role of cation-π interactions at various protein-protein interfaces, we hypothesized that EAD-target binding involves polycation- π contacts between a disordered EAD and basic residues on the target. Herein we evaluated the polycation-π hypothesis via functional and theoretical interrogation of EAD variants. The experimental effects of a range of EAD sequence variations, including aromatic number, aromatic density and charge perturbations, all support the cation-π model. Moreover, the activity trends observed are well captured by a coarse-grained EAD chain model and a corresponding analytical model based on interaction between EAD aromatics and surface cations of a generic globular target. EAD-target binding, in the context of pathological Ewing's Sarcoma oncoproteins, is thus seen to be driven by a balance between EAD conformational entropy and favorable EAD-target cation-π contacts. Such a highly versatile mode of molecular recognition offers a general conceptual framework for promiscuous target recognition by polyvalent IDPs. © 2013 Song et al

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A

Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectopic bone formation and osteolysis related to osteosarcoma. Human recombinant (exogenous) Sema3A promoted the expression of osteoblastic phenotype in a panel of human osteosarcoma cell lines and inhibited the ability of these cells to migrate and enhance osteoclastogenesis in vitro. In vivo, administration of exogenous Sema3A in mice after paratibial inoculation of KHOS cells increased bone volume in non-inoculated and tumour-bearing legs. In contrast, Sema3A overexpression reduced the ability of KHOS cells to cause ectopic bone formation in mice and to increase bone nodule formation by engaging DKK1/β-catenin signalling. Thus, Sema3A is of potential therapeutic efficacy in osteosarcoma. However, inhibition of bone formation associated with continuous exposure to Sema3A may limit its long-term usefulness as therapeutic agent

What can we learn about stellar activity cycles from ZDI?

It is known that activity cycles, similar to the 11 year cycle of the Sun, can exist on other stars. Previous work suggests that stars may lie on two branches in a cycle period vs rotation period diagram though there is no definitive explanation for why this should be the case.Fundamentally, activity cycles occur as a result of the underlying dynamo. Indeed, a great deal has been learnt about the Sun's activity cycle by studying how its magnetic field evolves over each activity cycle. In the same way, we should be able to learn about the activity cycles of other stars by studying their magnetic field properties. In this talk, I will present new insights into stellar activity cycles by analysing the magnetic maps of stars that are known to present activity cycles. I will show that stars along each of the branches appear to have different magnetic field topologies.Publisher PDFPeer reviewe

Survival of the Fittest: Positive Selection of CD4+ T Cells Expressing a Membrane-Bound Fusion Inhibitor Following HIV-1 Infection

Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been carried out. Moreover, most studies have not examined whether genetic inhibitors are able to induce a survival advantage that results in an expansion of genetically-modified cells following HIV infection. We evaluated the efficacy of three leading genetic strategies to inhibit HIV replication: 1) an HIV-1 tat/rev-specific small hairpin (sh) RNA; 2) an RNA antisense gene specific for the HIV-1 envelope; and 3) a viral entry inhibitor, maC46. In stably transduced cell lines selected such that >95% of cells expressed the genetic inhibitor, the RNA antisense envelope and viral entry inhibitor maC46 provided the strongest inhibition of HIV-1 replication. However, when mixed populations of transduced and untransduced cells were challenged with HIV-1, the maC46 fusion inhibitor resulted in highly efficient positive selection of transduced cells, an effect that was evident even in mixed populations containing as few as 1% maC46-expressing cells. The selective advantage of the maC46 fusion inhibitor was also observed in HIV-1-infected cultures of primary T lymphocytes as well as in HIV-1-infected humanized mice. These results demonstrate robust inhibition of HIV replication with the fusion inhibitor maC46 and the antisense Env inhibitor, and importantly, a survival advantage of cells expressing the maC46 fusion inhibitor both in vitro and in vivo. Evaluation of the ability of genetic inhibitors of HIV-1 replication to confer a survival advantage on genetically-modified cells provides unique information not provided by standard techniques that may be important in the in vivo efficacy of these genes