431 research outputs found
Researching a segmented market:reflections on telephone interviewing
Purpose The purpose of this paper was to review the effectiveness of telephone interviewing for capturing data and to consider in particular the challenges faced by telephone interviewers when capturing information about market segments. Design/methodology/approach The platform for this methodological critique was a market segment analysis commissioned by Sport Wales which involved a series of 85 telephone interviews completed during 2010. Two focus groups involving the six interviewers involved in the study were convened to reflect on the researchers’ experiences and the implications for business and management research. Findings There are three principal sets of findings. First, although telephone interviewing is generally a cost-effective data collection method, it is important to consider both the actual costs (i.e. time spent planning and conducting interviews) as well as the opportunity costs (i.e. missed appointments, “chasing participants”). Second, researchers need to be sensitised to and sensitive to the demographic characteristics of telephone interviewees (insofar as these are knowable) because responses are influenced by them. Third, the anonymity of telephone interviews may be more conducive for discussing sensitive issues than face-to-face interactions. Originality/value The present study adds to this modest body of literature on the implementation of telephone interviewing as a research technique of business and management. It provides valuable methodological background detail about the intricate, personal experiences of researchers undertaking this method “at a distance” and without visual cues, and makes explicit the challenges of telephone interviewing for the purposes of data capture
THE RURAL POPULATION TURNROUND: A CASE STUDY OF NORTH DEVON
St. David's University College, Lampete
Beyond TTM and ABC: A Practice Perspective on Physical Activity Promotion for Adolescent Females from Disadvantaged Backgrounds
This paper builds on a growing body of literature on the promise of practice theory in understanding and promoting behavior change in society and develops upon Blue (2017) and Spotswood et al.’s (2019) rationale for evolving theories of practice into the domain of contemporary physical activity research. We begin by considering the intersectional nature of the problem. Statistics reveal that physical activity gradients exist based on gender, as well as socio-economic position. Women, girls, and disadvantaged populations report lower levels of activity than more affluent males and females. More problematic still is what StreetGames (2017) call the “double jeopardy”, where these characteristics intersect, intensifying the negative gradient. Our argument then comprises three parts. First, we provide a critical discussion of intervention studies seeking to transform exercise behavior amongst these populations. The issue we identify is that studies typically rely on behavior change models, such as the Transtheoretical Model (TTM) and the ABC framework. However, these models tend to take insufficient account of the practical and social aspects of behavior change in physical activity, and thus their subjects often succumb to value-action gaps (Shove, 2010). Second, in contrast, we propose that practice theory provides a promising alternative theoretical lens for promoting behavior change in disadvantaged and often resistant populations. Third, the paper highlights a range of conceptual considerations for exploring the relationship between young, disadvantaged women and physical activity, as well as the development of tangible solutions to improve participatio
Social Preferences, Skill Segregation and Wage Dynamics
We study the earning structure and the equilibrium asignment of workers to firms in a model in which workers have social preferences, and skills are perfectly substitutable in production. Firms offer long-term contracts, and we allow for frictions in the labour market in the form of mobility costs. The model delivers specific predictions about the nature of worker flows, about the characteristic of workplace skill segregation, and about wage dispersion both within and cross firms. We shows that long-term contracts in the resence of social preferences associate within-firm wage dispersion with novel "internal labour market" features such as gradual promotions, productivity-unrelated wage increases, and downward wage flexibility. These three dynamic features lead to productivity-unrelated wage volatily within firms.Publicad
Unveiling the Active Nucleus of Centaurus A
We report new HST WFPC2 and NICMOS observations of the center of the nearest
radio galaxy Centaurus A (NGC 5128) and discuss their implications for our
understanding of the active nucleus and jet. We detect the active nucleus in
the near-IR (K and H) and, for the first time, in the optical (I and V),
deriving the spectral energy distribution of the nucleus from the radio to
X-rays. The optical and part of the near-IR emission can be explained by the
extrapolation of the X-ray power law reddened by A_V~14mag, a value consistent
with other independent estimates.
The 20pc-scale nuclear disk discovered by Schreier et al. (1998) is detected
in the [FeII] 1.64mic line and presents a morphology similar to that observed
in Pa alpha with a [FeII]/Pa alpha ratio typical of low ionization Seyfert
galaxies and LINERs. NICMOS 3 Pa alpha observations in a 50"x50" circumnuclear
region suggest enhanced star formation (~0.3Msun/yr) at the edges of the
putative bar seen with ISO, perhaps due to shocks driven into the gas.
The light profile, reconstructed from V, H and K observations, shows that
Centaurus A has a core profile with a resolved break at ~4" and suggests a
black--hole mass of ~10^9 Msun. A linear blue structure aligned with the
radio/X-ray jet may indicate a channel of relatively low reddening in which
dust has been swept away by the jet.Comment: 19 pages, 13 figures, Astrophysical Journal, in press. High quality
figures available at http://www.arcetri.astro.it/~marconi/colpic.htm
A review to inform the assessment of the risk of collision and displacement in petrels and shearwaters from offshore wind developments in Scotland
The report presents a review of the published literature to collate and synthesise the existing evidence base for the assessment of the impacts of offshore wind farms and associated activities on three focal species: Manx Shearwater, European Storm-petrel and Leach's Storm-petrel. It identifies critical gaps in existing knowledge, outlines the challenges to filling data gaps, and makes recommendations for possible approaches for improving the existing evidence base. The report includes particular reference to Scotland's Sectoral Marine Plan Options, the specific risks posed to nocturnally active petrels and shearwaters by artificial lighting, and how light attraction may influence assessment of other risks (e.g. collision). Potential mitigation methods are outlined
Treatment with PBI-4050 in patients with Alström syndrome: study protocol for a phase 2, single-Centre, single-arm, open-label trial
Background
Alström syndrome (ALMS) is a very rare autosomal recessive monogenic disorder caused by a mutation in the ALMS1 gene and characterised by childhood onset obesity, dyslipidaemia, advanced non-alcoholic fatty liver disease, diabetes and extreme insulin resistance. There is evidence of multi-organ fibrosis in ALMS and severity of the disease often leads to organ failure with associated morbidities, resulting in reduced life expectancy. There are no specific treatments for this disease, and current management consists of only symptomatic therapies. PBI-4050 is a new molecular entity with demonstrated anti-inflammatory and anti-fibrotic activities in preclinical models, including animal models of human diseases characterized by progressive fibrosis in the kidney, heart, liver and lungs. Moreover, completed Phase 2 studies in type 2 diabetes mellitus with metabolic syndrome and idiopathic pulmonary fibrosis further support the anti-inflammatory and anti-fibrotic activity of PBI-4050. Together, these data suggest that PBI-4050 has the potential to treat the pathological inflammatory and fibrotic features of ALMS. The aim of this study is to evaluate the safety and anti-inflammatory and anti-fibrotic activities of PBI-4050 in subjects with ALMS.
Methods
This is a Phase 2, single-centre, single-arm, open-label trial. A total of 18 patients with ALMS will be enrolled to receive PBI-4050 at a total daily oral dose of 800 mg for an initial 24 weeks with continuation for an additional 36 or 48 weeks. Standard assessments of safety include adverse events, clinical laboratory tests, vital signs, physical examination and electrocardiograms. Efficacy assessments include adipose tissue biopsy, hyperinsulinaemic-euglycaemic glucose clamp, adipose tissue microdialysis, liver transient elastography, liver and cardiac magnetic resonance imaging, and laboratory blood tests.
Discussion
This is the first clinical study of PBI-4050 in subjects with ALMS. Given the rarity and complexity of the disease, a single-centre, single-arm, open-label design has been chosen to maximise subject exposure and increase the likelihood of achieving our study endpoints. The results will provide valuable safety and preliminary evidence of the effects of PBI-4050 in ALMS, a rare heterogeneous disease associated with progressive fibrosis and premature mortality.
Trial registration
The trial is registered on ClinicalTrials.gov (Identifier; NCT02739217, February 2016) and European Union Drug Regulating Authorities Clinical Trials (EudraCT Number 2015–001625-16, Sept 2015)
The central dark matter content of early-type galaxies: scaling relations and connections with star formation histories
We examine correlations between the masses, sizes, and star formation
histories for a large sample of low-redshift early-type galaxies, using a
simple suite of dynamical and stellar populations models. We confirm an
anti-correlation between size and stellar age, and survey for trends with the
central content of dark matter (DM). An average relation between central DM
density and galaxy size of ~ Reff^-2 provides the first clear
indication of cuspy DM haloes in these galaxies -- akin to standard LCDM haloes
that have undergone adiabatic contraction. The DM density scales with galaxy
mass as expected, deviating from suggestions of a universal halo profile for
dwarf and late-type galaxies. We introduce a new fundamental constraint on
galaxy formation by finding that the central DM fraction decreases with stellar
age. This result is only partially explained by the size-age dependencies, and
the residual trend is in the opposite direction to basic DM halo expectations.
Therefore we suggest that there may be a connection between age and halo
contraction, and that galaxies forming earlier had stronger baryonic feedback
which expanded their haloes, or else lumpier baryonic accretion that avoided
halo contraction. An alternative explanation is a lighter initial mass function
for older stellar populations.Comment: 24 pages, 23 figures. MNRAS, submitted with minor modifications
following referee report
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Do emotional difficulties and peer problems hew together from childhood to adolescence? The case of children with a history of developmental language disorder (DLD)
Children and adolescents with developmental language disorder (DLD) are, overall, vulnerable to difficulties in emotional adjustment and in peer relations. However, previous research has shown that different subgroups follow different trajectories in respect of quality of peer relations. Less is known of the trajectories of emotional development. We consider here the possibility that development in these two domains is interrelated: that is, the trajectories of emotional and peer problems will proceed in parallel. We conducted longitudinal joint trajectories analyses of emotional and peer relations in a sample of young people identified as having DLD at age 7 years and seen at intervals up to 16 years. Potential influences on joint trajectory group membership were examined. Findings revealed five distinct joint trajectories. Emotional and peer difficulties do hew together from childhood to adolescence for just over half of the sample, but not all. The variables most clearly associated with group membership were pragmatic language ability, prosociality and parental mental health. This is the first study to examine joint longitudinal trajectories of emotional and peer difficulties in individuals with DLD. We demonstrate that development in individuals with DLD is heterogeneous and identify three key variables associated with personal and social adjustment from childhood to adolescence. Theoretical and clinical implications of these findings are discussed
Exploring the cognitive features in children with autism spectrum disorder, their co-twins, and typically developing children within a population-based sample
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