Making the Digital Humanities More Open

BrailleSC will undertake its second stage of development by designing and deploying a WordPress-based accessibility tool that will create braille content for endusers who are blind or low vision. Specifically, we plan to extend the use of Anthologize--a free and open source plug-in for WordPress that currently translates any RSS text into PDF, ePub, HTML, or TEI--to include the conversion of text to braille. As a result, we will not only make it easy for content creators to convert a text into braille, thereby extending humanities content to hundreds of thousands of visually disabled readers, but we will also experiment with making braille available visually through the WordPress interface. In partnership with the Maryland Institute for Technology in the Humanities (MITH) at the University of Maryland, College Park, we will continue to model the ways in which digital humanities projects should be designed and implemented with the needs of disabled users in mind

The Art and Science of Networking Extension

As Extension professionals are increasingly tasked with moving beyond program delivery into the murky realm of systems change, networks represent an essential organizing framework for this transition. In this article, we examine the ways in which networks are becoming a modern mode for social change. By providing examples from our work with food networks, we demonstrate how these collaborative approaches can produce a greater impact for Extension and the communities we serve. Lastly, we discuss the critical characteristics of successful networks and the role Extension can play in their optimization

Gagliardi

This thesis is composed of the single novella 'Gagliardi" the germ of which was lodged in my head for over two years before I found a suitable way to release it. I had long imagined the prototype of the main character, who was in a heterosexual bind like Gagliardi, in a situation similar to the one which Mitch has to face in A Streetcar Named Desire; this was the what-if quality of my original, rather simple conception. The way to tell the story came to me in a flash while I was working in a sheet metal factory in Minnesota in the summer of 1971. First person narration was the only way to get my fictional juices flowing and to capture the repressed vitality of the main character. Things had finally opened up for me as they do for Gagliardi. Although a number of readers have found Gagliardi to be unsympathetic, I intended otherwise. Gagliardi will be sympathetic to the extent that the reader can empathize with the acuteness of his identity crisis vis-à-vis his repressive upbringing and environment towards which he feels so ambivalent. Red and Pete are naturally more sympathetic because they have less to learn about human suffering, but they are also involved in similar identity crises. The novella, then, can be seen as a dialectic, in a sense, between main characters who have arrived at varying degrees of compromise with or freedom from their upbringings and environments

Raman spectra of MgB2 at high pressure and topological electronic transition

Raman spectra of the MgB2 ceramic samples were measured as a function of pressure up to 32 GPa at room temperature. The spectrum at normal conditions contains a very broad peak at ~590 cm-1 related to the E2g phonon mode. The frequency of this mode exhibits a strong linear dependence in the pressure region from 5 to 18 GPa, whereas beyond this region the slope of the pressure-induced frequency shift is reduced by about a factor of two. The pressure dependence of the phonon mode up to ~ 5GPa exhibits a change in the slope as well as a "hysteresis" effect in the frequency vs. pressure behavior. These singularities in the E2g mode behavior under pressure support the suggestion that MgB2 may undergo a pressure-induced topological electronic transition.Comment: 2 figure

Electromagnetic absorption mechanisms in metal nanospheres: Bulk and surface effects in radiofrequency-terahertz heating of nanoparticles

The following article appeared in Journal of Applied Physics 109.12 (2011): 124306 and may be found at http://scitation.aip.org/content/aip/journal/jap/109/12/10.1063/1.3600222We report on the absorption of electromagnetic radiation by metallic nanoparticles in the radio and far infrared frequency range, and subsequent heating of nanoparticle solutions. A recent series of papers has measured considerable radio frequency (RF) heating of gold nanoparticle solutions. In this work, we show that claims of RF heating by metallic nanoparticles are not supported by theory. We analyze several mechanisms by which nonmagnetic metallic nanoparticles can absorb low frequency radiation, including both classical and quantum effects. We conclude that none of these absorption mechanisms, nor any combination of them, can increase temperatures at the rates recently reported. A recent experiment supports this finding.Support by the Spanish Ministerio de Ciencia e Innovación Grant No. FIS2008-04209 and the Swedish Foundation for Strategic Research (metamaterial Grant No. SSF RMA08-0109) is acknowledged

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

Activation of client proteins by the Hsp90 molecular chaperone is dependent on binding and hydrolysis of ATP, which drives a molecular clamp via transient dimerization of the N-terminal domains. The crystal structure of the middle segment of yeast Hsp90 reveals considerable evolutionary divergence from the equivalent regions of other GHKL protein family members such as MutL and GyrB, including an additional domain of new fold. Using the known structure of the N-terminal nucleotide binding domain, a model for the Hsp90 dimer has been constructed. From this structure, residues implicated in the ATPase-coupled conformational cycle and in interactions with client proteins and the activating cochaperone Aha1 have been identified, and their roles functionally characterized in vitro and in vivo

Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha

Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from nine patients with ATLL at the time of diagnosis and immediately after combination therapy with zidovudine (AZT) and interferon alpha (IFNalpha). GEPs were also related to genetic aberrations determined by comparative genomic hybridization. We identified several genes anomalously over-expressed in the ATLL leukemic cells at the mRNA level, including LYN, CSPG2, and LMO2, and confirmed LMO2 expression in ATLL cells at the protein level. In vivo AZT-IFNalpha therapy evoked a marked induction of interferon-induced genes accompanied by repression of cell-cycle regulated genes, including those encoding ribosomal proteins. Remarkably, patients not responding to AZT-IFNalpha differed most from responding patients in lower expression of these same IFN-responsive genes, as well as components of the antigen processing and presentation apparatus. Demonstration of specific gene expression signatures associated with response to AZT-IFNalpha therapy may provide novel insights into the mechanisms of action in ATLL

Seguridad de los Sistemas Informáticos Universitarios: : Retos Pendientes

The objective of this article is to analyze the security challenges of university computer systems. Methodologically, this article is descriptive and documentary and was based on the drafting of a series of security challenges for university computer systems. For the development of this article, a search was carried out in the Google Scholar database, in addition, the "specific interval" filter was indicated in this search engine, which corresponded to the period between 2018 and 2022, ordered by relevance. Specified by search string, language, and document type were subsequently dropped, certain books. Papers from a period of five years with respect to the date of completion of this research (2022) were included: journal articles (indexed), conference reports, book chapters, books and end-of-degree, master's and doctoral theses. The search was based on three criteria: title, abstract and keywords (the most used were: computer systems, university, computer security, computer security policies, among others). It is concluded that the security challenges of computer systems are: computer security management, establishment of computer security policies, application of standards, adoption of methodologies for the incorporation of computer security elements according to the university reality. , the establishment of legal frameworks, the establishment of a university government of technology, the training and training of collaborators, analysis of computer security vulnerabilities and finally, the need for the University to carry out external audits of its computer system.El objetivo de este artículo es analizar los retos de la seguridad de los sistemas informáticos de las universidades.  Metodológicamente, este artículo es descriptivo y documental y se basó en la redacción del planteamiento de una serie de retos de la seguridad de los sistemas informáticos universitarios.  Para el desarrollo de este artículo se realizó una búsqueda en la base de datos de Google Académico, además, se indicó en este motor de búsqueda el filtro de “intervalo específico”, que correspondió al período comprendido entre 2018 y 2022, ordenado por relevancia.  Se especificó mediante la cadena de búsqueda, el idioma y el tipo de documento; se descartaron posteriormente ciertos tipos de documentos. Se incluyeron trabajos de un período de cinco años respecto a la fecha de realización de esta investigación (2022): artículos de revistas (indexadas), informes de conferencias, capítulos de libros, libros y tesis de fin de grado, de maestría y doctorales.  La búsqueda estuvo basada en tres criterios: título, resumen y palabras clave (las más utilizadas fueron: sistemas informáticos, universidad, seguridad informática, políticas de seguridad informática, entre otras). Se concluye que los retos de la seguridad de los sistemas informáticos son: la gestión de la seguridad informática, el establecimiento de políticas de seguridad informática, aplicación de estándares, adopción de metodologías para la incorporación de los elementos de seguridad informática acordes a la realidad universitaria, el establecimiento de marcos jurídicos, el establecimiento de un gobierno universitario de tecnología, la formación y capacitación de los colaboradores, análisis de vulnerabilidades de la seguridad informática  y finalmente, se plantea la necesidad que tiene la Universidad de realizar auditorías externas a su sistema informático

Monitoring a simple hydrolysis process in an organic solid by observing methyl group rotation

We report a variety of experiments and calculations and their interpretations regarding methyl group (CH3) rotation in samples of pure 3-methylglutaric anhydride (1), pure 3-methylglutaric acid (2), and samples where the anhydride is slowly absorbing water from the air and converting to the acid [C6H8O3(1) + H2O → C6H10O4(2)]. The techniques are solid state 1H nuclear magnetic resonance (NMR) spin-lattice relaxation, single-crystal X-ray diffraction, electronic structure calculations in both isolated molecules and in clusters of molecules that mimic the crystal structure, field emission scanning electron microscopy, differential scanning calorimetry, and high resolution 1H NMR spectroscopy. The solid state 1H spin-lattice relaxation experiments allow us to observe the temperature dependence of the parameters that characterize methyl group rotation in both compounds and in mixtures of the two compounds. In the mixtures, both types of methyl groups (that is, molecules of 1 and 2) can be observed independently and simultaneously at low temperatures because the solid state 1H spin-lattice relaxation is appropriately described by a double exponential. We have followed the conversion 1 → 2 over periods of two years. The solid state 1H spin-lattice relaxation experiments in pure samples of 1 and 2 indicate that there is a distribution of NMR activation energies for methyl group rotation in 1 but not in 2 and we are able to explain this in terms of the particle sizes seen in the field emission scanning electron microscopy images

Family-level coparenting processes and child gender as moderators of family stress and toddler adjustment

The goal of this multi-method study was to examine how child gender and coparenting processes influence associations between family stress and toddlers' social adjustment. The participants, 104 dual-earner couples and their 2-year-old children, were videotaped in their home during a freeplay activity. Mothers and fathers completed questionnaires about stress in their roles as partners, workers, and parents and their child's social–emotional adjustment. Consistent with previous research, higher levels of family stress were associated with poorer adjustment for children. Family harmony, represented by warmth and cooperation, was significantly associated with fewer internalizing problems for children even when family stress was considered. Conversely, coparental banter or ‘playful humour’ between parents moderated the nature of the association between family stress and children's adjustment. Banter between parents was especially protective for girls suggesting that, even in families with toddler-aged children, gender plays an important role in family-level coparenting processes. Future research needs to consider more fully the impact that child characteristics, such as gender, have on the interplay between the family context and children's development. Copyright © 2008 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/61329/1/577_ftp.pd